Abstract：
:Primary contact sensitivity (CS) to Ox and non-specific unresponsiveness to other unrelated delayed-type hypersensitivity (DTH) containing CS were induced simultaneously by i.v. administration of oxazolone(Ox)-conjugated spleen cells. The subpopulation of spleen cells which serves as carriers for the induction of primary CS consisted of plastic-adherent, Thy 1-negative macrophage-like cells, and the carriers for the induction of non-specific unresponsiveness were non-adherent, Thy 1-positive cells. Further, allogeneic spleen cells were not capable of acting as carriers for the induction of primary CS, though H-2 restriction was not observed in the induction of non-specific unresponsiveness by Ox-conjugated cells. Thus, these two phenomena were shown to be induced by distinct pathways or distinct mechanisms. Adult thymectomy or treatment with cyclophosphamide (CY) prevents the induction of non-specific unresponsiveness. Moreover, an interval of 7 days was required for almost complete suppression of CS between treatment with Ox-conjugated spleen cells and sensitization with picryl chloride (PCl). These results suggest that relatively short-lived, CY-sensitive T cells participate in the induction of the non-specific unresponsiveness induced with Ox-conjugated cells.
journal_name
Immunologyjournal_title
Immunologyauthors
Nakano Y,Nakano Ksubject
Has Abstractpub_date
1985-02-01 00:00:00pages
307-16issue
2eissn
0019-2805issn
1365-2567journal_volume
54pub_type
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