Differential expression of complement regulatory proteins decay-accelerating factor (CD55), membrane cofactor protein (CD46) and CD59 during human spermatogenesis.

abstract：:BALB/c mice develop myasthenic symptoms after immunization with rodent acetylcholine receptor (AChR). After immunization with Torpedo AChR (TAChR), their CD4+ cells become strongly sensitized against a conserved region of the TAChR alpha subunit sequence (residues alpha 304-322), and cross-react vigorously with the ho...

journal_title：Immunology

authors： Karachunski PI,Ostlie N,Conti-Tronconi BM,Bellone M

更新日期：1994-05-01 00:00:00

abstract：:The adult cockroach generates an adaptive humoral immune response exhibiting specificity and immunological memory when immunized with soluble proteins. In contrast, the response induced by bacteria in holometabolous insects is non-specific and short term, generally losing activity after 72 hr. We have found that the r...

journal_title：Immunology

authors： Faulhaber LM,Karp RD

更新日期：1992-02-01 00:00:00

abstract：:The MHC class I and II antigen processing and presentation pathways display peptides to circulating CD8+ cytotoxic and CD4+ helper T cells respectively to enable pathogens and transformed cells to be identified. Once detected, T cells become activated and either directly kill the infected / transformed cells (CD8+ cyt...

journal_title：Immunology

authors： Reeves E,James E

更新日期：2017-01-01 00:00:00

abstract：:This study describes a subtractive hybridization analysis to identify differences in gene expression between sibling Th memory clones, elicited by virus infection and expressing identical T-cell receptor (TCR)-alphabeta rearrangements but distinct lymphokine phenotype: clone Bpp9 secretes interleukin (IL)-4, IL-5 and ...

journal_title：Immunology

authors： Graham CM,Thomas DB

更新日期：2004-10-01 00:00:00

abstract：:The in vitro treatment with Fusarenon-X, a mycotoxin produced by Fusarium nivale Fn 2B, depressed the mitogenic responses of mouse lymphocytes to the T-cell mitogens, phytohaemagglutinin (PHA) and concanavalin A (Con A), but to a lesser extent to B-cell mitogen, a bacterial lypopolysaccharide (LPS). The in vitro treat...

journal_title：Immunology

authors： Masuda E,Takemoto T,Tatsuno T,Obara T

更新日期：1982-04-01 00:00:00

abstract：:A sudden upsurge of fever cases with joint pain was observed in the outpatient department, Community Health Centre, Rangat during July-August 2010 in Rangat Middle Andaman, India. The aetiological agent responsible for the outbreak was identified as chikungunya virus (CHIKV), by using RT-PCR and IgM ELISA. The study i...

journal_title：Immunology

authors： Chaaithanya IK,Muruganandam N,Anwesh M,Rajesh R,Ghosal SR,Kartick C,Prasad KN,Muthumani K,Vijayachari P

更新日期：2013-10-01 00:00:00

abstract：:Toll-like receptors (TLR) are sentinel receptors capable of recognizing pathogen-associated molecule patterns (PAMP) such as lipopolysaccharide (LPS) and CpG-containing oligonucleotides (CpG ODN). TLR2 and TLR4 are major receptors for Gram-positive and Gram-negative bacterial cell wall components, respectively. TLR9 i...

journal_title：Immunology

authors： An H,Yu Y,Zhang M,Xu H,Qi R,Yan X,Liu S,Wang W,Guo Z,Guo J,Qin Z,Cao X

更新日期：2002-05-01 00:00:00

abstract：:Porcine alveolar macrophages (AM) metabolize leukotriene D4 (LTD4) to leukotriene E4 (LTE4). In the present study, the ability of a fluid-phase AM stimulus (A23187) and a phagocytic stimulus (opsonized zymosan) to augment LTD4 metabolism was examined. Both stimuli increased the release of superoxide (O-2) anions. Howe...

journal_title：Immunology

authors： Paterson NA,McIver DJ,Schurch S

更新日期：1985-09-01 00:00:00

abstract：:The ultimate outcome of T-cell recognition of peptide-major histocompatibility complex (MHC) complexes is determined by the molecular context in which antigen presentation is provided. The paradigm is that, after exposure to peptides presented by steady-state dendritic cells (DCs), inhibitory signals dominate, leading...

journal_title：Immunology

authors： Konkel JE,Frommer F,Leech MD,Yagita H,Waisman A,Anderton SM

更新日期：2010-05-01 00:00:00

abstract：:The third component of complement (C3) is synthesized and released by cultured human capillary endothelial cells. After the incubation of cells in a methionine-free medium containing 35S-methionine for 48 hr, culture supernatants were immunoprecipitated with anti-human C3 serum. SDS solubilization and 2-ME reduction o...

journal_title：Immunology

authors： Ueki A,Sai T,Oka H,Tabata M,Hosokawa K,Mochizuki Y

更新日期：1987-05-01 00:00:00

abstract：:The secondary humoral response evoked in W/Fu rats by the weakly immunogenic soluble Gross cell surface antigen (GCSAa) extracted from the syngeneic (C58NT)D lymphoma can be enhanced when GCSAa is presented in liposomes, and this requires the antigen to be strongly associated with the phospholipid bilayers. In order t...

journal_title：Immunology

authors： Bakouche O,Gerlier D

更新日期：1986-07-01 00:00:00

abstract：:There is much evidence to suggest that potentially immunogenic tumour cells can escape cytolytic immune destruction by loss of class I antigen expression. Many tumours are allele-specific class I negative and, in murine systems, reconstitution of class I expression by gene transfection leads to an increase in tumour i...

journal_title：Immunology

authors： James RF,Edwards S,Hui KM,Bassett PD,Grosveld F

更新日期：1991-02-01 00:00:00

abstract：:6-Sulpho LacNAc dendritic cells (slanDC) are a major population of human blood DC that are highly pro-inflammatory, as characterized by their outstanding capacity to produce tumour necrosis factor-α and interleukin-12 (IL-12) and to prime antigen-specific T-cell responses. SlanDC were found to be present in inflamed t...

journal_title：Immunology

authors： Gschwandtner M,Schäkel K,Werfel T,Gutzmer R

更新日期：2011-01-01 00:00:00

abstract：:The cellular prion protein (PrPc) is a glycosyl-phosphatidylinositol (GPI)-linked cell surface protein, which is expressed at high density on nervous tissues and at lower levels on most other solid-organ tissues. It is also expressed on peripheral blood mononuclear cells (PBMC) of all lineages. In lymphocytes, its lev...

journal_title：Immunology

authors： Morelon E,Dodelet V,Lavery P,Cashman NR,Loertscher R

更新日期：2001-02-01 00:00:00

abstract：:Over the last few years, natural killer (NK) cells have been shown to express major histocompatibility complex (MHC) molecules recognizing receptors that are thought to function primarily as negative signalling receptors. Much attention has been focused on the NK cell receptors CD158a (EB6) and CD158b (GI 183), which ...

journal_title：Immunology

authors： Frohn C,Schlenke P,Kirchner H

更新日期：1997-12-01 00:00:00

abstract：:Using a cell culture system, age-associated changes in immune activities were investigated in newly developed, short-lived mouse strains. These SAM-P strains of mice (H-2k), which have a remarkably short life span (around 9 months) under conventional breeding conditions, showed an age-associated early decline in sever...

journal_title：Immunology

authors： Hosokawa T,Hosono M,Higuchi K,Aoike A,Kawai K,Takeda T

更新日期：1987-11-01 00:00:00

abstract：:Release of immunoglobulin-binding factors was induced from cultured human lymphoblastoid cells in a serum-free environment by incubation at 37 degrees. RPMI-8866 cells expressing Fc receptors for IgE (Fc epsilon R) and Daudi cells expressing Fc receptors for IgG (Fc gamma R) released IgE- and IgG-binding factors, resp...

journal_title：Immunology

authors： Jensen JR,Sand TT,Spiegelberg HL

更新日期：1984-09-01 00:00:00

abstract：:Tumour-associated macrophages (TAMs) represent a predominant population of inflammatory cells that present in solid tumours. TAMs are mostly characterized as alternatively activated M2-like macrophages and are known to orchestrate nearly all stages of tumour progression. Experimental investigations indicate that TAMs ...

journal_title：Immunology

authors： Tang X,Mo C,Wang Y,Wei D,Xiao H

更新日期：2013-02-01 00:00:00

abstract：:Much of the pathology of malaria may be due to the interactions of cytokines, especially tumour necrosis factor (TNF), with various cell types, including endothelial cells, with consequent widespread systemic effects. It has been shown previously that heat-stable exoantigens in the supernatants of blood-stage parasite...

journal_title：Immunology

authors： Bate CA,Taverne J,Davé A,Playfair JH

更新日期：1990-07-01 00:00:00

abstract：:The synthetic antigen denoted P2-A--L, comprising the fragment P2 of the coat protein of MS-2 coliphage attached to multichain poly-DL-alanine, served for the immunization of guinea-pigs. Immunization was carried out either in phosphate buffered saline (PBS) or in Freund's incomplete adjuvant (FIA) in the presence or ...

journal_title：Immunology

authors： Langbeheim H,Arnon R,Sela M

更新日期：1978-10-01 00:00:00

abstract：:Growth of Salmonella enterica in mammalian tissues results from continuous spread of bacteria to new host cells. Our previous work indicated that infective S. enterica are liberated from host cells via stochastic necrotic burst independently of intracellular bacterial numbers. Here we report that liver phagocytes can ...

journal_title：Immunology

authors： Grant AJ,Sheppard M,Deardon R,Brown SP,Foster G,Bryant CE,Maskell DJ,Mastroeni P

更新日期：2008-09-01 00:00:00

abstract：:Ligation of T-cell receptor (TCR) causes mature T cells to proliferate or, on re-exposure to antigen, can cause them to die by activation-induced cell death (AICD). In proliferative responses, costimulatory and adhesive interactions are required and activation of protein kinase C (PKC) has been shown to be essential. ...

journal_title：Immunology

authors： Tchilian EZ,Anderson G,Moore NC,Owen JJ,Jenkinson EJ

更新日期：1996-04-01 00:00:00

abstract：:Dendritic cells (DC) are powerful inducers of primary T-cell responses, but their role in secondary responses has not been extensively analysed. Here, we address the role of two DC subsets derived from human CD16(+) (16(+) mDC) or CD16(-) (16(-) mDC) monocytes on the reactivation of memory responses. CD4(+) CD45RA(-) ...

journal_title：Immunology

authors： Bajaña S,Herrera-González N,Narváez J,Torres-Aguilar H,Rivas-Carvalho A,Aguilar SR,Sánchez-Torres C

更新日期：2007-11-01 00:00:00

abstract：:Oxygenated derivatives of cholesterol (oxysterols), a family of naturally occurring compounds, possess marked anti-proliferative and immunosuppressive activities, in particular they have been shown to inhibit T-cell responses to different stimuli. 25-Hydroxycholesterol (25-OHC) and 7 beta,25-dihydroxycholesterol (7.25...

journal_title：Immunology

authors： Christ M,Luu B,Mejia JE,Moosbrugger I,Bischoff P

更新日期：1993-03-01 00:00:00

abstract：:Environmental factors have significant effects on the development of autoimmune diseases. The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) is controlled by endogenous and environmental small molecules. Hence, AHR provides a molecular pathway by which endogenous and environmental signals can in...

journal_title：Immunology

authors： Quintana FJ

更新日期：2013-03-01 00:00:00

abstract：:Tumour necrosis factor-alpha (TNF-alpha) and cis-urocanic acid (UCA) have recently been implicated in the process by which ultraviolet B radiation (UVB) impairs the induction of contact hypersensitivity when dinitrofluorobenzene (DNFB) is painted on UVB-exposed skin. The evidence supports the hypothesis that UVB radia...

journal_title：Immunology

authors： Shimizu T,Streilein JW

更新日期：1994-05-01 00:00:00

abstract：:In this paper we report that treatment with 17 beta-oestradiol depresses cutaneous delayed-type hypersensitivity (DTH) to oxazolone (OXA) in female oophorectomized NZB/W mice. Analysis of the parental strains revealed that this oestrogen-induced inhibition of DTH mice is a trait inherited from the healthy NZW and not ...

journal_title：Immunology

authors： Carlsten H,Holmdahl R,Tarkowski A,Nilsson LA

更新日期：1989-06-01 00:00:00

abstract：:A model of immediate-type hypersensitivity (ITH) in the dog using keyhole limpet haemocyanin (KLH) as the antigen was studied. Long-lasting ITH was induced in fifteen of sixteen dogs by the i.v. (Kepron & Tse, 1975), intradermal (Rockey, Schwartzmann & Halliwell, 1971), inhalation (Patterson & Kelley, 1974) and i.d. p...

journal_title：Immunology

authors： Schatz M,Patterson R,Sommers HM,Harris KE,Suszko IM,Roberts M

更新日期：1977-01-01 00:00:00

abstract：:We examined the mechanisms of disturbed T-lymphocyte function that occurred during Schistosoma japonicum infection of BALB/c mice from the viewpoint of the interleukin cascade reaction. Each point of the interleukin cascade reaction was examined. First, IL-1 production by adherent peritoneal or spleen cells, as a sour...

journal_title：Immunology

authors： Yamashita T,Watanabe T,Sendo F

更新日期：1987-10-01 00:00:00

abstract：:The requirement for activity of the enzyme ADP-ribosyl transferase (ADPRT) and changes in single-strand DNA breaks were assessed during the initial stimulation of quiescent murine splenic lymphocytes with mitogen alone, the stimulation of activated blasts with IL-2-containing medium and, for comparison, the serum stim...

journal_title：Immunology

authors： Johnstone AP,Darling D

更新日期：1985-08-01 00:00:00