The immunological response of the rat to infection with Taenia taeniaeformis. V. Sequence of appearance of protective immunoglobulins and the mechanism of action of 7Sgamma2a antibodies.

abstract：:T- and B-cell participation in the immune response induced by immune ribonucleic acid (iRNA) preparations against T-dependent antigens was studied using athymic nude, neonatally thymectomized (NT) and cyclophosphamide-treated (CY) mice. The iRNA(T + B) preparations were made from the spleen of BALB/c mice immunized wi...

journal_title：Immunology

authors： Saito K,Natsuno T,Mitsuhashi S

更新日期：1980-12-01 00:00:00

abstract：:Trinitrophenyl (TNP)-specific humoral response was tested after immunization with TNP-protein conjugates composed of either native proteins or proteins modified by chlorination. Significant enhancement of the hapten-specific response was observed as a result of carrier chlorination. This effect was dose dependent and ...

journal_title：Immunology

authors： Marcinkiewicz J,Olszowska E,Olszowski S,Zgliczynski JM

更新日期：1992-07-01 00:00:00

abstract：:Chronic antigenic stimulation leads to gradual accumulation of late-differentiated, antigen-specific, oligoclonal T cells, particularly within the CD8(+) T-cell compartment. They are characterized by critically shortened telomeres, loss of CD28 and/or gain of CD57 expression and are defined as either CD8(+) CD28(-) or...

journal_title：Immunology

authors： Strioga M,Pasukoniene V,Characiejus D

更新日期：2011-09-01 00:00:00

abstract：:Despite extensive investigation of the signals required for development of T helper type 1 (Th1) and type 2 (Th2) immune responses, the mechanisms involved are still not well-defined. A critical role for Epstein-Barr virus-induced gene 3 (EBI3) in these responses has been proposed. EBI3, initially discovered as a tran...

journal_title：Immunology

authors： Dokmeci E,Xu L,Robinson E,Golubets K,Bottomly K,Herrick CA

更新日期：2011-04-01 00:00:00

abstract：:Levels of IgA and IgG antibodies were measured in uterine and vaginal secretions to examine the effect of uterine immunization on the genital tract humoral immune system. When ovariectomized animals were immunized on Day 0 and boosted 13 days later by placing sheep erythrocytes (SRBC) directly in the uterine lumen (UT...

journal_title：Immunology

authors： Wira CR,Sandoe CP

更新日期：1989-09-01 00:00:00

abstract：:Growth of Salmonella enterica in mammalian tissues results from continuous spread of bacteria to new host cells. Our previous work indicated that infective S. enterica are liberated from host cells via stochastic necrotic burst independently of intracellular bacterial numbers. Here we report that liver phagocytes can ...

journal_title：Immunology

authors： Grant AJ,Sheppard M,Deardon R,Brown SP,Foster G,Bryant CE,Maskell DJ,Mastroeni P

更新日期：2008-09-01 00:00:00

abstract：:Functional and phenotypic properties of porcine peripheral blood CD4/CD8 double-positive (DP) lymphocytes were examined. In cross-sectional and longitudinal studies involving a total of 103 pigs, this lymphocyte population was found to increase gradually in proportion with age, comprising < 2% of the total peripheral ...

journal_title：Immunology

authors： Zuckermann FA,Husmann RJ

更新日期：1996-03-01 00:00:00

abstract：:Vitamins A and E and select flavonoids in the family of catechins are well-defined small molecules that, if proven to possess immunomodulatory properties, hold promise as vaccine adjuvants and various therapies. In an effort to determine the in vivo immunomodulatory properties of these molecules, we found that althoug...

journal_title：Immunology

authors： Patel S,Akalkotkar A,Bivona JJ 3rd,Lee JY,Park YK,Yu M,Colpitts SL,Vajdy M

更新日期：2016-08-01 00:00:00

abstract：:The effect of invasive bacteria on the release of proinflammatory mediators (oxygen radicals, leukotriene release) from human polymorphonuclear neutrophils was studied. Bacterial stimuli were used including genetically cloned invasive Yersinia enterocolitica strains 108-P (bearing the phagocytosis-resistance plasmid) ...

journal_title：Immunology

authors： Gröne M,Scheffer J,König W

更新日期：1992-11-01 00:00:00

abstract：:Conjugates carrying a single 2-carboxy-4,6-dinitrophenyl hapten and as auxiliary group various thiazolidine substituents related to penicilloyl, were prepared and studied in guinea-pig passive cutaneous anaphylaxis (PCA). Included are monohaptenic model conjugates with discrete hydrocarbon auxiliary groups. One of the...

journal_title：Immunology

authors： Guenin R,Schneider CH

更新日期：1984-05-01 00:00:00

abstract：:Among their diverse roles as transcriptional regulators during development and cell fate specification, the RUNX transcription factors are best known for the parts they play in haematopoiesis. RUNX proteins are expressed throughout all haematopoietic lineages, being necessary for the emergence of the first haematopoie...

journal_title：Immunology

authors： Voon DC,Hor YT,Ito Y

更新日期：2015-12-01 00:00:00

abstract：:The role of oral-associated lymphoid tissues during induction of oral tolerance still remains elusive. Therefore, the aim was to compare T-cell activation and induction of tolerance to ovalbumin (OVA) presented through either of two routes; deposited into the oral cavity, or the stomach, thereby bypassing the oral cav...

journal_title：Immunology

authors： Bankvall M,Östberg AK,Jontell M,Wold A,Östman S

更新日期：2016-09-01 00:00:00

abstract：:Regeneration of the thymus was studied in rats that were treated with a single oral dose of the organotin compound di-n-butyltin dichloride (DBTC). After an initial maximum depletion of cortical BrdU+ thymocytes on day 2 after treatment, repopulation appeared to start on day 3 as indicated by an increased number of Br...

journal_title：Immunology

authors： Pieters RH,Bol M,Lam BW,Seinen W,Bloksma N,Penninks AH

更新日期：1993-04-01 00:00:00

abstract：:Interleukin-19 (IL-19) plays an important role in asthma by stimulating T helper type 2 (Th2) cytokine production. Interestingly, IL-4, a key Th2 cytokine, in turn up-regulates IL-19 expression in bronchial epithelial cells, so forming a positive feedback loop. In atopic dermatitis (AD), another Th2 disease closely re...

journal_title：Immunology

authors： Bao L,Alexander JB,Shi VY,Mohan GC,Chan LS

更新日期：2014-12-01 00:00:00

abstract：:Several functional parameters and surface markers were studied serially in rnu/rnu rats and compared to rnu/+ controls. Expressed as a percentage of labelled splenocytes, rnu/rnu animals had decreased W3/13 (P less than 0.01) and W3/25 (P less than 0.01) positive cells. Both W3/13 and W3/25 antigens peaked at Week 16 ...

journal_title：Immunology

authors： Sfaksi A,Bonneville M,Soulillou JP

更新日期：1985-08-01 00:00:00

abstract：:CD4 T cells help immune responses, but knowledge of how memory CD4 T cells are regulated and how they regulate adaptive immune responses and induce immunopathology is limited. Using adoptive transfer of virus-specific CD4 T cells, we show that naive CD4 T cells undergo substantial expansion following infection, but ca...

journal_title：Immunology

authors： Bhattacharyya M,Madden P,Henning N,Gregory S,Aid M,Martinot AJ,Barouch DH,Penaloza-MacMaster P

更新日期：2017-10-01 00:00:00

abstract：:Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infection with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necro...

journal_title：Immunology

authors： Kang TJ,Yeum CE,Kim BC,You EY,Chae GT

更新日期：2004-08-01 00:00:00

abstract：:We have previously presented indirect evidence that both specific immunosuppression and lymphocyte mitogenicity induced in mice by p36, a proteinaceous factor of virulence produced by porcine monocytes infected by African swine fever virus, were consistent with a Th2-driven response. Here we show: (1) Interleukin-4 (I...

journal_title：Immunology

authors： Vilanova M,Ferreira P,Ribeiro A,Arala-Chaves M

更新日期：1999-03-01 00:00:00

abstract：:Endodontic infections are polymicrobial infections resulting in bone destruction and tooth loss. The host response to these infections is complex, including both innate and adaptive mechanisms. Osteopontin (OPN), a secreted, integrin-binding protein, functions in the regulation of immune responses and enhancement of l...

journal_title：Immunology

authors： Rittling SR,Zetterberg C,Yagiz K,Skinner S,Suzuki N,Fujimura A,Sasaki H

更新日期：2010-01-01 00:00:00

abstract：:In this study we followed the in vivo fate and distribution of hapten-coupled sheep red blood cells (TNP-SRBC) coated with 125I-labelled anti-hapten antibody in mice. The majority of these complexes was rapidly taken up by the liver, and by macrophages in the marginal zone of the spleen. Within a few hours, however, m...

journal_title：Immunology

authors： Enriquez-Rincon F,Klaus GG

更新日期：1984-05-01 00:00:00

abstract：:We investigated the individual CD8+ populations with natural killer (NK) cell markers (NK-type T cell); CD56 single positive (CD56)-T cells, CD56/CD57 double positive (DP)-T cells and CD57 single positive (CD57)-T cells in the peripheral blood. All NK-type T-cell populations expressed CD122 and intermediate levels of ...

journal_title：Immunology

authors： Takayama E,Koike Y,Ohkawa T,Majima T,Fukasawa M,Shinomiya N,Yamaguchi T,Konishi M,Hiraide H,Tadakuma T,Seki S

更新日期：2003-02-01 00:00:00

abstract：:Degradation of the extracellular matrix plays an important role in rheumatoid articular destruction. Rheumatoid synovial fibroblasts secrete a large amount of matrix-degrading metalloproteinases (MMPs), which initiate tissue damage by proteolytic degradation of collagens and proteoglycans. Cytokines, such as interleuk...

journal_title：Immunology

authors： Migita K,Eguchi K,Kawabe Y,Ichinose Y,Tsukada T,Aoyagi T,Nakamura H,Nagataki S

更新日期：1996-12-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) produce a significant amount of interleukin-5 (IL-5), which supports eosinophil responses in various tissues; they also produce IL-13, which induces mucus production and contributes to tissue repair or fibrosis. The ILC2s are activated by alarmins, such as IL-33 released from epit...

journal_title：Immunology

authors： Kudo F,Ikutani M,Seki Y,Otsubo T,Kawamura YI,Dohi T,Oshima K,Hattori M,Nakae S,Takatsu K,Takaki S

更新日期：2016-01-01 00:00:00

abstract：:We quantified immunoglobulin E (IgE) on peritoneal mast cells of interleukin-4 (IL-4)-gene knockout (-/-) mice and wild-type (+/+) controls using a cytofluorometric method, and examined the expression of IgE receptors, estimated by quantifying the total binding of IgE on the mast cells of IL-4 (-/-) mice. The mast cel...

journal_title：Immunology

authors： Chen XJ,Lycke N,Enerbäck L

更新日期：1999-04-01 00:00:00

abstract：:Tumour necrosis factor-alpha (TNF-alpha) stimulated invasion by mouse T-cell hybridomas and cytotoxic T-lymphocyte clones into rat embryo fibroblast monolayers. The effect on these highly invasive cells was limited: invasion was stimulated maximally to 130% of controls. However, when cells were pretreated with pertuss...

journal_title：Immunology

authors： La Rivière G,Klein Gebbinck JW,Schipper CA,Roos E

更新日期：1992-02-01 00:00:00

abstract：:The concentration of CXCL12/SDF-1 in the bloodstream is tightly regulated, given its central role in leucocyte and stem/progenitor cell egress from bone marrow and recruitment to sites of inflammation or injury. The mechanism responsible for this regulation is unknown. Here we show that both genetic deletion and pharm...

journal_title：Immunology

authors： Berahovich RD,Zabel BA,Lewén S,Walters MJ,Ebsworth K,Wang Y,Jaen JC,Schall TJ

更新日期：2014-01-01 00:00:00

abstract：:Animals contain an enormous load of non-pathogenic bacteria in the lower intestine, which exploit an environment with a stable temperature and abundant carbon sources. Our load of bacteria outnumbers our own cells. In order to survive with such a high number of organisms in very close proximity to host tissues the int...

journal_title：Immunology

authors： Macpherson AJ,Geuking MB,McCoy KD

更新日期：2005-06-01 00:00:00

abstract：:Isolated human mononuclear cells were fractionated according to their membrane characteristics or physical properties. Adherent cells were depleted by filtration through glass columns; phagocytic cells were removed by iron treatment and cell subpopulations capable of forming rosettes with sheep erythrocytes (E), eryth...

journal_title：Immunology

authors： De Bracco MM,Isturiz MA,Manni JA

更新日期：1976-03-01 00:00:00

abstract：:Polyclonal rabbit anti-idiotypic (Ab2) antibodies raised against the antiprogesterone mAb DB3 (Ab1) were used to induce an Ab3 antiprogesterone response in BALB/c mice. While the affinity of Ab3 sera for progesterone was 10-50-times lower than that of DB3, their steroid-binding specificity showed considerable similari...

journal_title：Immunology

authors： Kirsch RD,Beale D,He M,Corper AL,Krawinkel-Brenig U,Taussig MJ

更新日期：2000-06-01 00:00:00

abstract：:Immunodeficiency syndromes associated with protein-energy malnutrition (PEM) have been documented extensively, although to date the mechanism underlying these defects remains uncharacterized. In this study, we have evaluated T, B, and antigen-presenting cell functions of malnourished mice fed a 4% protein diet compare...

journal_title：Immunology

authors： Conzen SD,Janeway CA

更新日期：1988-04-01 00:00:00