当前位置： SCI文献检索 > IMMUNOLOGY期刊下所有文献 > T-cell activation. V. Anti-major histocompatibility complex class I antibody-induced activation and clonal abortion in Jurkat T-leukaemic cells.

T-cell activation. V. Anti-major histocompatibility complex class I antibody-induced activation and clonal abortion in Jurkat T-leukaemic cells.

Abstract：

:We have studied activation-induced changes in intracellular calcium [Ca2+]i, interleukin-2 (IL-2) secretion, and clonal abortion of the human leukaemic T-cell line Jurkat and three T-cell receptor (TcR)/CD3 receptor negative clones deficient for the TcR alpha, TcR beta and CD3 gamma chains respectively, as well as three transfectant clones reconstituted with the appropriate TcR/CD3 cDNA. For activation, the cells were exposed to anti-TcR/CD3, anti-CD2 and anti-major histocompatibility complex (anti-MHC) class I monoclonal antibodies (mAb) respectively. Cellular activation by these mAb leading to an increased IL-2 secretion was preceded by a rise in [Ca2+]i and was relatively dependent on the expression of the a TcR/CD3 complex. In contrast, anti-MHC class I mAb-induced clonal abortion in Jurkat T cells may occur without previous fluctuations in [Ca2+]i and appeared to be independent of TcR/CD3 expression. The present observation suggest the existence of different secondary messenger systems operating in Jurkat cells following activation via the TcR/CD3, CD2 and the MHC class I pathways, respectively.

journal_name

Immunology

journal_title

Immunology

authors

Claesson MH,Dissing S,Tscherning T,Geisler C

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

444-8

issue

3

eissn

0019-2805

issn

1365-2567

journal_volume

78

pub_type

杂志文章

相关文献

IMMUNOLOGY文献大全
  • Th1 and Th2 cell involvement in immune response to Salmonella typhimurium porins.

    abstract：:In understanding the regulation of the specific immune response to Salmonella typhimurium, the role of a surface major component (porins) was studied. In this study we demonstrate that purified porins are able to induce a different response to that induced by the porins present on the S. typhimurium cell surface. Pori...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2567.1998.00492.x

    authors： Galdiero M,De Martino L,Marcatili A,Nuzzo I,Vitiello M,Cipollaro de l'Ero G

    更新日期：1998-05-01 00:00:00

  • Heteroantisera prepared against B lymphocytes at different stages of differentiation. II. Functional analysis of cytotoxicity to different B-cell populations.

    abstract：:Functional studies on heteroantisera raised against mouse B cells in rabbits suggest a correlation between thymus-independent B cells and LPS-responsive B cells, and differences in either from thymus-dependent B cells. Furthermore it seems possible to follow B-lymphocyte differentiation from antigen-uncommitted precur...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Gorczynski RM

    更新日期：1977-05-01 00:00:00

  • Production of type-1 and type-2 cytokines by peripheral blood mononuclear cells of psoriatic patients.

    abstract：:We investigated the function of peripheral blood mononuclear cells (PBMC) in 16 patients with active psoriasis, in 15 patients with static psoriasis and in 27 healthy volunteers, by examining in vitro proliferation and antigen- and mitogen-stimulated production of interleukin-2 (IL-2) and IL-4. Plasma levels of the ne...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Mozzanica N,Cattaneo A,Trabattoni D,Finzi AF,Schmitt E,Ferrario E,Clerici M,Vignati G,Villa ML

    更新日期：1995-11-01 00:00:00

  • Complement activation by interaction of polyanions and polycations.

    abstract：:Interactions between heparin and protamine in normal human serum previously were found to activate the primary complement pathway and deplete the early-acting complement components. In the present investigation, the role of heparin-protamine complexes, immunoglobulins, C1q and C1-INH in this interaction was studied. H...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Fiedel BA,Rent R,Myhrman R,Gewurz H

    更新日期：1976-02-01 00:00:00

  • Embryonic stem cell-derived haematopoietic progenitor cells down-regulate the CD3 ξ chain on T cells, abrogating alloreactive T cells.

    abstract：:Murine embryonic stem (ES) cell-derived haematopoietic progenitor cells (HPCs) engraft and populate lymphoid organs. In vivo, HPCs engraft across MHC barriers protecting donor-type allografts from rejection. However, the underlying phenomenon remains elusive. Here, we sought to determine the mechanism by which ES cell...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：10.1111/imm.12268

    authors： Kim EM,Miyake B,Aggarwal M,Voetlause R,Griffith M,Zavazava N

    更新日期：2014-07-01 00:00:00

  • Mature monocyte-derived dendritic cells respond more strongly to CCL19 than to CXCL12: consequences for directional migration.

    abstract：:The chemokine receptor CCR7 is crucial for migration of mature dendritic cells (DC) directed toward secondary lymphoid organs; however, there is little knowledge about the function of the homeostatic chemokine receptor CXCR4 in DC and its contribution to directional migration of DC during inflammation. By comparing th...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2567.2005.02292.x

    authors： Humrich JY,Humrich JH,Averbeck M,Thumann P,Termeer C,Kämpgen E,Schuler G,Jenne L

    更新日期：2006-02-01 00:00:00

  • Increased sensitivity to antigen in high avidity CD8(+) T cells results from augmented membrane proximal T-cell receptor signal transduction.

    abstract：:The functional avidity of a cytotoxic T lymphocyte (CTL) is known to be a critical determinant of the efficacy with which it clears pathogens. High avidity cells, which are by definition highly sensitive to peptide antigen, are superior for elimination of viruses and tumours. Our studies have established the ability o...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2567.2011.03440.x

    authors： Sharma SK,Alexander-Miller MA

    更新日期：2011-07-01 00:00:00

  • Defined chemically cross-linked oligomers of human C-reactive protein: characterization and reactivity with the complement system.

    abstract：:Chemically cross-linked C-reactive protein (CRP) oligomers were prepared and characterized, and C1q binding and C activation were investigated. Purified human CRP was polymerized in the presence of both non-cleavable and cleavable cross-linking agents and further separated by Superose 12 analytical FPLC column chromat...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Jiang H,Lint TF,Gewurz H

    更新日期：1991-12-01 00:00:00

  • CXCR4 expression on monocytes is up-regulated by dexamethasone and is modulated by autologous CD3+ T cells.

    abstract：:Chemokines and their receptors regulate cell migration to sites of inflammation. The glucocorticoid dexamethasone has potent anti-inflammatory effects, yet paradoxically up-regulates expression of some cytokine receptors. We have examined the effects of dexamethasone on chemokine receptor expression. Using an RNase pr...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：10.1046/j.0019-2805.2001.01359.x

    authors： Caulfield J,Fernandez M,Snetkov V,Lee T,Hawrylowicz C

    更新日期：2002-02-01 00:00:00

  • Activation, survival and apoptosis of CD45RO+ and CD45RO- T cells of human immunodeficiency virus-infected individuals: effects of interleukin-15 and comparison with interleukin-2.

    abstract：:HIV infection is associated with increased representation of T cells bearing an activated, memory (CD45RO+) phenotype. Although administration of antiretroviral agents and interleukin-2 (IL-2) augment depleted CD4+ T-cell numbers, such therapies have been preferentially beneficial for CD45RO+ T cells. Interleukin-15 (...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2567.1999.00807.x

    authors： Naora H,Gougeon M

    更新日期：1999-06-01 00:00:00

  • Regulation of allotype expression in heterozygous rabbits. I. Concomitant modulation of cell surface allotypes on peripheral blood lymphocytes from b4b6 rabbits.

    abstract：:Treatment of b4b6 rabbit peripheral blood lymphocytes with b5b5 anti-b4 antibodies at 4 degrees resulted in the modulation (disappearance) ob b4 and b6 cell surface allotype after subsequent incubation in serum-free medium for 1 h at 37 degrees. A clear dose dependence on the sensitizing anti-b4 antibody was observed....

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Kimball ES,Wolf B

    更新日期：1978-04-01 00:00:00

  • Relative immunogenicity of hepatitis B virus-encoded antigens as targets for cytotoxic T-cell response.

    abstract：:To analyse the immunological mechanism of hepatocellular injury in hepatitis B virus (HBV) infection, the immunoreactivity of HBV-encoded antigens as a target for cytotoxic T lymphocyte (CTL) response was examined using recombinant vaccinia virus (RVV) expressing surface protein (S), precore/core protein (PC), and cor...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Ishikawa T,Kakumu S,Yoshioka K,Yamada M,Tanaka K,Higashi Y,Takayanagi M,Okumura A,Kojima A,Tamura T

    更新日期：1993-10-01 00:00:00

  • The serum polymeric IgA antibody response to typhoid vaccination; its relationship to the intestinal IgA response.

    abstract：:The relationship between the IgA antibody response in serum (total and polymeric IgA) and intestinal secretions was examined in volunteers subjected to oral and parenteral typhoid vaccination. After oral vaccination (three doses of 10(11) live Ty21a vaccine given at 48-hr intervals), serum pIgA antibody to typhoid lip...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Bartholomeusz RC,Forrest BD,Labrooy JT,Ey PL,Pyle D,Shearman DJ,Rowley D

    更新日期：1990-02-01 00:00:00

  • The relation between the cell-mediated immunological response and the induction of circulating antibodies to collagen in guinea-pigs.

    abstract：:Cutaneous delayed hypersensitivity reactions to collagen in guinea-pigs were partially but specifically suppressed if the animals had been pretreated with collagen and Freund's incomplete adjuvant. Such animals responded normally to skin-reactive factor prepared with ovalbumin. Lymphoid cells from animals with normal ...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Gentner GJ,Adelmann BC

    更新日期：1976-07-01 00:00:00

  • Collagen-induced arthritis in B10.RIII mice (H-2r): identification of an arthritogenic T-cell determinant.

    abstract：:Susceptibility to collagen-induced arthritis (CIA), a murine model of autoimmune arthritis, is strongly linked to only two major histocompatibility complex (MHC) haplotypes, H-2q and H-2r. In order to identify the determinants of type II collagen (CII) required to induce arthritis in H-2r-bearing mice, B10.RIII mice w...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Myers LK,Miyahara H,Terato K,Seyer JM,Stuart JM,Kang AH

    更新日期：1995-04-01 00:00:00

  • Apoptosis of macrophages during pulmonary Mycobacterium bovis infection: correlation with intracellular bacillary load and cytokine levels.

    abstract：:Apoptosis of macrophages infected with pathogenic mycobacteria is an alternative host defence capable of removing the environment supporting bacterial growth. In this work the influence of virulence and bacterial load on apoptosis of alveolar macrophages during the initial phase of infection by Mycobacterium bovis was...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2567.2009.03062.x

    authors： Rodrigues MF,Barsante MM,Alves CC,Souza MA,Ferreira AP,Amarante-Mendes GP,Teixeira HC

    更新日期：2009-09-01 00:00:00

  • Inhibition by chloroquine of the class II major histocompatibility complex-restricted presentation of endogenous antigens varies according to the cellular origin of the antigen-presenting cells, the nature of the T-cell epitope, and the responding T cell.

    abstract：:Chloroquine treatment of antigen-presenting cells (APC) was explored as a tool to investigate the processing pathway for major histocompatibility complex (MHC) class II-restricted presentation of the endogenous secreted hen egg lysozyme (HEL) and transmembrane measles virus haemagglutinin (HA). A 72-hr pretreatment of...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Lombard-Platlet S,Bertolino P,Deng H,Gerlier D,Rabourdin-Combe C

    更新日期：1993-12-01 00:00:00

  • Ige antibody formation in BALB/c mice without adjuvant: induction of responses to grass pollen extract and to a hapten-carrier conjugate.

    abstract：:The IgE antibody responses of inbred BALB/c mice to subcutaneously injected antigens, given without adjuvant, were studied. Cocksfoot grass pollen extract (GPE) (100-100,000 pnu) induced no detectable primary IgE antibody responses but following second and subsequent injections, substantial secondary responses were pr...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Taylor WA,Sheldon D,Francis DH

    更新日期：1980-04-01 00:00:00

  • Mast cells are activated by Staphylococcus aureus in vitro but do not influence the outcome of intraperitoneal S. aureus infection in vivo.

    abstract：:Staphylococcus aureus is a major pathogen that can cause a broad spectrum of serious infections including skin infections, pneumonia and sepsis. Peritoneal mast cells have been implicated in the host response towards various bacterial insults and to provide mechanistic insight into the role of mast cells in intraperit...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：10.1111/imm.12297

    authors： Rönnberg E,Johnzon CF,Calounova G,Garcia Faroldi G,Grujic M,Hartmann K,Roers A,Guss B,Lundequist A,Pejler G

    更新日期：2014-10-01 00:00:00

  • The role of donor T cells for target organ injuries in acute and chronic graft-versus-host disease.

    abstract：:Donor T cells are crucial for target organ injury in graft-versus-host disease (GVHD). We examined the effects of donor T cells on the target organs using a parent-into-F1 model of acute and chronic GVHD. Donor T cells showed engraftment in the spleen, small intestine and liver of mice with acute GVHD, causing typical...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2567.2001.01240.x

    authors： Kataoka Y,Iwasaki T,Kuroiwa T,Seto Y,Iwata N,Hashimoto N,Ogata A,Hamano T,Kakishita E

    更新日期：2001-07-01 00:00:00

  • Recovery from chemically induced thymus atrophy starts with CD4- CD8- CD2high TcR alpha beta-/low thymocytes and results in an increased formation of CD4- CD8- TcR alpha beta high thymocytes.

    abstract：:Regeneration of the thymus was studied in rats that were treated with a single oral dose of the organotin compound di-n-butyltin dichloride (DBTC). After an initial maximum depletion of cortical BrdU+ thymocytes on day 2 after treatment, repopulation appeared to start on day 3 as indicated by an increased number of Br...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Pieters RH,Bol M,Lam BW,Seinen W,Bloksma N,Penninks AH

    更新日期：1993-04-01 00:00:00

  • Lymphatic mast cells in response to in vitro stimulation by non-specific T-cell mitogens.

    abstract：:Activation of lymph nodes by the T-cell mitogens PHA and Con A is correlated with a depletion of lymphatic mast cells. This result, and our earlier reports on the depletion of mast cells in lymph nodes stimulated by allogeneic and tumour cells, as well as on the elevation of mast cell number in thymus-less 'nude' mice...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Włodarski K,Rychlik G,Mazur S

    更新日期：1985-06-01 00:00:00

  • The liver as an immunological barrier redefined by single-cell analysis.

    abstract：:The liver is a front-line immune tissue that plays a major role in the detection, capture and clearance of pathogens and foreign antigens entering the bloodstream, especially from the gut. Our largest internal organ maintains this immune barrier in the face of constant exposure to external but harmless antigens throug...

    journal_title：Immunology

    pub_type： 杂志文章,评审

    doi：10.1111/imm.13193

    authors： Stamataki Z,Swadling L

    更新日期：2020-06-01 00:00:00

  • Interleukin-16 stimulates the expression and production of pro-inflammatory cytokines by human monocytes.

    abstract：:Interleukin-16 (IL-16) acts as a chemoattractant for CD4+ cells, as a modulator of T-cell activation, and plays a key role in asthma. This report describes the cytokine-inducing effects of IL-16 on total peripheral blood mononuclear cells (PBMC) and PBMC subpopulations. While CD4+ T lymphocytes did not secrete cytokin...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2567.2000.00997.x

    authors： Mathy NL,Scheuer W,Lanzendörfer M,Honold K,Ambrosius D,Norley S,Kurth R

    更新日期：2000-05-01 00:00:00

  • Non-precipitating guinea-pig antibodies as products of limited recognition of antigenic sites on the ovalbumin molecule.

    abstract：:The non-precipitating guinea-pig IgG1 and IgG2 antibodies, produced by administration of an excessive dose of hen ovalbumin (OA), were capable of forming only certain soluble complexes having molar ratios of antibody to antigen lower than 1-5:1, which were lower than the minimum ratio of 2-5:1 shown by anti-OA antibod...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Tamoto K,Koyama J

    更新日期：1976-07-01 00:00:00

  • Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses.

    abstract：:Cytokines and their receptors represent key targets for therapeutic intervention. Ligands are being used to supplement cell numbers that become depleted as a result of disease (organ failure, infection) or subsequent disease treatments (i.e. chemotherapy). Conversely, the inhibition of target cell binding by cytokines...

    journal_title：Immunology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2567.2004.01886.x

    authors： Sivakumar PV,Foster DC,Clegg CH

    更新日期：2004-06-01 00:00:00

  • Effect of 22-32 carbon n-3 polyunsaturated fatty acids on superoxide production in human neutrophils: synergism of docosahexaenoic acid with f-met-leu-phe and phorbol ester.

    abstract：:Docosahexaenoic (22:6 n-3) and eicosapentaenoic acid (20:5 n-3) stimulated the oxygen-dependent respiratory burst in intact neutrophils in a dose-dependent manner as measured by either superoxide dismutase (SOD)-inhibitable cytochrome c reduction and lucigenin-dependent chemiluminescence. A number of longer chain hexa...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Poulos A,Robinson BS,Ferrante A,Harvey DP,Hardy SJ,Murray AW

    更新日期：1991-05-01 00:00:00

  • Monocytes mediate shaving of B-cell-bound anti-CD20 antibodies.

    abstract：:Anti-CD20 monoclonal antibodies are promising for the treatment of B-cell malignancies such as chronic lymphocytic leukaemia and autoimmune diseases where auto-antibodies play an important role. Anti-CD20 such as rituximab (RTX) mediates B-cell depletion through mechanisms such as complement-mediated cytotoxicity and ...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2567.2011.03434.x

    authors： Pedersen AE,Jungersen MB,Pedersen CD

    更新日期：2011-06-01 00:00:00

  • Trypanosoma cruzi induces suppression of DNA synthesis and inhibits expression of interleukin-2 receptors by stimulated human B lymphocytes.

    abstract：:Trypanosoma cruzi, the causative agent of Chagas' disease, suppresses immune responses during the acute phase and has been shown to induce multiple cellular alterations in activated human T lymphocytes. However, no information is available regarding the effects of this parasite on human B cells. Using an in vitro cult...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Kierszenbaum F,Moretti E,Sztein MB

    更新日期：1991-10-01 00:00:00

  • Interleukin-3 production as a sensitive measure of T-lymphocyte activation in the mouse.

    abstract：:Interleukin-3 activity is produced by T cells at an early phase after antigenic stimulation, and its quantitation provides a sensitive and non-destructive method for assaying T-cell activation. It can be detected before increased uptake of [3H]thymidine into DNA occurs, and is more sensitive than measuring [3H]thymidi...

    journal_title：Immunology

    pub_type： 杂志文章

    doi：

    authors： Dotsika EN,Sanderson CJ

    更新日期：1987-12-01 00:00:00