Vitamin A and dendritic cell differentiation.

abstract：:The existence of competing and blocking IgG antibodies and their interrelationship with IgE antibodies was investigated in the IgE immune response of CBA/J mice to bee venom phospholipase A2 (PLA2) and keyhole limpet haemocyanin (KLH). Minute doses of antigen induced high titres of both IgE and IgG antibodies, whereas...

journal_title：Immunology

authors： Kolbe L,Heusser CH,Kölsch E

更新日期：1995-02-01 00:00:00

abstract：:The role of genetic factors associated with the immunoglobulin heavy chain locus (Igh) in the development of benign monoclonal gammapathy (BMG), a benign B-cell proliferative disorder, was investigated in six Igh congenic mouse strains during ageing. The strains used had a C57BL or BALB background: C57BL/6, BALB.Igb a...

journal_title：Immunology

authors： van den Akker TW,de Glopper-van der Veer E,Radl J,Benner R

更新日期：1988-09-01 00:00:00

abstract：:The mouse T-cell tumours E1-4 and WEHI-22 produce an immunoglobulin (TCT Ig) which suppresses the antibody response to T- dependent antigens in vitro while having no effect on responses to T-independent antigens. TCT Ig also augments IgG responses to both kinds of antigen. TCT Ig appears to be a new class of mouse Ig ...

journal_title：Immunology

authors： Boylston AW,Watson SR,Anderson RL

更新日期：1976-11-01 00:00:00

abstract：:Compared with adults, the circulating Vγ2Vδ2 T-cell population in cord blood is present at low levels and does not show the strong bias for Vγ2-Jγ1.2 rearrangements. These features may be a result of limited exposure to stimulatory phosphoantigens, lack of T-cell-derived interleukin-2 (IL-2) or both. In cord blood mon...

journal_title：Immunology

authors： Cairo C,Sagnia B,Cappelli G,Colizzi V,Leke RG,Leke RJ,Pauza CD

更新日期：2013-04-01 00:00:00

abstract：:We have previously shown that chlorpromazine (CPZ) inhibits tumour necrosis factor (TNF) production and protects against endotoxic shock in mice. In this paper we investigated the effect of pretreatment with CPZ, 4 mg/kg i.p. 30 min before, compared with dexamethasone (DEX; 3 mg/kg) on the induction of other endotoxin...

journal_title：Immunology

authors： Mengozzi M,Fantuzzi G,Faggioni R,Marchant A,Goldman M,Orencole S,Clark BD,Sironi M,Benigni F,Ghezzi P

更新日期：1994-06-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I-specific inhibitory natural killer receptors (iNKRs) are expressed by subsets of T cells but the mechanisms inducing their expression are poorly understood, particularly for killer-cell immunoglobulin-like receptors (KIRs). The iNKRs are virtually absent from the surface ...

journal_title：Immunology

authors： Hermann E,Berthe A,Truyens C,Alonso-Vega C,Parrado R,Torrico F,Carlier Y,Braud VM

更新日期：2010-03-01 00:00:00

abstract：:When cultured on a collagen matrix at a density of 7 X 10(4) cells/cm2 for 48 hr, 80 +/- 10% of unfractionated and 70 +/- 14% of T-enriched human blood lymphocytes from eight healthy individuals developed a motile morphology defined as the presence of lamellar surface activity and cytoplasmic flattening. During cultur...

journal_title：Immunology

authors： Sundqvist KG,Otteskog P

更新日期：1986-07-01 00:00:00

abstract：:Our goal was to study the small lymphocytes that were recruited to cutaneous DTH lesions in order to determine if there existed a subset of small lymphocytes which preferentially migrated into cutaneous inflammatory sites rather than into lymphoid tissues. Lymphocytes were radiolabelled and injected i.v. into sensitiz...

journal_title：Immunology

authors： Issekutz TB,Webster DM,Stoltz JM

更新日期：1986-05-01 00:00:00

abstract：:In an attempt to produce monoclonal antibodies against human large granular lymphocytes (LGL), the effector cells of natural killer (NK) and killer (K) activity, a monoclonal IgM antibody (VEP10) has been obtained. This antibody is reactive by indirect membrane immunofluorescence (IMF) with 14.7 +/- 8.5% peripheral bl...

journal_title：Immunology

authors： Rumpold H,Kraft D,Obexer G,Böck G,Möschl P

更新日期：1983-06-01 00:00:00

abstract：:Pregnancy in sheep is associated with changes in numbers of specific T-lymphocyte populations in the uterine endometrium. These changes probably contribute to evasion by the conceptus of maternal immunological rejection and indicate a possible role for T cells in placental growth, parturition and post-parturient uteri...

journal_title：Immunology

authors： Majewski AC,Tekin S,Hansen PJ

更新日期：2001-03-01 00:00:00

abstract：:Attempts were made to break the tolerance of lymph node B cells to deaggregated human gamma globulin. Using allotype-congenic mice, lymph node cells from virgin or tolerant (5 mg) CBA/Igb donors were transferred tonormal CBA/Iga recipients and the proportion of responding donor B cells estimated 1 and 13 days later. T...

journal_title：Immunology

authors： Elson CJ,Taylor RB

更新日期：1977-11-01 00:00:00

abstract：:Bacterial superantigens bind to major histocompatibility complex (MHC) class II and subsequently activate both CD4+ and CD8+ T lymphocytes expressing certain T-cell receptor (TCR)-Vbeta chains. In response to superantigen exposure these subsets proliferate, produce large amounts of proinflammatory cytokines and in add...

journal_title：Immunology

authors： Sundstedt A,Grundström S,Dohlsten M

更新日期：1998-09-01 00:00:00

abstract：:Alteration in the frequency of monocyte subsets is a hallmark of tuberculosis-diabetes co-morbidity (TB-DM). To study this association, we examined the plasma levels of sCD14, sCD163, C-reactive protein (CRP) and soluble tissue factor (sTF) in individuals with TB-DM, TB or diabetes mellitus (DM), and in healthy contro...

journal_title：Immunology

authors： Kumar NP,Moideen K,Bhootra Y,Nancy A,Viswanathan V,Shruthi BS,Sivakumar S,Natarajan M,Kornfeld H,Babu S

更新日期：2019-03-01 00:00:00

abstract：:Chemically cross-linked C-reactive protein (CRP) oligomers were prepared and characterized, and C1q binding and C activation were investigated. Purified human CRP was polymerized in the presence of both non-cleavable and cleavable cross-linking agents and further separated by Superose 12 analytical FPLC column chromat...

journal_title：Immunology

authors： Jiang H,Lint TF,Gewurz H

更新日期：1991-12-01 00:00:00

abstract：:The affinity of anti-DNP antibodies produced by mice of various ages has been studied at the cellular level by the plaque inhibition technique. The affinity of PFC produced shortly after a single injection of antigen was found to increase during the first 6 weeks of life. The responses of 1- and 2-week-old animals als...

journal_title：Immunology

authors： Marshall-Clarke S,Playfair JH

更新日期：1975-09-01 00:00:00

abstract：:It is becoming increasingly clear that the T-cell-mediated immune response is important in many diseases. In this study, we used concanavalin A (Con A) -induced hepatitis to investigate the role of CD49a in the molecular and cellular mechanism of the T-cell-mediated immune response. We found that CD49a(-/-) mice had s...

journal_title：Immunology

authors： Chen Y,Peng H,Chen Y,Wei H,Sun R,Tian Z

更新日期：2014-03-01 00:00:00

abstract：:Although the co-stimulatory interaction between B and T cells is well defined, recent evidence suggests that B cells also have a regulatory role. Here, we show that B cells activated using anti-IgD conjugated to dextran (α-δ-dex) directly inhibit TCR-induced CD4 T cell activation, proliferation and cytokine production...

journal_title：Immunology

authors： Preciado-Llanes L,Wing JB,Foster RA,Carlring J,Lees A,Read RC,Heath AW

更新日期：2014-09-20 00:00:00

abstract：:A subpopulation of human peripheral blood natural killer (NK) cells, defined by sedimentation at Percoll high buoyant densities (P greater than 1.0635-1.0640 g/ml) and unresponsiveness to interleukin-2 (IL-2), contained two distinct populations based on the intensity of CD16 (FcR gamma III) expression, namely CD16dim ...

journal_title：Immunology

authors： Warren HS,Skipsey LJ

更新日期：1991-01-01 00:00:00

abstract：:In lipopolysaccharide (LPS)-hyporesponsive C3H/HeJ mice, alveolar macrophages (AMphi) produce much more tumour necrosis factor-alpha than peritoneal macrophages (PMphi) when stimulated with LPS (10 microgram/ml), but the induction of inducible nitric oxide synthase (iNOS) gene expression and production of nitric oxide...

journal_title：Immunology

authors： Wang MJ,Jeng KC,Shih PC

更新日期：1999-12-01 00:00:00

abstract：:The influence of the thymus and the possible requirement for surface immunoglobulin expression for the development of K and NK activity were assessed in rats. This species was chosen in preference to mice as they show good levels of K-cell activity. Studies were carried out in athymic (rnu/rnu) rats some of which were...

journal_title：Immunology

authors： Chassoux D,Kolb JP,Bazin H,MacLennan IC

更新日期：1983-11-01 00:00:00

abstract：:The influence of changes of the cation-transporting activity of the membrane Na,K ATP-ase of human peripheral blood lymphocytes on their ability to form 'early' and 'late' rosettes with SRBC was investigated. It was shown that inhibition of the Na,K ATP-ase-dependent cation transport through the lymphocyte membrane by...

journal_title：Immunology

authors： Witkowski J

更新日期：1985-06-01 00:00:00

abstract：:Successful elimination of the hepatitis C virus (HCV) during acute infection has been linked to strong HCV-specific in vitro T-cell proliferation, whereas T cells from patients with chronic hepatitis C respond only weakly to HCV antigens. Lipid-coupled peptides are immunostimulants, which might provide a basis for nov...

journal_title：Immunology

authors： Langhans B,Braunschweiger I,Schweitzer S,Jung G,Inchauspé G,Sauerbruch T,Spengler U

更新日期：2001-04-01 00:00:00

abstract：:We produced three murine monoclonal antibodies (mAb) directed against the human T-cell differentiation antigen CD2 (formerly T11) and analysed their epitope specificity by E-rosette inhibition, cross-blocking and proliferation-induction experiments. When added together, two mAb (both IgG1 kappa) were able to induce pr...

journal_title：Immunology

authors： van Lier R,Bloemena E,Brouwer M,Van Heijst J,Weinreich S,Aarden L

更新日期：1989-07-01 00:00:00

abstract：:This paper describes experiments undertaken to determine more uniform conditions for the generation of cytotoxic lymphokine--'lymphotoxin' (LT) in differently stimulated rat lymphocyte cultures, and to compare the sensitivity of different test systems for detecting rat LT activity in vitro. Wistar rat lymphoid cells w...

journal_title：Immunology

authors： Ryzewska AG,Darbrowska BK

更新日期：1976-11-01 00:00:00

abstract：:Mice injected at birth with semi-allogeneic lymphoid cells develop a lupus-like autoimmune syndrome in which donor B cells are polyclonally activated by host alloreactive CD4+ T cells, producing autoantibodies and immune complex-mediated glomerulonephritis. It has been demonstrated that the recognition of major histoc...

journal_title：Immunology

authors： Ramos A,Merino R,Merino J

更新日期：1994-06-01 00:00:00

abstract：:The interleukin-2 receptor alpha chain (IL-2R alpha) is a T-cell growth factor receptor and is known to be induced in helper T cells by infection with human T-cell leukaemia virus type-1 (HTLV-1). The Rex protein of HTLV-1 has been shown to stabilize IL-2R alpha mRNA. Although the 3' untranslated region of many RNA ha...

journal_title：Immunology

authors： Kanamori H,Kodama T,Yazaki Y

更新日期：1995-12-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic, synovial inflammation affecting multiple joints, finally leading to extra-articular lesions for which limited effective treatment options are currently available. Interleukin-34 (IL-34), recently discovered as the second colony-stimul...

journal_title：Immunology

authors： Zhou RP,Wu XS,Xie YY,Dai BB,Hu W,Ge JF,Chen FH

更新日期：2016-12-01 00:00:00

abstract：:Mouse models of multiple sclerosis (MS) have shown the importance of interleukin-10 (IL-10) -producing regulatory B (Breg) cells in dampening disease activity and inhibiting disease initiation and progression. In MS and other autoimmune diseases decreased frequency and functionality of Breg cells correlate with diseas...

journal_title：Immunology

authors： Lundqvist S,Modvig S,Fischer EA,Frederiksen JL,Degn M

更新日期：2019-03-01 00:00:00

abstract：:A hapten-specific lymphocyte proliferation assay, which measures the in vitro stimulation of DNA synthesis (as assessed by [3H]thymidine incorporation), was used to determine systemic immunization induced by an epicutaneously applied hapten in addition to the more commonly used method which measures ear (or footpad) s...

journal_title：Immunology

authors： Suzuki K,Kanamori S,Takada K,Kawana S

更新日期：2003-04-01 00:00:00

abstract：:Oral administration of antigen induces a state of tolerance that is associated with activation of CD8+ T cells that can transfer unresponsiveness to naïve syngeneic hosts. These T cells are not lytic, but they inhibit development of antibody, CD4+ T helper cell, and CD8+ cytotoxic T lymphocyte (CTL) responses upon ado...

journal_title：Immunology

authors： Kapp JA,Kapp LM,McKenna KC,Lake JP

更新日期：2004-02-01 00:00:00