Role of membrane structures in B-lymphocyte activation. The effect of binding anti-immunoglobulin, aggregated IgG and immune complexes.

abstract：:Following exposure of mice to contact sensitizing chemicals, dendritic cells (DC) rapidly accumulate in the draining lymph nodes. A proportion, at least, of the DC which arrive in the nodes bear significant amounts of antigen and are derived from epidermal Langerhans' cells (LC). It is of interest that although LC are...

journal_title：Immunology

authors： Cumberbatch M,Gould SJ,Peters SW,Kimber I

更新日期：1991-11-01 00:00:00

abstract：:An interleukin-12 (IL-12) expression plasmid was transferred, using a gene gun, to mice infected with Leishmania major or Trypanosoma cruzi. Transfer of the IL-12 gene to susceptible BALB/c mice resulted in regression of lesion size and reduced the number of parasites in draining lymph nodes (LN) at the site of L. maj...

journal_title：Immunology

authors： Sakai T,Hisaeda H,Nakano Y,Ishikawa H,Maekawa Y,Ishii K,Nitta Y,Miyazaki J,Himeno K

更新日期：2000-04-01 00:00:00

abstract：:Killer cell immunoglobulin-like receptors (KIRs) interact with polymorphic human leucocyte antigen (HLA) class I molecules, modulating natural killer (NK) cell functions and affecting both the susceptibility and outcome of immune-mediated diseases. The KIR locus is highly diverse in gene content, copy number and allel...

journal_title：Immunology

authors： Tao S,Kichula KM,Harrison GF,Farias TDJ,Palmer WH,Leaton LA,Hajar CGN,Zefarina Z,Edinur HA,Zhu F,Norman PJ

更新日期：2020-12-06 00:00:00

abstract：:The ability of the chemical carcinogen dimethylbenz(a)anthracene (DMBA) to deplete Langerhans' cells (LC) from murine skin is crucial to the development of antigen-specific suppression. This depletion is a consequence of the LC recognizing the DMBA as antigenic and migrating to the draining lymph nodes to attempt to e...

journal_title：Immunology

authors： Woods GM,Qu M,Ragg SJ,Muller HK

更新日期：1996-05-01 00:00:00

abstract：:A rat thymic epithelial cell (TEC) line (R-TNC.1) was established from a long-term TEC culture. Based on its ultrastructure, phenotype and cytokeratin profile, this line was characterized as a type of cortical TEC. R-TNC.1 cells had nursing activity which was manifested by the binding and subsequent engulfment of thym...

journal_title：Immunology

authors： Colić M,Vucević D,Miyasaka M,Tamatani T,Pavlović MD,Dujić A

更新日期：1994-11-01 00:00:00

abstract：:Immunohistochemical analysis of frozen sections of rat lung tissue identified a widely distributed population of highly pleiomorphic Ia+ cells in alveolar septal walls, which are negative for the pan-macrophage marker ED4 and the related markers ED1, ED2 and ED9. Semi-purified dendritic cells (DC) prepared from lungs ...

journal_title：Immunology

authors： Holt PG,Oliver J,McMenamin C,Schon-Hegrad MA

更新日期：1992-04-01 00:00:00

abstract：:The glycoprotein counter-receptors for E-selectin borne on skin-homing T cells are poorly defined. In this study we have used flow cytometry to investigate the surface expression of potential carbohydrate ligands for E-selectin on HUT78, a skin-homing cutaneous T-cell lymphoma. These cells possessed high surface expre...

journal_title：Immunology

authors： Priest R,Bird MI,Malhotra R

更新日期：1998-08-01 00:00:00

abstract：:We have characterized two unusual T-cell hybridomas, 1E3 and 3B8, from H-2k mice immunized with I-Ab-transfected L cells (H-2k), that are stimulated by L cells transfected with I-Ab, I-Ak or I-Eb, but not by non-transfected L cells. These hybridomas could not be stimulated by spleen cells from H-2i3, H-2k, H-2b or H-2...

journal_title：Immunology

authors： Mendiratta SK,Singh N,Bal V,Rath S

更新日期：1996-10-01 00:00:00

abstract：:The suppression of immune responsiveness to heterologous antigenic stimulation during concurrent infection with Nematospiroides dubius was reproduced using soluble antigens derived from adult parasites. Immunosuppression appeared to be selective in that the administration of equivalent quantities of an irrelevant hete...

journal_title：Immunology

authors： Pritchard DI,Ali NM,Behnke JM

更新日期：1984-04-01 00:00:00

abstract：:Incubation of sensitized mononuclear cells from patients with schistosomiasis with specific antigen containing a suspension of viable Schistosoma haematobium ova resulted in the release of a soluble factor which was chemotactic for eosinophils. Production of this substance was detectable at 24 h and demonstrated peak ...

journal_title：Immunology

authors： Wadee AA,Sher R

更新日期：1980-12-01 00:00:00

abstract：:Susceptibility to collagen-induced arthritis (CIA), a murine model of autoimmune arthritis, is strongly linked to only two major histocompatibility complex (MHC) haplotypes, H-2q and H-2r. In order to identify the determinants of type II collagen (CII) required to induce arthritis in H-2r-bearing mice, B10.RIII mice w...

journal_title：Immunology

authors： Myers LK,Miyahara H,Terato K,Seyer JM,Stuart JM,Kang AH

更新日期：1995-04-01 00:00:00

abstract：:The present study aimed to determine whether the frequency of double positive (DP) thymocytes expressing alphabeta T-cell receptor (TCR) clonotypes at the time of selection regulates peripheral CD4 T-cell compartment size. Scid recipients were inoculated with various ratios of TCR Calpha(0/0) and wild-type bone marrow...

journal_title：Immunology

authors： Reed AJ,Zarrabi Y,Perate AL,Jeganathan A,Naji A,Noorchashm H

更新日期：2005-11-01 00:00:00

abstract：:The activation of macrophages by various stimuli leading to chemotactic migration and phagocytosis is known to be mediated by an increase in intracellular Ca2+ concentration ([Ca2+]i). We measured changes in [Ca2+]i using a Ca2+ imaging method in individual human macrophages differentiated from freshly prepared periph...

journal_title：Immunology

authors： Oshimi Y,Miyazaki S,Oda S

更新日期：1999-10-01 00:00:00

abstract：:The influence of the thymus and the possible requirement for surface immunoglobulin expression for the development of K and NK activity were assessed in rats. This species was chosen in preference to mice as they show good levels of K-cell activity. Studies were carried out in athymic (rnu/rnu) rats some of which were...

journal_title：Immunology

authors： Chassoux D,Kolb JP,Bazin H,MacLennan IC

更新日期：1983-11-01 00:00:00

abstract：:Currently, the limited supply and stability of some human autoantigens pose formidable difficulties in characterizing patients' T cells specific for them; recombinant preparations may contain bacterial contaminants, and synthetic peptides have arbitrarily chosen start and stop points. In order to provide a stable anti...

journal_title：Immunology

authors： Mulcahy AF,Beeson DM,Willcox N,Diamond AG

更新日期：1995-09-01 00:00:00

abstract：:Antibodies against lymphocytes have been shown in human immunodeficiency virus (HIV)-infected patients, but their relevance in the pathogenesis of acquired immune deficiency syndrome (AIDS) remains controversial. We investigated increased levels of lymphocyte surface Ig and antibodies against CD4+ T cells in the plasm...

journal_title：Immunology

authors： Müller C,Kukel S,Bauer R

更新日期：1993-06-01 00:00:00

abstract：:Preincubation of macrophages with immune complexes suppresses the interferon-gamma (IFN-gamma) induction of tumouricidal activity and Ia surface expression. The studies reported in this manuscript were designed to test if immune complexes alter the interaction of IFN-gamma with macrophages. The binding of IFN-gamma to...

journal_title：Immunology

authors： Celada A

更新日期：1988-06-01 00:00:00

abstract：:An examination was made of the effects of eosinophilia on acute inflammation. Sprague Dawley rats were infected with Trichinella spiralis larvae which resulted in a blood eosinophilia. Groups of rats with the induced eosinophilia, and untreated rats without the eosinophilia, were treated with carrageenan, bradykinin o...

journal_title：Immunology

authors： Popper H,Picher O,Auer H

更新日期：1982-07-01 00:00:00

abstract：:Immunoregulatory CD4(-)  CD8(-) (double-negative; DN) T cells exhibit a unique antigen-specific mode of suppression, yet the ontogeny of DN T cells remains enigmatic. We have recently shown that 3A9 T-cell receptor (TCR) transgenic mice bear a high proportion of immunoregulatory 3A9 DN T cells, facilitating their stud...

journal_title：Immunology

authors： Dugas V,Chabot-Roy G,Beauchamp C,Guimont-Desrochers F,Hillhouse EE,Liston A,Lesage S

更新日期：2013-05-01 00:00:00

abstract：:Eosinophil function is regulated by several cytokines, including interleukin-3 (IL-3), IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF). Culture of human eosinophils with IL-3 produced a marked, dose-dependent up-regulation of CR3 expression. This was maximal after 1 day in culture and dependent on p...

journal_title：Immunology

authors： Hartnell A,Kay AB,Wardlaw AJ

更新日期：1992-12-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) produce a significant amount of interleukin-5 (IL-5), which supports eosinophil responses in various tissues; they also produce IL-13, which induces mucus production and contributes to tissue repair or fibrosis. The ILC2s are activated by alarmins, such as IL-33 released from epit...

journal_title：Immunology

authors： Kudo F,Ikutani M,Seki Y,Otsubo T,Kawamura YI,Dohi T,Oshima K,Hattori M,Nakae S,Takatsu K,Takaki S

更新日期：2016-01-01 00:00:00

abstract：:Mice, immunized with liposome-associated bovine serum albumin (LSM-BSA), showed a significantly higher BSA-specific plaque-forming cell (PFC) response than did mice injected with fluid BSA (fBSA). Physical association between the liposome carrier and the protein antigen is imperative for potentiating the PFC response,...

journal_title：Immunology

authors： Shek PN,Sabiston BH

更新日期：1982-02-01 00:00:00

abstract：:Isolated human mononuclear cells were fractionated according to their membrane characteristics or physical properties. Adherent cells were depleted by filtration through glass columns; phagocytic cells were removed by iron treatment and cell subpopulations capable of forming rosettes with sheep erythrocytes (E), eryth...

journal_title：Immunology

authors： De Bracco MM,Isturiz MA,Manni JA

更新日期：1976-03-01 00:00:00

abstract：:The ability of freshly isolated primary human alveolar epithelial cells (type II pneumocytes) to induce leucocyte migration across an endothelial monolayer was investigated. Three-way factorial analysis of variance (ANOVA) demonstrated that resting alveolar endothelial cells (AEC) could produce detectable quantities o...

journal_title：Immunology

authors： Eghtesad M,Jackson HE,Cunningham AC

更新日期：2001-02-01 00:00:00

abstract：:We established in previous studies that the binding of Salmonella lipopolysaccharide (LPS) to constitutive receptors of low affinity triggers the expression of the inducible LPS-binding molecule CD14 in bone marrow cells (BMC) of C3H/HeOU mice, but not in BMC from C3H/HeJ mice. We show in this study that BMC from C3H/...

journal_title：Immunology

authors： Pedron T,Girard R,Jeyaretnam B,Carlson RW,Chaby R

更新日期：2000-10-01 00:00:00

abstract：:Extracorporeal photochemotherapy (ECP) has been shown to be a potent activator of peripheral blood macrophages because it causes a marked release of macrophage-dependent proinflammatory cytokines, and it is therefore currently considered to be a safe and non-toxic immunomodulatory treatment. On this basis we studied t...

journal_title：Immunology

authors： Di Renzo M,Rubegni P,De Aloe G,Paulesu L,Pasqui AL,Andreassi L,Auteri A,Fimiani M

更新日期：1997-09-01 00:00:00

abstract：:Bacterial superantigens bind to major histocompatibility complex (MHC) class II and subsequently activate both CD4+ and CD8+ T lymphocytes expressing certain T-cell receptor (TCR)-Vbeta chains. In response to superantigen exposure these subsets proliferate, produce large amounts of proinflammatory cytokines and in add...

journal_title：Immunology

authors： Sundstedt A,Grundström S,Dohlsten M

更新日期：1998-09-01 00:00:00

abstract：:We have shown that human endothelial cells (EC) are protected against complement-mediated injury by the inducible expression of decay-accelerating factor (DAF). To understand further the importance of DAF regulation, we characterized EC DAF expression on murine EC in vitro and in vivo using a model of glomerulonephrit...

journal_title：Immunology

authors： Ahmad SR,Lidington EA,Ohta R,Okada N,Robson MG,Davies KA,Leitges M,Harris CL,Haskard DO,Mason JC

更新日期：2003-10-01 00:00:00

abstract：:The immunizing ability of immune complexes preformed between EA and EA-hyperimmune serum was investigated in adult rats. After immunization with complexes at equivalence, the pattern of suppressed IgE responsiveness was similar to that induced when a small volume of immune serum accompanied routine immunization. We ha...

journal_title：Immunology

authors： Hall EP,Gault EA

更新日期：1987-08-01 00:00:00

abstract：:MRL/Mp-lpr/lpr (lpr/lpr) mice but not the congenic MRL/Mp-+/+ (+/+) mice, develop a generalized lymph node (LN) hypertrophy reflecting the expansion of a T-cell population that acts as an enhancing factor for autoimmunity. In order to characterize better this T-cell population, we investigated some of its surface prop...

journal_title：Immunology

authors： Dumont F,Habbersett RG

更新日期：1982-10-01 00:00:00