Studies in the rat of antibody-coated and N-ethylmaleimide-treated erythrocyte clearance by the spleen. II. Effects of immune complex infusion.

abstract：:With an increase in the importance of umbilical cord blood (CB) as an alternative source of haematopoietic progenitors for allogenic transplantation, donor lymphocyte infusion (DLI) with donor CB-derived activated CD4(+) T cells in the unrelated CB transplantation setting is expected to be of increased usefulness as a...

journal_title：Immunology

authors： Miyagawa Y,Kiyokawa N,Ochiai N,Imadome K,Horiuchi Y,Onda K,Yajima M,Nakamura H,Katagiri YU,Okita H,Morio T,Shimizu N,Fujimoto J,Fujiwara S

更新日期：2009-11-01 00:00:00

abstract：:The contribution of gut-associated lymphoid tissue (GALT) to the local immune response in the respiratory mucosa of sheep has been investigated. Sheep were primed intraperitoneally (i.p.) with antigen in Freund's complete adjuvant, a procedure known to produce a large IgA-specific antibody-containing cell (ACC) respon...

journal_title：Immunology

authors： Scicchitano R,Husband AJ,Clancy RL

更新日期：1984-10-01 00:00:00

abstract：:We studied the immunoregulatory mechanisms of responsiveness and non-responsiveness to hepatitis B (HB) vaccine by analysing the influence of HB surface antigen (HBsAg) on lymphokine- or mitogen-stimulated peripheral lymphocytes from healthy volunteers. Stimulation with pokeweed mitogen (PWM) led to a reduced producti...

journal_title：Immunology

authors： Knöller I,Hoffmann UJ,Werchau HH,König W

更新日期：1990-11-01 00:00:00

abstract：:The human histocompatibility leucocyte antigen (HLA) class II-associated invariant chain comprises at least four polypeptides. One of these is expressed as a membrane-bound subunit and has been designated as CD74. We investigated the expression of CD74 on B- and T-cell types utilizing monoclonal antibodies (mAb) speci...

journal_title：Immunology

authors： Wilson KM,Labeta MO,Pawelec G,Fernandez N

更新日期：1993-06-01 00:00:00

abstract：:Silica, or silicon dioxide, has been shown to be toxic for macrophages. This is probably because it damages phagolysosomal membranes, allowing lysosomal enzymes to disrupt the cell. Neutrophils also take up particles such as silica and in addition they contain lysosomes. The purpose of this study was to determine whet...

journal_title：Immunology

authors： Zimmerman BT,Canono BP,Campbell PA

更新日期：1986-12-01 00:00:00

abstract：:Staphylococcal protein A is a cell wall-attached polypeptide that acts as a B-lymphocyte superantigen. This activation correlates with specific VH gene segment usage in the B-cell receptor. B-cell receptor assembled from members of the VH3 family in humans, or S107 family in mice, has an intrinsic affinity for protein...

journal_title：Immunology

authors： Feijó GC,Sabbaga J,Carneiro CR,Brígido MM

更新日期：1997-07-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) pathway is an important integrator of nutrient-sensing signals in all mammalian cells, and acts to coordinate the cell proliferation with the availability of nutrients such as glucose, amino acids and energy (oxygen and ATP). A large part of the immune response depends on the p...

journal_title：Immunology

authors： Cobbold SP

更新日期：2013-12-01 00:00:00

abstract：:The glucocorticoid-induced tumour necrosis factor receptor family related gene (GITR) has been reported to be expressed on the activated T and CD4(+)CD25(+) regulatory T cells (Treg). Signalling triggered by GITR not only neutralizes the suppressive effect of Treg cells, but also augments activation, proliferation and...

journal_title：Immunology

authors： Lee SK,Choi BK,Kim YH,Kang WJ,Kim KH,Sakaguchi S,Suh JH,Kim TY,Kwon BS

更新日期：2006-12-01 00:00:00

abstract：:IgM was purified from normal human colostrum and salivary secretions devoid of IgA. The isolated immunoglobulin was found to contain J chain, and showed a slight affinity for free secretory component (SC). In the secretions IgM was saturated with SC, but only 60--70 per cent of the molecules had retained the component...

journal_title：Immunology

authors： Brandtzaeg P

更新日期：1975-09-01 00:00:00

abstract：:When mice were homozygous for the Wf allele at W locus, the delayed-type hypersensitivity (DTH) reaction observed in mice primed i.v. or s.c. with optimal doses of sheep red blood cells was greatly decreased. The number of sensitized splenic cells able to transfer a delayed-type hypersensitivity reaction was identical...

journal_title：Immunology

authors： Marchal G,Milon G,Guénet JL

更新日期：1980-02-01 00:00:00

abstract：:In general, the majority of bacteria are pre-inflammatory when injected in experimental animals. However, Mycobacterium leprae has no inflammatory effect when injected into mouse footpad, but using the delipidated mycobacteria we observed a mild significant increase in footpad oedema. Other mycobacteria, Mycobacterium...

journal_title：Immunology

authors： Moura AC,Mariano M

更新日期：1996-12-01 00:00:00

abstract：:Mucosa-associated invariant T (MAIT) cells express the semi-invariant T-cell receptor TRAV1-2 and detect a range of bacteria and fungi through the MHC-like molecule MR1. However, knowledge of the function and phenotype of bacteria-reactive MR1-restricted TRAV1-2(+) MAIT cells from human blood is limited. We broadly ch...

journal_title：Immunology

authors： Sharma PK,Wong EB,Napier RJ,Bishai WR,Ndung'u T,Kasprowicz VO,Lewinsohn DA,Lewinsohn DM,Gold MC

更新日期：2015-07-01 00:00:00

abstract：:To date, the most potent mucosal vaccine adjuvants to be identified have been bacterial toxins. The present data demonstrate that the type 2 ribosome-inactivating protein (type 2 RIP), mistletoe lectin I (ML-I) is a strong mucosal adjuvant of plant origin. A number of plant lectins were investigated as intranasal (i.n...

journal_title：Immunology

authors： Lavelle EC,Grant G,Pusztai A,Pfüller U,O'Hagan DT

更新日期：2001-01-01 00:00:00

abstract：:BLT mice, constructed by surgical implantation of human fetal thymus-liver tissues and intravenous delivery of autologous CD34+ haematopoietic stem cells into adult non-obese diabetic/severe combined immunodeficiency mice, were evaluated for vaccine-induced humoral immune responses. Following engraftment, these mice d...

journal_title：Immunology

authors： Biswas S,Chang H,Sarkis PT,Fikrig E,Zhu Q,Marasco WA

更新日期：2011-12-01 00:00:00

abstract：:Thioglycollate-stimulated, adherence and density gradient-enriched peritoneal exudate cells were used for the preparation of a specific, highly active antimacrophage reagent. After absorption with mouse lymphoid cells, an antimacrophage globulin (AMG) fraction was shown to be cytotoxic for peritoneal exudate macrophag...

journal_title：Immunology

authors： Herscowitz HB,Diblasio RC

更新日期：1976-01-01 00:00:00

abstract：:Human papillomaviruses (HPVs) are obligate epithelial pathogens and typically cause localized mucosal infections. We therefore hypothesized that T-cell responses to HPV antigens would be greater at sites of pathology than in the blood. Focusing on HPV-16 because of its association with cervical cancer, the magnitude o...

journal_title：Immunology

authors： Passmore JA,Milner M,Denny L,Sampson C,Marais DJ,Allan B,Gumbi PP,Hitzeroth II,Rybicki EP,Williamson AL

更新日期：2006-12-01 00:00:00

abstract：:The discovery of host-encoded gene products that sense molecular patterns in infectious microbes, and the demonstration of their role in triggering innate and adaptive immune responses, has been a key milestone in our understanding of immunology. Twenty-three years after Janeway first outlined the fundamental concepts...

journal_title：Immunology

authors： Browne EP

更新日期：2012-08-01 00:00:00

abstract：:Different kinds of IgM antibodies were tested for their activity in antibody-dependent cellular cytotoxicity (ADCC): firstly an anti-benzylpenicilloyl (BPO) IgM antibody from immune rabbit serum purified by affinity, ion exchange, and molecular-sieving chromatography, secondly two monoclonal rat anti-BPO IgM antibodie...

journal_title：Immunology

authors： Rumpold H,Wiedermann G,Scheiner O,Kraft D,Stemberger H

更新日期：1981-05-01 00:00:00

abstract：:Monoclonal antibodies (MAb) against sequential or conformational epitopes on foot-and-mouth disease virus (FMDV) passively protected neonatal syngeneic (BALB/c) mice at dilutions at which they could not neutralize virus infectivity in vitro. The B2, D9, 1C6 and 4C9 MAb, against the Group 1 (sequential) and Group 2 (co...

journal_title：Immunology

authors： McCullough KC,Crowther JR,Butcher RN,Carpenter WC,Brocchi E,Capucci L,De Simone F

更新日期：1986-07-01 00:00:00

abstract：:In many species, the rejection of liver allografts is milder than that of other organs. This is especially so in the rat where, without immunosuppressive treatment, liver grafts between certain strain combinations are accepted permanently, whereas skin, heart and renal allografts undergo acute rejection. Reliable surg...

journal_title：Immunology

authors： Kamada N

更新日期：1985-07-01 00:00:00

abstract：:Colorectal cancer is considered a non-immunogenic malignany. One strategy to augment the immunogenicity of such tumours is represented by the expression of costimulatory molecules by gene transfer. Using transfected variants of the human colorectal cancer cell line SW480 we tested various costimulatory molecules (CD80...

journal_title：Immunology

authors： Lindauer M,Rudy W,Gückel B,Doeberitz MV,Meuer SC,Moebius U

更新日期：1998-03-01 00:00:00

abstract：:The role of T-cell receptor (TCR) gammadelta T cells in the induction of protective TCR alphabeta T cells against infection by the intracellular bacteria Listeria monocytogenes was analysed. We found that depletion of gammadelta T cells by anti-TCR delta monoclonal antibody treatment before intravenous immunization of...

journal_title：Immunology

authors： Nomura A,Matsuzaki G,Takada H,Hiromatsu K,Nabeshima S,Nakamura T,Kishihara K,Nomoto K

更新日期：1998-10-01 00:00:00

abstract：:Hyper-immunoglobulin M (IgM) syndrome (HIGM) is a rare primary immunodeficiency characterized by elevated or normal IgM and absent or markedly decreased amounts of IgG, IgA and IgE. The X-linked form (HIGM1) is the most common type and is caused by mutations in the gene for CD40L, a T-cell surface molecule required fo...

journal_title：Immunology

authors： Van Hoeyveld E,Zhang PX,De Boeck K,Fuleihan R,Bossuyt X

更新日期：2007-04-01 00:00:00

abstract：:Extracorporeal photochemotherapy (ECP) has been shown to be a potent activator of peripheral blood macrophages because it causes a marked release of macrophage-dependent proinflammatory cytokines, and it is therefore currently considered to be a safe and non-toxic immunomodulatory treatment. On this basis we studied t...

journal_title：Immunology

authors： Di Renzo M,Rubegni P,De Aloe G,Paulesu L,Pasqui AL,Andreassi L,Auteri A,Fimiani M

更新日期：1997-09-01 00:00:00

abstract：:The effect of stem cell factor (SCF) on histamine and tumour necrosis factor-alpha (TNF-alpha) release from rat peritoneal mast cells (PMC) was determined and the intracellular pathways involved in the potentiation of histamine secretion were investigated. The effects of SCF (2-100 ng/ml) were examined following both ...

journal_title：Immunology

authors： Lin TJ,Bissonnette EY,Hirsh A,Befus AD

更新日期：1996-10-01 00:00:00

abstract：:Loss of ζ-associated protein 70 (Zap70) results in severe immunodeficiency in humans and mice because of the critical role of Zap70 in T-cell receptor (TCR) signalling. Here we describe a novel mouse strain generated by N-ethyl-N-nitrosourea mutagenesis, with the reduced protein stability (rps) mutation in Zap70. The ...

journal_title：Immunology

authors： Cauwe B,Tian L,Franckaert D,Pierson W,Staats KA,Schlenner SM,Liston A

更新日期：2014-03-01 00:00:00

abstract：:In the rat strain combination of DA into PVG, an orthotopic liver graft has the ability to abrogate an existing state of sensitization against donor (DA) antigens. Fifty-four percent of PVG rats sensitized against DA by skin grafting accepted a DA liver graft permanently, and about half of these became systemically to...

journal_title：Immunology

authors： Kamada N,Shinomiya T

更新日期：1985-05-01 00:00:00

abstract：:During the immune response to H-2 and Mls alloantigens, murine lymphocytes showed altered sensitivity to polyclonal mitogens. The reactivity to the T-cell mitogen PHA followed a similar pattern in both H-2 and Mls-immunized mice while the reactivity to the B-cell mitogen LPS was contrasting in the two groups. In the f...

journal_title：Immunology

authors： Matossian-Rogers A

更新日期：1979-08-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) may play an important role in the control of human papillomavirus (HPV)-induced anogenital neoplasias, but have been difficult to study owing to the difficulty in obtaining sufficient quantities of infectious virus. To address this we have stimulated human HPV-specific CTL in vitro using ...

journal_title：Immunology

authors： Tarpey I,Stacey S,Hickling J,Birley HD,Renton A,McIndoe A,Davies DH

更新日期：1994-02-01 00:00:00

abstract：:Oral administration of a protein antigen generates a serum factor that induces tolerance when transferred into naïve recipients. This serum factor has been described in rats as consisting of exosome-like structures or tolerosomes, which express major histocompatibility complex class II molecules (MHCII) and mediate an...

journal_title：Immunology

authors： Ostman S,Taube M,Telemo E

更新日期：2005-12-01 00:00:00