Abstract：
:MRL/Mp-lpr/lpr (lpr/lpr) mice but not the congenic MRL/Mp-+/+ (+/+) mice, develop a generalized lymph node (LN) hypertrophy reflecting the expansion of a T-cell population that acts as an enhancing factor for autoimmunity. In order to characterize better this T-cell population, we investigated some of its surface properties in comparison with those of +/+ T cells. Electrophoretic measurements revealed that lpr/lpr T cells possess a lower electronegative surface charge than %/% T cells which indicates that the two cell types differ in the molecular composition of their plasmic membrane periphery. This notion was substantiated by the quantification of T- and B-cell markers and of lectin-binding sites on these cells using single- and two-colour flow cytofluorimetry. In agreement with recent observations by Lewis, Giorgi & Warner (1981) lpr/lpr T cells exhibited lower levels of Thy-1 and Lyt-1 antigens than +/+ T cells and were mostly devoid of Lyt-2 antigen. Although lpr/lpr lymph node (LN) cells displayed similar amounts of surface receptors for peanut agglutinin as +/+ LN cells, the expression of surface receptors for other lectins were either lower (Limulus polyphemus agglutinin, Maclura pomifera agglutinin, Concanavalin A) or higher (Helix pomatia agglutinin, Soya bean agglutinin, Bandeiraea simplicifolia agglutinin I, Phytohaemagglutinin L) on lpr/lpr T cells than on +/+ T cells. These data indicate that the T cells accumulating in hypertrophied lpr/lpr LN are endowed with unique surface characteristics which may explain some of the functional abnormalities of these cells.
journal_name
Immunologyjournal_title
Immunologyauthors
Dumont F,Habbersett RGsubject
Has Abstractpub_date
1982-10-01 00:00:00pages
271-81issue
2eissn
0019-2805issn
1365-2567journal_volume
47pub_type
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