Functional and phenotypic analysis of porcine peripheral blood CD4/CD8 double-positive T cells.

abstract：:We have studied activation-induced changes in intracellular calcium [Ca2+]i, interleukin-2 (IL-2) secretion, and clonal abortion of the human leukaemic T-cell line Jurkat and three T-cell receptor (TcR)/CD3 receptor negative clones deficient for the TcR alpha, TcR beta and CD3 gamma chains respectively, as well as thr...

journal_title：Immunology

authors： Claesson MH,Dissing S,Tscherning T,Geisler C

更新日期：1993-03-01 00:00:00

abstract：:We report the cloning of cDNA encoding the pig homologue of human integrin-associated protein (IAP or CD47). A pig CD47-specific probe was generated by polymerase chain reaction (PCR) amplification of pig leucocyte cDNA, using primers based on consensus regions among the known sequences of CD47 from different species....

journal_title：Immunology

authors： Shahein YE,de Andrés DF,Pérez de la Lastra JM

更新日期：2002-08-01 00:00:00

abstract：:The migration of leucocytes into tissues is a process mediated by leucocyte endothelial interactions, in which adhesion receptors play a crucial role. Recently, it was found that 80-90% of T cells in inflammatory skin diseases were reactive to the monoclonal antibody (mAb) HECA-452+ in contrast to inflamed non-cutaneo...

journal_title：Immunology

authors： De Boer OJ,Horst E,Pals ST,Bos JD,Das PK

更新日期：1994-03-01 00:00:00

abstract：:The opossum major histocompatibility complex (MHC) shares a similar organization with that of non-mammals while containing a diverse set of class I genes more like that of eutherian (placental) mammals. There are 11 class I loci in the opossum MHC region, seven of which are known to be transcribed. The previously desc...

journal_title：Immunology

authors： Baker ML,Melman SD,Huntley J,Miller RD

更新日期：2009-09-01 00:00:00

abstract：:This study investigates the effect of feeding fermented milks with Lactobacillus casei, Lactobacillus acidophilus and a mixture of both micro-organisms on the specific and non-specific host defence mechanisms in Swiss mice. Animals fed with fermented milk for 8 days (100 micrograms/day) showed an increase in both phag...

journal_title：Immunology

authors： Perdigón G,de Macias ME,Alvarez S,Oliver G,de Ruiz Holgado AP

更新日期：1988-01-01 00:00:00

abstract：:Protein kinase C (PKC) form a key family of enzymes involved in signalling pathways that specifically phosphorylates substrates at serine/threonine residues. Phosphorylation by PKC is important in regulating a variety of cellular events such as cell proliferation and the regulation of gene expression. In the immune sy...

journal_title：Immunology

authors： Lim PS,Sutton CR,Rao S

更新日期：2015-12-01 00:00:00

abstract：:Effect of macrophage culture fluid (MF) on thymic independent (TI) antibody responses was examined. MF potentiated antibody responses of spleen cells to dinitrophenyl (DNP)-Ficoll and DNP-liposome, TI-2 antigens, but not to trinitrophenyl (TNP)-BA and TNP-LPS, TI-1 antigens. The enhancing effect of MF on the anti-DNP-...

journal_title：Immunology

authors： Mizuguchi J,Kakiuchi T,Nariuchi H,Matuhasi T

更新日期：1982-09-01 00:00:00

abstract：:Mice homozygous for the gld (generalized lymphoproliferative disease) and lpr (lymphoproliferation) mutations display similar autoimmune and lymphoproliferative diseases. Both result from defective apoptosis, the targets of the lpr and gld mutations being the genes for, respectively, an apoptosis-signalling receptor [...

journal_title：Immunology

authors： Rosenblatt N,Hartmann KU,Loor F

更新日期：1995-04-01 00:00:00

abstract：:This paper uses B-lymphocyte cloning methods to quantify the effects of anti-mu chain antibody on immature and mature B cells. Nude mouse spleen lymphocytes were incubated with various concentrations of sheep anti-mouse mu chain antibody for times varying from 10 min to 24 h. They were then washed and plated in the ag...

journal_title：Immunology

authors： Nossal GJ,Pike BL,Battye FL

更新日期：1979-05-01 00:00:00

abstract：:Anti-idiotypic sera (aIds) were raised in C57BL/6 mice against monoclonal antibodies (McAbs) which bind poly(Tyr,Glu)-poly(DLAla)--poly(Lys)--abbreviated to (T,G)-A--L--and (Tyr-Tyr-Glu-Glu)-poly(DLAla)--poly(Lys)--abbreviated to (T-T-G-G)-A--L--(nos. 103 and 160) and McAbs which react only with (T-T-G-G)-A--L (nos. 1...

journal_title：Immunology

authors： Parhami-Seren B,Eshhar Z,Mozes E

更新日期：1984-02-01 00:00:00

abstract：:Neutrophil migration inhibition factor from T lymphocytes (NIF-T) is produced in response to mitogens as the result of cellular interactions between T and B lymphocytes. The requirement for B-cell alloantigen in this interaction process was indicated by (1) collaboration between peripheral blood T cells with various B...

journal_title：Immunology

authors： Weisbart RH,Billing R

更新日期：1980-04-01 00:00:00

abstract：:Dogs with immunoglobulin E (IgE) allergy for ragweed that are sensitized by intrapulmonary exposure to ragweed can be used to study the pulmonary immune response that is important in allergic asthma. Using this model, we tested the hypothesis that T lymphocytes are activated locally in the airways shortly after allerg...

journal_title：Immunology

authors： Out TA,Wang SZ,Rudolph K,Bice DE

更新日期：2002-04-01 00:00:00

abstract：:Lipoprotein was isolated from tumour cells by sonication and ultracentrifugal flotation on KBr gradients. It contained H-2 antigen detectable by antibody binding and induced a primary or secondary cell-mediated cytotoxic response in vitro which was H-2 specific. In a syngeneic model only a secondary cell-mediated resp...

journal_title：Immunology

authors： Dennert G

更新日期：1979-12-01 00:00:00

abstract：:Mutation of the interleukin-2 (IL-2) receptor gamma chain, which also serves as a component of the receptor complexes for IL-4, 7, 9 and 15, results in severe immune deficiency. We hypothesized that the immunological immaturity of healthy neonates might be associated with low levels of expression of this receptor mole...

journal_title：Immunology

authors： Zola H,Fusco M,Weedon H,Macardle PJ,Ridings J,Roberton DM

更新日期：1996-01-01 00:00:00

abstract：:Oral tolerance promotes a generalized decrease in specific immune responsiveness to proteins previously encountered via the oral route. In addition, parenteral immunization with a tolerated protein also triggers a significant reduction in the primary responsiveness to a second unrelated antigen. This is generally expl...

journal_title：Immunology

authors： Ramos GC,Rodrigues CM,Azevedo GM Jr,Pinho V,Carvalho CR,Vaz NM

更新日期：2009-03-01 00:00:00

abstract：:All but one of nine Acholeplasma strains were susceptible to killing by gnotobiotic-calf serum while all but one of fifteen Mycoplasma strains were resistant. The mechanism of killing was examined using inhibitors of complement, viz. EDTA. MgEGTA. epsilon-amino caproic acid, and also by desalting serum and adding MgCl...

journal_title：Immunology

authors： Howard CJ

更新日期：1980-11-01 00:00:00

abstract：:Immunoregulatory CD4(-)  CD8(-) (double-negative; DN) T cells exhibit a unique antigen-specific mode of suppression, yet the ontogeny of DN T cells remains enigmatic. We have recently shown that 3A9 T-cell receptor (TCR) transgenic mice bear a high proportion of immunoregulatory 3A9 DN T cells, facilitating their stud...

journal_title：Immunology

authors： Dugas V,Chabot-Roy G,Beauchamp C,Guimont-Desrochers F,Hillhouse EE,Liston A,Lesage S

更新日期：2013-05-01 00:00:00

abstract：:Exposure of thioglycollate-elicited murine peritoneal macrophages to wheat germ agglutinin (WGA) increased markedly the uptake of six different bacteria, which have surface receptors for the lectin. Uptake of Staphylococcus aureus H was higher by 3-5-fold, of S. aureus 52A2 by 1.8-fold, of S. aureus 52A5 by 1.7-fold, ...

journal_title：Immunology

authors： Gallily R,Vray B,Stain I,Sharon N

更新日期：1984-08-01 00:00:00

abstract：:A fully humanized anti-CD4 antibody was studied for its effects on resting and activated CD4 T cells. Whereas the antibody was poorly lytic, it induced dramatic down-modulation of CD4 expression on both types of cell. In order to down-modulate CD4 on resting, normal CD4 T cells there was an absolute requirement for Fc...

journal_title：Immunology

authors： Bartholomew M,Brett S,Barber K,Rossman C,Crowe S,Tite J

更新日期：1995-05-01 00:00:00

abstract：:We investigated the individual CD8+ populations with natural killer (NK) cell markers (NK-type T cell); CD56 single positive (CD56)-T cells, CD56/CD57 double positive (DP)-T cells and CD57 single positive (CD57)-T cells in the peripheral blood. All NK-type T-cell populations expressed CD122 and intermediate levels of ...

journal_title：Immunology

authors： Takayama E,Koike Y,Ohkawa T,Majima T,Fukasawa M,Shinomiya N,Yamaguchi T,Konishi M,Hiraide H,Tadakuma T,Seki S

更新日期：2003-02-01 00:00:00

abstract：:A major role has been recently ascribed to the neutrophil in the resistance to infection by Listeria monocytogenes (L. monocytogenes). Here we evaluated whether such neutrophils played a role in the non-specific resistance to listeriosis that develops in hosts infected by mycobacteria. We found that the depletion of n...

journal_title：Immunology

authors： Leal IS,Appelberg R,Silva MT

更新日期：1996-11-01 00:00:00

abstract：:The role of endogenously mediated fever and exogenous hyperthermia as modulators of immune functions remains poorly understood. It is known that fever is mediated by several cytokines, including interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta), interleukin-6 (IL-6), tumour necrosis factor-alpha (T...

journal_title：Immunology

authors： Kappel M,Diamant M,Hansen MB,Klokker M,Pedersen BK

更新日期：1991-07-01 00:00:00

abstract：:Protectin (CD59) is a glycolipid-anchored inhibitor of the membrane attack complex (MAC) of human complement (C) that protects blood cells, endothelial cells and various epithelial cells from C-mediated lysis. Because of its activities protectin is a candidate molecule for use in the treatment of paroxysmal nocturnal ...

journal_title：Immunology

authors： Hakulinen J,Meri S

更新日期：1995-07-01 00:00:00

abstract：:Treatment of b4b6 rabbit peripheral blood lymphocytes with b5b5 anti-b4 antibodies at 4 degrees resulted in the modulation (disappearance) ob b4 and b6 cell surface allotype after subsequent incubation in serum-free medium for 1 h at 37 degrees. A clear dose dependence on the sensitizing anti-b4 antibody was observed....

journal_title：Immunology

authors： Kimball ES,Wolf B

更新日期：1978-04-01 00:00:00

abstract：:Thymocytes incubated with either ATP or GTP exhibit a brief period of enhanced DNA synthesis in contrast to the prolonged period of enhanced synthesis observed when thymocytes were incubated with concanavalin A. The cells responding to nucleotides represent a sub-population of theta antigen-bearing T cells comprising ...

journal_title：Immunology

authors： Gregory SH,Kern M

更新日期：1981-03-01 00:00:00

abstract：:The CD40 ligand (gp39) is transiently expressed on activated CD4+ T cells and mediates cognate helper function by interacting with CD40 on B cells. Increasing evidence suggests, however, critical involvement of gp39 not only in antibody-mediated responses but also in the development of effector T cells. Here, we have ...

journal_title：Immunology

authors： Carayanniotis G,Masters SR,Noelle RJ

更新日期：1997-03-01 00:00:00

abstract：:One of the hallmarks of systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), is the immune response to nuclear autoantigens. Several studies have proposed that dendritic cells may acquire the nuclear autoantigens from the apoptotic cells to initiate the systemic autoimmune responses. To examine th...

journal_title：Immunology

authors： Suen JL,Chuang YH,Chiang BL

更新日期：2002-07-01 00:00:00

abstract：:BALB/c mice injected with lyophilized vaccine from Streptococcus pneumoniae R36a (Pn) predominantly responded with antibody molecules the vast majority of which expressed the public idiotype T15 and were directed to the immunodominant epitope phosphorylcholine (PC). However, after a single immunization with Pn vaccine...

journal_title：Immunology

authors： Borghesi C,Nicoletti C

更新日期：1996-10-01 00:00:00

abstract：:When mice were homozygous for the Wf allele at W locus, the delayed-type hypersensitivity (DTH) reaction observed in mice primed i.v. or s.c. with optimal doses of sheep red blood cells was greatly decreased. The number of sensitized splenic cells able to transfer a delayed-type hypersensitivity reaction was identical...

journal_title：Immunology

authors： Marchal G,Milon G,Guénet JL

更新日期：1980-02-01 00:00:00

abstract：:Endothelial cell activation antigens may play important roles in immune responses and in inflammation. This report describes the identification and characterization of a monoclonal antibody, named EAA-B, which reacts specifically with human umbilical vein endothelial (HUVE) cells pre-treated with tumour necrosis facto...

journal_title：Immunology

authors： To SS,Magoulas T,Nicholson E,Schrieber L

更新日期：1992-08-01 00:00:00