The differential effect of cyclic AMP on lymphocyte stimulation by T- or B-cell mitogens.

abstract：:Non-obese diabetic (NOD) mice spontaneously develop insulin-dependent diabetes mellitus (IDDM) as a consequence of autoimmune aggression of beta cells of the endocrine pancreas by T cells. T lymphocytes of NOD mice are resistant to apoptosis induced by glucocorticoids, or by starving or DNA-damaging treatments, a feat...

journal_title：Immunology

authors： Martins TC,Aguas AP

更新日期：1998-11-01 00:00:00

abstract：:Host-versus-graft (HVG) syndrome is the fatal allogenic disease which develops in susceptible strains of inbred mice following their perinatal inoculation with related F1 hybrid spleen cells. Deaths are caused by pathogenic immune complexes. It is thought that the antibody components of these complexes are produced by...

journal_title：Immunology

authors： Hard RC,Patel MR,Keller LM,Linna TJ

更新日期：1988-03-01 00:00:00

abstract：:Immunoglobulin E is quantitatively a minor immunoglobulin class in serum, but nevertheless the major class of antibody mediating type I hypersensitivity reactions and hence, type I allergic phenomena. The bovine epsilon gene is one of the as yet uncharacterized mammalian immunoglobulin genes. We have therefore cloned ...

journal_title：Immunology

authors： Mousavi M,Rabbani H,Hammarström L

更新日期：1997-11-01 00:00:00

abstract：:Co-stimulation of highly purified peripheral T lymphocytes from healthy blood donors with the adhesion molecules CD2 and CD28 in association with recombinant interleukin-7 (rIL-7) induced T-cell proliferation, multiple cytokine secretion and IL-2 receptivity. We demonstrated that rIL-7 is as potent as rIL-2 in inducin...

journal_title：Immunology

authors： Costello R,Brailly H,Mallet F,Mawas C,Olive D

更新日期：1993-11-01 00:00:00

abstract：:Although interleukin-21 (IL-21) potently activates and controls the differentiation of immune cells after stimulation in vitro, the role for this pleiotropic cytokine during in vivo infection remains poorly defined. Herein, the requirement for IL-21 in innate and adaptive host defence after Listeria monocytogenes infe...

journal_title：Immunology

authors： Ertelt JM,Johanns TM,Rowe JH,Way SS

更新日期：2010-10-01 00:00:00

abstract：:The haemolymph of the colonial ascidian Botrylloides leachii contains two haemagglutinins which have been termed HA-1 and HA-2 respectively. The HA-1 agglutinin is specific for guinea-pig erythrocytes, requires Ca2+ ions for its activity and has an apparent mol. wt. of about 200,000. It can be adsorbed by guinea-pig b...

journal_title：Immunology

authors： Schluter SF,Ey PL,Keough DR,Jenkin CR

更新日期：1981-02-01 00:00:00

abstract：:The inhibitory effects of IgA from human colostrum, and IgA1 and IgA2 from human serum on the chemiluminescence (CL) response and phagocytosis of polymorphonuclear leucocytes (PML) to Staphylococcus epidermidis and the CL response to formylmethionyl-leucyl-phenylalanine (FMLP) were studied. The dose-dependent inhibiti...

journal_title：Immunology

authors： Saito K,Kato C,Katsuragi H,Komatsuzaki A

更新日期：1991-09-01 00:00:00

abstract：:Many experiments have demonstrated that the nervous and immune systems interact in a bidirectional fashion. Neuropeptides, including substance P, have been shown to modulate lymphocyte DNA, RNA and immunoglobulin synthesis in vitro and to play a role in inflammatory and hypersensitivity disease states. However, the ro...

journal_title：Immunology

authors： Scicchitano R,Biennenstock J,Stanisz AM

更新日期：1988-04-01 00:00:00

abstract：:Cytokines are the most important inducers of T helper (Th) cell differentiation. Interleukin-12 (IL-12) and interferon-alpha (IFN-alpha) are responsible for human Th1-cell differentiation, while IL-4 is the critical cytokine promoting Th2-cell development. These two subsets of cells co-ordinate immunological responses...

journal_title：Immunology

authors： Aho TL,Lund RJ,Ylikoski EK,Matikainen S,Lahesmaa R,Koskinen PJ

更新日期：2005-09-01 00:00:00

abstract：:Toll-like receptor-4 (TLR4) is important in protection against lethal Salmonella enterica serovar Typhimurium (S. Typhimurium) infection. Control of the early stages of sublethal S. Typhimurium infection in mice depends on TLR4-dependent activation of macrophages and natural killer (NK) cells to drive an inflammatory ...

journal_title：Immunology

authors： Talbot S,Tötemeyer S,Yamamoto M,Akira S,Hughes K,Gray D,Barr T,Mastroeni P,Maskell DJ,Bryant CE

更新日期：2009-12-01 00:00:00

abstract：:Interleukin-15 (IL-15) is a proinflammatory cytokine that is overexpressed in rheumatoid arthritis (RA), a disease characterized by activation of monocytes/macrophages (MPhi), and by expansion of autoreactive CD4(+) T cells. We hypothesized that IL-15 plays a major role for this expansion of CD4(+) T cells and modulat...

journal_title：Immunology

authors： Rückert R,Brandt K,Ernst M,Marienfeld K,Csernok E,Metzler C,Budagian V,Bulanova E,Paus R,Bulfone-Paus S

更新日期：2009-01-01 00:00:00

abstract：:Using monoclonal antibodies (mAb) characterized at the last International Workshop on Human Leucocyte Antigens, we examined the expression of CDw75 antigens (beta-galactoside alpha 2,6-sialyltransferase) on normal peripheral blood cells and on cells from patients with B-cell chronic lymphocytic leukaemia (CLL). The mA...

journal_title：Immunology

authors： Guy K,Andrew JM

更新日期：1991-10-01 00:00:00

abstract：:Bovine respiratory syncytial virus (RSV) is a major cause of respiratory disease in young calves. Recent studies in calves, in which different T-cell subsets were depleted, have shown that CD8+ T cells play a central role in recovery from RSV infection. The present study demonstrates that RSV-specific, major histocomp...

journal_title：Immunology

authors： Gaddum RM,Cook RS,Thomas LH,Taylor G

更新日期：1996-07-01 00:00:00

abstract：:The fluorescence-activated cell sorter and a rosette-depletion technique were used to separate rat spleen lymphocytes and BCG-activated lymphocytes into subpopulations with and without the antigens defined by W3/13, W3/23 and OX8 monoclonal antibodies. The resultant populations were then tested for natural killer (NK)...

journal_title：Immunology

authors： Cantrell DA,Robins RA,Brooks CG,Baldwin RW

更新日期：1982-01-01 00:00:00

abstract：:We produced three murine monoclonal antibodies (mAb) directed against the human T-cell differentiation antigen CD2 (formerly T11) and analysed their epitope specificity by E-rosette inhibition, cross-blocking and proliferation-induction experiments. When added together, two mAb (both IgG1 kappa) were able to induce pr...

journal_title：Immunology

authors： van Lier R,Bloemena E,Brouwer M,Van Heijst J,Weinreich S,Aarden L

更新日期：1989-07-01 00:00:00

abstract：:Chronic antigenic stimulation leads to gradual accumulation of late-differentiated, antigen-specific, oligoclonal T cells, particularly within the CD8(+) T-cell compartment. They are characterized by critically shortened telomeres, loss of CD28 and/or gain of CD57 expression and are defined as either CD8(+) CD28(-) or...

journal_title：Immunology

authors： Strioga M,Pasukoniene V,Characiejus D

更新日期：2011-09-01 00:00:00

abstract：:It has been suggested that tumour cell lysis by gamma-radiation induces a tumoral antigen release eliciting an immune response. It is not clear how a specific immune response in cervical cancer patients is developed after radiotherapy. This study is an attempt to investigate the role of the human papillomavirus type 1...

journal_title：Immunology

authors： Delgado FG,Martínez E,Céspedes MA,Bravo MM,Navas MC,Cómbita Rojas AL

更新日期：2009-04-01 00:00:00

abstract：:The capacity of the immune system to respond efficiently to new antigens depends upon a continuous source of naive CD4+ T cells. Such cells exit from the thymus and join the recirculated T-cell pool. Factors present at the sites of naive CD4+ T-cell circulation must be responsible for their survival, since upon remova...

journal_title：Immunology

authors： Webb LM,Foxwell BM,Feldmann M

更新日期：1999-11-01 00:00:00

abstract：:The discovery of host-encoded gene products that sense molecular patterns in infectious microbes, and the demonstration of their role in triggering innate and adaptive immune responses, has been a key milestone in our understanding of immunology. Twenty-three years after Janeway first outlined the fundamental concepts...

journal_title：Immunology

authors： Browne EP

更新日期：2012-08-01 00:00:00

abstract：:We performed a genomic study combining single-cell mRNA differential display and RNA subtractive hybridization to elucidate CD8 T-cell quiescence/ignorance. By comparing actively maintained quiescent CD8 T cells from liver tumour tumour-infiltrating lymphocytes (TILs) with quiescent T cells at the single-cell level, w...

journal_title：Immunology

authors： Zhang W,Ding J,Qu Y,Hu H,Lin M,Datta A,Larson A,Liu GE,Li B

更新日期：2009-05-01 00:00:00

abstract：:As the burden of infectious diseases becomes reduced in many countries, a remarkable increase in the incidence of allergies has occurred. The basis for the rise in atopic disorders as a correlate of the decline in infectious diseases has not been defined. In the present study, we tested experimentally whether prior sy...

journal_title：Immunology

authors： Yang X,Wang S,Fan Y,Zhu L

更新日期：1999-11-01 00:00:00

abstract：:Glucosamine (GlcN) has been reported to possess several biomedical properties, and currently a great deal of attention has been focused on improving the functional properties of GlcN for different applications. Therefore, this study was conducted to introduce a carboxybutyryl functional group to GlcN and to find out t...

journal_title：Immunology

authors： Rajapakse N,Kim MM,Mendis E,Kim SK

更新日期：2008-03-01 00:00:00

abstract：:Bile acids (BAs) play important roles not only in lipid metabolism, but also in signal transduction. TGR5, a transmembrane receptor of BAs, is an immunomodulative factor, but its detailed mechanism remains unclear. Here, we aimed to delineate how BAs operate in immunological responses via the TGR5 pathway in human mon...

journal_title：Immunology

authors： Yoneno K,Hisamatsu T,Shimamura K,Kamada N,Ichikawa R,Kitazume MT,Mori M,Uo M,Namikawa Y,Matsuoka K,Sato T,Koganei K,Sugita A,Kanai T,Hibi T

更新日期：2013-05-01 00:00:00

abstract：:In the present study we have investigated whether bovine erythrocytes (Eb) specifically sensitized with human polyclonal IgA1 (Eb-IgA1) are able to bind to resident adherent rat peritoneal cells (PM phi). Rat PM phi formed rosettes with Eb-IgA1 at room temperature and at 37 degrees. The formation of these rosettes cou...

journal_title：Immunology

authors： Gorter A,Hiemstra PS,van der Voort EA,van Es LA,Daha MR

更新日期：1988-06-01 00:00:00

abstract：:Interleukin-6 (IL-6) is an important B-cell growth and differentiation factor. IL-6 treatment of the human lymphoblastoid cell line, SKW6.4, leads to increased IgM production. We have previously shown that IL-6 induces activation of JAK1 and JAK2 in human B cell lines. A chimeric IL-6 receptor, comprised of the intrac...

journal_title：Immunology

authors： Faris M,Kokot N,Stahl N,Nel AE

更新日期：1997-03-01 00:00:00

abstract：:Immunization of mice with cognate cancer-derived heat-shock protein (hsp) preparations leads to protection from cancer growth. As hsp used for vaccination or therapy are derived from autologous cancers, questions of pathological autoimmunity are of immense significance for the ongoing translation of this approach to t...

journal_title：Immunology

authors： Ménoret A,Chandawarkar RY,Srivastava PK

更新日期：2000-11-01 00:00:00

abstract：:In chronic inflammatory conditions, mononuclear cells infiltrate the involved connective tissue and may persist, perhaps because of binding to adhesion molecules on connective tissue cells, as well as extracellular matrix. Here we investigated whether vascular cell adhesion molecule-1 (VCAM-1) may be induced on human ...

journal_title：Immunology

authors： Gao JX,Issekutz AC

更新日期：1996-11-01 00:00:00

abstract：:Mouse peritoneal macrophages (M phi) expressed enhanced tumoricidal activity upon in vitro stimulation either with the lymphokine M phi-activating factor (MAF) or with fibroblast interferon (IFN-beta). In contrast, M phi suppressive activity on lymphoproliferation was not affected by MAF pretreatment, but was drastica...

journal_title：Immunology

authors： Boraschi D,Ghezzi P,Pasqualetto E,Salmona M,Nencioni L,Soldateschi D,Villa L,Tagliabue A

更新日期：1983-11-01 00:00:00

abstract：:Induction of all forms of protective immunity by oral immunization with subunit vaccines is an ideal goal for the development of novel vaccines, but creates several theoretical problems from the point of view of antigen processing mechanisms. We show here that incorporation of the protein antigen ovalbumin (OVA) in li...

journal_title：Immunology

authors： Mowat AM,Donachie AM,Reid G,Jarrett O

更新日期：1991-03-01 00:00:00

abstract：:There is increasing evidence that primitive progenitors migrate from the bone marrow (BM) via the peripheral circulation to tissue sites where they undergo in situ differentiation to provide a continued source of effector cells, such as eosinophils, during an allergic inflammatory response. To study mechanisms of prog...

journal_title：Immunology

authors： Sehmi R,Dorman S,Baatjes A,Watson R,Foley R,Ying S,Robinson DS,Kay AB,O'Byrne PM,Denburg JA

更新日期：2003-08-01 00:00:00