Immunosuppressive therapy modulates T lymphocyte gene expression in patients with systemic lupus erythematosus.

abstract：:Doxorubicin-stimulated whole rat glomeruli and dissociated mesangial and resident glomerular macrophage cells produced the release of interleukin (IL)-1 beta cytokine. This activity increased after the addition of lipopolysaccharide (LPS) or LPS plus indomethacin to the cultures. In the presence of WEB2086 [platelet-a...

journal_title：Immunology

authors： Bricio T,Molina A,Martin A,Mampaso F

更新日期：1994-01-01 00:00:00

abstract：:The number, distribution and surface phenotype of dividing cells in the thymus, and differences between the cell cycle status of thymocyte subpopulations, were studied in fetal and post-natal lambs using double-labelling techniques. Dividing cells were labelled in vivo for various periods with 5-bromo-2-deoxyuridine (...

journal_title：Immunology

authors： McClure S,Dudler L,Thorpe D,Hein WR

更新日期：1988-11-01 00:00:00

abstract：:The kinetics of anti-paternal alloantibody production in syngeneically and allogeneically mated mice previously immunized with allogenic spleen cells has been investigated. In allogeneically mated females, total and cytotoxic alloantibody levels increased during the final 3 days of pregnancy to reach maximal levels ar...

journal_title：Immunology

authors： Roe R,Bell SC

更新日期：1982-05-01 00:00:00

abstract：:The opossum major histocompatibility complex (MHC) shares a similar organization with that of non-mammals while containing a diverse set of class I genes more like that of eutherian (placental) mammals. There are 11 class I loci in the opossum MHC region, seven of which are known to be transcribed. The previously desc...

journal_title：Immunology

authors： Baker ML,Melman SD,Huntley J,Miller RD

更新日期：2009-09-01 00:00:00

abstract：:Mucosal immunization offers the potential for inducing IgA antibody responses in the vagina, the site of infection for many viruses, including herpes simplex type 2 (HSV-2). To investigate this possibility, mice were immunized intranasally with 10 micrograms glycoprotein D2 (gD2) from HSV combined with a series of adj...

journal_title：Immunology

authors： Ugozzoli M,O'Hagan DT,Ott GS

更新日期：1998-04-01 00:00:00

abstract：:Monoclonal antibodies (MAb) against sequential or conformational epitopes on foot-and-mouth disease virus (FMDV) passively protected neonatal syngeneic (BALB/c) mice at dilutions at which they could not neutralize virus infectivity in vitro. The B2, D9, 1C6 and 4C9 MAb, against the Group 1 (sequential) and Group 2 (co...

journal_title：Immunology

authors： McCullough KC,Crowther JR,Butcher RN,Carpenter WC,Brocchi E,Capucci L,De Simone F

更新日期：1986-07-01 00:00:00

abstract：:This paper describes experiments undertaken to determine more uniform conditions for the generation of cytotoxic lymphokine--'lymphotoxin' (LT) in differently stimulated rat lymphocyte cultures, and to compare the sensitivity of different test systems for detecting rat LT activity in vitro. Wistar rat lymphoid cells w...

journal_title：Immunology

authors： Ryzewska AG,Darbrowska BK

更新日期：1976-11-01 00:00:00

abstract：:Among immunological abnormalities present in human immunodeficiency virus type 1 (HIV-1)-infected individuals are dysregulation of cytokine production and CD4 down-regulation in both T-helper cells and monocytes/macrophages. The HIV-1 envelope glycoprotein 120 (gp120) has the ability to induce different cytokines in p...

journal_title：Immunology

authors： Karsten V,Gordon S,Kirn A,Herbein G

更新日期：1996-05-01 00:00:00

abstract：:Mice injected in the footpad with carrageenin developed local inflammation which peaked at 48 hr. This delayed-type footpad swelling was significantly reduced in mice injected intraperitoneally (i.p.) with a specific nitric oxide (NO) synthase inhibitor, L-NGmonomethyl-arginine (L-NMMA). The draining lymph node (DLN) ...

journal_title：Immunology

authors： Ianaro A,O'Donnell CA,Di Rosa M,Liew FY

更新日期：1994-07-01 00:00:00

abstract：:The intestinal lamina propria (LP) contains antigen-presenting cells with features of dendritic cells and macrophages, collectively referred to as mononuclear phagocytes (MNPs). Association of MNPs with the epithelium is thought to play an important role in multiple facets of intestinal immunity including imprinting M...

journal_title：Immunology

authors： McDonald KG,Wheeler LW,McDole JR,Joerger S,Gustafsson JK,Kulkarni DH,Knoop KA,Williams IR,Miller MJ,Newberry RD

更新日期：2017-12-01 00:00:00

abstract：:Glucosamine (GlcN) has been reported to possess several biomedical properties, and currently a great deal of attention has been focused on improving the functional properties of GlcN for different applications. Therefore, this study was conducted to introduce a carboxybutyryl functional group to GlcN and to find out t...

journal_title：Immunology

authors： Rajapakse N,Kim MM,Mendis E,Kim SK

更新日期：2008-03-01 00:00:00

abstract：:The IgE immune response was studied in female athymic, nude (Lewis rnu/rnu) and euthymic (Lewis +/+) rats infected with the nematode Nippostrongylus brasiliensis. During the course of the infection, serum IgE levels were followed using an enzyme-linked immunosorbent assay technique (ELISA), while the surface expressio...

journal_title：Immunology

authors： Chen XJ,Wiedermann U,Dahlgren U,Hanson LA,Enerbäck L

更新日期：1995-11-01 00:00:00

abstract：:T lymphocytes are a critical component of the adaptive immune system mediating protection against infection and malignancy, but also implicated in many immune pathologies. Upon recognition of specific antigens T cells clonally expand, traffic to inflamed sites and acquire effector functions, such as the capacity to ki...

journal_title：Immunology

authors： Dimeloe S,Burgener AV,Grählert J,Hess C

更新日期：2017-01-01 00:00:00

abstract：:Drug abuse is a global problem of considerable concern to health. One such health concern stems from the fact that many drugs of abuse have immunosuppressive actions and consequently have the potential to increase susceptibility to infectious disease. This article is focused on the impact of the amphetamine derivative...

journal_title：Immunology

authors： Connor TJ

更新日期：2004-04-01 00:00:00

abstract：:When Trypanosoma cruzi is co-cultured with activated human lymphocytes the latter manifest a marked level of suppression in their capacity to express high-affinity interleukin-2 receptors (IL-2R). In this study we asked whether this effect could result from reduced expression of the p75 component of the IL-2R, a condi...

journal_title：Immunology

authors： Kierszenbaum F,Sztein MB

更新日期：1992-03-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a global health problem characterized by a high rate of chronic infection, which may in part be due to a defect in myeloid dendritic cells (mDCs). This defect appears to be remedied by treatment with interferon-α (IFN-α) -based antiviral therapies; however, the molecular mechanisms...

journal_title：Immunology

authors： Ma L,Zhou Y,Zhang Y,Li Y,Guo Y,He Y,Wang J,Lian J,Hao C,Moorman JP,Yao ZQ,Zhou Y,Jia Z

更新日期：2014-12-01 00:00:00

abstract：:The relationship between the IgA antibody response in serum (total and polymeric IgA) and intestinal secretions was examined in volunteers subjected to oral and parenteral typhoid vaccination. After oral vaccination (three doses of 10(11) live Ty21a vaccine given at 48-hr intervals), serum pIgA antibody to typhoid lip...

journal_title：Immunology

authors： Bartholomeusz RC,Forrest BD,Labrooy JT,Ey PL,Pyle D,Shearman DJ,Rowley D

更新日期：1990-02-01 00:00:00

abstract：:Immunoglobulin E is quantitatively a minor immunoglobulin class in serum, but nevertheless the major class of antibody mediating type I hypersensitivity reactions and hence, type I allergic phenomena. The bovine epsilon gene is one of the as yet uncharacterized mammalian immunoglobulin genes. We have therefore cloned ...

journal_title：Immunology

authors： Mousavi M,Rabbani H,Hammarström L

更新日期：1997-11-01 00:00:00

abstract：:We have previously shown that chlorpromazine (CPZ) inhibits tumour necrosis factor (TNF) production and protects against endotoxic shock in mice. In this paper we investigated the effect of pretreatment with CPZ, 4 mg/kg i.p. 30 min before, compared with dexamethasone (DEX; 3 mg/kg) on the induction of other endotoxin...

journal_title：Immunology

authors： Mengozzi M,Fantuzzi G,Faggioni R,Marchant A,Goldman M,Orencole S,Clark BD,Sironi M,Benigni F,Ghezzi P

更新日期：1994-06-01 00:00:00

abstract：:Immunoglobulin E (IgE)-dependent mechanisms play a pivotal role in mediating allergic disease. Previously, VH-Cepsilon transcripts from blood or spleen of atopic asthmatics have been analysed for VH gene usage and patterns of somatic mutation. An over-representation of the minor VH5 family has been observed, consisten...

journal_title：Immunology

authors： Snow RE,Djukanovic R,Stevenson FK

更新日期：1999-12-01 00:00:00

abstract：:Interleukin 27 (IL-27) has been identified as a potent cytokine in the differentiation of type 1 regulatory T (Tr1) cells through interactions with several key elements, including transcription factors such as aryl hydrocarbon receptor and IL-21. Autocrine production of IL-21 is known to be important for maintaining I...

journal_title：Immunology

authors： Nadya NA,Tezuka H,Ohteki T,Matsuda S,Azuma M,Nagai S

更新日期：2017-11-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune chronic inflammatory disease of unknown etiology, although genetic and environmental factors appear to contribute to its pathogenesis. Specifically, infectious processes are associated with SLE onset and exacerbation. However, we are far from a complete understanding...

journal_title：Immunology

authors： Illescas-Montes R,Corona-Castro CC,Melguizo-Rodríguez L,Ruiz C,Costela-Ruiz VJ

更新日期：2019-11-01 00:00:00

abstract：:The linker protein LAT is expressed mainly in T and natural killer (NK) cells. LAT-deficient mice have an arrest of intrathymic T-cell development at the CD4+ CD8+ stage and lack mature T cells in the periphery. However, no gross abnormality in development and function of the B and NK cells has been described. Here we...

journal_title：Immunology

authors： Oya K,Wang J,Watanabe Y,Koga R,Watanabe T

更新日期：2003-07-01 00:00:00

abstract：:Age-related macular maculopathy (ARM) and age-related macular degeneration (AMD) are the leading causes of blindness in the Western world. Despite the magnitude of this clinical problem, very little is known about the pathogenesis of the disease. In this study, we analysed the sera (using indirect immunohistochemistry...

journal_title：Immunology

authors： Patel N,Ohbayashi M,Nugent AK,Ramchand K,Toda M,Chau KY,Bunce C,Webster A,Bird AC,Ono SJ,Chong V

更新日期：2005-07-01 00:00:00

abstract：:Cells expressing indoleamine 2,3-dioxygenase (IDO), an enzyme which catabolizes tryptophan, prevent T-cell proliferation in vitro, suppress maternal antifetal immunity during pregnancy and inhibit T-cell-mediated responses to tumour-associated antigens. To examine the mechanistic basis of these phenomena we activated ...

journal_title：Immunology

authors： Lee GK,Park HJ,Macleod M,Chandler P,Munn DH,Mellor AL

更新日期：2002-12-01 00:00:00

abstract：:Haptenated murine Langerhans' cells (LCs) have been reported to induce contact sensitivity when injected via the subcutaneous, intraperitoneal and, in some instances, the intravenous route. Similar studies were undertaken to elucidate the role of the LC in the induction of contact sensitivity in the guinea-pig. The su...

journal_title：Immunology

authors： Baker D,Parker D,Healey DG,Turk JL

更新日期：1987-12-01 00:00:00

abstract：:When cultured on a collagen matrix at a density of 7 X 10(4) cells/cm2 for 48 hr, 80 +/- 10% of unfractionated and 70 +/- 14% of T-enriched human blood lymphocytes from eight healthy individuals developed a motile morphology defined as the presence of lamellar surface activity and cytoplasmic flattening. During cultur...

journal_title：Immunology

authors： Sundqvist KG,Otteskog P

更新日期：1986-07-01 00:00:00

abstract：:Experiments were designed to determine the in vivo cell-cycle phase of lymphocytes in secondary lymphoid follicles, and whether B-cell proliferation and apoptosis occur within follicular dendritic cell (FDC)-associated clusters. Using frozen serial sections of human tonsils, lymphoid follicles were stained to reveal h...

journal_title：Immunology

authors： Orui H,Yamakawa M,Imai Y

更新日期：1997-04-01 00:00:00

abstract：:Serum antibodies to glucosyltransferase (GTF) of Streptococcus mutans serotype c were assayed sequentially by means of an enzyme inhibition radio-assay in twenty-six Rhesus monkeys immunized with S. mutans. Pre-immune and control sera had a GTP-enhancing effect which was shown also by albumin and non-immune immunoglob...

journal_title：Immunology

authors： Russell MW,Challacombe SJ,Lehner T

更新日期：1976-05-01 00:00:00

abstract：:Immunoglobulin G4 (IgG4) antibodies have been known for some time to be functionally monovalent. Recently, the structural basis for this monovalency has been elucidated: the in vivo exchange of IgG half-molecules (one H-plus one L-chain) among IgG4. This process results in bispecific antibodies that in most situations...

journal_title：Immunology

authors： Aalberse RC,Schuurman J

更新日期：2002-01-01 00:00:00