Enhancement of trinitrophenyl-specific humoral response to TNP proteins as the result of carrier chlorination.

abstract：:Resveratrol is a polyphenol that acts on multiple molecular targets important for cell differentiation and activation. Dendritic cells (DCs) are a functionally diverse cell type and represent the most potent antigen-presenting cells of the immune system. In this study, we investigated resveratrol-induced effects on DC...

journal_title：Immunology

authors： Svajger U,Obermajer N,Jeras M

更新日期：2010-04-01 00:00:00

abstract：:The shedding and resynthesis of Fc, C3 receptors, and receptors binding SRBC has been studied in normal peripheral lymphocytes, in lymphocytes from CLL patients and in a Raji cell line during 4 h incubation at 37 degrees. During the first part of the incubation, an increased release of receptors was observed. The shed...

journal_title：Immunology

authors： Sármay G,István L,Gergely J

更新日期：1978-02-01 00:00:00

abstract：:Four types of lymphocyte chemotactic factor (LCF-a, -b, -c and -d) could be isolated from extract of 24-hr-old delayed-type hypersensitivity (DTH) skin reaction sites induced with purified protein derivative (PPD) in guinea-pigs by gel filtration on Sephadex G-100 followed by chromatography with DEAE-Sephadex. Partial...

journal_title：Immunology

authors： Shimokawa Y,Harita S,Hayashi H

更新日期：1984-02-01 00:00:00

abstract：:Immunoglobulin E (IgE)-dependent mechanisms play a pivotal role in mediating allergic disease. Previously, VH-Cepsilon transcripts from blood or spleen of atopic asthmatics have been analysed for VH gene usage and patterns of somatic mutation. An over-representation of the minor VH5 family has been observed, consisten...

journal_title：Immunology

authors： Snow RE,Djukanovic R,Stevenson FK

更新日期：1999-12-01 00:00:00

abstract：:Co-stimulation of highly purified peripheral T lymphocytes from healthy blood donors with the adhesion molecules CD2 and CD28 in association with recombinant interleukin-7 (rIL-7) induced T-cell proliferation, multiple cytokine secretion and IL-2 receptivity. We demonstrated that rIL-7 is as potent as rIL-2 in inducin...

journal_title：Immunology

authors： Costello R,Brailly H,Mallet F,Mawas C,Olive D

更新日期：1993-11-01 00:00:00

abstract：:Runx1 transcription factor is highly expressed at a CD4/CD8-double-negative (DN) stage of thymocyte development but is down-regulated when cells proceed to the double-positive (DP) stage. In the present study, we examined whether the down-regulation of Runx1 is necessary for thymocyte differentiation from the DN to DP...

journal_title：Immunology

authors： Wong WF,Nakazato M,Watanabe T,Kohu K,Ogata T,Yoshida N,Sotomaru Y,Ito M,Araki K,Telfer J,Fukumoto M,Suzuki D,Sato T,Hozumi K,Habu S,Satake M

更新日期：2010-06-01 00:00:00

abstract：:The ability of preparations of cobra factor (CoF) to convert C3 via the properdin pathway (anticomplementary activity) has been demonstrated to be unrelated to its ascribed ability to convert a tolerogenic signal into an immunogenic stimulus (adjuvant activity). It has been shown that CoF preparations which have becom...

journal_title：Immunology

authors： Morrison DC,Louis JA,Weigle WO

更新日期：1976-03-01 00:00:00

abstract：:Recent suggestions of a thymic origin or thymo-dependent differentiation of tissue mast cells prompted an investigation in the athymic nude (nu/nu) mouse. The outbred nu/nu examined were found to possess mast cells in at least comparable numbers to the phenotypically normal nu/+. These nu/nu were superior to nu/+ as r...

journal_title：Immunology

authors： Lynch NR,Prin J,Salomon JC

更新日期：1977-01-01 00:00:00

abstract：:Human neutrophils express Toll-like receptor 4 (TLR4) at low levels, and the role of this receptor in neutrophil responses to microbial stimuli has been questioned. Genetic manipulation of these cells to enable the study of the role of proteins such as TLR4 in their function is challenging. Here, we show that primary ...

journal_title：Immunology

authors： Dick EP,Prince LR,Prestwich EC,Renshaw SA,Whyte MK,Sabroe I

更新日期：2009-06-01 00:00:00

abstract：:Deficiency in gammadelta T cells aggravates colitis in animal models suggesting that gammadelta T cells have regulatory properties. Therefore, proliferation, suppression and cytokine secretion of human gammadelta T cells were determined in vitro. Human peripheral gammadelta T cells were isolated from the whole blood o...

journal_title：Immunology

authors： Kühl AA,Pawlowski NN,Grollich K,Blessenohl M,Westermann J,Zeitz M,Loddenkemper C,Hoffmann JC

更新日期：2009-12-01 00:00:00

abstract：:Ribonucleic acid (immune RNA, iRNA), extracted from the spleens of mice immunized with sheep red blood cells (SRBC), induced specific immunological memory. The humoral immune responses of iRNA-treated animals were compared with in vivo and in vitro primary and secondary responses, using the haemolytic plaque-forming c...

journal_title：Immunology

authors： Kodama K,Yoshida T,Shibiya T,Kurashige S,Mitsuhashi S

更新日期：1981-11-01 00:00:00

abstract：:To define the role of memory T cells in a non-persistent viral infection, we have delineated the phenotype of memory CD8+ T cells specific for influenza A virus (FluA; matrix protein M158-66) based on the expression of several memory/effector lineage markers and relevant chemokine receptors. We found a majority of Flu...

journal_title：Immunology

authors： Hoji A,Rinaldo CR Jr

更新日期：2005-06-01 00:00:00

abstract：:Mice injected at birth with semi-allogeneic lymphoid cells develop a lupus-like autoimmune syndrome in which donor B cells are polyclonally activated by host alloreactive CD4+ T cells, producing autoantibodies and immune complex-mediated glomerulonephritis. It has been demonstrated that the recognition of major histoc...

journal_title：Immunology

authors： Ramos A,Merino R,Merino J

更新日期：1994-06-01 00:00:00

abstract：:Immunization of mice with cognate cancer-derived heat-shock protein (hsp) preparations leads to protection from cancer growth. As hsp used for vaccination or therapy are derived from autologous cancers, questions of pathological autoimmunity are of immense significance for the ongoing translation of this approach to t...

journal_title：Immunology

authors： Ménoret A,Chandawarkar RY,Srivastava PK

更新日期：2000-11-01 00:00:00

abstract：:The OKT3 antibody activates locomotion of human blood T lymphocytes as measured by polarization assays and invasion of collagen gels. The proportion of motile cells increases during a period of 24-48 hr of culture, even following only a brief initial contact with OKT3. The motile cells are the growing population. Loco...

journal_title：Immunology

authors： Wilkinson PC,Higgins A

更新日期：1987-03-01 00:00:00

abstract：:Lymphotoxin (TNF beta) and tumour necrosis factor alpha (TNF alpha) stimulate locomotion and chemotaxis of human blood neutrophils as measured in three assays. Both cytokines stimulate morphological polarization of neutrophils in suspension; both stimulate locomotion of neutrophils into micropore filters; both cause o...

journal_title：Immunology

authors： Newman I,Wilkinson PC

更新日期：1989-02-01 00:00:00

abstract：:Anti-CD20 monoclonal antibodies are promising for the treatment of B-cell malignancies such as chronic lymphocytic leukaemia and autoimmune diseases where auto-antibodies play an important role. Anti-CD20 such as rituximab (RTX) mediates B-cell depletion through mechanisms such as complement-mediated cytotoxicity and ...

journal_title：Immunology

authors： Pedersen AE,Jungersen MB,Pedersen CD

更新日期：2011-06-01 00:00:00

abstract：:Polysorbate 80 (PS80 or Tween-80) is often used as an additive to promote the rapid solubilization of pharmaceuticals in aqueous solutions. We investigated whether coinjection of a minimal amount of PS80 had a modulatory effect on the immunotherapeutic effects of Cry (Cryptomeria)-consensus peptide, a novel peptide de...

journal_title：Immunology

authors： Kozutsumi D,Tsunematsu M,Yamaji T,Murakami R,Yokoyama M,Kino K

更新日期：2006-07-01 00:00:00

abstract：:We have used a number of in vitro and in vivo techniques to identify the molecules that can bind to the cytoplasmic tail of the Ly49A receptor. Affinity chromatography using peptides corresponding to the N-terminal 18 amino acids of Ly49A allowed the recovery of a number of proteins that bound preferentially to the ty...

journal_title：Immunology

authors： Daws MR,Eriksson M,Oberg L,Ullén A,Sentman CL

更新日期：1999-08-01 00:00:00

abstract：:Isolated normal human peripheral neutrophils became cytotoxic to chicken red blood cells (CRBC) in the presence of phytohaemagglutinin (PHA) and concanavalin A (Con A), a phenomenon which we have termed lectin-dependent neutrophilmediated cytotoxicity (LDNMC). Substantial cytotoxicity could be demonstrated by 1 h of i...

journal_title：Immunology

authors： Simchowitz L,Schur PH

更新日期：1976-08-01 00:00:00

abstract：:Anti-idiotypic sera (aIds) were raised in C57BL/6 mice against monoclonal antibodies (McAbs) which bind poly(Tyr,Glu)-poly(DLAla)--poly(Lys)--abbreviated to (T,G)-A--L--and (Tyr-Tyr-Glu-Glu)-poly(DLAla)--poly(Lys)--abbreviated to (T-T-G-G)-A--L--(nos. 103 and 160) and McAbs which react only with (T-T-G-G)-A--L (nos. 1...

journal_title：Immunology

authors： Parhami-Seren B,Eshhar Z,Mozes E

更新日期：1984-02-01 00:00:00

abstract：:HIV infection is associated with increased representation of T cells bearing an activated, memory (CD45RO+) phenotype. Although administration of antiretroviral agents and interleukin-2 (IL-2) augment depleted CD4+ T-cell numbers, such therapies have been preferentially beneficial for CD45RO+ T cells. Interleukin-15 (...

journal_title：Immunology

authors： Naora H,Gougeon M

更新日期：1999-06-01 00:00:00

abstract：:Suramin, a polyanionic and polycyclic compound, was initially used for the treatment of trypanosomiasis and onchocerciasis. In the last decade, it has been used in therapy of cancer and acquired immune deficiency syndrome (AIDS). The influence of suramin on the expression of various markers by human mononuclear phagoc...

journal_title：Immunology

authors： Schiller C,Spittler A,Willheim M,Szépfalusi Z,Agis H,Köller M,Peterlik M,Boltz-Nitulescu G

更新日期：1994-04-01 00:00:00

abstract：:CD4 and CD8 T-cell clones were generated using the Mx9 monoclonal antibody (mAb), which recognizes the V beta 8 T-cell receptor (TcR) gene family. The interaction of these clones with the Mx9 antibody was analysed and all were found to be specifically stimulated to proliferate by plastic-adherent Mx9. In the presence ...

journal_title：Immunology

authors： De Berardinis P,Londei M,Carrel S,Feldmann M

更新日期：1988-07-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease that can attack many different body organs; the triggering event is unknown. SLE has been associated with more than 100 different autoantibody reactivities - anti-dsDNA is prominent. Nevertheless, autoantibodies to dsDNA occur in only two-thirds of SLE patien...

journal_title：Immunology

authors： Fattal I,Shental N,Molad Y,Gabrielli A,Pokroy-Shapira E,Oren S,Livneh A,Langevitz P,Pauzner R,Sarig O,Gafter U,Domany E,Cohen IR

更新日期：2014-02-01 00:00:00

abstract：:Successful elimination of the hepatitis C virus (HCV) during acute infection has been linked to strong HCV-specific in vitro T-cell proliferation, whereas T cells from patients with chronic hepatitis C respond only weakly to HCV antigens. Lipid-coupled peptides are immunostimulants, which might provide a basis for nov...

journal_title：Immunology

authors： Langhans B,Braunschweiger I,Schweitzer S,Jung G,Inchauspé G,Sauerbruch T,Spengler U

更新日期：2001-04-01 00:00:00

abstract：:The levels of IgM, IgA and IgG secreting cells were examined in control, Corynebacterium parvum-stimulated and tumour-bearing, normal and athymic (Nu/Nu) mice. The percentage of IgA to IgM or IgG secreting cells is relatively higher in peripheral blood than in the spleen or peritoneum of normal mice. Within tumours, i...

journal_title：Immunology

authors： Howie S,McBride WH,James K

更新日期：1982-05-01 00:00:00

abstract：:Experiments were conducted to test the hypothesis that opsonic and non-opsonic phagocytic capacities are differentially regulated by resting and wound-derived macrophages. Furthermore, the phagocytosis of non-opsonized zymosan and beta-glucan particles was quantified to determine whether cells differentially regulate ...

journal_title：Immunology

authors： Reichner JS,Fitzpatrick PA,Wakshull E,Albina JE

更新日期：2001-10-01 00:00:00

abstract：:Peroxisome proliferator activated receptor-gamma (PPARgamma) has been reported to exert anti-inflammatory properties in endotoxic shock and sepsis. One phenomenon that alters the inflammatory response to endotoxin [lipopolysaccharide (LPS)] is endotoxin tolerance, which is caused by previous exposure to endotoxin. Her...

journal_title：Immunology

authors： Zingarelli B,Fan H,Ashton S,Piraino G,Mangeshkar P,Cook JA

更新日期：2008-05-01 00:00:00

abstract：:Resident glomerular macrophages from normal rats were isolated and grown through long-term cultures in order to obtain confluent cell monolayers. These cells have a secretory function as revealed by the production of a cytokine with a molecular weight similar to interleukin-1 (IL-1). The demonstration that rat glomeru...

journal_title：Immunology

authors： Mampaso F,Bricio T,Martin A,Molina A

更新日期：1992-07-01 00:00:00