The Toll-like receptor 1/2 agonists Pam(3) CSK(4) and human β-defensin-3 differentially induce interleukin-10 and nuclear factor-κB signalling patterns in human monocytes.

abstract：:Despite extensive investigation of the signals required for development of T helper type 1 (Th1) and type 2 (Th2) immune responses, the mechanisms involved are still not well-defined. A critical role for Epstein-Barr virus-induced gene 3 (EBI3) in these responses has been proposed. EBI3, initially discovered as a tran...

journal_title：Immunology

authors： Dokmeci E,Xu L,Robinson E,Golubets K,Bottomly K,Herrick CA

更新日期：2011-04-01 00:00:00

abstract：:Ribonucleic acid (RNA) extracts were obtained from lymph nodes of guinea-pigs that had previously been immunized with a purified testicular antigen emulsified in Freund's complete adjuvant. The RNA extracts were incubated with normal guinea-pig peritoneal exudate cells (NGP-PEC). After treatment, the NGP-PEC cells sho...

journal_title：Immunology

authors： Fainboim L,Sztein MB,Serrate S,Satz L

更新日期：1979-10-01 00:00:00

abstract：:Previous studies in our laboratory have shown that bone-marrow-derived mast cells (BMMC) could present immunogenic peptides, from soluble antigens endocytosed through fluid phase, only if they were subjected to a 48-hr treatment with interleukin-4 (IL-4) and granulocyte-macrophage colony-stimulating factor (GM-CSF). I...

journal_title：Immunology

authors： Tkaczyk C,Villa I,Peronet R,David B,Mécheri S

更新日期：1999-06-01 00:00:00

abstract：:The non-specific normal immunosuppressive protein (Nip) has been described in our laboratory and its biological activity was extensively studied. In the present study, further purification analyses of Nip were conducted. Fractionation of Nip by Ultrogel AcA 34 column resulted in peak (I) that displayed Nip activity in...

journal_title：Immunology

authors： Gavison-Goren R,Nelken D

更新日期：1983-08-01 00:00:00

abstract：:The induction of T-cell growth by the T-cell antigen receptor (TcR) is dependent on a co-ordinated process of phosphorylation and dephosphorylation of intracellular proteins. An intermediary in this signalling pathway is the serine kinase, p42 mitogen-activated protein kinase (p42MAPK), also known as microtubule-assoc...

journal_title：Immunology

authors： Amaral MC,Casillas AM,Nel AE

更新日期：1993-05-01 00:00:00

abstract：:The antibody response in rhino mice, which carry a mutant gene hrrh, to thymus-dependent (TD) or thymus-independent (TI) antigens was compared with that of phenotypically normal littermates. The magnitude of antibody response to TD antigens in rhino mice decreased as they grew up, whereas the antibody response to TI a...

journal_title：Immunology

authors： Takaoki M,Kawaji H

更新日期：1980-05-01 00:00:00

abstract：:Intestinal inflammatory disease or infection often results in the loss of the epithelial layer as a result mainly of the action of proteases, including the leucocyte serine proteinases (neutrophil elastase), lysosomal cathepsins and the matrix metalloproteinases from recruited inflammatory cells. Previous studies have...

journal_title：Immunology

authors： Miller TL,McGee DW

更新日期：2002-01-01 00:00:00

abstract：:Membrane sialoglycoprotein (GP) of mouse erythrocytes were incorporated into artificial membranes of liposomes which also contained DNP-aminocaproylphosphatidylethanolamine hapten. The liposomes were tested for their potential to modulate the anti-hapten antibody response in mice as a plausible model of haptenated iso...

journal_title：Immunology

authors： Hitsumoto Y,Hineno T,Utsumi S

更新日期：1984-12-01 00:00:00

abstract：:It has been reported previously that environmental antigens such as intestinal microflora play an important role in an age-associated increase in number of T-cell receptor gamma/delta-bearing T cells. To extend the scope of this finding, this study examined the influences of local inflammation on the accumulation and/...

journal_title：Immunology

authors： Yoshikai Y,Matsuzaki G,Inoue T,Nomoto K

更新日期：1990-05-01 00:00:00

abstract：:Incubation of sensitized mononuclear cells from patients with schistosomiasis with specific antigen containing a suspension of viable Schistosoma haematobium ova resulted in the release of a soluble factor which was chemotactic for eosinophils. Production of this substance was detectable at 24 h and demonstrated peak ...

journal_title：Immunology

authors： Wadee AA,Sher R

更新日期：1980-12-01 00:00:00

abstract：:We have previously reported that placental macrophages of fetal origin have a decreased ability to present antigen. To clarify the underlying mechanism for this deficiency, we have generated primary fetal macrophage cell lines. Our data show that despite their defective antigen-presenting ability, fetal macrophages do...

journal_title：Immunology

authors： Khalili H,Deshpande R,Chang MY

更新日期：1997-12-01 00:00:00

abstract：:Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is an important molecule in the down-regulation of T-cell activation. A study was undertaken to evaluate the association of the CTLA-4 gene polymorphisms -319C/T, +49A/G, (AT)(n), CT60A/G and Jo31G/T with the levels of membrane CTLA-4 (mCTLA-4) and cytoplasmic CTLA-4 (cCTLA-4)...

journal_title：Immunology

authors： Karabon L,Kosmaczewska A,Bilinska M,Pawlak E,Ciszak L,Jedynak A,Jonkisz A,Noga L,Pokryszko-Dragan A,Koszewicz M,Frydecka I

更新日期：2009-09-01 00:00:00

abstract：:We have established lines and clones of helper T cells specific for the antigen fowl gamma globulin (FGG) and maintained these cells in continuous proliferation in vitro for up to 8 months. During this period the specific helper activity was assessed in vitro in T cell-dependent anti-hapten responses. These pure popul...

journal_title：Immunology

authors： Cammisuli S,Schreier MH

更新日期：1981-07-01 00:00:00

abstract：:Paratyphoid vaccine injected between 4 days and 3 hours before injection of labelled immune complexes (125-I-labelled BGG-anti-BGG), inhibits follicular trapping of these complexes in the mouse spleen. Inhibition is maximal when paratyphoid vaccine is given 1 day before, almost no label being found in the spleen folli...

journal_title：Immunology

authors： van Rooijen N

更新日期：1975-06-01 00:00:00

abstract：:Dendritic cells (DCs) operate as the link between innate and adaptive immunity. Their expression of pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and C-type lectin receptors (CLRs), enables antigen recognition and mediates appropriate immune responses. Distinct subsets of human DCs have been...

journal_title：Immunology

authors： Lundberg K,Rydnert F,Greiff L,Lindstedt M

更新日期：2014-06-01 00:00:00

abstract：:Mouse models of multiple sclerosis (MS) have shown the importance of interleukin-10 (IL-10) -producing regulatory B (Breg) cells in dampening disease activity and inhibiting disease initiation and progression. In MS and other autoimmune diseases decreased frequency and functionality of Breg cells correlate with diseas...

journal_title：Immunology

authors： Lundqvist S,Modvig S,Fischer EA,Frederiksen JL,Degn M

更新日期：2019-03-01 00:00:00

abstract：:Long-term bovine lymphocyte cultures were initiated by stimulation with alloantigens and maintained in continuous culture using medium containing recombinant human interleukin-2 (rh IL-2). The development of specific and lectin-dependent killing was monitored following primary alloantigen challenge. Cytolytic activity...

journal_title：Immunology

authors： Carter J,Magnuson NS,Davis WC,Mason PH,Magnuson JA,Talmadge JE,Barr PJ

更新日期：1986-01-01 00:00:00

abstract：:Immunoregulatory CD4(-)  CD8(-) (double-negative; DN) T cells exhibit a unique antigen-specific mode of suppression, yet the ontogeny of DN T cells remains enigmatic. We have recently shown that 3A9 T-cell receptor (TCR) transgenic mice bear a high proportion of immunoregulatory 3A9 DN T cells, facilitating their stud...

journal_title：Immunology

authors： Dugas V,Chabot-Roy G,Beauchamp C,Guimont-Desrochers F,Hillhouse EE,Liston A,Lesage S

更新日期：2013-05-01 00:00:00

abstract：:The role of anti-idiotypic subclass-specific antibodies was analysed in the regulation of the immune response to BCG in the guinea-pig. The idiotypes to BCG were separated into subclasses and anti-idiotypes were carried out by immunizing with the purified IgG1 and IgG2 anti-idiotypes. The in vivo T cell response was r...

journal_title：Immunology

authors： Daus H,Hammer HJ,Rajki K,Mauch H

更新日期：1984-08-01 00:00:00

abstract：:The natural response of immunocompetent adult animals to antigen inhalation is the development of T-lymphocyte mediated tolerance, particularly in the IgE-antibody class (Holt & Sedgwick, 1987). It has been suggested that this process functions as a protective mechanism to limit sensitization to aeroallergens. In the ...

journal_title：Immunology

authors： Holt PG,Vines J,Britten D

更新日期：1988-04-01 00:00:00

abstract：:Purified human and murine monocytes can be activated in vitro by human recombinant IL-2 to secrete tumour necrosis factor (TNF). TNF mRNA is detected within 4 h of addition of IL-2. Signal transduction does not appear to require expression of the Tac peptide of the IL-2 receptor. IL-2 does, however, induce Tac mRNA an...

journal_title：Immunology

authors： Economou JS,McBride WH,Essner R,Rhoades K,Golub S,Holmes EC,Morton DL

更新日期：1989-08-01 00:00:00

abstract：:We have previously shown that a subset of human osteoblast-like bone surface cells (HBC) derived from explants of trabecular bone constitutively express class II major histocompatibility complex (MHC) determinants in long-term culture. We now examine the capacity of HBC to stimulate allogeneic and autologous periphera...

journal_title：Immunology

authors： Skjødt H,Møller T,Freiesleben SF

更新日期：1989-11-01 00:00:00

abstract：:Major histocompatibility complex (MHC) alleles acting as immune response genes are coexpressed in heterozygous individuals and therefore control of immune responses is usually codominant. As an exception to this rule, however, several examples of recessive immune responses have been ascribed to regulatory, e.g. suppre...

journal_title：Immunology

authors： Barcenas-Morales G,Merkenschlager M,Wahid F,Döffinger R,Ivanyi J

更新日期：2000-02-01 00:00:00

abstract：:The anti-C6 monoclonal antibody WU 6-4 was shown to be unequivocally native restricted since it neither binds to the terminal complement complex (TCC) nor to C5b6. In addition, it was shown to inhibit TCC formation by interfering with C5b6 generation. Using the pUEX expression system and C6 cDNA the WU 6-4 epitope was...

journal_title：Immunology

authors： Würzner R,Mewar D,Fernie BA,Hobart MJ,Lachmann PJ

更新日期：1995-06-01 00:00:00

abstract：:B-lymphocyte maturation is considered to be independent of the thymus. However, there is circumstantial evidence suggesting that it may be impaired in nude animals that lack the thymus. Our study shows that the proportion of immature B-lymphocyte subsets (CD90(high) IgM(high) and CD90(high) IgM(low)) was significantly...

journal_title：Immunology

authors： Milićević NM,Nohroudi K,Milićević Z,Hedrich HJ,Westermann J

更新日期：2005-11-01 00:00:00

abstract：:The output and immunoglobulin class of antibody-containing cells (ACC) in lymph from different regions of adult sheep has been compared following intraperitoneal or subcutaneous injection of ovalbumin in Freund's complete adjuvant (FCA). Intraperitoneal injection of antigen in FCA elicited no response at all in poplit...

journal_title：Immunology

authors： Beh KJ,Lascelles AK

更新日期：1981-04-01 00:00:00

abstract：:Colorectal cancer is considered a non-immunogenic malignany. One strategy to augment the immunogenicity of such tumours is represented by the expression of costimulatory molecules by gene transfer. Using transfected variants of the human colorectal cancer cell line SW480 we tested various costimulatory molecules (CD80...

journal_title：Immunology

authors： Lindauer M,Rudy W,Gückel B,Doeberitz MV,Meuer SC,Moebius U

更新日期：1998-03-01 00:00:00

abstract：:The composition of the microbiome in health and disease has only recently become a major research focus. Although it is clear that an imbalance or dysbiosis in the microbiota is associated with disease, its interrelatedness to disease penetrance is largely unknown. Inflammatory bowel disease (IBD) is an excellent dise...

journal_title：Immunology

authors： Ray A,Dittel BN

更新日期：2015-11-01 00:00:00

abstract：:The class distribution of 4193 monoclonal gammopathies (MG), detected over approximately 10 years in western France (WF), was compared to that established by a compilation of twenty-seven series from the literature. Several points emerged from this study: the incidence of the light chain MG (4.8%) was slightly lower t...

journal_title：Immunology

authors： Hurez D,Youinou P,Gombert J,Preud'Homme JL

更新日期：1985-11-01 00:00:00

abstract：:The vitamin D receptor (VDR) is a nuclear receptor expressed in a number of different cells of the immune system. This study was performed to determine the effect of VDR deficiency on immune function and inflammation of the gastrointestinal tract in a model of inflammatory bowel disease, namely interleukin-10 (IL-10) ...

journal_title：Immunology

authors： Froicu M,Zhu Y,Cantorna MT

更新日期：2006-03-01 00:00:00