Antigen-initiated B-lymphocyte differentiation. VII. Quantification of AFC progenitor levels in adoptive and culture responses to NIP-POL antigen.

abstract：:Recent studies involving T cells that express gamma delta T-cell receptor (gamma delta TcR) have raised the possibility that Qa-1/Tla region class I major histocompatibility complex (MHC)-like molecules are antigen-presenting molecules for gamma delta TcR. In this report, cytotoxic T lymphocyte (CTL) clones specific f...

journal_title：Immunology

authors： Germana S,Shinohara N

更新日期：1991-12-01 00:00:00

abstract：:Examples suggesting that all or part of the V(H) segment of a rearranged V(H)DJ(H) may be replaced by all or part of another V(H) have been appearing since the 1980s. Evidence has been presented of two rather different types of replacement. One of these has gained acceptance and has now been clearly demonstrated to oc...

journal_title：Immunology

authors： Darlow JM,Stott DI

更新日期：2005-02-01 00:00:00

abstract：:Metabolism of ss-DNA in Swiss Webster mice and NZB/W mice was studied. The delay in intra-hepatic catabolism of ssDNA in old NZB/W female mice seems to correlate with the presence of increased anti-DNA antibodies; similar to effects produced in Swiss Webster mice that have been pretreated with a small dose of carbon b...

journal_title：Immunology

authors： Chia D,Dorsch C,Barnett EV,Levy L

更新日期：1977-03-01 00:00:00

abstract：:Incubation of sensitized mononuclear cells from patients with schistosomiasis with specific antigen containing a suspension of viable Schistosoma haematobium ova resulted in the release of a soluble factor which was chemotactic for eosinophils. Production of this substance was detectable at 24 h and demonstrated peak ...

journal_title：Immunology

authors： Wadee AA,Sher R

更新日期：1980-12-01 00:00:00

abstract：:IgM was purified from normal human colostrum and salivary secretions devoid of IgA. The isolated immunoglobulin was found to contain J chain, and showed a slight affinity for free secretory component (SC). In the secretions IgM was saturated with SC, but only 60--70 per cent of the molecules had retained the component...

journal_title：Immunology

authors： Brandtzaeg P

更新日期：1975-09-01 00:00:00

abstract：:The present study aimed to determine whether the frequency of double positive (DP) thymocytes expressing alphabeta T-cell receptor (TCR) clonotypes at the time of selection regulates peripheral CD4 T-cell compartment size. Scid recipients were inoculated with various ratios of TCR Calpha(0/0) and wild-type bone marrow...

journal_title：Immunology

authors： Reed AJ,Zarrabi Y,Perate AL,Jeganathan A,Naji A,Noorchashm H

更新日期：2005-11-01 00:00:00

abstract：:T lymphocytes and macrophages (M phi) have been seen to accumulate at sites of lesions in blood vessel walls, suggesting that these cells may contribute to the pathogenesis of inflammatory reactions. Tumour necrosis factor-alpha (TNF-alpha), a cytokine produced by both M phi and T lymphocytes, plays a major role in in...

journal_title：Immunology

authors： Hershkoviz R,Gilat D,Miron S,Mekori YA,Aderka D,Wallach D,Vlodavsky I,Cohen IR,Lider O

更新日期：1993-01-01 00:00:00

abstract：:Previous studies have shown that the degradation of soluble immune complexes or aggregates (AIgG) by normal peritoneal macrophages can be enhanced by complement. The enhancement of degradation was shown to be at least in part dependent on the number of C3b molecules bound per complex. The present investigations indica...

journal_title：Immunology

authors： Daha MR,Van Es LA

更新日期：1983-09-01 00:00:00

abstract：:In many types of tumours, especially pancreatic adenocarcinoma, miR-301a is over-expressed. This over-expression results in negative regulation of the target gene of miR-301a, the nuclear factor-κB (NF-κB) repressing factor (NKRF), increasing the activation of NF-κB and production of NF-κB-responsive pro-inflammatory ...

journal_title：Immunology

authors： Huang L,Liu Y,Wang L,Chen R,Ge W,Lin Z,Zhang Y,Liu S,Shan Y,Lin Q,Jiang M

更新日期：2013-11-01 00:00:00

abstract：:Pre-exposure to bacterial lipopolysaccharide (LPS) or certain cytokines is known to enhance the ability of murine macrophages to generate a respiratory burst in response to subsequent stimulation, a phenomenon referred to as 'priming'. We report here that the cytokine interleukin-4 (IL-4) can prime murine macrophages....

journal_title：Immunology

authors： Phillips WA,Croatto M,Hamilton JA

更新日期：1990-08-01 00:00:00

abstract：:We examined the mechanisms of disturbed T-lymphocyte function that occurred during Schistosoma japonicum infection of BALB/c mice from the viewpoint of the interleukin cascade reaction. Each point of the interleukin cascade reaction was examined. First, IL-1 production by adherent peritoneal or spleen cells, as a sour...

journal_title：Immunology

authors： Yamashita T,Watanabe T,Sendo F

更新日期：1987-10-01 00:00:00

abstract：:To evaluate the T-cell large-scale differential gene expression in systemic lupus erythematosus (SLE) patients presenting with glomerulonephritis we studied SLE patients before and after immunosuppressive treatment. Large-scale gene expression of peripheral blood mononuclear T cells was evaluated using cDNA microarray...

journal_title：Immunology

authors： Pereira E,Tamia-Ferreira MC,Cardoso RS,Mello SS,Sakamoto-Hojo ET,Passos GA,Donadi EA

更新日期：2004-09-01 00:00:00

abstract：:CD4(+) FOXP3(+) regulatory T (Treg) cells constitute a heterogeneous and plastic T-cell lineage that plays a pivotal role in maintaining immune homeostasis and immune tolerance. However, the fate of human Treg cells after loss of FOXP3 expression and the epigenetic mechanisms contributing to such a phenotype switch re...

journal_title：Immunology

authors： He H,Ni B,Tian Y,Tian Z,Chen Y,Liu Z,Yang X,Lv Y,Zhang Y

更新日期：2014-03-01 00:00:00

abstract：:Over the past years, increasing numbers of distinct subsets have been discovered and identified for a T lymphocytes' entity. Differentiation and function of each T cell subset are controlled by a specific master transcription factor. Importantly, Runt-related transcription factors, particularly Runx1 and Runx3, interp...

journal_title：Immunology

authors： Wong WF,Kohu K,Chiba T,Sato T,Satake M

更新日期：2011-02-01 00:00:00

abstract：:Enriched CD4+CD8-/CD4-CD8-, CD4-CD8+/CD4-CD8- and CD4-CD8- cell suspensions were prepared from normal peripheral blood by selective immunomagnetic depletion of monoclonal antibody-defined lymphocyte populations. Subsequent examination of these modified cell fractions by two-colour flow cytometry provided a means of de...

journal_title：Immunology

authors： Scott CS,Richards SJ,Roberts BE

更新日期：1990-07-01 00:00:00

abstract：:Four types of lymphocyte chemotactic factor (LCF-a, -b, -c and -d) could be isolated from extract of 24-hr-old delayed-type hypersensitivity (DTH) skin reaction sites induced with purified protein derivative (PPD) in guinea-pigs by gel filtration on Sephadex G-100 followed by chromatography with DEAE-Sephadex. Partial...

journal_title：Immunology

authors： Shimokawa Y,Harita S,Hayashi H

更新日期：1984-02-01 00:00:00

abstract：:The non-obese diabetic (NOD) mouse is an animal model for insulin-dependent diabetes that has many similarities to the human disease. NOD mice transgenic for the Ea gene, allowing expression of the E molecule, are protected from diabetes and rarely develop insulitis. An Ea transgene mutated in the promoter region, (De...

journal_title：Immunology

authors： Brenden N,Böhme J

更新日期：1998-09-01 00:00:00

abstract：:In this paper we report that treatment with 17 beta-oestradiol depresses cutaneous delayed-type hypersensitivity (DTH) to oxazolone (OXA) in female oophorectomized NZB/W mice. Analysis of the parental strains revealed that this oestrogen-induced inhibition of DTH mice is a trait inherited from the healthy NZW and not ...

journal_title：Immunology

authors： Carlsten H,Holmdahl R,Tarkowski A,Nilsson LA

更新日期：1989-06-01 00:00:00

abstract：:The liver is a front-line immune tissue that plays a major role in the detection, capture and clearance of pathogens and foreign antigens entering the bloodstream, especially from the gut. Our largest internal organ maintains this immune barrier in the face of constant exposure to external but harmless antigens throug...

journal_title：Immunology

authors： Stamataki Z,Swadling L

更新日期：2020-06-01 00:00:00

abstract：:The plaque-forming cell (PFC) responses to sheep red blood cell (SRBC) dinitrophenyl-lysine-Ficoll (DNP-lys-Ficoll), and dinitrophenylated bovine serum albumin (DNP-BSA) have been studied in both germ-free and conventionally reared ICR mice. In germ-free mice, the IgG response to SRBC and the IgM and IgG responses to ...

journal_title：Immunology

authors： Ohwaki M,Yasutake N,Yasui H,Ogura R

更新日期：1977-01-01 00:00:00

abstract：:Electron microscopic findings made on microsomal fractions of rat liver after treatment with microsomal antibodies obtained from the blood of patients diagnosed as having chronic aggressive hepatitis and liver cirrhosis and after incubation with peroxidase-labelled antihuman IgG are described and presented in this pap...

journal_title：Immunology

authors： Storch W,Cossel L,Dargel R

更新日期：1977-06-01 00:00:00

abstract：:T-cell mediated immunity (CMI) is crucial for protection against genital chlamydial infection in mice. To define the underlying molecular mechanism for this protection, several T-cell clones generated against the Chlamydia trachomatis agent of mouse pneumonitis (MoPn) were analysed in an in vitro model of the mucosal ...

journal_title：Immunology

authors： Igietseme JU

更新日期：1996-01-01 00:00:00

abstract：:The discovery that corticosteroids can alter leucocyte distribution implies that suppression of PFC in the spleen is not necessarily indicative of suppression of the antibody response as a whole. Therefore we have examined IgM and IgG serum antibodies and PFC in the thymus, spleen, femoral marrow, popliteal, thoracic ...

journal_title：Immunology

authors： Dracott BN,Smith CE

更新日期：1979-10-01 00:00:00

abstract：:Feeding antigens induces an immunological unresponsiveness termed oral tolerance but under some conditions, for example following the administration of cyclophosphamide (CY), immunity can be induced. These observations have usually been made by studying antibody production and delayed hypersensitivity with little atte...

journal_title：Immunology

authors： Hoyne GF,Callow MG,Kuhlman J,Thomas WR

更新日期：1993-04-01 00:00:00

abstract：:We have previously demonstrated that immunoglobulin A (IgA)(-/-) knockout (KO) mice exhibit levels of susceptibility to influenza virus infection that are similar to those of their normal IgA(+/+) littermates. To understand the mechanism of this apparent mucosal immunity without IgA, immunoglobulin isotype and T helpe...

journal_title：Immunology

authors： Zhang Y,Pacheco S,Acuna CL,Switzer KC,Wang Y,Gilmore X,Harriman GR,Mbawuike IN

更新日期：2002-03-01 00:00:00

abstract：:We have studied activation-induced changes in intracellular calcium [Ca2+]i, interleukin-2 (IL-2) secretion, and clonal abortion of the human leukaemic T-cell line Jurkat and three T-cell receptor (TcR)/CD3 receptor negative clones deficient for the TcR alpha, TcR beta and CD3 gamma chains respectively, as well as thr...

journal_title：Immunology

authors： Claesson MH,Dissing S,Tscherning T,Geisler C

更新日期：1993-03-01 00:00:00

abstract：:The intestinal epithelium is rich in γδ T cells and the gut is a site of residence for a wide variety of pathogens, including nematodes. Although CD4+ T-cell receptor (TCR) -αβ+ T helper type 2 T cells are essential for the expulsion of intestinal nematodes, little information is available on the function of γδ T cell...

journal_title：Immunology

authors： Inagaki-Ohara K,Sakamoto Y,Dohi T,Smith AL

更新日期：2011-12-01 00:00:00

abstract：:Complement activation within lymph nodes has been shown to alter lymphocyte traffic through the node. Challenge of cannulated sheep lymph nodes with either immune complexes or complement activators was found to initiate the phenomenon of cell shutdown associated with antigenic challenge of lymph nodes in primed animal...

journal_title：Immunology

authors： McConnell I,Hopkins J

更新日期：1981-02-01 00:00:00

abstract：:Thioglycollate-stimulated, adherence and density gradient-enriched peritoneal exudate cells were used for the preparation of a specific, highly active antimacrophage reagent. After absorption with mouse lymphoid cells, an antimacrophage globulin (AMG) fraction was shown to be cytotoxic for peritoneal exudate macrophag...

journal_title：Immunology

authors： Herscowitz HB,Diblasio RC

更新日期：1976-01-01 00:00:00

abstract：:Using double staining for T-cell receptor (TCR) and 5-bromo-2'-deoxyuridine (BRdU) we have examined the proliferation rates and lifespan of murine intraepithelial lymphocytes (IEL's) in vivo. After a 24-hr pulse of BRdU the number of labelled alpha beta TCR+ IEL was significantly higher in the ileum than the duodenum....

journal_title：Immunology

authors： Penney L,Kilshaw PJ,MacDonald TT

更新日期：1995-10-01 00:00:00