Appearance of the LAT protein at an early stage of B-cell development and its possible role.

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease that involves dysregulation of B and T cells. A tolerogenic peptide, designated hCDR1, ameliorates disease manifestations in SLE-afflicted mice. In the present study, the effect of treatment with hCDR1 on the CD74/macrophage migration inhibitory factor (MIF) ...

journal_title：Immunology

authors： Lapter S,Ben-David H,Sharabi A,Zinger H,Telerman A,Gordin M,Leng L,Bucala R,Shachar I,Mozes E

更新日期：2011-01-01 00:00:00

abstract：:A superantigen (Streptococcus pyogenes mitogen-2; SPM-2) that stimulates human helper T cells bearing unique types of variable domains of T-cell receptor beta-chain (TCR V beta) was isolated from the culture supernatant of S. pyogenes strain T12. The active molecule isolated by diethylaminoethyl (DEAE)-cellulose chrom...

journal_title：Immunology

authors： Rikiishi H,Okamoto S,Sugawara S,Tamura K,Liu ZX,Kumagai K

更新日期：1997-07-01 00:00:00

abstract：:Anti-Gal is the most abundant natural antibody in humans, constituting ~ 1% of immunoglobulins. Anti-Gal is naturally produced also in apes and Old World monkeys. The ligand of anti-Gal is a carbohydrate antigen called the 'α-gal epitope' with the structure Galα1-3Galβ1-4GlcNAc-R. The α-gal epitope is present as a maj...

journal_title：Immunology

authors： Galili U

更新日期：2013-09-01 00:00:00

abstract：:Chemokines and their receptors regulate cell migration to sites of inflammation. The glucocorticoid dexamethasone has potent anti-inflammatory effects, yet paradoxically up-regulates expression of some cytokine receptors. We have examined the effects of dexamethasone on chemokine receptor expression. Using an RNase pr...

journal_title：Immunology

authors： Caulfield J,Fernandez M,Snetkov V,Lee T,Hawrylowicz C

更新日期：2002-02-01 00:00:00

abstract：:The genes coding for the main molecules involved in the human immune system--immunoglobulins, human leucocyte antigen (HLA) molecules and killer-cell immunoglobulin-like receptors (KIR)--exhibit a very high level of polymorphism that reveals remarkable frequency variation in human populations. 'Genetic marker' (GM) al...

journal_title：Immunology

authors： Sanchez-Mazas A,Fernandez-Viña M,Middleton D,Hollenbach JA,Buhler S,Di D,Rajalingam R,Dugoujon JM,Mack SJ,Thorsby E

更新日期：2011-06-01 00:00:00

abstract：:We have previously reported that human granulocyte-macrophage colony-stimulating factor (hGM-CSF) causes a stage-specific inhibition of T-cell receptor (TCR) alphabeta cell development in the thymus of transgenic mice constitutively expressing the hGM-CSF receptor. Since it has been reported that the addition of inter...

journal_title：Immunology

authors： Yasuda Y,Kaneko A,Nishijima I,Miyatake S,Arai K

更新日期：2002-06-01 00:00:00

abstract：:The CD40 ligand (gp39) is transiently expressed on activated CD4+ T cells and mediates cognate helper function by interacting with CD40 on B cells. Increasing evidence suggests, however, critical involvement of gp39 not only in antibody-mediated responses but also in the development of effector T cells. Here, we have ...

journal_title：Immunology

authors： Carayanniotis G,Masters SR,Noelle RJ

更新日期：1997-03-01 00:00:00

abstract：:The effect of cyclosporin A (CyA) on the response of murine splenocytes to B-cell mitogens, TI-1 and TI-2 antigens was investigated. The proliferative response to LPS was found to be four- to five-fold less sensitive to inhibition than that to dextran sulphate. Antibody responses to a TI-2 antigen in vivo were suppres...

journal_title：Immunology

authors： Higham AD,Sells RA,Marshall-Clarke S

更新日期：1986-10-01 00:00:00

abstract：:Injection of heat-killed Escherichia coli into rats results in massive loss of IgM + ve, IgD - ve B cells from the marginal zones of their spleen within 4 hr. This is matched by a concomitant increase of cells with this phenotype in the splenic follicles. The marginal zone remains depleted and the follicles distended ...

journal_title：Immunology

authors： Gray D,Kumararatne DS,Lortan J,Khan M,MacLennan IC

更新日期：1984-08-01 00:00:00

abstract：:Functional and phenotypic properties of porcine peripheral blood CD4/CD8 double-positive (DP) lymphocytes were examined. In cross-sectional and longitudinal studies involving a total of 103 pigs, this lymphocyte population was found to increase gradually in proportion with age, comprising < 2% of the total peripheral ...

journal_title：Immunology

authors： Zuckermann FA,Husmann RJ

更新日期：1996-03-01 00:00:00

abstract：:The role of oral-associated lymphoid tissues during induction of oral tolerance still remains elusive. Therefore, the aim was to compare T-cell activation and induction of tolerance to ovalbumin (OVA) presented through either of two routes; deposited into the oral cavity, or the stomach, thereby bypassing the oral cav...

journal_title：Immunology

authors： Bankvall M,Östberg AK,Jontell M,Wold A,Östman S

更新日期：2016-09-01 00:00:00

abstract：:alpha 1-Acid glycoprotein (AG), a serum component elevated during acute inflammation, has been implicated in the suppression of various immunological responses. Pretreatment of lymphoid cells with AG at a concentration commonly found in patients with acute inflammation results in the inhibition of mitogen induced lymp...

journal_title：Immunology

authors： Cheresh DA,Haynes DH,Distasio JA

更新日期：1984-03-01 00:00:00

abstract：:HIV infection is associated with increased representation of T cells bearing an activated, memory (CD45RO+) phenotype. Although administration of antiretroviral agents and interleukin-2 (IL-2) augment depleted CD4+ T-cell numbers, such therapies have been preferentially beneficial for CD45RO+ T cells. Interleukin-15 (...

journal_title：Immunology

authors： Naora H,Gougeon M

更新日期：1999-06-01 00:00:00

abstract：:Activated T cells, through the production of the receptor activator of NF-kappaB ligand (RANKL) cytokine, have been implicated in the osteoclast development and bone loss that are associated with autoimmune diseases such as rheumatoid arthritis. However, the cellular pathways that regulate the expression of RANKL and ...

journal_title：Immunology

authors： Gendron S,Boisvert M,Chetoui N,Aoudjit F

更新日期：2008-11-01 00:00:00

abstract：:The class distribution of 4193 monoclonal gammopathies (MG), detected over approximately 10 years in western France (WF), was compared to that established by a compilation of twenty-seven series from the literature. Several points emerged from this study: the incidence of the light chain MG (4.8%) was slightly lower t...

journal_title：Immunology

authors： Hurez D,Youinou P,Gombert J,Preud'Homme JL

更新日期：1985-11-01 00:00:00

abstract：:Recent studies in mice have highlighted the importance of polymorphic genetic loci such as the major histocompatibility complex (MHC) or minor lymphocyte-stimulating antigen (Mls) in determining the nature of the peripheral T-cell receptor (TcR) population. As our knowledge of the equivalent process in humans is incom...

journal_title：Immunology

authors： Loveridge JA,Rosenberg WM,Kirkwood TB,Bell JI

更新日期：1991-10-01 00:00:00

abstract：:Identifying the properties of a molecule involved in the efficient activation of the innate and adaptive immune responses that lead to long-lasting immunity is crucial for vaccine and adjuvant development. Here we show that the papaya mosaic virus (PapMV) is recognized by the immune system as a pathogen-associated mol...

journal_title：Immunology

authors： Acosta-Ramírez E,Pérez-Flores R,Majeau N,Pastelin-Palacios R,Gil-Cruz C,Ramírez-Saldaña M,Manjarrez-Orduño N,Cervantes-Barragán L,Santos-Argumedo L,Flores-Romo L,Becker I,Isibasi A,Leclerc D,López-Macías C

更新日期：2008-06-01 00:00:00

abstract：:Anti-idiotypic sera (aIds) were raised in C57BL/6 mice against monoclonal antibodies (McAbs) which bind poly(Tyr,Glu)-poly(DLAla)--poly(Lys)--abbreviated to (T,G)-A--L--and (Tyr-Tyr-Glu-Glu)-poly(DLAla)--poly(Lys)--abbreviated to (T-T-G-G)-A--L--(nos. 103 and 160) and McAbs which react only with (T-T-G-G)-A--L (nos. 1...

journal_title：Immunology

authors： Parhami-Seren B,Eshhar Z,Mozes E

更新日期：1984-02-01 00:00:00

abstract：:The opossum major histocompatibility complex (MHC) shares a similar organization with that of non-mammals while containing a diverse set of class I genes more like that of eutherian (placental) mammals. There are 11 class I loci in the opossum MHC region, seven of which are known to be transcribed. The previously desc...

journal_title：Immunology

authors： Baker ML,Melman SD,Huntley J,Miller RD

更新日期：2009-09-01 00:00:00

abstract：:Rat mast cells with the properties of mucosal mast cells (MMC) proliferate in cultures of haemopoietic tissue in the presence of conditioned medium (CM) from antigen- or mitogen-activated T lymphocytes. The present study shows that recombinant rat interleukin-3 (rIL-3) both stimulated the development of MMC from bone ...

journal_title：Immunology

authors： Haig DM,McMenamin C,Redmond J,Brown D,Young IG,Cohen SD,Hapel AJ

更新日期：1988-10-01 00:00:00

abstract：:Programmed death-1 (PD-1) plays an important role in protecting against inflammation and myocyte damage in T-cell-mediated myocarditis. To understand whether fibrinogen-like protein-2 (FGL2) can affect the role of the PD-1/PD-L1 pathway in experimental autoimmune myocarditis (EAM), we investigated cardiac function in ...

journal_title：Immunology

authors： Zheng Z,Yu Y,Potla R,Wu Y,Wu H

更新日期：2018-02-01 00:00:00

abstract：:When spleen cells of C57BL/6 mice or mast cell-deficient W/Wv mice were cultured, their histidine decarboxylase (HDC) activity increased with increases in the histamine concentration in the cells and the medium. Addition of concanavalin A (Con A) or Escherichia coli lipopolysaccharide (LPS) enhanced the increase. The ...

journal_title：Immunology

authors： Aoi R,Nakashima I,Kitamura Y,Asai H,Nakano K

更新日期：1989-02-01 00:00:00

abstract：:The role of Foxp3(+) regulatory T (Treg) cells in the course of the early hyper-inflammatory and subsequent hypo-inflammatory phases of sepsis is ambiguous. Whereas Nrp1 expression has been reported to discriminate natural Treg cells from induced Treg cells, the Treg cell stability depends on the methylation status of...

journal_title：Immunology

authors： Tatura R,Zeschnigk M,Hansen W,Steinmann J,Vidigal PG,Hutzler M,Pastille E,Westendorf AM,Buer J,Kehrmann J

更新日期：2015-09-01 00:00:00

abstract：:In this report the antigen and restriction specificity of human T-cell clones induced with Dermatophagoides farinae (D. farinae) and isolated from an atopic individual with perennial rhinitis has been investigated. Of the six clones analysed, four were species specific and two showed cross-reactivity for the closely r...

journal_title：Immunology

authors： O'Hehir RE,Eckels DD,Frew AJ,Kay AB,Lamb JR

更新日期：1988-08-01 00:00:00

abstract：:Ribonucleic acid (immune RNA, iRNA), extracted from the spleens of mice immunized with sheep red blood cells (SRBC), induced specific immunological memory. The humoral immune responses of iRNA-treated animals were compared with in vivo and in vitro primary and secondary responses, using the haemolytic plaque-forming c...

journal_title：Immunology

authors： Kodama K,Yoshida T,Shibiya T,Kurashige S,Mitsuhashi S

更新日期：1981-11-01 00:00:00

abstract：:Trypanosoma cruzi, the aetiological agent of Chagas disease, has a highly efficient detoxification system to deal with the oxidative burst imposed by its host. One of the antioxidant enzymes involved is the cytosolic tryparedoxin peroxidase (c-TXNPx), which catalyses the reduction to hydrogen peroxide, small-chain org...

journal_title：Immunology

authors： Girard MC,Acevedo GR,López L,Ossowski MS,Piñeyro MD,Grosso JP,Fernandez M,Hernández Vasquez Y,Robello C,Gómez KA

更新日期：2018-11-01 00:00:00

abstract：:The kinetics of ingestion and degradation of guinea-pig IgG2-containing soluble immune complexes by guinea-pig macrophages and neutrophils have been compared and aspects of the biochemical control of these events in neutrophils have been investigated using a selection of inhibitors. Differences were observed between t...

journal_title：Immunology

authors： Leslie RG,Coupland K

更新日期：1985-04-01 00:00:00

abstract：:In our efforts to identify products that might be used for active immunotherapy in human immunodeficiency virus (HIV) infection, we have studied synthetic peptides derived from the CD4 attachment site of gp120. Two peptides have emerged with particularly interesting properties. The first (B138) is linear and spans the...

journal_title：Immunology

authors： Morrow WJ,Williams WM,Whalley AS,Ryskamp T,Newman R,Kang CY,Chamat S,Köhler H,Kieber-Emmons T

更新日期：1992-04-01 00:00:00

abstract：:Mice simultaneously injected intravenously and subcutaneously with herpes simplex virus fail to adoptively transfer delayed hypersensitivity (DH) to syngeneic recipients. The transferred lymph node cells also failed to rapidly eliminate infectious herpes from the pinna, despite the presence of cytotoxic T cells in the...

journal_title：Immunology

authors： Nash AA,Ashford NP

更新日期：1982-04-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class II molecules present antigenic peptides derived from engulfed exogenous proteins to CD4(+) T cells. Exogenous antigens are processed in mature endosomes and lysosomes where acidic proteases reside and peptide-binding to class II alleles is favoured. Hence, maintenance of th...

journal_title：Immunology

authors： Crotzer VL,Glosson N,Zhou D,Nishino I,Blum JS

更新日期：2010-11-01 00:00:00