Distinct activation phenotype of a highly conserved novel HLA-B57-restricted epitope during dengue virus infection.

abstract：:Rapid expulsion of the nematode Trichinella spiralis from immune rats is associated with an increase in volume of intestinal exudate and the presence of large numbers of tissue mucosal mast cells (MMC) and eosinophils. We have measured the concentrations of leukotrienes (LT) C4 (LTC4) and B4 (LTB4) in gut perfusates a...

journal_title：Immunology

authors： Moqbel R,Wakelin D,MacDonald AJ,King SJ,Grencis RK,Kay AB

更新日期：1987-03-01 00:00:00

abstract：:Adult normal mice and those mice which had been thymectomized, X-irradiated, and reconstituted either with bone marrow cells and thymus cells (TxXBT) or with bone marrow cells along (TxXB), were given varying amounts (0.1-5 mg) of deaggregated soluble bovine serum albumin (sBSA). They were challenged 10 days later wit...

journal_title：Immunology

authors： Muramatsu S,Amagai T,Katura Y

更新日期：1975-05-01 00:00:00

abstract：:A monolayer depletion/adoptive immunization protocol that biased the immune response towards recognition of placental macrophage (pMO) antigens was established. BALB/c spleen cells immune to human pMO were adsorbed onto monolayers of the B-cell line QIMR-WIL. Monolayer-depleted or unfractionated cells were transferred...

journal_title：Immunology

authors： Nash AD,Uren S,Hawes CS,Boyle W

更新日期：1989-11-01 00:00:00

abstract：:A major role has been recently ascribed to the neutrophil in the resistance to infection by Listeria monocytogenes (L. monocytogenes). Here we evaluated whether such neutrophils played a role in the non-specific resistance to listeriosis that develops in hosts infected by mycobacteria. We found that the depletion of n...

journal_title：Immunology

authors： Leal IS,Appelberg R,Silva MT

更新日期：1996-11-01 00:00:00

abstract：:We quantified immunoglobulin E (IgE) on peritoneal mast cells of interleukin-4 (IL-4)-gene knockout (-/-) mice and wild-type (+/+) controls using a cytofluorometric method, and examined the expression of IgE receptors, estimated by quantifying the total binding of IgE on the mast cells of IL-4 (-/-) mice. The mast cel...

journal_title：Immunology

authors： Chen XJ,Lycke N,Enerbäck L

更新日期：1999-04-01 00:00:00

abstract：:Class switch recombination (CSR) is a T-cell-dependent mechanism regulating isotype switching in activated mature B cells. Recently we showed that T-cell-independent CSRs occur spontaneously during B lymphopoiesis, but such cells are negatively selected by Fas signalling. In immunoglobulin mu-deficient mice, lack of F...

journal_title：Immunology

authors： Seagal J,Melamed D

更新日期：2004-06-01 00:00:00

abstract：:Lipoprotein lipase (LPL) is the key enzyme in the metabolism of triglyceride-rich lipoproteins. The patterns of LPL mRNA expression and secretion of the enzyme have not yet been established in natural killer (NK) cells. We show in the present communication that CD3- CD16+ cells (NK cells) transcribe LPL mRNA, express ...

journal_title：Immunology

authors： de Sanctis JB,Blanca I,Radzioch D,Bianco NE

更新日期：1994-10-01 00:00:00

abstract：:Macrophage activating factor (MAF) is produced by antigen-stimulated lymphocytes and activates macrophages for antimicrobial function. The capacity of individual microbial antigens to evoke and regulate this response has been explored using an affinity purified antigen (TB68) of Mycobacterium tuberculosis in combinati...

journal_title：Immunology

authors： Matthews R,Scoging A,Rees AD

更新日期：1985-01-01 00:00:00

abstract：:Dengue virus (DENV) infection causes dengue fever, dengue haemorrhagic fever, or dengue shock syndrome. Mast cells have been speculated to play a role in DENV disease although their precise roles are unclear. In this study, we used mast cell-deficient Kit(W-sh/W-sh) mice to investigate the involvement of mast cells af...

journal_title：Immunology

authors： Chu YT,Wan SW,Anderson R,Lin YS

更新日期：2015-09-01 00:00:00

abstract：:Synthesis of interferon (IFN)-gamma by natural killer (NK) cells is an important pro-inflammatory event with interleukin (IL)-12 and IL-18 playing major inductive roles. However, other temporal events are likely to regulate such processes and as prostaglandin E2 (PGE2) is ubiquitous during inflammation this study test...

journal_title：Immunology

authors： Walker W,Rotondo D

更新日期：2004-03-01 00:00:00

abstract：:Rat mast cells with the properties of mucosal mast cells (MMC) proliferate in cultures of haemopoietic tissue in the presence of conditioned medium (CM) from antigen- or mitogen-activated T lymphocytes. The present study shows that recombinant rat interleukin-3 (rIL-3) both stimulated the development of MMC from bone ...

journal_title：Immunology

authors： Haig DM,McMenamin C,Redmond J,Brown D,Young IG,Cohen SD,Hapel AJ

更新日期：1988-10-01 00:00:00

abstract：:In mice arthritis model induced by anti-type II collagen (CII) antibodies and lipopolysaccharide (LPS), most of cells that infiltrated into the joint space were neutrophils. To investigate the role of neutrophils in the pathogenesis of arthritis, we depleted the neutrophils in vivo by injection of the antibody against...

journal_title：Immunology

authors： Tanaka D,Kagari T,Doi H,Shimozato T

更新日期：2006-10-01 00:00:00

abstract：:A panel of four mimotopes of the epitope recognized by the highly protective monoclonal antibody against Schistosoma mansoni (152-66-9B) was obtained by screening a solid-phase 8mer random peptide library. Three of the four mimotopes (p28, p29 and p30) were efficiently recognized in an in vitro radioimmunoassay by the...

journal_title：Immunology

authors： Arnon R,Tarrab-Hazdai R,Steward M

更新日期：2000-12-01 00:00:00

abstract：:The decay-accelerating factor (DAF) contains four complement control protein repeats (CCPs) with a single N-linked glycan positioned between CCPs 1 and 2. In previous studies we found that the classical pathway regulatory activity of DAF resides in CCPs 2 and 3 while its alternative pathway regulatory activity resides...

journal_title：Immunology

authors： Brodbeck WG,Kuttner-Kondo L,Mold C,Medof ME

更新日期：2000-09-01 00:00:00

abstract：:The influence of antigens of the major histocompatibility complex (MHC) on the production of interferon (IFN) alpha or IFN gamma by human peripheral blood leucocytes (PBL) in vitro has been studied. Synthesis of IFN gamma by PBL stimulated with purified phytohaemagglutinin (PHA-P) or protein A of Staphylococcus aureus...

journal_title：Immunology

authors： Abb J,Zander H,Abb H,Albert E,Deinhardt F

更新日期：1983-06-01 00:00:00

abstract：:HIV infection is associated with increased representation of T cells bearing an activated, memory (CD45RO+) phenotype. Although administration of antiretroviral agents and interleukin-2 (IL-2) augment depleted CD4+ T-cell numbers, such therapies have been preferentially beneficial for CD45RO+ T cells. Interleukin-15 (...

journal_title：Immunology

authors： Naora H,Gougeon M

更新日期：1999-06-01 00:00:00

abstract：:Lipoprotein was isolated from tumour cells by sonication and ultracentrifugal flotation on KBr gradients. It contained H-2 antigen detectable by antibody binding and induced a primary or secondary cell-mediated cytotoxic response in vitro which was H-2 specific. In a syngeneic model only a secondary cell-mediated resp...

journal_title：Immunology

authors： Dennert G

更新日期：1979-12-01 00:00:00

abstract：:Antibody response to a T-cell dependent antigen, sheep erythrocytes and to a B-cell mitogen, purified lipopolysaccharide (LPS), has been studied in mice kept on protein deficient (2 and 4 per cent casein) diets. The number of plaque-forming cells (PFC) to SRBC were 20-5 +/- 7-7 per million spleen cells in protein-defi...

journal_title：Immunology

authors： Narayanan RB,Nath I,Bhuyan UN,Talwar GP

更新日期：1977-03-01 00:00:00

abstract：:Membrane sialoglycoprotein (GP) of mouse erythrocytes were incorporated into artificial membranes of liposomes which also contained DNP-aminocaproylphosphatidylethanolamine hapten. The liposomes were tested for their potential to modulate the anti-hapten antibody response in mice as a plausible model of haptenated iso...

journal_title：Immunology

authors： Hitsumoto Y,Hineno T,Utsumi S

更新日期：1984-12-01 00:00:00

abstract：:A rat thymic epithelial cell (TEC) line (R-TNC.1) was established from a long-term TEC culture. Based on its ultrastructure, phenotype and cytokeratin profile, this line was characterized as a type of cortical TEC. R-TNC.1 cells had nursing activity which was manifested by the binding and subsequent engulfment of thym...

journal_title：Immunology

authors： Colić M,Vucević D,Miyasaka M,Tamatani T,Pavlović MD,Dujić A

更新日期：1994-11-01 00:00:00

abstract：:Initial stages of tumour growth are not easily accessible to investigation. Therefore an experimental procedure was developed to mimic tumorigenesis as closely as possible. BALB/c mice received intraperitoneally exponentially increasing numbers of irradiated syngeneic ADJ-PC-5 plasmacytoma cells. The initial injection...

journal_title：Immunology

authors： Haubeck HD,Kölsch E

更新日期：1982-11-01 00:00:00

abstract：:Although lymphocyte traffic through the brain is normally low, this can increase dramatically in response to infection or an autoimmune reaction. We have studied the adhesion of lymphocytes to cerebral endothelium in vitro in an attempt to model the first step of the infiltration process--that is, the initial interact...

journal_title：Immunology

authors： Hughes CC,Male DK,Lantos PL

更新日期：1988-08-01 00:00:00

abstract：:Suppressor T (Ts) cells specific for minor alloantigens can be generated by intravenous administration of high doses (10(8) cells) of alloantigenic spleen cells. Such Ts cells have previously been shown to inhibit the in vivo induction of CTL responses and are now shown to suppress in vitro proliferative responses to ...

journal_title：Immunology

authors： Nanda NK

更新日期：1989-10-01 00:00:00

abstract：:Two dermatophyte strains, Trichophyton quinckeanum and Trichophyton rubrum, were highly susceptible to in vitro killing by components of the H2O2-peroxidase-halide system. Both strains were, however, resistant to relatively high concentrations of reagent H2O2 or H2O2 enzymatically generated by glucose and glucose oxid...

journal_title：Immunology

authors： Calderon RA,Shennan GI

更新日期：1987-07-01 00:00:00

abstract：:We aimed to establish a panel of MHC-peptide multimers suitable as a positive control in the detection of HLA A*0201 restricted antigen specific T cells (ASTC) by flow cytometry. MHC Dextramers were loaded with HLA A*0201 binding peptides from viral antigens and melanoma targets identified from a literature search and...

journal_title：Immunology

authors： Fløe A,Løppke C,Hilberg O,Wejse C,Brix L,Jacobsen K

更新日期：2017-10-01 00:00:00

abstract：:The current study sought to delineate the gene expression profile of the host response in the caecum and colon during acute infection with Clostridium difficile in a mouse model of infection, and to investigate the nature of the unfolded protein response in this process. The infected mice displayed a significant up-re...

journal_title：Immunology

authors： Sadighi Akha AA,Theriot CM,Erb-Downward JR,McDermott AJ,Falkowski NR,Tyra HM,Rutkowski DT,Young VB,Huffnagle GB

更新日期：2013-09-01 00:00:00

abstract：:The specificities of antibodies raised in rabbits against rat mast cell proteinase 1 (RMCP 1) from connective tissue mast cells (CTMC), and against RMCP II from mucosal mast cells (MMC), were analysed by SDS-PAGE and Western blotting. Significant cross-reactivity was detected, and was eliminated by affinity purificati...

journal_title：Immunology

authors： Gibson S,Miller HR

更新日期：1986-05-01 00:00:00

abstract：:We have previously presented indirect evidence that both specific immunosuppression and lymphocyte mitogenicity induced in mice by p36, a proteinaceous factor of virulence produced by porcine monocytes infected by African swine fever virus, were consistent with a Th2-driven response. Here we show: (1) Interleukin-4 (I...

journal_title：Immunology

authors： Vilanova M,Ferreira P,Ribeiro A,Arala-Chaves M

更新日期：1999-03-01 00:00:00

abstract：:Intraepithelial lymphocytes (IEL) in normal human small intestine exhibit cytotoxicity. This study was undertaken to characterize the effector cells and their mode of action. Freshly isolated jejunal IEL and lamina propria lymphocytes (LPL), as well as IEL and LPL depleted of CD4+, CD8+ and T-cell receptor (TCR)-gamma...

journal_title：Immunology

authors： Melgar S,Bas A,Hammarström S,Hammarström ML

更新日期：2002-08-01 00:00:00

abstract：:The IgG and IgA subclass distribution of anti-carbohydrate antibodies in normal and immunodeficient donors was investigated. In normal donors, the specific anti-dextran antibodies were mainly of the IgG2 and IgA2 subclass, although substantial amounts of antibodies could also be of the IgG1 subclass. In children, IgG1...

journal_title：Immunology

authors： Hammarström L,Persson MA,Smith CI

更新日期：1985-04-01 00:00:00