Abstract：
:Over the past 10 years we have made great strides in our understanding of T helper cell differentiation, expansion and effector functions. Within the context of T helper type 2 (Th2) cell development, novel innate-like cells with the capacity to secrete large amounts of interleukin-5 (IL-5), IL-13 and IL-9 as well as IL-4-producing and antigen-processing basophils have (re)-emerged onto the type 2 scene. To what extent these new players influence αβ+ CD4+ Th2 cell differentiation is discussed throughout this appraisal of the current literature. We highlight the unique features of Th2 cell development, highlighting the three necessary signals, T-cell receptor ligation, co-stimulation and cytokine receptor ligation. Finally, putting these into context, microbial and allergenic properties that trigger Th2 cell differentiation and how these influence Th2 effector function are discussed and questioned.
journal_name
Immunologyjournal_title
Immunologyauthors
Okoye IS,Wilson MSdoi
10.1111/j.1365-2567.2011.03497.xsubject
Has Abstractpub_date
2011-12-01 00:00:00pages
368-77issue
4eissn
0019-2805issn
1365-2567journal_volume
134pub_type
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