Abstract：
:N-Methyl-N-nitrosourea (MNU) but not methyl methanesulphonate (MMS) induced both autoimmune haemolytic anaemia and thymic lymphoma in susceptible strains of mice, particularly the C57BL/6. These effects could be positively correlated with the formation of O6-methylguanine in target DNA. All murine lymphoid cells showed lack of ability to remove O6-methylguanine from their DNA, therefore the variation of responses between different mouse strains indicated that other host factors, probably genetic, must be involved. The results do indicate however that a potent pre-mutagenic DNA base modification can initiate the events leading to autoimmune disease in susceptible mice.
journal_name
Immunologyjournal_title
Immunologyauthors
Harris G,Lawley PD,Asbery LJ,Chandler PM,Jones MGsubject
Has Abstractpub_date
1983-07-01 00:00:00pages
439-49issue
3eissn
0019-2805issn
1365-2567journal_volume
49pub_type
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