Trypanosoma cruzi suppresses the expression of the p75 chain of interleukin-2 receptors on the surface of activated helper and cytotoxic human lymphocytes.

abstract：:In many types of tumours, especially pancreatic adenocarcinoma, miR-301a is over-expressed. This over-expression results in negative regulation of the target gene of miR-301a, the nuclear factor-κB (NF-κB) repressing factor (NKRF), increasing the activation of NF-κB and production of NF-κB-responsive pro-inflammatory ...

journal_title：Immunology

authors： Huang L,Liu Y,Wang L,Chen R,Ge W,Lin Z,Zhang Y,Liu S,Shan Y,Lin Q,Jiang M

更新日期：2013-11-01 00:00:00

abstract：:To analyse the immunological mechanism of hepatocellular injury in hepatitis B virus (HBV) infection, the immunoreactivity of HBV-encoded antigens as a target for cytotoxic T lymphocyte (CTL) response was examined using recombinant vaccinia virus (RVV) expressing surface protein (S), precore/core protein (PC), and cor...

journal_title：Immunology

authors： Ishikawa T,Kakumu S,Yoshioka K,Yamada M,Tanaka K,Higashi Y,Takayanagi M,Okumura A,Kojima A,Tamura T

更新日期：1993-10-01 00:00:00

abstract：:It has been reported previously that environmental antigens such as intestinal microflora play an important role in an age-associated increase in number of T-cell receptor gamma/delta-bearing T cells. To extend the scope of this finding, this study examined the influences of local inflammation on the accumulation and/...

journal_title：Immunology

authors： Yoshikai Y,Matsuzaki G,Inoue T,Nomoto K

更新日期：1990-05-01 00:00:00

abstract：:A group of fifteen rabbits were immunized five times, at weekly intervals, by intravenous injection of mouse thymocytes. After an interval of 3 months the rabbits were then re-immunized three times at intervals of 7 days. The rabbits were bled prior to the commencement of immunization to obtain normal rabbit serum (NR...

journal_title：Immunology

authors： Lai T,Symes MO

更新日期：1976-07-01 00:00:00

abstract：:The in vitro frequency and proliferative capacity of B cells and B-cell precursors in old mice was assessed. The mitogenic response to the B-cell mitogens lipopolysaccharide (LPS) and dextran sulphate decline later and at a slower rate than the T-cell response to phytohaemagglutinin and concanavalin A. The response to...

journal_title：Immunology

authors： Duwe AK,Roder JC,Singhal SK

更新日期：1979-06-01 00:00:00

abstract：:Complement activation within lymph nodes has been shown to alter lymphocyte traffic through the node. Challenge of cannulated sheep lymph nodes with either immune complexes or complement activators was found to initiate the phenomenon of cell shutdown associated with antigenic challenge of lymph nodes in primed animal...

journal_title：Immunology

authors： McConnell I,Hopkins J

更新日期：1981-02-01 00:00:00

abstract：:Anti-proteinase 3 antibodies are implicated in the pathogenesis of small vessel vasculitis. These are primarily immunoglobulin G (IgG), with different subclasses predominating at different stages of disease. However, little is known of their respective roles in pathogenesis. We have previously shown that patient IgG4 ...

journal_title：Immunology

authors： Hussain A,Pankhurst T,Goodall M,Colman R,Jefferis R,Savage CO,Williams JM

更新日期：2009-10-01 00:00:00

abstract：:The Ig subunit structure of murine B lymphocytes was studied by employing different radiolabelling techniques in combination with chemical cross-linking. The main membrane structure of IgM was a half molecule that was disulphide-linked to proteins with MW 30,000, 45,000 and 55,000, respectively. Small amounts of mu 2L...

journal_title：Immunology

authors： Vogel L,Haustein D

更新日期：1989-06-01 00:00:00

abstract：:Cells expressing indoleamine 2,3-dioxygenase (IDO), an enzyme which catabolizes tryptophan, prevent T-cell proliferation in vitro, suppress maternal antifetal immunity during pregnancy and inhibit T-cell-mediated responses to tumour-associated antigens. To examine the mechanistic basis of these phenomena we activated ...

journal_title：Immunology

authors： Lee GK,Park HJ,Macleod M,Chandler P,Munn DH,Mellor AL

更新日期：2002-12-01 00:00:00

abstract：:Protein kinase C (PKC) form a key family of enzymes involved in signalling pathways that specifically phosphorylates substrates at serine/threonine residues. Phosphorylation by PKC is important in regulating a variety of cellular events such as cell proliferation and the regulation of gene expression. In the immune sy...

journal_title：Immunology

authors： Lim PS,Sutton CR,Rao S

更新日期：2015-12-01 00:00:00

abstract：:The ability of preparations of cobra factor (CoF) to convert C3 via the properdin pathway (anticomplementary activity) has been demonstrated to be unrelated to its ascribed ability to convert a tolerogenic signal into an immunogenic stimulus (adjuvant activity). It has been shown that CoF preparations which have becom...

journal_title：Immunology

authors： Morrison DC,Louis JA,Weigle WO

更新日期：1976-03-01 00:00:00

abstract：:Previous studies in our laboratory have shown that bone-marrow-derived mast cells (BMMC) could present immunogenic peptides, from soluble antigens endocytosed through fluid phase, only if they were subjected to a 48-hr treatment with interleukin-4 (IL-4) and granulocyte-macrophage colony-stimulating factor (GM-CSF). I...

journal_title：Immunology

authors： Tkaczyk C,Villa I,Peronet R,David B,Mécheri S

更新日期：1999-06-01 00:00:00

abstract：:Individual young adult, middle-aged, and old C57BL/6J male mice were tested for in vitro generated proliferative and cytotoxic responses to H-2 alloantigens under a variety of sensitization conditions. Proliferation in mixed lymphocyte culture (MLC) had decreased by 14 months of age (middle-aged), whether measured by ...

journal_title：Immunology

authors： Gottesman SR,Kristie JA,Walford RL

更新日期：1981-11-01 00:00:00

abstract：:Young (15-week-old) CBA/Ca mice were injected intravenously with spleen cells from individual young (15-week-old) or old (18-24-month-old) CBA/T6T6 mice. Samples of peripheral blood were taken at monthly intervals and cultured with phytohaemagglutinin (PHA) to stimulate T lymphocytes into mitosis. In the recipients of...

journal_title：Immunology

authors： Wallis VJ,Chaudhuri M,Jacob MC,Valkova BA,Davies AJ

更新日期：1984-12-01 00:00:00

abstract：:Mice simultaneously injected intravenously and subcutaneously with herpes simplex virus fail to adoptively transfer delayed hypersensitivity (DH) to syngeneic recipients. The transferred lymph node cells also failed to rapidly eliminate infectious herpes from the pinna, despite the presence of cytotoxic T cells in the...

journal_title：Immunology

authors： Nash AA,Ashford NP

更新日期：1982-04-01 00:00:00

abstract：:We have investigated the potential of CD4+ T cells isolated from Peyer's patches and mesenteric lymph nodes (mucosa-associated lymphoid tissues) and from spleens and peripheral lymph nodes (systemic lymphoid tissues) to secrete a variety of lymphokines. The results show several pronounced differences in the kinetics o...

journal_title：Immunology

authors： Tonkonogy SL,Swain SL

更新日期：1993-12-01 00:00:00

abstract：:Donor mice were painted on the skin of the abdomen with the contact sensitizing agent, oxazolone. One day later 2-5 x 10(6) cells from the regional lymph nodes were injected into the footpads of recipient mice. Contact sensitivity was detected 6 days later by challenging the ears of the recipients and measuring the in...

journal_title：Immunology

authors： Asherson GL,Mayhew B,Perera MA

更新日期：1979-05-01 00:00:00

abstract：:We examined the mechanisms of disturbed T-lymphocyte function that occurred during Schistosoma japonicum infection of BALB/c mice from the viewpoint of the interleukin cascade reaction. Each point of the interleukin cascade reaction was examined. First, IL-1 production by adherent peritoneal or spleen cells, as a sour...

journal_title：Immunology

authors： Yamashita T,Watanabe T,Sendo F

更新日期：1987-10-01 00:00:00

abstract：:We have previously presented indirect evidence that both specific immunosuppression and lymphocyte mitogenicity induced in mice by p36, a proteinaceous factor of virulence produced by porcine monocytes infected by African swine fever virus, were consistent with a Th2-driven response. Here we show: (1) Interleukin-4 (I...

journal_title：Immunology

authors： Vilanova M,Ferreira P,Ribeiro A,Arala-Chaves M

更新日期：1999-03-01 00:00:00

abstract：:Mice injected intravenously with a high dose (5 X 10(7) ) of BCG fail to develop delayed hypersensitivity to BCG and are described as anergic or unresponsive. Spleen cells from these mice release factors on culture which suppress DNA synthesis induced by concanavalin A in vitro. Cell separation experiments showed that...

journal_title：Immunology

authors： Colizzi V,Ferluga J,Garreau F,Malkovsky M,Asherson GL

更新日期：1984-01-01 00:00:00

abstract：:The gut microbiota provides an important stimulus for the induction of regulatory T (Treg) cells in mice, whether this applies to newborn children is unknown. In Swedish children, Staphylococcus aureus has become a common early colonizer of the gut. Here, we sought to study the effects of bacterial stimulation on neon...

journal_title：Immunology

authors： Rabe H,Nordström I,Andersson K,Lundell AC,Rudin A

更新日期：2014-03-01 00:00:00

abstract：:The isolation and characterization of a new eosinophil-derived protein, eosinophil protein X (EPX) is here described. The purified EPX is a highly basic glycoprotein and shows one band on sodium dodecyl sulphate polyacrylamide gel electrophoresis and on agarose electrophoresis. The molecular weight of the unreduced pr...

journal_title：Immunology

authors： Peterson CG,Venge P

更新日期：1983-09-01 00:00:00

abstract：:Three-week-old chickens were given sheep erythrocytes or bovine serum albumin intravenously. Seven days later their tears and saliva possessed low levels of antibody to those antigens. Concurrent infection with lentogenic Newcastle disease virus (NDV) caused a significant increase in transuded antibody in those fluids...

journal_title：Immunology

authors： Aitken ID,Parry SH

更新日期：1976-07-01 00:00:00

abstract：:Mouse spleen cells from animals immunized with bovine peripheral blood lymphocytes were fused to X63 . Ag8 myeloma cells and the activity of one of the resulting myeloma hybrids was characterized. The product of this clone (B5/4.1.4) binds to pentameric bovine IgM isolated from serum but not to serum IgG1 or IgG2. Thi...

journal_title：Immunology

authors： Pinder M,Musoke AJ,Morrison WI,Roelants GE

更新日期：1980-07-01 00:00:00

abstract：:Over the past 10 years we have made great strides in our understanding of T helper cell differentiation, expansion and effector functions. Within the context of T helper type 2 (Th2) cell development, novel innate-like cells with the capacity to secrete large amounts of interleukin-5 (IL-5), IL-13 and IL-9 as well as ...

journal_title：Immunology

authors： Okoye IS,Wilson MS

更新日期：2011-12-01 00:00:00

abstract：:A sudden upsurge of fever cases with joint pain was observed in the outpatient department, Community Health Centre, Rangat during July-August 2010 in Rangat Middle Andaman, India. The aetiological agent responsible for the outbreak was identified as chikungunya virus (CHIKV), by using RT-PCR and IgM ELISA. The study i...

journal_title：Immunology

authors： Chaaithanya IK,Muruganandam N,Anwesh M,Rajesh R,Ghosal SR,Kartick C,Prasad KN,Muthumani K,Vijayachari P

更新日期：2013-10-01 00:00:00

abstract：:BALB/c mice develop myasthenic symptoms after immunization with rodent acetylcholine receptor (AChR). After immunization with Torpedo AChR (TAChR), their CD4+ cells become strongly sensitized against a conserved region of the TAChR alpha subunit sequence (residues alpha 304-322), and cross-react vigorously with the ho...

journal_title：Immunology

authors： Karachunski PI,Ostlie N,Conti-Tronconi BM,Bellone M

更新日期：1994-05-01 00:00:00

abstract：:We have shown that human endothelial cells (EC) are protected against complement-mediated injury by the inducible expression of decay-accelerating factor (DAF). To understand further the importance of DAF regulation, we characterized EC DAF expression on murine EC in vitro and in vivo using a model of glomerulonephrit...

journal_title：Immunology

authors： Ahmad SR,Lidington EA,Ohta R,Okada N,Robson MG,Davies KA,Leitges M,Harris CL,Haskard DO,Mason JC

更新日期：2003-10-01 00:00:00

abstract：:The differentiation mechanisms that force thymocytes into the T-cell receptor (TCR)-alpha beta or TCR-gamma delta lineage are poorly understood, but rearrangement processes in the TCR-alpha/delta locus are likely to play an important role. It is assumed that the TCR-delta gene is deleted prior to V alpha-J alpha rearr...

journal_title：Immunology

authors： Verschuren MC,Wolvers-Tettero IL,Breit TM,van Dongen JJ

更新日期：1998-02-01 00:00:00

abstract：:Secretory component (SC or polymeric immunoglobulin receptor) on mucosal epithelial cells mediates transcytosis of polymeric immunoglobulin into external fluids and functions as a receptor for polymeric immunoglobulin. SC expression in a human colonic adenocarcinoma cell line, HT-29 has been reported to be up-regulate...

journal_title：Immunology

authors： Hayashi M,Takenouchi N,Asano M,Kato M,Tsurumachi T,Saito T,Moro I

更新日期：1997-10-01 00:00:00