The regulation of DNAse activities in subcellular compartments of activated thymocytes.

abstract：:Macrophages play important roles in the clearance of dying and dead cells. Typically, and perhaps simplistically, they are viewed as the professional phagocytes of apoptotic cells. Clearance by macrophages of cells undergoing apoptosis is a non-phlogistic phenomenon which is often associated with actively anti-inflamm...

journal_title：Immunology

authors： Gregory CD,Devitt A

更新日期：2004-09-01 00:00:00

abstract：:The cytokine interleukin-12 (IL-12) is essential for resistance to Trypanosoma cruzi infection because it stimulates the synthesis of interferon-gamma (IFN-gamma), a major activator of the parasiticidal effect of macrophages. A less studied property of IL-12 is its ability to amplify the proliferation of T or natural ...

journal_title：Immunology

authors： Galvão da Silva AP,de Almeida Abrahamsohn I

更新日期：2001-11-01 00:00:00

abstract：:Individual young adult, middle-aged, and old C57BL/6J male mice were tested for in vitro generated proliferative and cytotoxic responses to H-2 alloantigens under a variety of sensitization conditions. Proliferation in mixed lymphocyte culture (MLC) had decreased by 14 months of age (middle-aged), whether measured by ...

journal_title：Immunology

authors： Gottesman SR,Kristie JA,Walford RL

更新日期：1981-11-01 00:00:00

abstract：:MRL/Mp-lpr/lpr (lpr/lpr) mice but not the congenic MRL/Mp-+/+ (+/+) mice, develop a generalized lymph node (LN) hypertrophy reflecting the expansion of a T-cell population that acts as an enhancing factor for autoimmunity. In order to characterize better this T-cell population, we investigated some of its surface prop...

journal_title：Immunology

authors： Dumont F,Habbersett RG

更新日期：1982-10-01 00:00:00

abstract：:BLT mice, constructed by surgical implantation of human fetal thymus-liver tissues and intravenous delivery of autologous CD34+ haematopoietic stem cells into adult non-obese diabetic/severe combined immunodeficiency mice, were evaluated for vaccine-induced humoral immune responses. Following engraftment, these mice d...

journal_title：Immunology

authors： Biswas S,Chang H,Sarkis PT,Fikrig E,Zhu Q,Marasco WA

更新日期：2011-12-01 00:00:00

abstract：:We have confirmed previous observations that intestinal anaphylaxis induced in rats previously sensitized to ovalbumin (OVA) is associated with an increased uptake of an unrelated 'bystander' protein, bovine serum albumin (BSA) fed 1 hr previously. In this study, this enhanced protein uptake was associated with an inc...

journal_title：Immunology

authors： Turner MW,Boulton P,Shields JG,Strobel S,Gibson S,Miller HR,Levinsky RJ

更新日期：1988-01-01 00:00:00

abstract：:The members of the tumour necrosis factor (TNF) superfamily of cytokines play important roles in the regulation of various immune-cell functions. Likewise, induction of cell death by apoptosis is indispensable for the normal functioning of the immune system. There are two major pathways of apoptosis induction. The int...

journal_title：Immunology

authors： Falschlehner C,Schaefer U,Walczak H

更新日期：2009-06-01 00:00:00

abstract：:We hypothesized that the addition of polymer to the surface of liposome/DNA complexes may potentially enhance in vivo delivery of plasmid DNA to antigen-presenting cells and thereby facilitate enhanced immune responses to encoded protein. BALB/c mice were immunized subcutaneously or intramuscularly three times with a ...

journal_title：Immunology

authors： Bramwell VW,Eyles JE,Somavarapu S,Alpar HO

更新日期：2002-07-01 00:00:00

abstract：:The activation of guinea-pig eosinophils was studied by measuring the production of superoxide anion (O2-) and the secretion of eosinophil peroxidase (EPO). Phorbol myristate acetate (PMA), calcium ionophore, plasma-activated zymosan, concanavalin A and recombinant human anaphylatoxin C5a induced the release of varyin...

journal_title：Immunology

authors： Bach MK,Brashler JR

更新日期：1992-04-01 00:00:00

abstract：:Fc-gamma receptor III (Fc gamma RIII, CD16) type A is expressed on natural killer cells, on a small subset of peripheral blood monocytes and on mature macrophages. Along with differentiation into macrophages, monocytes will express Fc gamma RIII when cultured with transforming growth factor-beta (TGF-beta). In view of...

journal_title：Immunology

authors： Kruger M,Coorevits L,De Wit TP,Casteels-Van Daele M,Van De Winkel JG,Ceuppens JL

更新日期：1996-01-01 00:00:00

abstract：:Long-term bovine lymphocyte cultures were initiated by stimulation with alloantigens and maintained in continuous culture using medium containing recombinant human interleukin-2 (rh IL-2). The development of specific and lectin-dependent killing was monitored following primary alloantigen challenge. Cytolytic activity...

journal_title：Immunology

authors： Carter J,Magnuson NS,Davis WC,Mason PH,Magnuson JA,Talmadge JE,Barr PJ

更新日期：1986-01-01 00:00:00

abstract：:The B-cell development in a group of rats was suppressed for the first 45 days of life by serial administration of rabbit anti-rat IgM and IgD antibody. Total or near total suppression of B lymphopoiesis was achieved. At 45 days, suppression was stopped by injection of IgM and IgD rat paraproteins. The sequence of B-c...

journal_title：Immunology

authors： Bazin H,Platteau B,Maclennan IC,Johnson GD

更新日期：1985-01-01 00:00:00

abstract：:Selective Alzheimer disease indicator-1 (seladin-1) is a broadly expressed oxidoreductase and is related to Alzheimer disease, cholesterol metabolism and carcinogenesis. The effect of lipopolysaccharide (LPS) on the expression of seladin-1 was examined using RAW 264.7 macrophage-like cells and murine peritoneal macrop...

journal_title：Immunology

authors： Khuda II,Koide N,Noman AS,Dagvadorj J,Tumurkhuu G,Naiki Y,Komatsu T,Yoshida T,Yokochi T

更新日期：2010-09-01 00:00:00

abstract：:Interleukin-16 (IL-16) acts as a chemoattractant for CD4+ cells, as a modulator of T-cell activation, and plays a key role in asthma. This report describes the cytokine-inducing effects of IL-16 on total peripheral blood mononuclear cells (PBMC) and PBMC subpopulations. While CD4+ T lymphocytes did not secrete cytokin...

journal_title：Immunology

authors： Mathy NL,Scheuer W,Lanzendörfer M,Honold K,Ambrosius D,Norley S,Kurth R

更新日期：2000-05-01 00:00:00

abstract：:The CD40 ligand (gp39) is transiently expressed on activated CD4+ T cells and mediates cognate helper function by interacting with CD40 on B cells. Increasing evidence suggests, however, critical involvement of gp39 not only in antibody-mediated responses but also in the development of effector T cells. Here, we have ...

journal_title：Immunology

authors： Carayanniotis G,Masters SR,Noelle RJ

更新日期：1997-03-01 00:00:00

abstract：:Random-bred TO mice have been selectively bred into two lines on the basis of the relative affinity (KR) of antibody produced to protein antigens, one line producing high and the other low KR antibody. After four generations of selective breeding the difference in KR between the two lines was highly significant (P les...

journal_title：Immunology

authors： Katz FE,Steward MW

更新日期：1975-09-01 00:00:00

abstract：:Mouse lymph node cells cultured with Concanavalin A (Con A) in serum-free medium containing 59Fe-transferrin took up 59Fe more rapidly than cells cultured without Con-A. Uptake of iron commenced rapidly and preceded the onset of DNA synthesis in stimulated cells. Total uptake of transferrin during culture was much low...

journal_title：Immunology

authors： Brock JH,Rankin MC

更新日期：1981-06-01 00:00:00

abstract：:Antiserum specific for hamster thymus-derived lymphocytes, prepared by immunization of rabbits with brain tissue from MHA/ssLAK hamsters, was, in the presence of guinea-pig complement, cytotoxic to hamster thymocytes greater than lymph node cells greater than spleen cells, while virtually unreactive against bone marro...

journal_title：Immunology

authors： Blasecki JW,Houston KJ

更新日期：1978-07-01 00:00:00

abstract：:Human neutrophils express Toll-like receptor 4 (TLR4) at low levels, and the role of this receptor in neutrophil responses to microbial stimuli has been questioned. Genetic manipulation of these cells to enable the study of the role of proteins such as TLR4 in their function is challenging. Here, we show that primary ...

journal_title：Immunology

authors： Dick EP,Prince LR,Prestwich EC,Renshaw SA,Whyte MK,Sabroe I

更新日期：2009-06-01 00:00:00

abstract：:Cocultures of dispersed human fetal liver cells with murine Swiss 3T3 fibroblasts resulted in the development of human mast cells after 1 to 4 weeks of culture. Mast cells were detected by immunohistochemistry using a murine monoclonal anti-tryptase antibody, before metachromasia appeared with toluidine blue. When sub...

journal_title：Immunology

authors： Irani AA,Craig SS,Nilsson G,Ishizaka T,Schwartz LB

更新日期：1992-09-01 00:00:00

abstract：:Identifying the properties of a molecule involved in the efficient activation of the innate and adaptive immune responses that lead to long-lasting immunity is crucial for vaccine and adjuvant development. Here we show that the papaya mosaic virus (PapMV) is recognized by the immune system as a pathogen-associated mol...

journal_title：Immunology

authors： Acosta-Ramírez E,Pérez-Flores R,Majeau N,Pastelin-Palacios R,Gil-Cruz C,Ramírez-Saldaña M,Manjarrez-Orduño N,Cervantes-Barragán L,Santos-Argumedo L,Flores-Romo L,Becker I,Isibasi A,Leclerc D,López-Macías C

更新日期：2008-06-01 00:00:00

abstract：:Francisella tularensis is a Gram-negative intracellular bacterium that is the causative agent of tularaemia. Concerns regarding its use as a bioterrorism agent have led to a renewed interest in the biology of infection, host response and pathogenesis. A robust T-cell response is critical to confer protection against F...

journal_title：Immunology

authors： Valentino MD,Maben ZJ,Hensley LL,Woolard MD,Kawula TH,Frelinger JA,Frelinger JG

更新日期：2011-03-01 00:00:00

abstract：:When cultured on a collagen matrix at a density of 7 X 10(4) cells/cm2 for 48 hr, 80 +/- 10% of unfractionated and 70 +/- 14% of T-enriched human blood lymphocytes from eight healthy individuals developed a motile morphology defined as the presence of lamellar surface activity and cytoplasmic flattening. During cultur...

journal_title：Immunology

authors： Sundqvist KG,Otteskog P

更新日期：1986-07-01 00:00:00

abstract：:Over the past 10 years we have made great strides in our understanding of T helper cell differentiation, expansion and effector functions. Within the context of T helper type 2 (Th2) cell development, novel innate-like cells with the capacity to secrete large amounts of interleukin-5 (IL-5), IL-13 and IL-9 as well as ...

journal_title：Immunology

authors： Okoye IS,Wilson MS

更新日期：2011-12-01 00:00:00

abstract：:Antigen-induced allergic airway inflammation is mediated by T helper type 2 (Th2) cells and their cytokines, but the mechanism that initiates the Th2 immunity is not fully understood. Recent studies show that basophils play important roles in initiating Th2 immunity in some inflammatory models. Here we explored the ro...

journal_title：Immunology

authors： Zhong W,Su W,Zhang Y,Liu Q,Wu J,Di C,Zhang Z,Xia Z

更新日期：2014-06-01 00:00:00

abstract：:Functional studies on heteroantisera raised against mouse B cells in rabbits suggest a correlation between thymus-independent B cells and LPS-responsive B cells, and differences in either from thymus-dependent B cells. Furthermore it seems possible to follow B-lymphocyte differentiation from antigen-uncommitted precur...

journal_title：Immunology

authors： Gorczynski RM

更新日期：1977-05-01 00:00:00

abstract：:Forssman antiserum produced in rabbits immunized with sheep erythrocyte stromata was found to contain an IgG antibody which inhibited both passive anaphylactic sensitization of guinea-pig lung and also histamine-releasing activity of soluble immune complexes. This Forssman antibody did not itself cause histamine rele...

journal_title：Immunology

authors： Duravetz J,Baumal R,Broder I

更新日期：1976-01-01 00:00:00

abstract：:Lymphocytes are heterogeneous with respect to their life-span. Typical B cells, bearing on their membranes immunoglobulin receptors, easily detectable by immunofluorescence, belong mainly to the long-lived population: this can be observed using combined autoradiography and immunofluorescence. However, when primed mice...

journal_title：Immunology

authors： Hooghe V,Urbain-Vansanten G,Richard C,Urbain J

更新日期：1975-05-01 00:00:00

abstract：:Despite the capacity for antigen-specific activation and rapid clonal expansion, homeostatic mechanisms ensure that the mature immune system contains a relatively stable number of T cells. In recent years, it has become apparent that this stability is a consequence of apoptotic death of most of the specific T cells ge...

journal_title：Immunology

authors： O'Flaherty E,Wong WK,Pettit SJ,Seymour K,Ali S,Kirby JA

更新日期：2000-07-01 00:00:00

abstract：:We have characterized two unusual T-cell hybridomas, 1E3 and 3B8, from H-2k mice immunized with I-Ab-transfected L cells (H-2k), that are stimulated by L cells transfected with I-Ab, I-Ak or I-Eb, but not by non-transfected L cells. These hybridomas could not be stimulated by spleen cells from H-2i3, H-2k, H-2b or H-2...

journal_title：Immunology

authors： Mendiratta SK,Singh N,Bal V,Rath S

更新日期：1996-10-01 00:00:00