Abstract：
:Lymphotoxin (TNF beta) and tumour necrosis factor alpha (TNF alpha) stimulate locomotion and chemotaxis of human blood neutrophils as measured in three assays. Both cytokines stimulate morphological polarization of neutrophils in suspension; both stimulate locomotion of neutrophils into micropore filters; both cause orientation of neutrophils towards a gradient source. Orientation in a gradient suggests a chemotactic effect. The action of both cytokines is similar but is not as strong as that of formyl peptide used as a positive control. Myelomonocytic cell lines (U937 and HL-60) develop responsiveness to formyl peptides on maturation but not to TNF alpha or beta.
journal_name
Immunologyjournal_title
Immunologyauthors
Newman I,Wilkinson PCsubject
Has Abstractpub_date
1989-02-01 00:00:00pages
318-20issue
2eissn
0019-2805issn
1365-2567journal_volume
66pub_type
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