Natural killer cell activation-associated induction of target cell DNA fragmentation in a spontaneously regressing rat histiocytoma.

abstract：:The number, distribution and surface phenotype of dividing cells in the thymus, and differences between the cell cycle status of thymocyte subpopulations, were studied in fetal and post-natal lambs using double-labelling techniques. Dividing cells were labelled in vivo for various periods with 5-bromo-2-deoxyuridine (...

journal_title：Immunology

authors： McClure S,Dudler L,Thorpe D,Hein WR

更新日期：1988-11-01 00:00:00

abstract：:The interleukin-2 receptor alpha chain (IL-2R alpha) is a T-cell growth factor receptor and is known to be induced in helper T cells by infection with human T-cell leukaemia virus type-1 (HTLV-1). The Rex protein of HTLV-1 has been shown to stabilize IL-2R alpha mRNA. Although the 3' untranslated region of many RNA ha...

journal_title：Immunology

authors： Kanamori H,Kodama T,Yazaki Y

更新日期：1995-12-01 00:00:00

abstract：:Although the co-stimulatory interaction between B and T cells is well defined, recent evidence suggests that B cells also have a regulatory role. Here, we show that B cells activated using anti-IgD conjugated to dextran (α-δ-dex) directly inhibit TCR-induced CD4 T cell activation, proliferation and cytokine production...

journal_title：Immunology

authors： Preciado-Llanes L,Wing JB,Foster RA,Carlring J,Lees A,Read RC,Heath AW

更新日期：2014-09-20 00:00:00

abstract：:We have previously demonstrated that intranasal (i.n.) administration of the major encephalitogenic peptide, Ac1-9 of myelin basic protein (MBP), inhibited T-cell responsiveness in vitro and induced tolerance in the H-2u mouse model of experimental autoimmune encephalomyelitis (EAE). The peptide analogue Ac1-9[4Y] wit...

journal_title：Immunology

authors： Metzler B,Wraith DC

更新日期：1999-06-01 00:00:00

abstract：:Phagocytes such as dendritic cells (DC) and macrophages employ phagocytosis to take up pathogenic bacteria into phagosomes, digest the bacteria and present the bacteria-derived peptide antigens to the adaptive immunity. Hence, efficient antigen presentation depends greatly on a well-regulated phagocytosis process. Lip...

journal_title：Immunology

authors： Chua RY,Wong SH

更新日期：2013-05-01 00:00:00

abstract：:Microbial adjuvants are essential for the development of T-cell-dependent antibody production, recall T-cell proliferation and interferon-gamma production following immunization with protein antigens. Using an adoptive transfer approach, we showed that the adjuvant lipopolysaccharide enhanced the frequency of cells pr...

journal_title：Immunology

authors： Costalonga M,Zell T

更新日期：2007-09-01 00:00:00

abstract：:Injected recombinant interleukin-6 (IL-6), tumour necrosis factor (TNF) and IL-1 all protect mice against experimental infection with Listeria monocytogenes. We have therefore investigated the interaction of these cytokines during infection. Treatment with recombinant (r)IL-6 enhanced TNF production by spleen cells du...

journal_title：Immunology

authors： Liu Z,Simpson RJ,Cheers C

更新日期：1995-08-01 00:00:00

abstract：:A model of immediate-type hypersensitivity (ITH) in the dog using keyhole limpet haemocyanin (KLH) as the antigen was studied. Long-lasting ITH was induced in fifteen of sixteen dogs by the i.v. (Kepron & Tse, 1975), intradermal (Rockey, Schwartzmann & Halliwell, 1971), inhalation (Patterson & Kelley, 1974) and i.d. p...

journal_title：Immunology

authors： Schatz M,Patterson R,Sommers HM,Harris KE,Suszko IM,Roberts M

更新日期：1977-01-01 00:00:00

abstract：:Blood dendritic cells carry the terminal complement complex (TCC) on their surface, as detected by three monoclonal antibodies (mAb). Two of these mAb were generated by immunizing mice with the terminal complement complex, whereas the third was generated by immunizing mice with blood dendritic cells. All three mAb are...

journal_title：Immunology

authors： Würzner R,Xu H,Franzke A,Schulze M,Peters JH,Götze O

更新日期：1991-09-01 00:00:00

abstract：:CXCL2 (macrophage inflammatory protein-2 (MIP-2)), a critical chemokine for neutrophils, has been shown to be produced in the rat intestine in response to platelet-activating factor (PAF) and to mediate intestinal inflammation and injury. The intestinal epithelium, constantly exposed to bacterial products, is the firs...

journal_title：Immunology

authors： De Plaen IG,Han XB,Liu X,Hsueh W,Ghosh S,May MJ

更新日期：2006-06-01 00:00:00

abstract：:The tumour microenvironment is complex containing not only neoplastic cells but also a variety of host cells. The heterogeneous infiltrating immune cells include subsets of cells with opposing functions, whose activities are mediated either directly or through the cytokines they produce. Systemic delivery of cytokines...

journal_title：Immunology

authors： Gerber SA,Sorensen EW,Sedlacek AL,Lim JY,Skrombolas D,Frelinger JG,Lord EM

更新日期：2013-03-01 00:00:00

abstract：:We describe a high-throughput screening system to detect interactions between leucocyte surface proteins, taking into account that these interactions are usually of very low affinity. The method involves producing the extracellular regions of leucocyte proteins with tags so that they can be bound to nanoparticles to p...

journal_title：Immunology

authors： Jiang L,Barclay AN

更新日期：2010-01-01 00:00:00

abstract：:Experimental protocols have been devised to deliniate the importance of T-cell subsets in immunity to Moloney sarcoma virus-induced tumours using the surface antigens L3T4 and Lyt-2 as markers of helper and cytotoxic cells, respectively. Because the monoclonal antibodies used have been shown to deplete T-cell subsets ...

journal_title：Immunology

authors： Bateman WJ,Jenkinson EJ,Owen JJ

更新日期：1987-07-01 00:00:00

abstract：:Lymphocyte migration into inflammatory sites involves a change from a spherical, non-motile phenotype to an irregular, constantly shape-changing, motile phenotype. We have previously shown that lymphocytes are maintained in the non-motile state by the constitutive activity of protein kinase C (PKC). In this paper we h...

journal_title：Immunology

authors： Thorp KM,Verschueren H,De Baetselier P,Southern C,Matthews N

更新日期：1996-03-01 00:00:00

abstract：:The requirement for activity of the enzyme ADP-ribosyl transferase (ADPRT) and changes in single-strand DNA breaks were assessed during the initial stimulation of quiescent murine splenic lymphocytes with mitogen alone, the stimulation of activated blasts with IL-2-containing medium and, for comparison, the serum stim...

journal_title：Immunology

authors： Johnstone AP,Darling D

更新日期：1985-08-01 00:00:00

abstract：:Class switch recombination (CSR) is a T-cell-dependent mechanism regulating isotype switching in activated mature B cells. Recently we showed that T-cell-independent CSRs occur spontaneously during B lymphopoiesis, but such cells are negatively selected by Fas signalling. In immunoglobulin mu-deficient mice, lack of F...

journal_title：Immunology

authors： Seagal J,Melamed D

更新日期：2004-06-01 00:00:00

abstract：:T. brucei infection in mice causes generalized immunosuppression with multiple changes in the cells of the lymphoid tissue. Loss of B cell responsiveness to antigens and mitogens, and the induction of suppressive T-cells and macrophages, have been previously reported (Hudson, Byner, Freeman & Terry, 1976; Corsini, Cla...

journal_title：Immunology

authors： Askonas BA,Corsini AC,Clayton CE,Ogilvie BM

更新日期：1979-02-01 00:00:00

abstract：:Glucosamine (GlcN) has been reported to possess several biomedical properties, and currently a great deal of attention has been focused on improving the functional properties of GlcN for different applications. Therefore, this study was conducted to introduce a carboxybutyryl functional group to GlcN and to find out t...

journal_title：Immunology

authors： Rajapakse N,Kim MM,Mendis E,Kim SK

更新日期：2008-03-01 00:00:00

abstract：:Lysine prevented the activation of Cl at low ionic strength or by heat aggregated IgG (aggIgG) measured by the hydrolysis of acetyl tyrosine ethyl ester (ATEe) by Cls. When serum was mixed with aggIgG, complement was activated and consumed. If lysine was present in the serum containing aggIgG, the activation of comple...

journal_title：Immunology

authors： Takada A,Takada Y

更新日期：1982-12-01 00:00:00

abstract：:The molecular characteristics of a serum IL-2 inhibitor were determined by fractionating active sera from normal and malaria-infected mice, and assaying inhibitory activity in blocking production and expression of IL-2 activity. Using isoelectric focusing and ion exchange chromatography, the activity resolved in a sin...

journal_title：Immunology

authors： Male D,Lelchuk R,Curry S,Pryce G,Playfair JH

更新日期：1985-09-01 00:00:00

abstract：:A fully humanized anti-CD4 antibody was studied for its effects on resting and activated CD4 T cells. Whereas the antibody was poorly lytic, it induced dramatic down-modulation of CD4 expression on both types of cell. In order to down-modulate CD4 on resting, normal CD4 T cells there was an absolute requirement for Fc...

journal_title：Immunology

authors： Bartholomew M,Brett S,Barber K,Rossman C,Crowe S,Tite J

更新日期：1995-05-01 00:00:00

abstract：:Type A chrysotile fibres (white asbestos) were tested in vitro for activation of the complement system. Fibres were incubated in normal human serum (NHS), factor B-depleted human serum, and normal and C4-deficient guinea-pig sera; the supernates were assayed for the remaining complement activity. Activation of the alt...

journal_title：Immunology

authors： Saint-Remy JM,Cole P

更新日期：1980-10-01 00:00:00

abstract：:Natural cell-mediated cytotoxicity is mediated by a family of effector cells that express cytolytic activities distinct from those generally attributed to B cells, T cells and macrophages; it includes both natural killer (NK) and natural cytotoxic (NC) activities. There is now convincing evidence to show that NC activ...

journal_title：Immunology

authors： Patek PQ,Lin Y

更新日期：1989-08-01 00:00:00

abstract：:Intraepithelial lymphocytes (IEL) in normal human small intestine exhibit cytotoxicity. This study was undertaken to characterize the effector cells and their mode of action. Freshly isolated jejunal IEL and lamina propria lymphocytes (LPL), as well as IEL and LPL depleted of CD4+, CD8+ and T-cell receptor (TCR)-gamma...

journal_title：Immunology

authors： Melgar S,Bas A,Hammarström S,Hammarström ML

更新日期：2002-08-01 00:00:00

abstract：:A plasmid encoding the influenza nucleoprotein gene from A/NT/60/68 virus was transduced into the attenuated Salmonella typhimurium aroA- strain SL3261. The bacterial vector expressing the viral gene product was able to induce both humoral and cell-mediated immune responses to the nucleoprotein antigen. CD4+ virus-spe...

journal_title：Immunology

authors： Tite JP,Gao XM,Hughes-Jenkins CM,Lipscombe M,O'Callaghan D,Dougan G,Liew FY

更新日期：1990-08-01 00:00:00

abstract：:Accumulating evidence indicates that B cells may undergo sequential rearrangements at the light chain loci, despite already expressing light chain receptors. This phenomenon may occur in the bone marrow and, perhaps, in germinal centers. As immunoglobulin (Ig)kappa light chains usually rearrange before Iglambda light ...

journal_title：Immunology

authors： Perfetti V,Vignarelli MC,Palladini G,Navazza V,Giachino C,Merlini G

更新日期：2004-07-01 00:00:00

abstract：:From our experiments and those of others in which cells were cultured at a density of 100,000 cells per well, it has been suggested that autoantibody production against mouse bromelain-treated erythrocytes (mouse brom-RBC) was independent of T cells, and further, was enhanced by the removal of T cells from responsive ...

journal_title：Immunology

authors： Daenke S,Cox KO

更新日期：1987-06-01 00:00:00

abstract：:Antibodies against lymphocytes have been shown in human immunodeficiency virus (HIV)-infected patients, but their relevance in the pathogenesis of acquired immune deficiency syndrome (AIDS) remains controversial. We investigated increased levels of lymphocyte surface Ig and antibodies against CD4+ T cells in the plasm...

journal_title：Immunology

authors： Müller C,Kukel S,Bauer R

更新日期：1993-06-01 00:00:00

abstract：:The influence of the synthetic corticosteroid dexamethasone sodium phosphate (DEXA) upon mouse B cells was studied. This was done by in vivo treatment of mice with a single or multiple injection of DEXA, and by culturing murine spleen cells and bone marrow cells in vitro in the presence of different concentrations of ...

journal_title：Immunology

authors： Sabbele NR,Van Oudenaren A,Hooijkaas H,Benner R

更新日期：1987-10-01 00:00:00

abstract：:We previously reported that FTY720 is an efficient inducer of apoptosis in lymphocytes and cultured cell lines. In the present study, HL-60 human promyerocytoma cells also induced apoptosis through in vitro treatment with the drug, demonstrating extensive DNA fragmentation 6 hr after incubation. The major target of FT...

journal_title：Immunology

authors： Shinomiya T,Li XK,Amemiya H,Suzuki S

更新日期：1997-08-01 00:00:00