A comparison of immunogenicity of norovirus GII-4 virus-like particles and P-particles.

abstract：:Allergic diseases are frequently exacerbated between midnight and early morning, suggesting a role for the biological clock. Mast cells (MC) and eosinophils are the main effector cells of allergic diseases and some MC-specific or eosinophil-specific markers, such as tryptase or eosinophil cationic protein, exhibit cir...

journal_title：Immunology

authors： Baumann A,Gönnenwein S,Bischoff SC,Sherman H,Chapnik N,Froy O,Lorentz A

更新日期：2013-12-01 00:00:00

abstract：:CD4(+) FOXP3(+) regulatory T (Treg) cells constitute a heterogeneous and plastic T-cell lineage that plays a pivotal role in maintaining immune homeostasis and immune tolerance. However, the fate of human Treg cells after loss of FOXP3 expression and the epigenetic mechanisms contributing to such a phenotype switch re...

journal_title：Immunology

authors： He H,Ni B,Tian Y,Tian Z,Chen Y,Liu Z,Yang X,Lv Y,Zhang Y

更新日期：2014-03-01 00:00:00

abstract：:The current study sought to delineate the gene expression profile of the host response in the caecum and colon during acute infection with Clostridium difficile in a mouse model of infection, and to investigate the nature of the unfolded protein response in this process. The infected mice displayed a significant up-re...

journal_title：Immunology

authors： Sadighi Akha AA,Theriot CM,Erb-Downward JR,McDermott AJ,Falkowski NR,Tyra HM,Rutkowski DT,Young VB,Huffnagle GB

更新日期：2013-09-01 00:00:00

abstract：:We performed a genomic study combining single-cell mRNA differential display and RNA subtractive hybridization to elucidate CD8 T-cell quiescence/ignorance. By comparing actively maintained quiescent CD8 T cells from liver tumour tumour-infiltrating lymphocytes (TILs) with quiescent T cells at the single-cell level, w...

journal_title：Immunology

authors： Zhang W,Ding J,Qu Y,Hu H,Lin M,Datta A,Larson A,Liu GE,Li B

更新日期：2009-05-01 00:00:00

abstract：:The role of endogenously mediated fever and exogenous hyperthermia as modulators of immune functions remains poorly understood. It is known that fever is mediated by several cytokines, including interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta), interleukin-6 (IL-6), tumour necrosis factor-alpha (T...

journal_title：Immunology

authors： Kappel M,Diamant M,Hansen MB,Klokker M,Pedersen BK

更新日期：1991-07-01 00:00:00

abstract：:Summary Diverse immunotherapy approaches have achieved success in controlling individual aspects of immune responses in animal models. Transfer of such immunotherapies to clinical trials has obtained some success in patients, with clinical responses observed or effective antigen specific immune responses achieved, but...

journal_title：Immunology

authors： Crittenden MR,Thanarajasingam U,Vile RG,Gough MJ

更新日期：2005-01-01 00:00:00

abstract：:Release of immunoglobulin-binding factors was induced from cultured human lymphoblastoid cells in a serum-free environment by incubation at 37 degrees. RPMI-8866 cells expressing Fc receptors for IgE (Fc epsilon R) and Daudi cells expressing Fc receptors for IgG (Fc gamma R) released IgE- and IgG-binding factors, resp...

journal_title：Immunology

authors： Jensen JR,Sand TT,Spiegelberg HL

更新日期：1984-09-01 00:00:00

abstract：:The development of improved vaccines and vaccination strategies against Mycobacterium tuberculosis has been hindered by a limited understanding of the immune correlates of anti-tuberculosis protective immunity. Simple measurement of interferon-γ frequency or production per se does not provide adequate prediction of im...

journal_title：Immunology

authors： Kang H,Yuan Q,Ma H,Hu ZD,Han DP,Wu K,Lowrie DB,Fan XY

更新日期：2014-12-01 00:00:00

abstract：:HIV infection is associated with increased representation of T cells bearing an activated, memory (CD45RO+) phenotype. Although administration of antiretroviral agents and interleukin-2 (IL-2) augment depleted CD4+ T-cell numbers, such therapies have been preferentially beneficial for CD45RO+ T cells. Interleukin-15 (...

journal_title：Immunology

authors： Naora H,Gougeon M

更新日期：1999-06-01 00:00:00

abstract：:Virus-specific cytotoxic T-cell (Tc) clones can lyse target cells in vitro in the presence of their specific peptide epitopes. The lytic potency of murine influenza nucleoprotein (NP)-specific Tc clones was investigated after observing that target cell killing was reduced in the presence of high (greater than 0.2 micr...

journal_title：Immunology

authors： Pemberton RM,Wraith DC,Askonas BA

更新日期：1990-06-01 00:00:00

abstract：:Cells expressing indoleamine 2,3-dioxygenase (IDO), an enzyme which catabolizes tryptophan, prevent T-cell proliferation in vitro, suppress maternal antifetal immunity during pregnancy and inhibit T-cell-mediated responses to tumour-associated antigens. To examine the mechanistic basis of these phenomena we activated ...

journal_title：Immunology

authors： Lee GK,Park HJ,Macleod M,Chandler P,Munn DH,Mellor AL

更新日期：2002-12-01 00:00:00

abstract：:The in vitro migration activity of monocytic cells and the effect of lymphocytes in the delayed hypersensitivity (DH) reaction induced by intrapleural injection of PPD into FCA-sensitized guinea-pigs was investigated. The in vitro migration of exudate mononuclear cells was lower than that of comparable blood cells, an...

journal_title：Immunology

authors： Yamamoto S,Dunn CJ,Willoughby DA

更新日期：1976-04-01 00:00:00

abstract：:The studies were designed to investigate the effect of ageing and low protein (4%) diet on antibody-dependent cell-mediated cytotoxicity (ADCC) and IgA concentration in the intestine. Both ADCC activity and IgA concentration were shown to reach mature levels at 17 weeks old. The effect of ageing was greater on ADCC ac...

journal_title：Immunology

authors： Lim TS,Messiha N,Watson RR

更新日期：1981-07-01 00:00:00

abstract：:The requirement for activity of the enzyme ADP-ribosyl transferase (ADPRT) and changes in single-strand DNA breaks were assessed during the initial stimulation of quiescent murine splenic lymphocytes with mitogen alone, the stimulation of activated blasts with IL-2-containing medium and, for comparison, the serum stim...

journal_title：Immunology

authors： Johnstone AP,Darling D

更新日期：1985-08-01 00:00:00

abstract：:Stimulation of human polymorphonuclear granulocytes with the calcium-ionophore A23187 and opsonized zymosan leads to the release of leukotrienes. The cell-free supernatants of the stimulated cells revealed gamma-glutamyl-transpeptidase and dipeptidase activity which induced the metabolism of exogeneously added LTC4 an...

journal_title：Immunology

authors： Raulf M,Stüning M,König W

更新日期：1985-05-01 00:00:00

abstract：:Suramin, a polyanionic and polycyclic compound, was initially used for the treatment of trypanosomiasis and onchocerciasis. In the last decade, it has been used in therapy of cancer and acquired immune deficiency syndrome (AIDS). The influence of suramin on the expression of various markers by human mononuclear phagoc...

journal_title：Immunology

authors： Schiller C,Spittler A,Willheim M,Szépfalusi Z,Agis H,Köller M,Peterlik M,Boltz-Nitulescu G

更新日期：1994-04-01 00:00:00

abstract：:NKG2D is one of the best characterized activating receptors and is expressed on natural killer cells and on various T-cell subsets. This receptor recognizes several different ligands that are induced by cellular stresses. In this review, we described the mechanisms controlling the expression of NKG2D ligands, with the...

journal_title：Immunology

authors： Stern-Ginossar N,Mandelboim O

更新日期：2009-09-01 00:00:00

abstract：:Five of twenty-three patients with paraproteinaemia (two IgM, three IgG) have been shown to exhibit marked classical pathway complement activation. The mechanisms of hypocomplementaemia proposed for the five patients are cryoglobulinaemia in one and in vivo immunoglobulin aggregation in the other four. Three further p...

journal_title：Immunology

authors： Naish PF,Collins C,Barratt J

更新日期：1977-10-01 00:00:00

abstract：:Although it is clear that the CD45 tyrosine phosphatase is required for efficient T-cell activation and T-cell development, the factors that regulate CD45 function remain uncertain. Previous data have indicated that there is an association of CD45 with CD4 and the T-cell receptor (TCR) complex controlled by the variab...

journal_title：Immunology

authors： Leitenberg D,Falahati R,Lu DD,Takeda A

更新日期：2007-08-01 00:00:00

abstract：:Eight human IgA1 myeloma proteins were analysed by SDS-PAGE. These experiments showed that purified IgA1 proteins comprise both fully S-S bonded and partly S-S bonded molecules. Pepsin digestion of the IgA1 proteins yielded three four-chain and two two-chain fragments. The four-chain fragments are likely to be derived...

journal_title：Immunology

authors： Biewenga J,Faber A,Pronk JC,Haaijman JJ

更新日期：1986-09-01 00:00:00

abstract：:Tuberculin-active peptide-reactive T-cell lines were established from the popliteal lymph node of BALB/cA mice immunized with heat-killed Mycobacterium tuberculosis to investigate the cellular mechanisms in the protective immunity of tuberculosis. These T-cell lines, consisting mainly of L3T4 surface antigen-positive ...

journal_title：Immunology

authors： Yamamoto S,Iwai H,Ueda K

更新日期：1989-10-01 00:00:00

abstract：:We identified CD8(+)  CD122(+) regulatory T cells (CD8(+)  CD122(+) Treg cells) and reported their importance in maintaining immune homeostasis. The absence of CD8(+)  CD122(+) Treg cells has been shown to lead to severe systemic autoimmunity in several mouse models, including inflammatory bowel diseases and experimen...

journal_title：Immunology

authors： Okuno Y,Murakoshi A,Negita M,Akane K,Kojima S,Suzuki H

更新日期：2013-07-01 00:00:00

abstract：:Thymocytes expressing self-reactive T-cell receptors (TCR) are eliminated in the thymus through a TCR-mediated signal. This cell death signal (negative selection) generates nuclear morphological change and DNA fragmentation in thymocytes. However, the pathway leading to DNA fragmentation of thymocytes following TCR en...

journal_title：Immunology

authors： Nagata T,Kishi H,Liu QL,Matsuda T,Imanaka T,Tsukada K,Kang D,Muraguchi A

更新日期：2002-04-01 00:00:00

abstract：:Lymphocyte migration into inflammatory sites involves a change from a spherical, non-motile phenotype to an irregular, constantly shape-changing, motile phenotype. We have previously shown that lymphocytes are maintained in the non-motile state by the constitutive activity of protein kinase C (PKC). In this paper we h...

journal_title：Immunology

authors： Thorp KM,Verschueren H,De Baetselier P,Southern C,Matthews N

更新日期：1996-03-01 00:00:00

abstract：:In order to elucidate possible roles of thymic nurse cells (TNC) we isolated them as lympho-epithelial cell complexes from spontaneous thymomas of BUF/Mna rats and characterized them using immuno- and enzyme-histochemical techniques. A remarkable increase in the number of TNC was seen at 8 months of age, immediately b...

journal_title：Immunology

authors： Ezaki T,Matsuno K,Kotani M

更新日期：1991-06-01 00:00:00

abstract：:The molecular characteristics of a serum IL-2 inhibitor were determined by fractionating active sera from normal and malaria-infected mice, and assaying inhibitory activity in blocking production and expression of IL-2 activity. Using isoelectric focusing and ion exchange chromatography, the activity resolved in a sin...

journal_title：Immunology

authors： Male D,Lelchuk R,Curry S,Pryce G,Playfair JH

更新日期：1985-09-01 00:00:00

abstract：:Membrane attack complexes of complement occur around thyroid follicles in Graves' disease and Hashimoto's thyroiditis. The lytic potential of such complexes is controlled by membrane-bound and fluid phase regulators and we have investigated the role of these in autoimmune thyroid disease. By immunohistochemical staini...

journal_title：Immunology

authors： Tandon N,Yan SL,Morgan BP,Weetman AP

更新日期：1994-04-01 00:00:00

abstract：:Corneal allografts contain few or no Ia+ Langerhans' cells and consistently fail to elicit allospecific delayed-type hypersensitivity (DTH). The present study examined the hypothesis that the inability of corneal allografts to induce allospecific DTH was the result of active suppression. However, the results indicated...

journal_title：Immunology

authors： Niederkorn JY,Mayhew E

更新日期：1993-12-01 00:00:00

abstract：:Radiation chimaeras, prepared from NIH (rapid-responder) mice or from the F1 progeny of a cross between H-2 compatible B10.G (slow-responder) and NIH mice, were tested for their ability to respond to infection with the intestinal nematode parasite Trichinella spiralis. Mice reconstituted with bone marrow (BM) from NIH...

journal_title：Immunology

authors： Wakelin D,Donachie AM

更新日期：1981-08-01 00:00:00

abstract：:Blood dendritic cells carry the terminal complement complex (TCC) on their surface, as detected by three monoclonal antibodies (mAb). Two of these mAb were generated by immunizing mice with the terminal complement complex, whereas the third was generated by immunizing mice with blood dendritic cells. All three mAb are...

journal_title：Immunology

authors： Würzner R,Xu H,Franzke A,Schulze M,Peters JH,Götze O

更新日期：1991-09-01 00:00:00