Abstract：
:Feeding antigens induces an immunological unresponsiveness termed oral tolerance but under some conditions, for example following the administration of cyclophosphamide (CY), immunity can be induced. These observations have usually been made by studying antibody production and delayed hypersensitivity with little attention given to other measurements of cellular activation. We have therefore examined the lymphokines produced by T cells obtained after the induction of oral tolerance or intragastric priming. Cells isolated from the spleen and Peyer's patches (PP) of tolerized mice could secrete high levels of interferon-gamma (IFN-gamma) and moderate levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) in response to antigen while interleukin-2 (IL-2), IL-3 and IL-4 could not be detected. Mesenteric lymph node (MLN) cells of tolerized mice did not respond to antigen unless spleen adherent cells were added to the cultures where IFN-gamma and GM-CSF were produced. Intragastric priming was achieved by feeding antigen to CY-treated mice. T cells from the spleen, MLN and PP of these mice could produce GM-CSF, IFN-gamma, some IL-3 but little or no IL-2 and IL-4. The ability of MLN cells to proliferate with antigen in vitro was low and corresponded to low IL-2 production. Thus T cells from fed mice secrete a defined pattern of lymphokines which differs in tolerizing and priming regimes.
journal_name
Immunologyjournal_title
Immunologyauthors
Hoyne GF,Callow MG,Kuhlman J,Thomas WRsubject
Has Abstractpub_date
1993-04-01 00:00:00pages
534-40issue
4eissn
0019-2805issn
1365-2567journal_volume
78pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:Major histocompatibility complex (MHC) class II molecules present antigenic peptides derived from engulfed exogenous proteins to CD4(+) T cells. Exogenous antigens are processed in mature endosomes and lysosomes where acidic proteases reside and peptide-binding to class II alleles is favoured. Hence, maintenance of th...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2010.03309.x
更新日期：2010-11-01 00:00:00
abstract：:The gut microbiota provides an important stimulus for the induction of regulatory T (Treg) cells in mice, whether this applies to newborn children is unknown. In Swedish children, Staphylococcus aureus has become a common early colonizer of the gut. Here, we sought to study the effects of bacterial stimulation on neon...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12209
更新日期：2014-03-01 00:00:00
abstract：:Epidermal keratinocytes are induced to express MHC class II molecules in a variety of disease states associated with immune activity. To investigate the mechanism of this process we have exposed murine and rat keratinocytes to a variety of lymphokines and monitored changes in their MHC molecule expression. Murine cult...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Highly enriched bovine polymorphonuclear neutrophils (PMN) were able to destroy herpesvirus-infected cells in the presence of complement. Our results suggest that some viral antigens are capable of activating the alternate complement pathway directly which results in cytotoxicity however, the addition of PMN plus comp...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1980-06-01 00:00:00
abstract：:A superantigen (Streptococcus pyogenes mitogen-2; SPM-2) that stimulates human helper T cells bearing unique types of variable domains of T-cell receptor beta-chain (TCR V beta) was isolated from the culture supernatant of S. pyogenes strain T12. The active molecule isolated by diethylaminoethyl (DEAE)-cellulose chrom...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.00277.x
更新日期：1997-07-01 00:00:00
abstract：:The effect of intravenous (i.v.) administration of bacterial alpha-amylase (B alpha A) on the IgG antibody response to a subsequent challenge with B alpha A in incomplete Freund's adjuvant (IFA) varied with the difference in responsiveness of the parental strains. High-responder C3H/He (C3) mice given injections of ei...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1986-02-01 00:00:00
abstract：:MCA44 is a monoclonal antibody (mAb) to guinea-pig decay-accelerating factor (DAF) and, using this mAb, tissue distribution of guinea-pig DAF was studied by immunofluorescence. Guinea-pig DAF was found to be expressed not only on the vascular endothelium but also on different types of cells, such as the tubular epithe...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1998.00592.x
更新日期：1998-10-01 00:00:00
abstract：:Mice, immunized with liposome-associated bovine serum albumin (LSM-BSA), showed a significantly higher BSA-specific plaque-forming cell (PFC) response than did mice injected with fluid BSA (fBSA). Physical association between the liposome carrier and the protein antigen is imperative for potentiating the PFC response,...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-02-01 00:00:00
abstract：:We have studied activation-induced changes in intracellular calcium [Ca2+]i, interleukin-2 (IL-2) secretion, and clonal abortion of the human leukaemic T-cell line Jurkat and three T-cell receptor (TcR)/CD3 receptor negative clones deficient for the TcR alpha, TcR beta and CD3 gamma chains respectively, as well as thr...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:This study addresses the question of whether human peripheral CD4+ CD45RA+ T cells possess antigen-specific immune memory. CD4+ CD45RA+ T cells were isolated by a combination of positive and negative selection. Putative CD4+ CD45RA+ cells expressed CD45RA (98.9%) and contained < 0.1% CD4+ CD45RO+ and < 0.5% CD4+ CD45R...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.00274.x
更新日期：1997-07-01 00:00:00
abstract：:Using a cell culture system, age-associated changes in immune activities were investigated in newly developed, short-lived mouse strains. These SAM-P strains of mice (H-2k), which have a remarkably short life span (around 9 months) under conventional breeding conditions, showed an age-associated early decline in sever...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1987-11-01 00:00:00
abstract：:Class switching and plasma cell differentiation occur at a high level within all mucosa-associated lymphoid tissues. The different classes of membrane immunoglobulin heavy chains are associated with the Igα/Igβ heterodimer within the B-cell receptor (BCR). Whether BCR isotypes convey specific signals adapted to the co...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2012.03557.x
更新日期：2012-05-01 00:00:00
abstract：:Macrophages play important roles in the clearance of dying and dead cells. Typically, and perhaps simplistically, they are viewed as the professional phagocytes of apoptotic cells. Clearance by macrophages of cells undergoing apoptosis is a non-phlogistic phenomenon which is often associated with actively anti-inflamm...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2004.01959.x
更新日期：2004-09-01 00:00:00
abstract：:We previously reported that FTY720 is an efficient inducer of apoptosis in lymphocytes and cultured cell lines. In the present study, HL-60 human promyerocytoma cells also induced apoptosis through in vitro treatment with the drug, demonstrating extensive DNA fragmentation 6 hr after incubation. The major target of FT...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1997.d01-2281.x
更新日期：1997-08-01 00:00:00
abstract：:Herpes simplex virus (HSV) encodes a protein, glycoprotein C (gC), which binds to the third complement component, the central mediator of complement activation. In this study the structural and functional relationships of gC from HSV type 1 (HSV-1) and known human complement regulatory proteins factor H, properdin, fa...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：:Canine cutaneous histiocytoma is a benign epidermal neoplasm of Langerhans cell origin, which usually displays spontaneous regression. Based on the degree of lymphocytic infiltration, 30 histiocytomas were classified into four groups representing different stages of tumour regression. To elucidate further the mechanis...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2006.02394.x
更新日期：2006-08-01 00:00:00
abstract：:Bursal and splenic lymphocytes in developing chick embryos were examined for the number of antigen binding cells (ABC) which could form rosettes with red blood cells from sheep, guinea-pig, rabbit or dinitrophenylated sheep red blood cells (DNP-SRBC). The kinetics of the development of bursal ABC to rabbit red blood c...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1979-08-01 00:00:00
abstract：:The interference of two simultaneous skin test reactions of intermediate strength has been studied in the guinea-pig, using four different antigens, i.e. ovalbumin, horse cytochrome c, PPD and oxazolone. Skin test reactions were evaluated at 4, 24 and 48 h by measuring three parameters: increase in skin thickness, dia...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1978-08-01 00:00:00
abstract：:To assess the role of the macrophage scavenger receptor type A (SRA) in immune activation by CpG DNA, cytokine induction and DNA uptake were tested in vitro and in vivo using SRA knockout (SRA-/-) and wild type (WT) mice. As a source of CpG DNA, Escherichia coli DNA (EC DNA) and a 20-mer phosphorothioate oligodeoxynuc...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2001.01222.x
更新日期：2001-06-01 00:00:00
abstract：:Electron microscopic study of the events occurring at the cell membrane during reactive lysis by complement, showed that a foliaceous particle was formed at the C5b-7 stage, that enlarged to a particle with a variable number of arms at the C5b-8 stage. Up to this point, no typical complement lesions were found. At the...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1978-08-01 00:00:00
abstract：:The fungus metabolite cyclosporin A is a small cyclic peptide acting as a novel antilymphocytic agent. It is effective following either parenteral or oral administration in mice, rats and guinea-pigs. The suppressive effect after short and prolonged treatment on plaque-forming cells, the inhibition of the secondary hu...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1977-06-01 00:00:00
abstract：:Antigenic encounter by T cells induces immunological synapse formation and T-cell activation. Using different concentrations of toxic shock syndrome toxin-1 (TSST-1) as stimulus, we examined the capacities of dendritic cells (DC) and macrophages (Mphi) to prime syngeneic naive T cells. DCs were, under all experimental...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2003.01758.x
更新日期：2003-12-01 00:00:00
abstract：:Rabbit spleen and mesenteric lymph node cells were treated with a monoclonal anti-rabbit T-lymphocyte antibody (MAb) and complement and the effect of the treatment on various lymphocyte functions was determined. Lysis of spleen and mesenteric lymph node cells reactive with this MAb, 9AE10, essentially eliminated their...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
abstract：:The locomotor capacity of human lymphocytes is cell cycle-related. Many small blood lymphocytes are non-motile but acquire locomotor capacity in G1 on appropriate activation with e.g. anti-CD3 antibody (aCD3) for T cells, or interleukin-4 (IL-4) for B cells. Once this capacity is acquired, the cells can then respond b...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：:Conjugates carrying a single 2-carboxy-4,6-dinitrophenyl hapten and as auxiliary group various thiazolidine substituents related to penicilloyl, were prepared and studied in guinea-pig passive cutaneous anaphylaxis (PCA). Included are monohaptenic model conjugates with discrete hydrocarbon auxiliary groups. One of the...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-05-01 00:00:00
abstract：:Initial stages of tumour growth are not easily accessible to investigation. Therefore an experimental procedure was developed to mimic tumorigenesis as closely as possible. BALB/c mice received intraperitoneally exponentially increasing numbers of irradiated syngeneic ADJ-PC-5 plasmacytoma cells. The initial injection...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-11-01 00:00:00
abstract：:B-lymphocyte maturation is considered to be independent of the thymus. However, there is circumstantial evidence suggesting that it may be impaired in nude animals that lack the thymus. Our study shows that the proportion of immature B-lymphocyte subsets (CD90(high) IgM(high) and CD90(high) IgM(low)) was significantly...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2005.02226.x
更新日期：2005-11-01 00:00:00
abstract：:The distribution of T lymphocytes expressing the different polypeptides of the leucocyte common antigen (LCA) family detected by CD45R and UCHL1 antibodies has been studied in normal lymphoid tissues. In the thymus most cortical thymocytes express UCHL1 and co-express CD4 and CD8. The more mature membrane CD3+ (mainly...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：:Acquisition of T-cell central tolerance involves distinct pathways of self-antigen presentation to thymocytes. One pathway termed indirect presentation requires a self-antigen transfer step from thymic epithelial cells (TECs) to bone marrow-derived cells before the self-antigen is presented to thymocytes. The role of ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12904
更新日期：2018-07-01 00:00:00
abstract：:Fifty-seven serum samples positive for antibodies to double-stranded DNA (dsDNA), single-stranded DNA (ssDNA) or small nuclear ribonucleoproteins (snRNP) selected from patients with systemic lupus erythematosus and mixed connective tissue disease, were examined for the IgG subclass distribution of these autoantibodies...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
