Abstract:
:Trinitrophenyl (TNP)-specific humoral response was tested after immunization with TNP-protein conjugates composed of either native proteins or proteins modified by chlorination. Significant enhancement of the hapten-specific response was observed as a result of carrier chlorination. This effect was dose dependent and affected mainly T-helper-cell activation. Since stimulated neutrophils chlorinate in vivo proteins, we propose that they take part in the induction phase of immune response by facilitation of antigen processing and/or presentation.
journal_name
Immunologyjournal_title
Immunologyauthors
Marcinkiewicz J,Olszowska E,Olszowski S,Zgliczynski JMkeywords:
subject
Has Abstractpub_date
1992-07-01 00:00:00pages
385-8issue
3eissn
0019-2805issn
1365-2567journal_volume
76pub_type
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