Helper and suppressor activities of an autoreactive mouse thyroglobulin-specific T-cell clone.

abstract：:We have established lines and clones of helper T cells specific for the antigen fowl gamma globulin (FGG) and maintained these cells in continuous proliferation in vitro for up to 8 months. During this period the specific helper activity was assessed in vitro in T cell-dependent anti-hapten responses. These pure popul...

journal_title：Immunology

authors： Cammisuli S,Schreier MH

更新日期：1981-07-01 00:00:00

abstract：:In general, the majority of bacteria are pre-inflammatory when injected in experimental animals. However, Mycobacterium leprae has no inflammatory effect when injected into mouse footpad, but using the delipidated mycobacteria we observed a mild significant increase in footpad oedema. Other mycobacteria, Mycobacterium...

journal_title：Immunology

authors： Moura AC,Mariano M

更新日期：1996-12-01 00:00:00

abstract：:Ly-49A is a member of the Ly-49 family of mouse natural killer cell receptors that inhibit cytotoxicity upon recognition of their ligands, the major histocompatibility complex (MHC) class I molecules, on the target cell surface. Although Ly-49A has an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytopl...

journal_title：Immunology

authors： Motoda K,Takata M,Kiura K,Nakamura I,Harada M

更新日期：2000-07-01 00:00:00

abstract：:The subcutaneous (s.c.) injection of sheep red blood cells (SRBC) without adjuvant into mice preferentially induced delayed hypersensitivity (DH) reaction, as measured by footpad swelling, while intraperitoneal (i.p.) measured by the haemagglutinin test. Under these conditions, the properties of the helper activities...

journal_title：Immunology

authors： Tamura SI,Egashira Y

更新日期：1975-05-01 00:00:00

abstract：:Both lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate (PMA) impeded monocyte to macrophage differentiation with respect to typical phenotypic modulation and certain phagocyte-related processes. The down-regulation of the porcine monocyte marker SWC1, and up-regulation of the SWC9 macrophage marker were ret...

journal_title：Immunology

authors： Basta S,Knoetig S,Summerfield A,McCullough KC

更新日期：2001-08-01 00:00:00

abstract：:The amount and relative affinity of antibodies to tetanus toxoid were measured, following immunization, in patients with chronic or recurrent acute chest infections and in healthy controls. The responding patients and controls produced similar amounts of antibody and, although antibody affinity was higher in the contr...

journal_title：Immunology

authors： Devey ME,Bleasdale KM,French MA,Harrison G

更新日期：1985-07-01 00:00:00

abstract：:Jacalin, a lectin(s) extracted from the seeds of Artocarpus integrifolia (Jackfruit), was shown to induce the production of gamma interferon (IFN gamma) in human peripheral blood mononuclear cells (PBMC) and human T-lymphocyte cultures. The amount of IFN gamma produced was enhanced in the presence of mezerein, a phorb...

journal_title：Immunology

authors： Crane I,Leung H,Barwick S,Parti S,Meager A

更新日期：1984-12-01 00:00:00

abstract：:Summary Diverse immunotherapy approaches have achieved success in controlling individual aspects of immune responses in animal models. Transfer of such immunotherapies to clinical trials has obtained some success in patients, with clinical responses observed or effective antigen specific immune responses achieved, but...

journal_title：Immunology

authors： Crittenden MR,Thanarajasingam U,Vile RG,Gough MJ

更新日期：2005-01-01 00:00:00

abstract：:Doxorubicin-stimulated whole rat glomeruli and dissociated mesangial and resident glomerular macrophage cells produced the release of interleukin (IL)-1 beta cytokine. This activity increased after the addition of lipopolysaccharide (LPS) or LPS plus indomethacin to the cultures. In the presence of WEB2086 [platelet-a...

journal_title：Immunology

authors： Bricio T,Molina A,Martin A,Mampaso F

更新日期：1994-01-01 00:00:00

abstract：:Bovine peripheral blood monocytes were isolated from buffy coats of ACD-anticoagulated whole blood. Cells cultivated on plastic surfaces for 20 h were judged to be 95% monocytes based on nonspecific esterase-1 staining, uptake of latex particles and surface receptor characteristics. Bovine monocytes were maintained up...

journal_title：Immunology

authors： Birmingham JR,Jeska EL

更新日期：1980-12-01 00:00:00

abstract：:Mice fed a protein-deficient diet containing 2% ovalbumin for 6 weeks (PD) show a reduced spleen IgA plaque-forming cell (PFC) response after oral immunization with sheep red blood cells (SRBC), compared to the response of mice fed a control diet containing 20% ovalbumin (C). This reduced IgA PFC response was partiall...

journal_title：Immunology

authors： McGee DW,McMurray DN

更新日期：1988-08-01 00:00:00

abstract：:Neutrophils make up an essential part of the innate immune system, and are involved both in the initial responses to pathogens, and in orchestrating later immune responses. Neutrophils recognize pathogens through pattern-recognition receptors (PRRs), which are activated by microbial motifs. The Nod-like receptors (nuc...

journal_title：Immunology

authors： Ekman AK,Cardell LO

更新日期：2010-05-01 00:00:00

abstract：:Interleukin-15 (IL-15) is a proinflammatory cytokine that is overexpressed in rheumatoid arthritis (RA), a disease characterized by activation of monocytes/macrophages (MPhi), and by expansion of autoreactive CD4(+) T cells. We hypothesized that IL-15 plays a major role for this expansion of CD4(+) T cells and modulat...

journal_title：Immunology

authors： Rückert R,Brandt K,Ernst M,Marienfeld K,Csernok E,Metzler C,Budagian V,Bulanova E,Paus R,Bulfone-Paus S

更新日期：2009-01-01 00:00:00

abstract：:When cultured on a collagen matrix at a density of 7 X 10(4) cells/cm2 for 48 hr, 80 +/- 10% of unfractionated and 70 +/- 14% of T-enriched human blood lymphocytes from eight healthy individuals developed a motile morphology defined as the presence of lamellar surface activity and cytoplasmic flattening. During cultur...

journal_title：Immunology

authors： Sundqvist KG,Otteskog P

更新日期：1986-07-01 00:00:00

abstract：:An investigation was made of the properties of cytotoxic T cells induced by Con A and exposure to LCM virus-infected cells. As a basis for such studies, the optimal conditions for in vitro Con A stimulation of in vivo LCM virus-primed C3H mouse splenocytes were determined. The most potent cytotoxicity was obtained whe...

journal_title：Immunology

authors： Marker O,Andersen GT

更新日期：1979-10-01 00:00:00

abstract：:We have previously shown that chlorpromazine (CPZ) inhibits tumour necrosis factor (TNF) production and protects against endotoxic shock in mice. In this paper we investigated the effect of pretreatment with CPZ, 4 mg/kg i.p. 30 min before, compared with dexamethasone (DEX; 3 mg/kg) on the induction of other endotoxin...

journal_title：Immunology

authors： Mengozzi M,Fantuzzi G,Faggioni R,Marchant A,Goldman M,Orencole S,Clark BD,Sironi M,Benigni F,Ghezzi P

更新日期：1994-06-01 00:00:00

abstract：:Haemolytic assays were used to compare alternative and classical complement (C) pathway activities in sera obtained from neonatal pigs reared on porcine colostrum, bovine colostrum or an immunoglobulin-free synthetic diet. Dramatic increases in immunoglobulin concentrations were noted in the colostrum-fed animals duri...

journal_title：Immunology

authors： Renshaw HW,Gilmore RJ

更新日期：1980-09-01 00:00:00

abstract：:Receptors for the Fc fragment of IgG (Fc gamma R) have a well-documented role in the generation of oxidative burst. It is tempting to speculate that the type of interaction with Fc gamma R could be a mechanism of regulation of this process. Here we report on a comparative study of the induction of oxidative burst in h...

journal_title：Immunology

authors： Casado JA,Merino J,Cid J,Subira ML,Sanchez-Ibarrola A

更新日期：1994-09-01 00:00:00

abstract：:Adult normal mice and those mice which had been thymectomized, X-irradiated, and reconstituted either with bone marrow cells and thymus cells (TxXBT) or with bone marrow cells along (TxXB), were given varying amounts (0.1-5 mg) of deaggregated soluble bovine serum albumin (sBSA). They were challenged 10 days later wit...

journal_title：Immunology

authors： Muramatsu S,Amagai T,Katura Y

更新日期：1975-05-01 00:00:00

abstract：:Acquisition of T-cell central tolerance involves distinct pathways of self-antigen presentation to thymocytes. One pathway termed indirect presentation requires a self-antigen transfer step from thymic epithelial cells (TECs) to bone marrow-derived cells before the self-antigen is presented to thymocytes. The role of ...

journal_title：Immunology

authors： Yap JY,Wirasinha RC,Chan A,Howard DR,Goodnow CC,Daley SR

更新日期：2018-07-01 00:00:00

abstract：:The discovery of host-encoded gene products that sense molecular patterns in infectious microbes, and the demonstration of their role in triggering innate and adaptive immune responses, has been a key milestone in our understanding of immunology. Twenty-three years after Janeway first outlined the fundamental concepts...

journal_title：Immunology

authors： Browne EP

更新日期：2012-08-01 00:00:00

abstract：:Experiments were conducted to test the hypothesis that opsonic and non-opsonic phagocytic capacities are differentially regulated by resting and wound-derived macrophages. Furthermore, the phagocytosis of non-opsonized zymosan and beta-glucan particles was quantified to determine whether cells differentially regulate ...

journal_title：Immunology

authors： Reichner JS,Fitzpatrick PA,Wakshull E,Albina JE

更新日期：2001-10-01 00:00:00

abstract：:Fifteen sera of patients with visceral leishmaniasis were investigated for the occurrence of autoantibodies. They were found in high incidence and titre, and with specificity to the intermediate filament (INFIL) proteins vimentin (12 out of 15 with a titre higher than 1:10) and keratin (9 out of 15 with a titre higher...

journal_title：Immunology

authors： Böhme MW,Evans DA,Miles MA,Holborow EJ

更新日期：1986-12-01 00:00:00

abstract：:Anti-Gal is the most abundant natural antibody in humans, constituting ~ 1% of immunoglobulins. Anti-Gal is naturally produced also in apes and Old World monkeys. The ligand of anti-Gal is a carbohydrate antigen called the 'α-gal epitope' with the structure Galα1-3Galβ1-4GlcNAc-R. The α-gal epitope is present as a maj...

journal_title：Immunology

authors： Galili U

更新日期：2013-09-01 00:00:00

abstract：:Although the co-stimulatory interaction between B and T cells is well defined, recent evidence suggests that B cells also have a regulatory role. Here, we show that B cells activated using anti-IgD conjugated to dextran (α-δ-dex) directly inhibit TCR-induced CD4 T cell activation, proliferation and cytokine production...

journal_title：Immunology

authors： Preciado-Llanes L,Wing JB,Foster RA,Carlring J,Lees A,Read RC,Heath AW

更新日期：2014-09-20 00:00:00

abstract：:Recent studies in mice have highlighted the importance of polymorphic genetic loci such as the major histocompatibility complex (MHC) or minor lymphocyte-stimulating antigen (Mls) in determining the nature of the peripheral T-cell receptor (TcR) population. As our knowledge of the equivalent process in humans is incom...

journal_title：Immunology

authors： Loveridge JA,Rosenberg WM,Kirkwood TB,Bell JI

更新日期：1991-10-01 00:00:00

abstract：:In understanding the regulation of the specific immune response to Salmonella typhimurium, the role of a surface major component (porins) was studied. In this study we demonstrate that purified porins are able to induce a different response to that induced by the porins present on the S. typhimurium cell surface. Pori...

journal_title：Immunology

authors： Galdiero M,De Martino L,Marcatili A,Nuzzo I,Vitiello M,Cipollaro de l'Ero G

更新日期：1998-05-01 00:00:00

abstract：:It has been reported that, in early pregnancy in mice, there is an increase in the number of immunoglobulin-secreting cells in the lymph nodes which drain the uterus. This paper describes the results of further investigations provoked by interest in these early changes. Increases in the numbers of immunoglobulin-secre...

journal_title：Immunology

authors： Hancock RJ,Popham AM,Faruki S,Dresser DW

更新日期：1985-06-01 00:00:00

abstract：:BALB/c mice develop myasthenic symptoms after immunization with rodent acetylcholine receptor (AChR). After immunization with Torpedo AChR (TAChR), their CD4+ cells become strongly sensitized against a conserved region of the TAChR alpha subunit sequence (residues alpha 304-322), and cross-react vigorously with the ho...

journal_title：Immunology

authors： Karachunski PI,Ostlie N,Conti-Tronconi BM,Bellone M

更新日期：1994-05-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease in which abnormal immune responses are mediated by tissue-binding autoantibodies and immune complex deposition. Because most SLE patients are women of child-bearing age, oestrogen has been suggested to play an important role in SLE pathogenesis. One proposed ...

journal_title：Immunology

authors： Lee J,Shin EK,Lee SY,Her YM,Park MK,Kwok SK,Ju JH,Park KS,Kim HY,Cho ML,Park SH

更新日期：2014-08-01 00:00:00