CD44 isoforms containing exons V6 and V7 are differentially expressed on mitogenically stimulated normal and Epstein-Barr virus-transformed human B cells.

abstract：:The aim of this study was to examine the role of T cells on the alteration of terminal sugars of goblet cell mucins in the small intestinal mucosa of parasitized rats and to clarify the biological significance of the altered mucins in the mucosal defence against intestinal helminths. For this purpose, Nippostrongylus ...

journal_title：Immunology

authors： Ishikawa N,Horii Y,Oinuma T,Suganuma T,Nawa Y

更新日期：1994-03-01 00:00:00

abstract：:Immune synapse formation is critical for T lymphocyte activation, and mitochondria have a role in this process, by localizing close to the immune synapse, regulating intracellular calcium concentration, and providing locally required ATP. The interaction between antigen presenting cells (APCs) and T lymphocytes is a t...

journal_title：Immunology

authors： Bonifaz L,Cervantes-Silva M,Ontiveros-Dotor E,López-Villegas E,Sánchez-García F

更新日期：2014-09-23 00:00:00

abstract：:A plasmid that contained the cytomegalovirus (CMV)-promoter-driven lacZ reporter gene (pCMV-lacZ) remained in the epaxial muscle of five of eight goldfish as covalently closed circles, the most functional form of plasmid, for at least 70 days at 22 degrees. It was not present in the gills or elsewhere by polymerase ch...

journal_title：Immunology

authors： Kanellos T,Sylvester ID,Ambali AG,Howard CR,Russell PH

更新日期：1999-02-01 00:00:00

abstract：:Cytokines and their receptors represent key targets for therapeutic intervention. Ligands are being used to supplement cell numbers that become depleted as a result of disease (organ failure, infection) or subsequent disease treatments (i.e. chemotherapy). Conversely, the inhibition of target cell binding by cytokines...

journal_title：Immunology

authors： Sivakumar PV,Foster DC,Clegg CH

更新日期：2004-06-01 00:00:00

abstract：:Rat mast cells with the properties of mucosal mast cells (MMC) proliferate in cultures of haemopoietic tissue in the presence of conditioned medium (CM) from antigen- or mitogen-activated T lymphocytes. The present study shows that recombinant rat interleukin-3 (rIL-3) both stimulated the development of MMC from bone ...

journal_title：Immunology

authors： Haig DM,McMenamin C,Redmond J,Brown D,Young IG,Cohen SD,Hapel AJ

更新日期：1988-10-01 00:00:00

abstract：:Intraepithelial lymphocytes (IEL) in normal human small intestine exhibit cytotoxicity. This study was undertaken to characterize the effector cells and their mode of action. Freshly isolated jejunal IEL and lamina propria lymphocytes (LPL), as well as IEL and LPL depleted of CD4+, CD8+ and T-cell receptor (TCR)-gamma...

journal_title：Immunology

authors： Melgar S,Bas A,Hammarström S,Hammarström ML

更新日期：2002-08-01 00:00:00

abstract：:The non-obese diabetic (NOD) mouse is a model for the study of insulin-dependent diabetes mellitus (IDDM). Recently transgenic NOD mice have been derived (NOD-E) that express the major histocompatibility complex (MHC) class II I-E molecule. NOD-E do not become diabetic and show negligible pancreatic insulitis. The pos...

journal_title：Immunology

authors： Parish NM,Acha-Orbea H,Simpson E,Qin SX,Lund T,Cooke A

更新日期：1993-04-01 00:00:00

abstract：:Iron-withholding by the chelating agent desferrioxamine abrogates the proliferative response of human peripheral blood mononuclear cells (PBMC) to phytohaemagglutinin (PHA). The present study investigated whether desferrioxamine operates late in the activation process or, as recently suggested, at an early stage, by i...

journal_title：Immunology

authors： Polson RJ,Jenkins R,Lombard M,Williams AC,Roberts S,Nouri-Aria K,Williams R,Bomford A

更新日期：1990-10-01 00:00:00

abstract：:In two consecutive studies, eighteen and forty-one normal subjects were given a standard tuberculin skin test of 1 tuberculin unit (0.02 mug of PPD). Two days later another skin test was given. Readings of the skin reactions showed that subjects exhibiting strongly positive skin reactions in their primary skin tests s...

journal_title：Immunology

authors： Thestrup-Pedersen K

更新日期：1975-02-01 00:00:00

abstract：:Interleukin 27 (IL-27) has been identified as a potent cytokine in the differentiation of type 1 regulatory T (Tr1) cells through interactions with several key elements, including transcription factors such as aryl hydrocarbon receptor and IL-21. Autocrine production of IL-21 is known to be important for maintaining I...

journal_title：Immunology

authors： Nadya NA,Tezuka H,Ohteki T,Matsuda S,Azuma M,Nagai S

更新日期：2017-11-01 00:00:00

abstract：:Repetitive stimulation of naïve T cells by immature splenic dendritic cells (DC) can result in the differentiation of T-cell lines with regulatory properties. In the present study we identified a population of DC in the mucosae that exhibit the plasmacytoid phenotype, secrete interferon-alpha (IFN-alpha) following sti...

journal_title：Immunology

authors： Bilsborough J,George TC,Norment A,Viney JL

更新日期：2003-04-01 00:00:00

abstract：:Guinea-pig erythrocytes that had been exposed to influenza A virus or Vibrio cholerae neuraminidase activated the classical complement pathway in autologous serum. Because all viral particles were eluted from the treated cells, activation was not dependent on anti-viral antibodies or on the particles themselves. After...

journal_title：Immunology

authors： Lambre CR,Thibon M,Le Maho S,Di Bella G

更新日期：1983-06-01 00:00:00

abstract：:The CD3-T-cell receptor complex is the clonotypic surface structure by which T lymphocytes recognize foreign antigens and are subsequently activated. Because of the low immunogenicity of the CD3 molecules, anti-CD3 monoclonal antibodies (mAb) are difficult to prepare and have not been available in several species. Fol...

journal_title：Immunology

authors： Yang H,Oura CA,Kirkham PA,Parkhouse RM

更新日期：1996-08-01 00:00:00

abstract：:T cells from mice injected with picryl sulphonic acid (PSA) inhibit the expression of contact sensitivity to picryl chloride. Adult thymectomy (aTx) prevents the production of cells which inhibit the effector stage but cells from aTx mice are, however, still able to suppress the induction of contact sensitivity. These...

journal_title：Immunology

authors： Thomas WR,Watkins MC,Asherson GL

更新日期：1981-01-01 00:00:00

abstract：:We previously identified a cis-acting element within the 3' untranslated region of CD40 ligand messenger RNA (mRNA) that is composed of three complex binding sites and acts to increase mRNA stability in both in vitro and in vivo systems. We now demonstrate the functional consequences of the three binding sites with re...

journal_title：Immunology

authors： Laughlin J,Oghlidos S,Porter JF,Matus-Nicodemos R,Sinquett FL,Marcelli V,Covey LR

更新日期：2008-07-01 00:00:00

abstract：:Cells expressing indoleamine 2,3-dioxygenase (IDO), an enzyme which catabolizes tryptophan, prevent T-cell proliferation in vitro, suppress maternal antifetal immunity during pregnancy and inhibit T-cell-mediated responses to tumour-associated antigens. To examine the mechanistic basis of these phenomena we activated ...

journal_title：Immunology

authors： Lee GK,Park HJ,Macleod M,Chandler P,Munn DH,Mellor AL

更新日期：2002-12-01 00:00:00

abstract：:The influence of pooled human IgG preparations for intravenous use (i.v.Ig) on in vitro-induced cytokine production was studied at the single-cell level using cytokine-specific monoclonal antibodies (mAb) and indirect immunofluorescent technique. Cultured mononuclear cells from peripheral blood from healthy adult dono...

journal_title：Immunology

authors： Andersson UG,Björk L,Skansén-Saphir U,Andersson JP

更新日期：1993-06-01 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease with high incidence and mortality in South East Asia and northern Australia. To date there is no protective vaccine and antibiotic treatment is prolonged and not always effective. Most people living in endemic areas have been expose...

journal_title：Immunology

authors： Nithichanon A,Gourlay LJ,Bancroft GJ,Ato M,Takahashi Y,Lertmemongkolchai G

更新日期：2017-05-01 00:00:00

abstract：:The numbers of murine hepatocytes and Kupffer cells with receptors for human polymeric (pIgA) or monomeric IgA (mIgA) were determined by rosette formation with immunobeads coated with human pIgA or mIgA. About 63% of hepatocytes were found to express receptors for pIgA. Receptors for mIgA were also found in a signific...

journal_title：Immunology

authors： Sancho J,Gonzalez E,Egido J

更新日期：1986-01-01 00:00:00

abstract：:Peroxisome proliferator activated receptor-gamma (PPARgamma) has been reported to exert anti-inflammatory properties in endotoxic shock and sepsis. One phenomenon that alters the inflammatory response to endotoxin [lipopolysaccharide (LPS)] is endotoxin tolerance, which is caused by previous exposure to endotoxin. Her...

journal_title：Immunology

authors： Zingarelli B,Fan H,Ashton S,Piraino G,Mangeshkar P,Cook JA

更新日期：2008-05-01 00:00:00

abstract：:Chlamydiae are a major cause of infertility and preventable blindness and there is currently no effective vaccine in humans or rodents against these organisms. We have previously shown that a peptide of 12 amino acids (termed TINKP) from a conserved region of the major outer membrane protein (MOMP) of Chlamydia tracho...

journal_title：Immunology

authors： Knight SC,Iqball S,Woods C,Stagg A,Ward ME,Tuffrey M

更新日期：1995-05-01 00:00:00

abstract：:It has previously been shown in mice that activated peritoneal macrophages, when first removed from the peritoneal cavity, suppress mitogen-stimulated lymphocyte transformation in vitro as measured by [3H]-thymidine incorporation. In this study, it is demonstrated that activated macrophages that have been incubated al...

journal_title：Immunology

authors： Wing EJ,Remington JS

更新日期：1980-06-01 00:00:00

abstract：:When Trypanosoma cruzi is co-cultured with activated human lymphocytes the latter manifest a marked level of suppression in their capacity to express high-affinity interleukin-2 receptors (IL-2R). In this study we asked whether this effect could result from reduced expression of the p75 component of the IL-2R, a condi...

journal_title：Immunology

authors： Kierszenbaum F,Sztein MB

更新日期：1992-03-01 00:00:00

abstract：:Primary contact sensitivity (CS) to Ox and non-specific unresponsiveness to other unrelated delayed-type hypersensitivity (DTH) containing CS were induced simultaneously by i.v. administration of oxazolone(Ox)-conjugated spleen cells. The subpopulation of spleen cells which serves as carriers for the induction of prim...

journal_title：Immunology

authors： Nakano Y,Nakano K

更新日期：1985-02-01 00:00:00

abstract：:Despite the current availability of Salmonella vaccines, typhoid fever remains a significant public health problem in developing countries. A greater understanding of T-cell activation and the development of immunological memory during Salmonella infection should lead to the development of more effective prophylactic ...

journal_title：Immunology

authors： Ravindran R,McSorley SJ

更新日期：2005-04-01 00:00:00

abstract：:The investigation of the role of the macrophage in cutaneous leishmaniasis has been prompted by observations of the clinical behaviour of the infection. In contrast to the self-healing oriental sore, chronic leishmaniasis is characterized by persistent lesions and leishmania recidiva by lesions that flare up locally l...

journal_title：Immunology

authors： Farah FS,Samra SA,Nuwayri-Salti N

更新日期：1975-10-01 00:00:00

abstract：:Bone-marrow-derived macrophages are divided into two phenotypically and functionally distinct subsets, M1 and M2 macrophages. Recently, it was shown that adoptive transfer of M2-polarized peritoneal macrophages reduced the severity of experimental colitis in mice. However, it is still unclear whether peritoneal macrop...

journal_title：Immunology

authors： Oishi S,Takano R,Tamura S,Tani S,Iwaizumi M,Hamaya Y,Takagaki K,Nagata T,Seto S,Horii T,Osawa S,Furuta T,Miyajima H,Sugimoto K

更新日期：2016-11-01 00:00:00

abstract：:The class distribution of 4193 monoclonal gammopathies (MG), detected over approximately 10 years in western France (WF), was compared to that established by a compilation of twenty-seven series from the literature. Several points emerged from this study: the incidence of the light chain MG (4.8%) was slightly lower t...

journal_title：Immunology

authors： Hurez D,Youinou P,Gombert J,Preud'Homme JL

更新日期：1985-11-01 00:00:00

abstract：:Membrane sialoglycoprotein (GP) of mouse erythrocytes were incorporated into artificial membranes of liposomes which also contained DNP-aminocaproylphosphatidylethanolamine hapten. The liposomes were tested for their potential to modulate the anti-hapten antibody response in mice as a plausible model of haptenated iso...

journal_title：Immunology

authors： Hitsumoto Y,Hineno T,Utsumi S

更新日期：1984-12-01 00:00:00

abstract：:This study reports the expression and functional characterization of the rat analogue of the human complement regulatory molecule CD59. We here describe the expression in chinese hamster ovary (CHO) cells of rat CD59 and a modified rat CD59 in which an N-glycosylation site at Asn-16 has been deleted by point mutation....

journal_title：Immunology

authors： Rushmere NK,Tomlinson S,Morgan BP

更新日期：1997-04-01 00:00:00