Abstract：
:Fc-gamma receptor III (Fc gamma RIII, CD16) type A is expressed on natural killer cells, on a small subset of peripheral blood monocytes and on mature macrophages. Along with differentiation into macrophages, monocytes will express Fc gamma RIII when cultured with transforming growth factor-beta (TGF-beta). In view of the involvement of granulocyte-macrophage colony-stimulating factor (GM-CSF) in myeloid cell differentiation, we investigated the effect of this cytokine on Fc gamma RIII expression in cultures of peripheral blood monocytes. GM-CSF antagonized TGF-beta-induced expression of Fc gamma RIII on monocytes in vitro in a dose-dependent way. The effect of GM-CSF persisted in cultures until at least day 7. The suppression was at the mRNA level, as shown by Northern analyses with a CD16 specific probe, and the signalling pathway involved tyrosine kinase activity. Interferon-gamma and interleukin-2 had no effect on the induced expression of Fc gamma RIII by TGF-beta, while interleukin-4, similar to GM-CSF, antagonized this induction. Our findings suggest that regulatory cytokine networks can drive monocytes into different effector functions and differentiation pathways.
journal_name
Immunologyjournal_title
Immunologyauthors
Kruger M,Coorevits L,De Wit TP,Casteels-Van Daele M,Van De Winkel JG,Ceuppens JLsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
162-7issue
1eissn
0019-2805issn
1365-2567journal_volume
87pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:Microbial adjuvants are essential for the development of T-cell-dependent antibody production, recall T-cell proliferation and interferon-gamma production following immunization with protein antigens. Using an adoptive transfer approach, we showed that the adjuvant lipopolysaccharide enhanced the frequency of cells pr...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2007.02620.x
更新日期：2007-09-01 00:00:00
abstract：:Immunohistological techniques have been used to study the stromal cells of the human placenta in both the chorionic villous mesenchyme and the connective tissue underlying the amnion. Throughout gestation many of these cells express an antigen (3C10) that is found on mononuclear phagocytes but not on dendritic cells o...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-05-01 00:00:00
abstract：:Vitamin A and its active metabolite retinoic acid are essential for the development and function of many tissues including the immune system. The induction of mucosal homing receptors on T and B cells by mucosal dendritic cells (DC) depends on the presence of vitamin A. Recent studies indicate that also the differenti...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/imm.12228
更新日期：2014-05-01 00:00:00
abstract：:The intestine immune response in rats following immunization with horseradish peroxidase (HRP) was studied morphologically. Various routes of immunization (intraperitoneal, intravenous, intraenteric and intra-Peyer's patch) were tested. Single injections did not evoke any specific antibody-containing (anti-HRP) cells ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1983-09-01 00:00:00
abstract：:Undesired immunological responses to products of therapeutic gene replacement have been obstacles to successful gene therapy. Understanding such responses of the host immune system to achieve immunological tolerance to a transferred gene product is therefore crucial. In this article, we review relevant studies of immu...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2009.03069.x
更新日期：2009-05-01 00:00:00
abstract：:Donor mice were painted on the skin of the abdomen with the contact sensitizing agent, oxazolone. One day later 2-5 x 10(6) cells from the regional lymph nodes were injected into the footpads of recipient mice. Contact sensitivity was detected 6 days later by challenging the ears of the recipients and measuring the in...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
abstract：:Several functional parameters and surface markers were studied serially in rnu/rnu rats and compared to rnu/+ controls. Expressed as a percentage of labelled splenocytes, rnu/rnu animals had decreased W3/13 (P less than 0.01) and W3/25 (P less than 0.01) positive cells. Both W3/13 and W3/25 antigens peaked at Week 16 ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-08-01 00:00:00
abstract：:We identified CD8(+) CD122(+) regulatory T cells (CD8(+) CD122(+) Treg cells) and reported their importance in maintaining immune homeostasis. The absence of CD8(+) CD122(+) Treg cells has been shown to lead to severe systemic autoimmunity in several mouse models, including inflammatory bowel diseases and experimen...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12067
更新日期：2013-07-01 00:00:00
abstract：:Vaccination strategies that can block or limit heterosexual human immunodeficiency virus (HIV) transmissions to local and systemic tissues are the goal of much research effort. Herein, in a mouse model, we aimed to determine whether the enhancement of antibody responses through mucosal and systemic immunizations, prev...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2007.02702.x
更新日期：2008-03-01 00:00:00
abstract：:Anti-human milk fat globule membrane monoclonal antibodies HMFG-1 and HMFG-2 recognize epitopes within the protein core of human polymorphic epithelial mucin (PEM). These have been identified as PDTR and DTR, respectively. Using the solid phase synthesis of immobilized tetrameric peptides, we have systematically inves...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:The ability to expand tumour-infiltrating lymphocytes in vitro has been greatly enhanced by the use of antigen-independent mechanisms of immune cell costimulation. We have produced human, using the K562 cell line, and murine, using YAC-1 cells, artificial antigen presenting cells (aAPC) and demonstrate that these cell...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2004.01853.x
更新日期：2004-05-01 00:00:00
abstract：:The aim of this study was to examine the role of T cells on the alteration of terminal sugars of goblet cell mucins in the small intestinal mucosa of parasitized rats and to clarify the biological significance of the altered mucins in the mucosal defence against intestinal helminths. For this purpose, Nippostrongylus ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:It is now well accepted that sex hormones have immunoregulatory activity and may prevent exacerbations in multiple sclerosis during pregnancy. Our previous studies demonstrated that oestrogen (17β-oestradiol; E(2) ) protection against experimental autoimmune encephalomyelitis (EAE) is mediated mainly through oestrogen...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12013
更新日期：2012-12-01 00:00:00
abstract：:Dendritic cells (DC) are powerful inducers of primary T-cell responses, but their role in secondary responses has not been extensively analysed. Here, we address the role of two DC subsets derived from human CD16(+) (16(+) mDC) or CD16(-) (16(-) mDC) monocytes on the reactivation of memory responses. CD4(+) CD45RA(-) ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2007.02650.x
更新日期：2007-11-01 00:00:00
abstract：:Experiments were conducted to test the hypothesis that opsonic and non-opsonic phagocytic capacities are differentially regulated by resting and wound-derived macrophages. Furthermore, the phagocytosis of non-opsonized zymosan and beta-glucan particles was quantified to determine whether cells differentially regulate ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01291.x
更新日期：2001-10-01 00:00:00
abstract：:Generation of an effective cellular immune response is key to the successful development of both humoral and cellular immune defences against most pathogens. However, while the type of cellular immune response elicited by any given pathogen is dictated by the entire array of antigens and molecules which comprise that ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1998.00631.x
更新日期：1998-12-01 00:00:00
abstract：:This study demonstrated that the greater infectivity of stationary-phase promastigotes of Leishmania donovani is related to increased complement fixation on the parasite surface, resulting in increased binding to host mononuclear phagocytes (MPs) via complement type 3 receptors (CR3). The in vivo infectivity of log- a...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1987-04-01 00:00:00
abstract：:It is becoming increasingly clear that the T-cell-mediated immune response is important in many diseases. In this study, we used concanavalin A (Con A) -induced hepatitis to investigate the role of CD49a in the molecular and cellular mechanism of the T-cell-mediated immune response. We found that CD49a(-/-) mice had s...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12201
更新日期：2014-03-01 00:00:00
abstract：:A positive association has been observed in Igh allotype "congenic' mice between skin graft rejection and a block to effective T--B co-operation in the development of both IgM and IgG responses to sheep erythrocytes. Mismatch of Igh alone is insufficient for such a block to become apparent since pairs of Igh-allotype ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
abstract：:Deficiency in gammadelta T cells aggravates colitis in animal models suggesting that gammadelta T cells have regulatory properties. Therefore, proliferation, suppression and cytokine secretion of human gammadelta T cells were determined in vitro. Human peripheral gammadelta T cells were isolated from the whole blood o...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2009.03162.x
更新日期：2009-12-01 00:00:00
abstract：:We explored the mechanisms of class B CpG-oligodeoxynucleotide-induced antitumour effects against weakly immunogenic tumours. Treatment with CpG-oligodeoxynucleotide 1826 (CpG) induced similar antitumour effects in B16 melanoma-bearing immunocompetent C57BL/6 mice and T-cell-deficient severe combined immunodeficient (...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2006.02517.x
更新日期：2007-03-01 00:00:00
abstract：:Cytokines and their receptors represent key targets for therapeutic intervention. Ligands are being used to supplement cell numbers that become depleted as a result of disease (organ failure, infection) or subsequent disease treatments (i.e. chemotherapy). Conversely, the inhibition of target cell binding by cytokines...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2004.01886.x
更新日期：2004-06-01 00:00:00
abstract：:Programmed death-1 (PD-1) plays an important role in protecting against inflammation and myocyte damage in T-cell-mediated myocarditis. To understand whether fibrinogen-like protein-2 (FGL2) can affect the role of the PD-1/PD-L1 pathway in experimental autoimmune myocarditis (EAM), we investigated cardiac function in ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12837
更新日期：2018-02-01 00:00:00
abstract：:We have previously reported that the 20-mer peptide p2340 (amino acids 2340-2359), of human thyroglobulin (Tg) has the unique feature that it causes experimental autoimmune thyroiditis (EAT) in mouse strains bearing high-responder (HR) or low-responder (LR) MHC haplotypes in Tg-induced EAT. In this study, we have empl...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2011.03538.x
更新日期：2012-03-01 00:00:00
abstract：:Specific and non-specific IgE antibody responses were studied in SD rats infected with between 5 and 2500 Nippostrongylus brasiliensis (NB) larvae. In rats with 2500 NB larvae, specific IgE antibody, measured by enzyme-linked immunosorbent assay (ELISA) using NB excretory/secretory substance as antigen, reached a peak...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The concept of immunological tolerance--the state of specific unresponsiveness to allogeneic transplants and all manner of other antigens--began in 1945 with R.D. Owen's finding that cattle dizygotic twins are red blood cell chimeras. Peter Medawar's group in Birmingham likewise discovered, quite independently, that c...
journal_title：Immunology
pub_type： 历史文章,杂志文章,评审
doi：10.1111/imm.12567
更新日期：2016-03-01 00:00:00
abstract：:The molecular characteristics of a serum IL-2 inhibitor were determined by fractionating active sera from normal and malaria-infected mice, and assaying inhibitory activity in blocking production and expression of IL-2 activity. Using isoelectric focusing and ion exchange chromatography, the activity resolved in a sin...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-09-01 00:00:00
abstract：:The soluble cytoplasmic fraction of an homogenate from peritoneal rat mast cells, demonstrated a considerable amount of catalytic activity which promotes the transfer of phosphate from creatine phosphate to ADP. The plasma membrane, mitochondrial and microsomal fractions show negligible amounts of the catalyst. Enzyme...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：:The role of T-cell receptor (TCR) gammadelta T cells in the induction of protective TCR alphabeta T cells against infection by the intracellular bacteria Listeria monocytogenes was analysed. We found that depletion of gammadelta T cells by anti-TCR delta monoclonal antibody treatment before intravenous immunization of...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1998.00593.x
更新日期：1998-10-01 00:00:00
abstract：:The effect of long chain and medium chain fatty acid absorption on transport and mitogen-induced blast transformation of lymphocytes in intestinal lymphatics was investigated. Intestinal lymph was collected from mesenteric lymph duct cannulated rats maintained in Bollman's cage. Following the intraduodenal administrat...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
