Mesangial cell complement receptor 1-related protein y limits complement-dependent neutrophil accumulation in immune complex glomerulonephritis.

abstract：:Membrane attack complexes of complement occur around thyroid follicles in Graves' disease and Hashimoto's thyroiditis. The lytic potential of such complexes is controlled by membrane-bound and fluid phase regulators and we have investigated the role of these in autoimmune thyroid disease. By immunohistochemical staini...

journal_title：Immunology

authors： Tandon N,Yan SL,Morgan BP,Weetman AP

更新日期：1994-04-01 00:00:00

abstract：:Donor mice were painted on the skin of the abdomen with the contact sensitizing agent, oxazolone. One day later 2-5 x 10(6) cells from the regional lymph nodes were injected into the footpads of recipient mice. Contact sensitivity was detected 6 days later by challenging the ears of the recipients and measuring the in...

journal_title：Immunology

authors： Asherson GL,Mayhew B,Perera MA

更新日期：1979-05-01 00:00:00

abstract：:Immunopotentiation has been demonstrated when Klebsiella O3 lipopolysaccharide (KO3 LPS), which possesses a linear mannan as the O-specific side chain, was injected subcutaneously into endotoxin resistant C3H/HeJ mice together with soluble protein antigens. The LPS exhibited significantly positive adjuvant effects on ...

journal_title：Immunology

authors： Ohta M,Kido N,Nakashima I,Kato N

更新日期：1985-11-01 00:00:00

abstract：:Undesired immunological responses to products of therapeutic gene replacement have been obstacles to successful gene therapy. Understanding such responses of the host immune system to achieve immunological tolerance to a transferred gene product is therefore crucial. In this article, we review relevant studies of immu...

journal_title：Immunology

authors： Eghtesad S,Morel PA,Clemens PR

更新日期：2009-05-01 00:00:00

abstract：:Release of immunoglobulin-binding factors was induced from cultured human lymphoblastoid cells in a serum-free environment by incubation at 37 degrees. RPMI-8866 cells expressing Fc receptors for IgE (Fc epsilon R) and Daudi cells expressing Fc receptors for IgG (Fc gamma R) released IgE- and IgG-binding factors, resp...

journal_title：Immunology

authors： Jensen JR,Sand TT,Spiegelberg HL

更新日期：1984-09-01 00:00:00

abstract：:The immunological basis for the production of autoantibodies characteristic of systemic lupus erythematosus (SLE) against a wide range of antigens remains obscure. The specificity of (NZB x NZW)F1 (BWF1) or MRL/Mp-lpr/lpr (MRL/lpr) mouse monoclonal antibodies (mAb) was examined by immunofluorescence, immunoblotting an...

journal_title：Immunology

authors： Bronze-da-Rocha E,Machado C,Staines NA,Sunkel CE

更新日期：1992-12-01 00:00:00

abstract：:Non-obese diabetic (NOD) mice spontaneously develop insulin-dependent diabetes mellitus (IDDM) as a consequence of autoimmune aggression of beta cells of the endocrine pancreas by T cells. T lymphocytes of NOD mice are resistant to apoptosis induced by glucocorticoids, or by starving or DNA-damaging treatments, a feat...

journal_title：Immunology

authors： Martins TC,Aguas AP

更新日期：1998-11-01 00:00:00

abstract：:Antigen-induced allergic airway inflammation is mediated by T helper type 2 (Th2) cells and their cytokines, but the mechanism that initiates the Th2 immunity is not fully understood. Recent studies show that basophils play important roles in initiating Th2 immunity in some inflammatory models. Here we explored the ro...

journal_title：Immunology

authors： Zhong W,Su W,Zhang Y,Liu Q,Wu J,Di C,Zhang Z,Xia Z

更新日期：2014-06-01 00:00:00

abstract：:Syngeneic (CB20) thymus and spleen T cells transferred to SCID mice, and shown to be present by flow cytometric analysis and functional by their ability to reject third-party skin grafts, do not lead to a detectable failure of syngeneic or allogeneic pregnancy. Unless the small number of B cells contaminating the T-ce...

journal_title：Immunology

authors： Hetherington CM,Dresser DW

更新日期：1990-11-01 00:00:00

abstract：:Fifteen sera of patients with visceral leishmaniasis were investigated for the occurrence of autoantibodies. They were found in high incidence and titre, and with specificity to the intermediate filament (INFIL) proteins vimentin (12 out of 15 with a titre higher than 1:10) and keratin (9 out of 15 with a titre higher...

journal_title：Immunology

authors： Böhme MW,Evans DA,Miles MA,Holborow EJ

更新日期：1986-12-01 00:00:00

abstract：:The ability of freshly isolated primary human alveolar epithelial cells (type II pneumocytes) to induce leucocyte migration across an endothelial monolayer was investigated. Three-way factorial analysis of variance (ANOVA) demonstrated that resting alveolar endothelial cells (AEC) could produce detectable quantities o...

journal_title：Immunology

authors： Eghtesad M,Jackson HE,Cunningham AC

更新日期：2001-02-01 00:00:00

abstract：:We have previously reported that human granulocyte-macrophage colony-stimulating factor (hGM-CSF) causes a stage-specific inhibition of T-cell receptor (TCR) alphabeta cell development in the thymus of transgenic mice constitutively expressing the hGM-CSF receptor. Since it has been reported that the addition of inter...

journal_title：Immunology

authors： Yasuda Y,Kaneko A,Nishijima I,Miyatake S,Arai K

更新日期：2002-06-01 00:00:00

abstract：:Evidence suggests that the immune and neuroendocrine systems cross talk by sharing ligands and receptors. Hormones and neuropeptides produced by the neuroendocrine system often modulate the function of lymphoid organs and immune cells. We have previously reported the intrathymic expression of somatostatin (SOM) in the...

journal_title：Immunology

authors： Silva AB,Aw D,Palmer DB

更新日期：2006-05-01 00:00:00

abstract：:When normal human spleen cells are pulsed with concanavalin A (Con A), a portion become suppressor cells which in co-culture can inhibit immunoglobulin synthesis by other normal spleen cells stimulated by pokeweed mitogen (PWM). One mechanism whereby these Con-A activated spleen cells suppress Ig synthesis appears to ...

journal_title：Immunology

authors： Krakauer RS,Cathcart MK,Ilfeld DN

更新日期：1980-05-01 00:00:00

abstract：:Simultaneous kinetic measurements have been made of basophil degranulation and of histamine release. Both antigen and ionophore A23187 were studied. Cells from the same donor under the same conditions undergo both reactions at a similar rate. Regression analysis indicated a statistically highly significant correlation...

journal_title：Immunology

authors： Pruzansky JJ,Zeiss CR,Patterson R

更新日期：1980-07-01 00:00:00

abstract：:Interleukin-13 (IL-13) is a cytokine which significantly enhances the proliferation and differentiation of B lymphocytes. We therefore evaluated its role in the formation of a humoral immune response in vivo. Upon oral immunization with the B subunit of Escherichia coli heat-labile enterotoxin (LT-B), rapid up-regulat...

journal_title：Immunology

authors： Bost KL,Holton RH,Cain TK,Clements JD

更新日期：1996-04-01 00:00:00

abstract：:Prior study has revealed that the expression of certain major histocompatibility complex (MHC) class I molecules on the membranes of normal or transformed cells can prevent natural killer (NK)-cell-mediated killing. This has been explained by either (1) the target interference model, or (2) the effector inhibition mod...

journal_title：Immunology

authors： Nishimura M,Mitsunaga S,Akaza T,Mitomi Y,Tadokoro K,Juji T

更新日期：1994-09-01 00:00:00

abstract：:Peripheral blood lymphocytes (PBL) from non-immunized rabbits or from rabbits immunized several months previously with a single dose of sheep red blood cells (SRBC) were cultured at several different cell densities in the presence of antigen for 5 days. The cells were then distributed in 10 microliter microcultures at...

journal_title：Immunology

authors： Luzzati AL,Giacomini E,Lefkovits I

更新日期：1985-12-01 00:00:00

abstract：:Protective CD4+ T cells against Mycobacterium bovis bacillus Calmette-Guérin (BCG), which are characterized by the ability to produce interferon-gamma (IFN-gamma), could be induced by immunization of mice with viable BCG but not with killed BCG. A high level of IFN-gamma mRNA was observed when normal spleen cells were...

journal_title：Immunology

authors： Yang J,Mitsuyama M

更新日期：1997-08-01 00:00:00

abstract：:Chemokines and their receptors regulate cell migration to sites of inflammation. The glucocorticoid dexamethasone has potent anti-inflammatory effects, yet paradoxically up-regulates expression of some cytokine receptors. We have examined the effects of dexamethasone on chemokine receptor expression. Using an RNase pr...

journal_title：Immunology

authors： Caulfield J,Fernandez M,Snetkov V,Lee T,Hawrylowicz C

更新日期：2002-02-01 00:00:00

abstract：:Myelin oligodendrocyte glycoprotein (MOG), a minor protein of the central nervous system myelin, is recognized as a potential target in multiple sclerosis and neuromyelitis optica. The extracellular domain of MOG is commonly used in a wide range of mouse strains and other animals to induce experimental autoimmune ence...

journal_title：Immunology

authors： Delarasse C,Smith P,Baker D,Amor S

更新日期：2013-12-01 00:00:00

abstract：:We have produced a mouse anti-rabbit Ia monoclonal antibody (MAb) that detects an isotypic determinant on all rabbit Ia molecules. This MAb precipitates three polypeptide chains with molecular weights of 28,000, 31,000 and 35,000, corresponding to the Ia beta, Ii and alpha chains, respectively. The anti-Ia MAb inhibit...

journal_title：Immunology

authors： Lobel SA,Knight KL

更新日期：1984-01-01 00:00:00

abstract：:The expression of Fc mu receptors was investigated using spleen cells from (LOU/M/Wsl X CFY) F1 rats bearing the IR202 tumour, an IgM-producing immunocytoma. It was found that the progressively growing solid tumour was accompanied by an extraordinary expansion of host splenocytes with Fc mu receptors. These cells were...

journal_title：Immunology

authors： Uher F,Puskás E,Gergely J,Bazin H

更新日期：1987-07-01 00:00:00

abstract：:Using double staining for T-cell receptor (TCR) and 5-bromo-2'-deoxyuridine (BRdU) we have examined the proliferation rates and lifespan of murine intraepithelial lymphocytes (IEL's) in vivo. After a 24-hr pulse of BRdU the number of labelled alpha beta TCR+ IEL was significantly higher in the ileum than the duodenum....

journal_title：Immunology

authors： Penney L,Kilshaw PJ,MacDonald TT

更新日期：1995-10-01 00:00:00

abstract：:Salmonella enterica serovar Typhimurium (S. typhimurium) causes a localized enteric infection and its elimination is dependent on a T helper type 1 immune response. However, the mechanism of the protective immune response against the pathogen in gut-associated lymphoid tissue (GALT) at an early stage of the infection ...

journal_title：Immunology

authors： Mayuzumi H,Inagaki-Ohara K,Uyttenhove C,Okamoto Y,Matsuzaki G

更新日期：2010-11-01 00:00:00

abstract：:A plasmid encoding the influenza nucleoprotein gene from A/NT/60/68 virus was transduced into the attenuated Salmonella typhimurium aroA- strain SL3261. The bacterial vector expressing the viral gene product was able to induce both humoral and cell-mediated immune responses to the nucleoprotein antigen. CD4+ virus-spe...

journal_title：Immunology

authors： Tite JP,Gao XM,Hughes-Jenkins CM,Lipscombe M,O'Callaghan D,Dougan G,Liew FY

更新日期：1990-08-01 00:00:00

abstract：:Haemolymph of the American lobster, Homarus americanus, contains several lectins. One of these, lobster agglutinin 1 (LAg1) is specific for N-acetylneuraminic acid and agglutinates mouse and human erythrocytes. In addition, this lectin agglutinates peripheral T cells and cortisone-resistant thymocytes, but agglutinate...

journal_title：Immunology

authors： Campbell PA,Hartman AL,Abel CA

更新日期：1982-01-01 00:00:00

abstract：:Montelukast is a leukotriene receptor antagonist that is known to prevent allergic rhinitis and asthma. Blocking the Cysteinyl leukotrienes receptor (CysLTR1), one of the primary receptors of leukotrienes, has been demonstrated to be efficacious in ameliorating experimental autoimmune encephalomyelitis (EAE), an anima...

journal_title：Immunology

authors： Han B,Zhang YY,Ye ZQ,Xiao Y,Rasouli J,Wu WC,Ye SM,Guo XY,Zhu L,Rostami A,Wang LB,Zhang Y,Li X

更新日期：2021-01-22 00:00:00

abstract：:Interaction between CD27 and its ligand CD70 provides a second signal for T-cell proliferation and tumour necrosis factor-alpha (TNF-alpha) production. Whereas CD27 is broadly expressed during T-cell development, expression of CD70 in vivo is restricted. To determine when CD27 CD70 interactions can occur in immune rea...

journal_title：Immunology

authors： Lens SM,Baars PA,Hooibrink B,van Oers MH,van Lier RA

更新日期：1997-01-01 00:00:00

abstract：:Toll-like receptors (TLR) are sentinel receptors capable of recognizing pathogen-associated molecule patterns (PAMP) such as lipopolysaccharide (LPS) and CpG-containing oligonucleotides (CpG ODN). TLR2 and TLR4 are major receptors for Gram-positive and Gram-negative bacterial cell wall components, respectively. TLR9 i...

journal_title：Immunology

authors： An H,Yu Y,Zhang M,Xu H,Qi R,Yan X,Liu S,Wang W,Guo Z,Guo J,Qin Z,Cao X

更新日期：2002-05-01 00:00:00