Blockade of OX40-ligand after initial triggering of the T helper 2 response inhibits mercuric chloride-induced autoimmunity.

abstract：:Anti-proteinase 3 antibodies are implicated in the pathogenesis of small vessel vasculitis. These are primarily immunoglobulin G (IgG), with different subclasses predominating at different stages of disease. However, little is known of their respective roles in pathogenesis. We have previously shown that patient IgG4 ...

journal_title：Immunology

authors： Hussain A,Pankhurst T,Goodall M,Colman R,Jefferis R,Savage CO,Williams JM

更新日期：2009-10-01 00:00:00

abstract：:The role of genetic factors associated with the immunoglobulin heavy chain locus (Igh) in the development of benign monoclonal gammapathy (BMG), a benign B-cell proliferative disorder, was investigated in six Igh congenic mouse strains during ageing. The strains used had a C57BL or BALB background: C57BL/6, BALB.Igb a...

journal_title：Immunology

authors： van den Akker TW,de Glopper-van der Veer E,Radl J,Benner R

更新日期：1988-09-01 00:00:00

abstract：:Epididymitis represents a serious threat to male fertility and usually develops following secondary bacterial infection of the epididymis such as urinary tract infections or sexually transmitted diseases. Surprisingly, very little is known about the innate host response triggered by bacterial infection in the male rep...

journal_title：Immunology

authors： Mühlbauer M,Cheely AW,Yenugu S,Jobin C

更新日期：2008-06-01 00:00:00

abstract：:Lymphotoxin (TNF beta) and tumour necrosis factor alpha (TNF alpha) stimulate locomotion and chemotaxis of human blood neutrophils as measured in three assays. Both cytokines stimulate morphological polarization of neutrophils in suspension; both stimulate locomotion of neutrophils into micropore filters; both cause o...

journal_title：Immunology

authors： Newman I,Wilkinson PC

更新日期：1989-02-01 00:00:00

abstract：:A critical role for leukotriene B(4) (LTB(4)) and/or platelet-activating factor (PAF) in regulating polymorphonuclear cell (PMN) trafficking to inflammatory sites has been reported in a number of experimental inflammatory models. In vitro, newly synthesized LTB(4) and PAF were shown to act in an autocrine/paracrine or...

journal_title：Immunology

authors： Bélanger C,Elimam H,Lefebvre J,Borgeat P,Marleau S

更新日期：2008-07-01 00:00:00

abstract：:Isolated human mononuclear cells were fractionated according to their membrane characteristics or physical properties. Adherent cells were depleted by filtration through glass columns; phagocytic cells were removed by iron treatment and cell subpopulations capable of forming rosettes with sheep erythrocytes (E), eryth...

journal_title：Immunology

authors： De Bracco MM,Isturiz MA,Manni JA

更新日期：1976-03-01 00:00:00

abstract：:Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infection with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necro...

journal_title：Immunology

authors： Kang TJ,Yeum CE,Kim BC,You EY,Chae GT

更新日期：2004-08-01 00:00:00

abstract：:The effect of long chain and medium chain fatty acid absorption on transport and mitogen-induced blast transformation of lymphocytes in intestinal lymphatics was investigated. Intestinal lymph was collected from mesenteric lymph duct cannulated rats maintained in Bollman's cage. Following the intraduodenal administrat...

journal_title：Immunology

authors： Miura S,Imaeda H,Shiozaki H,Ohkubo N,Tashiro H,Serizawa H,Tsuchiya M,Tso P

更新日期：1993-01-01 00:00:00

abstract：:The balance between pro- and anti-inflammatory cytokines has been implicated in the pathogenesis of infectious and auto-immune diseases, and its modulation has been proposed as a potential therapeutic target. The results reported in the present study show that modulators of the renin-angiotensin system, such as the an...

journal_title：Immunology

authors： Peeters AC,Netea MG,Kullberg BJ,Thien T,van der Meer JW

更新日期：1998-07-01 00:00:00

abstract：:Mice injected with rat erythrocytes developed anti-erythrocyte autoantibodies which reached a plateau at 4-12 weeks, then gradually declined until at about 24 weeks the majority of mice were negative. In such recovered mice re-challenge with rat erythrocytes produced an accelerated peak of autoantibody and a much more...

journal_title：Immunology

authors： Naysmith JD,Elson CJ,Dallman M,Fletcher E,Ortega-Pierres MG

更新日期：1980-04-01 00:00:00

abstract：:We investigated the individual CD8+ populations with natural killer (NK) cell markers (NK-type T cell); CD56 single positive (CD56)-T cells, CD56/CD57 double positive (DP)-T cells and CD57 single positive (CD57)-T cells in the peripheral blood. All NK-type T-cell populations expressed CD122 and intermediate levels of ...

journal_title：Immunology

authors： Takayama E,Koike Y,Ohkawa T,Majima T,Fukasawa M,Shinomiya N,Yamaguchi T,Konishi M,Hiraide H,Tadakuma T,Seki S

更新日期：2003-02-01 00:00:00

abstract：:Our goal was to study the small lymphocytes that were recruited to cutaneous DTH lesions in order to determine if there existed a subset of small lymphocytes which preferentially migrated into cutaneous inflammatory sites rather than into lymphoid tissues. Lymphocytes were radiolabelled and injected i.v. into sensitiz...

journal_title：Immunology

authors： Issekutz TB,Webster DM,Stoltz JM

更新日期：1986-05-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I-specific inhibitory natural killer receptors (iNKRs) are expressed by subsets of T cells but the mechanisms inducing their expression are poorly understood, particularly for killer-cell immunoglobulin-like receptors (KIRs). The iNKRs are virtually absent from the surface ...

journal_title：Immunology

authors： Hermann E,Berthe A,Truyens C,Alonso-Vega C,Parrado R,Torrico F,Carlier Y,Braud VM

更新日期：2010-03-01 00:00:00

abstract：:Thymocytes expressing self-reactive T-cell receptors (TCR) are eliminated in the thymus through a TCR-mediated signal. This cell death signal (negative selection) generates nuclear morphological change and DNA fragmentation in thymocytes. However, the pathway leading to DNA fragmentation of thymocytes following TCR en...

journal_title：Immunology

authors： Nagata T,Kishi H,Liu QL,Matsuda T,Imanaka T,Tsukada K,Kang D,Muraguchi A

更新日期：2002-04-01 00:00:00

abstract：:Mice infected by intraperitoneal injection of Mycobacterium tuberculosis were studied over a 23-week period. They showed progressive infection in the lung (with increasing microbial count and granuloma size) whereas viable bacillary counts remained largely stationary in the spleen and in the liver. The influence of H-...

journal_title：Immunology

authors： Brett S,Orrell JM,Swanson Beck J,Ivanyi J

更新日期：1992-05-01 00:00:00

abstract：:The tumour microenvironment is complex containing not only neoplastic cells but also a variety of host cells. The heterogeneous infiltrating immune cells include subsets of cells with opposing functions, whose activities are mediated either directly or through the cytokines they produce. Systemic delivery of cytokines...

journal_title：Immunology

authors： Gerber SA,Sorensen EW,Sedlacek AL,Lim JY,Skrombolas D,Frelinger JG,Lord EM

更新日期：2013-03-01 00:00:00

abstract：:The spontaneous regression of AK-5 histiocytoma is mediated by natural killer (NK) cells through antibody-dependent cell-mediated cellular cytotoxicity (ADCC) and the target cell death involves necrosis and apoptosis. We have studied the NK cell activation and the associated induction of apoptosis in the AK-5 tumour i...

journal_title：Immunology

authors： Bright JJ,Kausalya S,Khar A

更新日期：1995-08-01 00:00:00

abstract：:The immunological basis for the production of autoantibodies characteristic of systemic lupus erythematosus (SLE) against a wide range of antigens remains obscure. The specificity of (NZB x NZW)F1 (BWF1) or MRL/Mp-lpr/lpr (MRL/lpr) mouse monoclonal antibodies (mAb) was examined by immunofluorescence, immunoblotting an...

journal_title：Immunology

authors： Bronze-da-Rocha E,Machado C,Staines NA,Sunkel CE

更新日期：1992-12-01 00:00:00

abstract：:Interleukin-31 (IL-31) is a novel T-helper-lymphocyte-derived cytokine that plays an important role in allergic skin inflammation and atopic dermatitis. It has recently been implicated in bronchial inflammation. We investigated the functions and mechanisms of IL-31-induced activation of human bronchial epithelial cell...

journal_title：Immunology

authors： Ip WK,Wong CK,Li ML,Li PW,Cheung PF,Lam CW

更新日期：2007-12-01 00:00:00

abstract：:Passive transfer of immunity to Taenia taeniaeformis was achieved with serum taken 14, 21, 49 and 63 days after infection. The protective capacity of serum collected at 14 and 21 days resided in the 7Sgamma2 immunoglobulins and appeared to be partics the infection progressed the range of chromatographic fractions show...

journal_title：Immunology

authors： Musoke AJ,Williams JF

更新日期：1975-11-01 00:00:00

abstract：:The effects of cyclophosphamide (CY) on antigenic competition in IgE antibody production were studied in mice treated with the drug on different days and immunized with a mixture of two non-related antigens. Injection of 100 mg of CY/kg of body weight 3 days before or 6 days after immunization resulted in a partial or...

journal_title：Immunology

authors： de Macedo MS,Mota I

更新日期：1982-09-01 00:00:00

abstract：:A rat thymic epithelial cell (TEC) line (R-TNC.1) was established from a long-term TEC culture. Based on its ultrastructure, phenotype and cytokeratin profile, this line was characterized as a type of cortical TEC. R-TNC.1 cells had nursing activity which was manifested by the binding and subsequent engulfment of thym...

journal_title：Immunology

authors： Colić M,Vucević D,Miyasaka M,Tamatani T,Pavlović MD,Dujić A

更新日期：1994-11-01 00:00:00

abstract：:Guinea-pig erythrocytes that had been exposed to influenza A virus or Vibrio cholerae neuraminidase activated the classical complement pathway in autologous serum. Because all viral particles were eluted from the treated cells, activation was not dependent on anti-viral antibodies or on the particles themselves. After...

journal_title：Immunology

authors： Lambre CR,Thibon M,Le Maho S,Di Bella G

更新日期：1983-06-01 00:00:00

abstract：:Thioglycollate-stimulated, adherence and density gradient-enriched peritoneal exudate cells were used for the preparation of a specific, highly active antimacrophage reagent. After absorption with mouse lymphoid cells, an antimacrophage globulin (AMG) fraction was shown to be cytotoxic for peritoneal exudate macrophag...

journal_title：Immunology

authors： Herscowitz HB,Diblasio RC

更新日期：1976-01-01 00:00:00

abstract：:Human neutrophils express Toll-like receptor 4 (TLR4) at low levels, and the role of this receptor in neutrophil responses to microbial stimuli has been questioned. Genetic manipulation of these cells to enable the study of the role of proteins such as TLR4 in their function is challenging. Here, we show that primary ...

journal_title：Immunology

authors： Dick EP,Prince LR,Prestwich EC,Renshaw SA,Whyte MK,Sabroe I

更新日期：2009-06-01 00:00:00

abstract：:Oral administration of antigen induces a state of tolerance that is associated with activation of CD8+ T cells that can transfer unresponsiveness to naïve syngeneic hosts. These T cells are not lytic, but they inhibit development of antibody, CD4+ T helper cell, and CD8+ cytotoxic T lymphocyte (CTL) responses upon ado...

journal_title：Immunology

authors： Kapp JA,Kapp LM,McKenna KC,Lake JP

更新日期：2004-02-01 00:00:00

abstract：:N-Methyl-N-nitrosourea (MNU) but not methyl methanesulphonate (MMS) induced both autoimmune haemolytic anaemia and thymic lymphoma in susceptible strains of mice, particularly the C57BL/6. These effects could be positively correlated with the formation of O6-methylguanine in target DNA. All murine lymphoid cells showe...

journal_title：Immunology

authors： Harris G,Lawley PD,Asbery LJ,Chandler PM,Jones MG

更新日期：1983-07-01 00:00:00

abstract：:A group of fifteen rabbits were immunized five times, at weekly intervals, by intravenous injection of mouse thymocytes. After an interval of 3 months the rabbits were then re-immunized three times at intervals of 7 days. The rabbits were bled prior to the commencement of immunization to obtain normal rabbit serum (NR...

journal_title：Immunology

authors： Lai T,Symes MO

更新日期：1976-07-01 00:00:00

abstract：:Although it is well known that cases with silicosis exhibit various immunological abnormalities, the mechanisms involved in the occurrence of immuno-dysfunction or dysregulation induced by silica compounds have not yet been determined. Fas is a well-known cell surface molecule that is involved in the apoptosis pathway...

journal_title：Immunology

authors： Otsuki T,Sakaguchi H,Tomokuni A,Aikoh T,Matsuki T,Kawakami Y,Kusaka M,Ueki H,Kita S,Ueki A

更新日期：1998-06-01 00:00:00

abstract：:Iron-withholding by the chelating agent desferrioxamine abrogates the proliferative response of human peripheral blood mononuclear cells (PBMC) to phytohaemagglutinin (PHA). The present study investigated whether desferrioxamine operates late in the activation process or, as recently suggested, at an early stage, by i...

journal_title：Immunology

authors： Polson RJ,Jenkins R,Lombard M,Williams AC,Roberts S,Nouri-Aria K,Williams R,Bomford A

更新日期：1990-10-01 00:00:00