Blocking the encephalitogenic activity of the C-terminal part of the basic myelin protein in rabbits by treatment with serum.

abstract：:Corneal allografts contain few or no Ia+ Langerhans' cells and consistently fail to elicit allospecific delayed-type hypersensitivity (DTH). The present study examined the hypothesis that the inability of corneal allografts to induce allospecific DTH was the result of active suppression. However, the results indicated...

journal_title：Immunology

authors： Niederkorn JY,Mayhew E

更新日期：1993-12-01 00:00:00

abstract：:CD4 T cells help immune responses, but knowledge of how memory CD4 T cells are regulated and how they regulate adaptive immune responses and induce immunopathology is limited. Using adoptive transfer of virus-specific CD4 T cells, we show that naive CD4 T cells undergo substantial expansion following infection, but ca...

journal_title：Immunology

authors： Bhattacharyya M,Madden P,Henning N,Gregory S,Aid M,Martinot AJ,Barouch DH,Penaloza-MacMaster P

更新日期：2017-10-01 00:00:00

abstract：:The intestine immune response in rats following immunization with horseradish peroxidase (HRP) was studied morphologically. Various routes of immunization (intraperitoneal, intravenous, intraenteric and intra-Peyer's patch) were tested. Single injections did not evoke any specific antibody-containing (anti-HRP) cells ...

journal_title：Immunology

authors： Sminia T,Delemarre F,Janse EM

更新日期：1983-09-01 00:00:00

abstract：:Membrane sialoglycoprotein (GP) of mouse erythrocytes were incorporated into artificial membranes of liposomes which also contained DNP-aminocaproylphosphatidylethanolamine hapten. The liposomes were tested for their potential to modulate the anti-hapten antibody response in mice as a plausible model of haptenated iso...

journal_title：Immunology

authors： Hitsumoto Y,Hineno T,Utsumi S

更新日期：1984-12-01 00:00:00

abstract：:In order to analyse the molecular mechanism of lymphocyte activation defect in MRL/MP-lpr (MRL/1) mice, c-myc proto-oncogene expression was examined in MRL/1 lymph node cells stimulated by various agents. Since a transient increase of c-myc RNA in early hours is required for lymphocyte activation, detection of c-myc m...

journal_title：Immunology

authors： Koizumi T,Nakao Y,Matsui T,Katakami Y,Mihara K,Takahashi R,Maeda S,Sugiyama T,Fujita T

更新日期：1988-05-01 00:00:00

abstract：:The humoral and mucosal immune responses to oral immunization with xenogeneic antibodies were studied using an animal model in which female rabbits were fed daily doses of the MOPC-315 murine IgA antibody, and were mated during the course of the feeding programme. Serum and colostrum samples were assayed for the prese...

journal_title：Immunology

authors： Collins AM,Roberton DM,Hosking CS,Flannery GR

更新日期：1991-08-01 00:00:00

abstract：:Infection of nude mice with Mesocestoides corti results in spleen enlargement, with a decrease in percentage positive, but overall increase in Thy-1 positive cells. A low frequency of both parasite antigen-specific and alloantigen-reactive T-cell clones were isolated from the spleen, mesenteric lymph nodes, peritoneal...

journal_title：Immunology

authors： Sanderson CJ,Strath M

更新日期：1985-02-01 00:00:00

abstract：:Myelin oligodendrocyte glycoprotein (MOG), a minor protein of the central nervous system myelin, is recognized as a potential target in multiple sclerosis and neuromyelitis optica. The extracellular domain of MOG is commonly used in a wide range of mouse strains and other animals to induce experimental autoimmune ence...

journal_title：Immunology

authors： Delarasse C,Smith P,Baker D,Amor S

更新日期：2013-12-01 00:00:00

abstract：:The primary immunoglobulin repertoire of chickens is generated not by gene rearrangement but by a subsequent process of gene conversion in proliferating immature B cells within the follicles of a specialized gut-associated lymphoid organ, the bursa of Fabricius. Neonatal infection with infectious bursal disease virus ...

journal_title：Immunology

authors： Withers DR,Davison TF,Young JR

更新日期：2006-04-01 00:00:00

abstract：:Haptoglobin (Hp), a major acute-phase plasma protein, has been found in arthritic synovial fluid (SF). However, the function and structural modifications of Hp in arthritic SF are unknown. To investigate in vivo generation of modified Hp associated with inflammatory disease, we examined a new Hp isoform in SF from pat...

journal_title：Immunology

authors： Park HJ,Oh MK,Kim NH,Cho ML,Kim IS

更新日期：2013-09-01 00:00:00

abstract：:Aspergillus fumigatus is often associated in asthmatic patients with the exacerbation of asthma symptoms. The pathomechanism of this phenomenon has not been fully understood. Here, we evaluated the immunological mechanisms and the role of the prostaglandin D2 / Chemoattractant Receptor-Homologous Molecule Expressed on...

journal_title：Immunology

authors： Liu H,Zheng M,Qiao J,Dang Y,Zhang P,Jin X

更新日期：2014-05-01 00:00:00

abstract：:Innate immune responses vary in a circadian manner, and more recent investigations aim to understand the underlying molecular mechanisms. Cytokine production varies significantly over the course of a day depending on the time of stimulation by pathogens or Toll-like receptor ligands, and multiple signaling pathways li...

journal_title：Immunology

authors： Geiger SS,Curtis AM,O'Neill LAJ,Siegel RM

更新日期：2019-06-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMC) from a patient suffering from the hyper IgE syndrome were used to generate phytohaemagglutinin (PHA)-expanded T-cell clones (all CD4+, CD8-, CD23-). A selection of the clones was tested for their ability to help IgE secretion by culturing with normal B cells in the presence of...

journal_title：Immunology

authors： Quint DJ,Bolton EJ,McNamee LA,Solari R,Hissey PH,Champion BR,MacKenzie AR,Zanders ED

更新日期：1989-05-01 00:00:00

abstract：:Regeneration of the thymus was studied in rats that were treated with a single oral dose of the organotin compound di-n-butyltin dichloride (DBTC). After an initial maximum depletion of cortical BrdU+ thymocytes on day 2 after treatment, repopulation appeared to start on day 3 as indicated by an increased number of Br...

journal_title：Immunology

authors： Pieters RH,Bol M,Lam BW,Seinen W,Bloksma N,Penninks AH

更新日期：1993-04-01 00:00:00

abstract：:Blood dendritic cells carry the terminal complement complex (TCC) on their surface, as detected by three monoclonal antibodies (mAb). Two of these mAb were generated by immunizing mice with the terminal complement complex, whereas the third was generated by immunizing mice with blood dendritic cells. All three mAb are...

journal_title：Immunology

authors： Würzner R,Xu H,Franzke A,Schulze M,Peters JH,Götze O

更新日期：1991-09-01 00:00:00

abstract：:Over the last few years, natural killer (NK) cells have been shown to express major histocompatibility complex (MHC) molecules recognizing receptors that are thought to function primarily as negative signalling receptors. Much attention has been focused on the NK cell receptors CD158a (EB6) and CD158b (GI 183), which ...

journal_title：Immunology

authors： Frohn C,Schlenke P,Kirchner H

更新日期：1997-12-01 00:00:00

abstract：:BALB/c mice injected with lyophilized vaccine from Streptococcus pneumoniae R36a (Pn) predominantly responded with antibody molecules the vast majority of which expressed the public idiotype T15 and were directed to the immunodominant epitope phosphorylcholine (PC). However, after a single immunization with Pn vaccine...

journal_title：Immunology

authors： Borghesi C,Nicoletti C

更新日期：1996-10-01 00:00:00

abstract：:The association between three major spondyloarthritic diseases, ankylosing spondylitis, Reiter's syndrome, and reactive arthritis, and the major histocompatibility complex (MHC) class 1 antigen HLA-B27 is well documented. The hypothesis of cross-reactivity between HLA-B27 and the antecedent infection-causing Gram-nega...

journal_title：Immunology

authors： Kapasi K,Chui B,Inman RD

更新日期：1992-11-01 00:00:00

abstract：:Phagocytes such as dendritic cells (DC) and macrophages employ phagocytosis to take up pathogenic bacteria into phagosomes, digest the bacteria and present the bacteria-derived peptide antigens to the adaptive immunity. Hence, efficient antigen presentation depends greatly on a well-regulated phagocytosis process. Lip...

journal_title：Immunology

authors： Chua RY,Wong SH

更新日期：2013-05-01 00:00:00

abstract：:The induction of proliferation of murine splenocytes by lipopolysaccharide (LPS) of Shigella dysenteriae type 1 and its polysaccharide (PS) and lipid A fractions was investigated. The LPS-induced proliferation reached a maximum at a concentration of 30 ng/ml. The PS and lipid A induced proliferation of murine splenocy...

journal_title：Immunology

authors： Biswas T,Roy S,Banerjee KK

更新日期：1995-02-01 00:00:00

abstract：:The endogenous cannabinoid system plays an important role in regulating the immune system. Modulation of endogenous cannabinoids represents an attractive alternative for the treatment of inflammatory disorders. This study investigated the effects of URB597, a selective inhibitor of fatty acid amide hydrolase (FAAH), t...

journal_title：Immunology

authors： Roche M,Kelly JP,O'Driscoll M,Finn DP

更新日期：2008-10-01 00:00:00

abstract：:The effects of immune complex infusion on the clearance of antibody (R3/13)-coated and NEM-treated rat erythrocytes by the splenic component of the rat mononuclear phagocyte system (MPS) were investigated. Equivalence complexes of BSA-anti-BSA produced a significant delay in the clearance of the NEM cells (pre-infusio...

journal_title：Immunology

authors： Yousaf N,Howard JC,Williams BD

更新日期：1986-09-01 00:00:00

abstract：:Paratyphoid vaccine injected between 4 days and 3 hours before injection of labelled immune complexes (125-I-labelled BGG-anti-BGG), inhibits follicular trapping of these complexes in the mouse spleen. Inhibition is maximal when paratyphoid vaccine is given 1 day before, almost no label being found in the spleen folli...

journal_title：Immunology

authors： van Rooijen N

更新日期：1975-06-01 00:00:00

abstract：:In the chicken spleen, certain aspects of the complex of ellipsoid, peri-ellipsoid lymphocyte sheath (PELS), and ring of macrophages are morphologically and functionally similar to the marginal zone in the mammalian spleen. In this study, the role of this marginal zone-like complex was examined during the humoral immu...

journal_title：Immunology

authors： Jeurissen SH

更新日期：1993-09-01 00:00:00

abstract：:High-density human B lymphocytes were prepared from tonsillar mononuclear cells by depletion of adherent cells and T lymphocytes, followed by discontinuous density gradient centrifugation. The B cells were analysed for the levels of expression of the CD25 (Tac) antigen marker by flow cytometry following culture with a...

journal_title：Immunology

authors： Butcher RD,McGarvie GM,Cushley W

更新日期：1990-01-01 00:00:00

abstract：:Suppressor T (Ts) cells specific for minor alloantigens can be generated by intravenous administration of high doses (10(8) cells) of alloantigenic spleen cells. Such Ts cells have previously been shown to inhibit the in vivo induction of CTL responses and are now shown to suppress in vitro proliferative responses to ...

journal_title：Immunology

authors： Nanda NK

更新日期：1989-10-01 00:00:00

abstract：:Immunoglobulin E (IgE)-dependent mechanisms play a pivotal role in mediating allergic disease. Previously, VH-Cepsilon transcripts from blood or spleen of atopic asthmatics have been analysed for VH gene usage and patterns of somatic mutation. An over-representation of the minor VH5 family has been observed, consisten...

journal_title：Immunology

authors： Snow RE,Djukanovic R,Stevenson FK

更新日期：1999-12-01 00:00:00

abstract：:Thymocytes incubated with either ATP or GTP exhibit a brief period of enhanced DNA synthesis in contrast to the prolonged period of enhanced synthesis observed when thymocytes were incubated with concanavalin A. The cells responding to nucleotides represent a sub-population of theta antigen-bearing T cells comprising ...

journal_title：Immunology

authors： Gregory SH,Kern M

更新日期：1981-03-01 00:00:00

abstract：:Polyclonal rabbit anti-idiotypic (Ab2) antibodies raised against the antiprogesterone mAb DB3 (Ab1) were used to induce an Ab3 antiprogesterone response in BALB/c mice. While the affinity of Ab3 sera for progesterone was 10-50-times lower than that of DB3, their steroid-binding specificity showed considerable similari...

journal_title：Immunology

authors： Kirsch RD,Beale D,He M,Corper AL,Krawinkel-Brenig U,Taussig MJ

更新日期：2000-06-01 00:00:00

abstract：:The cellular elements of an antigen-specific suppressor system for secondary antibody responses have been identified, using positive cell-selection techniques in the fluorescence-activated cell sorter. In a double-adoptive transfer of memory cells for a thymus-dependent antigen, from one irradiated recipient to anothe...

journal_title：Immunology

authors： Thomas DB,Kennedy MW

更新日期：1983-10-01 00:00:00