Distribution of IgM, IgA and IgG secreting cells in the tissues of normal and tumour-bearing mice.

abstract：:The development of T lymphocytes in ovine fetal lymph nodes was studied immunohistologically using a panel of monoclonal antibodies. T lymphocyte subsets appeared within the ovine fetal lymph node in a specific sequence. SBU-T1- and SBU-T8-positive lymphocytes were seen at Day 47 of gestation. LCA, sIg, MHC I, MHC II,...

journal_title：Immunology

authors： Maddox JF,Mackay CR,Brandon MR

更新日期：1987-09-01 00:00:00

abstract：:To investigate the effect of carbohydrate on activation of the alternative pathway of complement by IgA immune complexes, aglycosylated monoclonal IgA was made biosynthetically in the presence of tunicamycin. When immune complexes were incubated with normal human serum (NHS), the aglycosylated IgA immune complexes cau...

journal_title：Immunology

authors： Zhang W,Lachmann PJ

更新日期：1994-01-01 00:00:00

abstract：:Epidermal keratinocytes are induced to express MHC class II molecules in a variety of disease states associated with immune activity. To investigate the mechanism of this process we have exposed murine and rat keratinocytes to a variety of lymphokines and monitored changes in their MHC molecule expression. Murine cult...

journal_title：Immunology

authors： Yeoman H,Anderton JG,Stanley MA

更新日期：1989-01-01 00:00:00

abstract：:Blood dendritic cells carry the terminal complement complex (TCC) on their surface, as detected by three monoclonal antibodies (mAb). Two of these mAb were generated by immunizing mice with the terminal complement complex, whereas the third was generated by immunizing mice with blood dendritic cells. All three mAb are...

journal_title：Immunology

authors： Würzner R,Xu H,Franzke A,Schulze M,Peters JH,Götze O

更新日期：1991-09-01 00:00:00

abstract：:The chemokine receptor CCR7 is crucial for migration of mature dendritic cells (DC) directed toward secondary lymphoid organs; however, there is little knowledge about the function of the homeostatic chemokine receptor CXCR4 in DC and its contribution to directional migration of DC during inflammation. By comparing th...

journal_title：Immunology

authors： Humrich JY,Humrich JH,Averbeck M,Thumann P,Termeer C,Kämpgen E,Schuler G,Jenne L

更新日期：2006-02-01 00:00:00

abstract：:Surface receptors on peripheral blood neutrophils and monocytes from normal and immunodeficient horses have been studied. Sheep erythrocytes (SRBC) coated with IgG, IgM, and complement but not IgG(T), readily bound to normal equine monocytes and neutrophils. More than 4000 molecules of IgG were required to sensitize e...

journal_title：Immunology

authors： Banks KL,McGuire TC

更新日期：1975-03-01 00:00:00

abstract：:In tumour (fibrosarcoma)-inoculated mice, alterations of host resistance to Listeria monocytogenes following tumour growth were examined. Non-immune macrophage-mediated antibacterial resistance was severely suppressed up to day 4 or so after tumour inoculation, but was enhanced thereafter. On the other hand, T cell-me...

journal_title：Immunology

authors： Miyata H,Himeno K,Miake S,Nomoto K

更新日期：1981-10-01 00:00:00

abstract：:Mice injected in the footpad with carrageenin developed local inflammation which peaked at 48 hr. This delayed-type footpad swelling was significantly reduced in mice injected intraperitoneally (i.p.) with a specific nitric oxide (NO) synthase inhibitor, L-NGmonomethyl-arginine (L-NMMA). The draining lymph node (DLN) ...

journal_title：Immunology

authors： Ianaro A,O'Donnell CA,Di Rosa M,Liew FY

更新日期：1994-07-01 00:00:00

abstract：:We have established lines and clones of helper T cells specific for the antigen fowl gamma globulin (FGG) and maintained these cells in continuous proliferation in vitro for up to 8 months. During this period the specific helper activity was assessed in vitro in T cell-dependent anti-hapten responses. These pure popul...

journal_title：Immunology

authors： Cammisuli S,Schreier MH

更新日期：1981-07-01 00:00:00

abstract：:Immunization of mice with cognate cancer-derived heat-shock protein (hsp) preparations leads to protection from cancer growth. As hsp used for vaccination or therapy are derived from autologous cancers, questions of pathological autoimmunity are of immense significance for the ongoing translation of this approach to t...

journal_title：Immunology

authors： Ménoret A,Chandawarkar RY,Srivastava PK

更新日期：2000-11-01 00:00:00

abstract：:Interleukin-2 (IL-2) is a mainstay for current immunotherapeutic protocols but its usefulness in patients is reduced by severe toxicities and because IL-2 facilitates regulatory T (Treg) cell development. IL-21 is a type I cytokine acting as a potent T-cell co-mitogen but less efficient than IL-2 in sustaining T-cell ...

journal_title：Immunology

authors： Battaglia A,Buzzonetti A,Baranello C,Fanelli M,Fossati M,Catzola V,Scambia G,Fattorossi A

更新日期：2013-05-01 00:00:00

abstract：:Staphylococcal enterotoxins (SE) are potent T-lymphocyte activators that stimulate T cells by directly cross-linking HLA-DR molecules on antigen-presenting cells with the V beta gene products of the T-cell receptor. The different SE activate all T cells expressing a given V beta, and, therefore, have been termed 'supe...

journal_title：Immunology

authors： Duan X,Nerl C,Janssen O,Kabelitz D

更新日期：1992-03-01 00:00:00

abstract：:The Ager assay was adapted to a porcine lymphocyte-rat high endothelial cell (HEC) system. Using this in vitro assay, the role of porcine CD44 in lymphocyte binding to HEC was examined. The results show that the presence of soluble CD44 molecules did not inhibit the binding of porcine lymphocytes to the cultured rat H...

journal_title：Immunology

authors： Yang H,Binns RM

更新日期：1993-07-01 00:00:00

abstract：:The role of T-cell receptor (TCR) gammadelta T cells in the induction of protective TCR alphabeta T cells against infection by the intracellular bacteria Listeria monocytogenes was analysed. We found that depletion of gammadelta T cells by anti-TCR delta monoclonal antibody treatment before intravenous immunization of...

journal_title：Immunology

authors： Nomura A,Matsuzaki G,Takada H,Hiromatsu K,Nabeshima S,Nakamura T,Kishihara K,Nomoto K

更新日期：1998-10-01 00:00:00

abstract：:Mice homozygous for the gld (generalized lymphoproliferative disease) and lpr (lymphoproliferation) mutations display similar autoimmune and lymphoproliferative diseases. Both result from defective apoptosis, the targets of the lpr and gld mutations being the genes for, respectively, an apoptosis-signalling receptor [...

journal_title：Immunology

authors： Rosenblatt N,Hartmann KU,Loor F

更新日期：1995-04-01 00:00:00

abstract：:The induction of proliferation of murine splenocytes by lipopolysaccharide (LPS) of Shigella dysenteriae type 1 and its polysaccharide (PS) and lipid A fractions was investigated. The LPS-induced proliferation reached a maximum at a concentration of 30 ng/ml. The PS and lipid A induced proliferation of murine splenocy...

journal_title：Immunology

authors： Biswas T,Roy S,Banerjee KK

更新日期：1995-02-01 00:00:00

abstract：:B lymphocyte-induced maturation protein-1 (Blimp-1), the transcription factor encoded by the gene Prdm1, plays a number of crucial roles in the adaptive immune system, which result in the maintenance of key effector functions of B- and T-cells. Emerging clinical data, as well as mechanistic evidence from mouse studies...

journal_title：Immunology

authors： Ulmert I,Henriques-Oliveira L,Pereira CF,Lahl K

更新日期：2020-12-01 00:00:00

abstract：:Mice injected intravenously with a high dose (5 X 10(7) ) of BCG fail to develop delayed hypersensitivity to BCG and are described as anergic or unresponsive. Spleen cells from these mice release factors on culture which suppress DNA synthesis induced by concanavalin A in vitro. Cell separation experiments showed that...

journal_title：Immunology

authors： Colizzi V,Ferluga J,Garreau F,Malkovsky M,Asherson GL

更新日期：1984-01-01 00:00:00

abstract：:Immunoglobulin D (IgD) is normally present in only low concentrations in serum. In the hyper-IgD and periodic fever syndrome (HIDS), however, serum levels exceed 140 mg/l. This syndrome is further characterized by recurrent inflammatory febrile attacks together with an acute phase response and appearance of cytokines ...

journal_title：Immunology

authors： Drenth JP,Göertz J,Daha MR,van der Meer JW

更新日期：1996-07-01 00:00:00

abstract：:The interleukin-2 receptor alpha chain (IL-2R alpha) is a T-cell growth factor receptor and is known to be induced in helper T cells by infection with human T-cell leukaemia virus type-1 (HTLV-1). The Rex protein of HTLV-1 has been shown to stabilize IL-2R alpha mRNA. Although the 3' untranslated region of many RNA ha...

journal_title：Immunology

authors： Kanamori H,Kodama T,Yazaki Y

更新日期：1995-12-01 00:00:00

abstract：:Peripheral blood mononuclear (PBM) cells from five of 21 patients with common variable immunodeficiency (CVI) stimulated in vitro by antigen produced antibodies normally. In 11 of the 16 non-responders, removal of adherent suppressor cells by Sephadex G-10 or removal of monocytes or OKT8 positive suppressor lymphocyte...

journal_title：Immunology

authors： Pollack S,Reisner Y,Koziner B,Good RA,Hoffman MK

更新日期：1985-01-01 00:00:00

abstract：:Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infection with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necro...

journal_title：Immunology

authors： Kang TJ,Yeum CE,Kim BC,You EY,Chae GT

更新日期：2004-08-01 00:00:00

abstract：:2B4 (CD244) is a member of the CD2 subset of the immunoglobulin superfamily and functions as a triggering molecule on natural killer (NK) cells. Previously, we have found that 2B4-mediated activation of NK cells involves complex interactions involving LAT, Ras, Raf, ERK and p38 and that cytolytic function and cytokine...

journal_title：Immunology

authors： Chuang SS,Lee JK,Mathew PA

更新日期：2003-07-01 00:00:00

abstract：:Anti-CD20 monoclonal antibodies are promising for the treatment of B-cell malignancies such as chronic lymphocytic leukaemia and autoimmune diseases where auto-antibodies play an important role. Anti-CD20 such as rituximab (RTX) mediates B-cell depletion through mechanisms such as complement-mediated cytotoxicity and ...

journal_title：Immunology

authors： Pedersen AE,Jungersen MB,Pedersen CD

更新日期：2011-06-01 00:00:00

abstract：:Thioglycollate-stimulated, adherence and density gradient-enriched peritoneal exudate cells were used for the preparation of a specific, highly active antimacrophage reagent. After absorption with mouse lymphoid cells, an antimacrophage globulin (AMG) fraction was shown to be cytotoxic for peritoneal exudate macrophag...

journal_title：Immunology

authors： Herscowitz HB,Diblasio RC

更新日期：1976-01-01 00:00:00

abstract：:Guinea-pigs immunized with homogenates of unfed larvae and nymphs of the tick Rhipicephalus appendiculatus developed significant levels of protective immunity to infestation with adults of this species. The mean engorged weight of female ticks feeding on immunized animals (181.96 +/- 05.63 mg and 170.11 +/- 11.54 mg) ...

journal_title：Immunology

authors： Varma MG,Heller-Haupt A,Trinder PK,Langi AO

更新日期：1990-09-01 00:00:00

abstract：:Virus plaque assay (VPA) was utilized for the quantitative evaluation of activated lymphocytes. We examined what types of cells, especially which of activated T and non-T lymphocytes, were detected as infective centres after infection with vesicular stomatitis virus. Marked increases in DNA synthesis and in virus-plaq...

journal_title：Immunology

authors： Kasahara T,Shioiri-Nakano K,Sugiura A

更新日期：1977-06-01 00:00:00

abstract：:In order to analyse the effects of glucocorticoids on interleukin-8 (IL-8) production more precisely, we examined the effects of dexamethasone on IL-8 production at the molecular level in a human fibrosarcoma cell line, 8387, which IL-1 induces to express IL-8 messenger RNA (mRNA) and to secrete IL-8. Over a wide dose...

journal_title：Immunology

authors： Mukaida N,Gussella GL,Kasahara T,Ko Y,Zachariae CO,Kawai T,Matsushima K

更新日期：1992-04-01 00:00:00

abstract：:Murine embryonic stem (ES) cell-derived haematopoietic progenitor cells (HPCs) engraft and populate lymphoid organs. In vivo, HPCs engraft across MHC barriers protecting donor-type allografts from rejection. However, the underlying phenomenon remains elusive. Here, we sought to determine the mechanism by which ES cell...

journal_title：Immunology

authors： Kim EM,Miyake B,Aggarwal M,Voetlause R,Griffith M,Zavazava N

更新日期：2014-07-01 00:00:00

abstract：:Staphylococcus aureus is a major pathogen that can cause a broad spectrum of serious infections including skin infections, pneumonia and sepsis. Peritoneal mast cells have been implicated in the host response towards various bacterial insults and to provide mechanistic insight into the role of mast cells in intraperit...

journal_title：Immunology

authors： Rönnberg E,Johnzon CF,Calounova G,Garcia Faroldi G,Grujic M,Hartmann K,Roers A,Guss B,Lundequist A,Pejler G

更新日期：2014-10-01 00:00:00