Clinical significance of the ratio between FOXP3 positive regulatory T cell and interleukin-17 secreting cell in renal allograft biopsies with acute T-cell-mediated rejection.

abstract：:Recent studies involving T cells that express gamma delta T-cell receptor (gamma delta TcR) have raised the possibility that Qa-1/Tla region class I major histocompatibility complex (MHC)-like molecules are antigen-presenting molecules for gamma delta TcR. In this report, cytotoxic T lymphocyte (CTL) clones specific f...

journal_title：Immunology

authors： Germana S,Shinohara N

更新日期：1991-12-01 00:00:00

abstract：:The effect of corticosteroid administration on the redistribution of sirculating lymphocytes was studied in the guinea-pig, since this species closely resembles man in its relative resistance to the lymphopenic effect of corticosteroids. A single intravenous injection of hydrocortisone (either 10 mg or 100 mg/kg) cau...

journal_title：Immunology

authors： Fauci AS

更新日期：1975-04-01 00:00:00

abstract：:The relationship between the IgA antibody response in serum (total and polymeric IgA) and intestinal secretions was examined in volunteers subjected to oral and parenteral typhoid vaccination. After oral vaccination (three doses of 10(11) live Ty21a vaccine given at 48-hr intervals), serum pIgA antibody to typhoid lip...

journal_title：Immunology

authors： Bartholomeusz RC,Forrest BD,Labrooy JT,Ey PL,Pyle D,Shearman DJ,Rowley D

更新日期：1990-02-01 00:00:00

abstract：:Compared with non-transgenic controls, mice bearing an Fv4 murine retroviral env transgene resist infection and do not become immunosuppressed when inoculated with Friend virus (FV). When immunized with FV antigens in the absence of infectious virus, they make antibodies and cytotoxic lymphocytes (CTL) to FV comparabl...

journal_title：Immunology

authors： Nihrane A,Silver J

更新日期：1997-02-01 00:00:00

abstract：:FTY720, a novel immunosuppressant, sequesters circulating mature lymphocytes, especially T cells, within lymph nodes and Peyer's patches by accelerating lymphocyte homing, and thereby causes lymphocyte depletion in the blood. The FTY720-induced acceleration of lymphocyte homing appears to be mediated by lymphocyte hom...

journal_title：Immunology

authors： Yanagawa Y,Masubuchi Y,Chiba K

更新日期：1998-12-01 00:00:00

abstract：:Sodium penicillin was conjugated to sheep erythrocytes and optimal quantities, added to a 5% SRBC suspension, were determined for haemagglutination (12-5 mg/ml) and for haemolysis (50 mg/ml) using carp antibodies and carp complement. The epitope density on the BSA molecule was gradually increased, when increasing amou...

journal_title：Immunology

authors： Avtalion RR,Milgrom L

更新日期：1976-10-01 00:00:00

abstract：:When normal human spleen cells are pulsed with concanavalin A (Con A), a portion become suppressor cells which in co-culture can inhibit immunoglobulin synthesis by other normal spleen cells stimulated by pokeweed mitogen (PWM). One mechanism whereby these Con-A activated spleen cells suppress Ig synthesis appears to ...

journal_title：Immunology

authors： Krakauer RS,Cathcart MK,Ilfeld DN

更新日期：1980-05-01 00:00:00

abstract：:In chronic inflammatory conditions, mononuclear cells infiltrate the involved connective tissue and may persist, perhaps because of binding to adhesion molecules on connective tissue cells, as well as extracellular matrix. Here we investigated whether vascular cell adhesion molecule-1 (VCAM-1) may be induced on human ...

journal_title：Immunology

authors： Gao JX,Issekutz AC

更新日期：1996-11-01 00:00:00

abstract：:The immunosuppression exhibited by a water-soluble condensate of tobacco smoke (WSC) has been studied in vivo and in vitro. When multiple sublethal doses of WSC were injected into C57Bl/6 mice, their ability to respond to immunization with sheep erythrocytes by the formation of plaque-forming cells was severely inhibi...

journal_title：Immunology

authors： Jacob CV,Stelzer GT,Wallace JH

更新日期：1980-08-01 00:00:00

abstract：:Toll-like receptors (TLRs) are important pattern recognition molecules that activate the nuclear factor (NF)-kappaB pathway leading to the production of antimicrobial immune mediators. As keratinocytes represent the first barrier against exogenous pathogens in human skin, we investigated their complete functional TLR1...

journal_title：Immunology

authors： Köllisch G,Kalali BN,Voelcker V,Wallich R,Behrendt H,Ring J,Bauer S,Jakob T,Mempel M,Ollert M

更新日期：2005-04-01 00:00:00

abstract：:Suramin, a polyanionic and polycyclic compound, was initially used for the treatment of trypanosomiasis and onchocerciasis. In the last decade, it has been used in therapy of cancer and acquired immune deficiency syndrome (AIDS). The influence of suramin on the expression of various markers by human mononuclear phagoc...

journal_title：Immunology

authors： Schiller C,Spittler A,Willheim M,Szépfalusi Z,Agis H,Köller M,Peterlik M,Boltz-Nitulescu G

更新日期：1994-04-01 00:00:00

abstract：:Alveolar macrophages (AM) present antigen poorly to CD4+ T cells and respond weakly to interferon-gamma (IFN-gamma) for up-regulation of major histocompatibility complex (MHC) class II and costimulatory molecule expression. In atopic asthma, however, AM exhibit enhanced antigen-presenting cell (APC) activity. Since gr...

journal_title：Immunology

authors： Caulfield JJ,Fernandez MH,Sousa AR,Lane SJ,Lee TH,Hawrylowicz CM

更新日期：1999-09-01 00:00:00

abstract：:Factors that influence the generation and maintenance of memory CD8+ T cells are not fully understood. The homeostasis of memory T cells is highly dynamic and tightly regulated by various stimuli, including cytokines and antigen-major histocompatibility complex ligands. We characterized the hepatitis C virus (HCV)-spe...

journal_title：Immunology

authors： Elrefaei M,El-Sheikh N,Kamal K,Cao H

更新日期：2003-12-01 00:00:00

abstract：:In this report the antigen and restriction specificity of human T-cell clones induced with Dermatophagoides farinae (D. farinae) and isolated from an atopic individual with perennial rhinitis has been investigated. Of the six clones analysed, four were species specific and two showed cross-reactivity for the closely r...

journal_title：Immunology

authors： O'Hehir RE,Eckels DD,Frew AJ,Kay AB,Lamb JR

更新日期：1988-08-01 00:00:00

abstract：:The relationship between allograft rejection and the response in the one-way mixed leucocyte reaction (MLR) of the WBC of allograft recipients was investigated. The responses of the WBC were assessed prior to skin allografting and subsequent to rejection of the allograft. The optimal MLR response of the WBC from the a...

journal_title：Immunology

authors： Milthorp P,Belanger R,Richter M

更新日期：1979-01-01 00:00:00

abstract：:Studies with gene-deficient and gnotobiotic mice have identified many host and microbial factors that contribute to induced colitis, but information on whether specific factors determine susceptibility under more physiological conditions is lacking. Using wild-type strains that differ in their IgA response but harbor ...

journal_title：Immunology

authors： Gupta S,Basu S,Bal V,Rath S,George A

更新日期：2019-09-01 00:00:00

abstract：:During the immune response to H-2 and Mls alloantigens, murine lymphocytes showed altered sensitivity to polyclonal mitogens. The reactivity to the T-cell mitogen PHA followed a similar pattern in both H-2 and Mls-immunized mice while the reactivity to the B-cell mitogen LPS was contrasting in the two groups. In the f...

journal_title：Immunology

authors： Matossian-Rogers A

更新日期：1979-08-01 00:00:00

abstract：:Class switching and plasma cell differentiation occur at a high level within all mucosa-associated lymphoid tissues. The different classes of membrane immunoglobulin heavy chains are associated with the Igα/Igβ heterodimer within the B-cell receptor (BCR). Whether BCR isotypes convey specific signals adapted to the co...

journal_title：Immunology

authors： Amin R,Carrion C,Decourt C,Pinaud E,Cogné M

更新日期：2012-05-01 00:00:00

abstract：:The fluorescence-activated cell sorter and a rosette-depletion technique were used to separate rat spleen lymphocytes and BCG-activated lymphocytes into subpopulations with and without the antigens defined by W3/13, W3/23 and OX8 monoclonal antibodies. The resultant populations were then tested for natural killer (NK)...

journal_title：Immunology

authors： Cantrell DA,Robins RA,Brooks CG,Baldwin RW

更新日期：1982-01-01 00:00:00

abstract：:Mice simultaneously injected intravenously and subcutaneously with herpes simplex virus fail to adoptively transfer delayed hypersensitivity (DH) to syngeneic recipients. The transferred lymph node cells also failed to rapidly eliminate infectious herpes from the pinna, despite the presence of cytotoxic T cells in the...

journal_title：Immunology

authors： Nash AA,Ashford NP

更新日期：1982-04-01 00:00:00

abstract：:Primary contact sensitivity (CS) to Ox and non-specific unresponsiveness to other unrelated delayed-type hypersensitivity (DTH) containing CS were induced simultaneously by i.v. administration of oxazolone(Ox)-conjugated spleen cells. The subpopulation of spleen cells which serves as carriers for the induction of prim...

journal_title：Immunology

authors： Nakano Y,Nakano K

更新日期：1985-02-01 00:00:00

abstract：:A monolayer depletion/adoptive immunization protocol that biased the immune response towards recognition of placental macrophage (pMO) antigens was established. BALB/c spleen cells immune to human pMO were adsorbed onto monolayers of the B-cell line QIMR-WIL. Monolayer-depleted or unfractionated cells were transferred...

journal_title：Immunology

authors： Nash AD,Uren S,Hawes CS,Boyle W

更新日期：1989-11-01 00:00:00

abstract：:The liver is where lymphocytes undergo activation-induced cell death (AICD) at the resolution phase of an immune response, which is crucial for homeostasis of the immune system and prevention of autoimmunity. Exploring the machinery of AICD in the liver, we found that a primary culture supernatant of murine hepatocyte...

journal_title：Immunology

authors： Ikeda M,Yoshikawa H,Liu J,Nakajima Y,Akahane Y,Tasaka K

更新日期：2003-01-01 00:00:00

abstract：:Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. Its pathogenesis is not completely understood, though the prevailing model is that the intestinal flora drives a strong intestinal T helper 1 (Th1)/Th17 type immune response and inflammation in the genetically susceptible host. This ...

journal_title：Immunology

authors： Ricciardelli I,Lindley KJ,Londei M,Quaratino S

更新日期：2008-10-01 00:00:00

abstract：:Previous studies have shown that depletion of Langerhans' cells (LC) from murine epidermis by the superantigen, staphylococcal enterotoxin A (SEA) involves interleukin-1alpha (IL-1alpha) and is inhibitable by agents that block G-protein-associated kinases. The purpose of this study was to determine whether specific ki...

journal_title：Immunology

authors： Shankar G,Johnson J,Kuschel L,Richins M,Burnham K

更新日期：1999-02-01 00:00:00

abstract：:The role of T-cell receptor (TCR) gammadelta T cells in the induction of protective TCR alphabeta T cells against infection by the intracellular bacteria Listeria monocytogenes was analysed. We found that depletion of gammadelta T cells by anti-TCR delta monoclonal antibody treatment before intravenous immunization of...

journal_title：Immunology

authors： Nomura A,Matsuzaki G,Takada H,Hiromatsu K,Nabeshima S,Nakamura T,Kishihara K,Nomoto K

更新日期：1998-10-01 00:00:00

abstract：:Cocultures of dispersed human fetal liver cells with murine Swiss 3T3 fibroblasts resulted in the development of human mast cells after 1 to 4 weeks of culture. Mast cells were detected by immunohistochemistry using a murine monoclonal anti-tryptase antibody, before metachromasia appeared with toluidine blue. When sub...

journal_title：Immunology

authors： Irani AA,Craig SS,Nilsson G,Ishizaka T,Schwartz LB

更新日期：1992-09-01 00:00:00

abstract：:Cholera toxin (CT) or its subunits were given orally to mice and division of intestinal intraepithelial lymphocytes (IEL) in vivo measured by double immunofluorescence using 5-bromo-2'-deoxyuridine (BRdU) and membrane alpha beta T-cell receptors (TCR) or gamma delta TCR staining in frozen sections. Cholera toxin (10 m...

journal_title：Immunology

authors： Penney I,Kilshaw PJ,MacDonald TT

更新日期：1996-09-01 00:00:00

abstract：:Natural killer (NK) cells, which can exert early and powerful anti-tumour and anti-viral responses, are important components of the innate immune system. DNAX accessory molecule-1 (DNAM-1) is an activating receptor molecule expressed on the surface of NK cells. Recent findings suggest that DNAM-1 is a critical regulat...

journal_title：Immunology

authors： Xiong P,Sang HW,Zhu M

更新日期：2015-11-01 00:00:00

abstract：:Montelukast is a leukotriene receptor antagonist that is known to prevent allergic rhinitis and asthma. Blocking the Cysteinyl leukotrienes receptor (CysLTR1), one of the primary receptors of leukotrienes, has been demonstrated to be efficacious in ameliorating experimental autoimmune encephalomyelitis (EAE), an anima...

journal_title：Immunology

authors： Han B,Zhang YY,Ye ZQ,Xiao Y,Rasouli J,Wu WC,Ye SM,Guo XY,Zhu L,Rostami A,Wang LB,Zhang Y,Li X

更新日期：2021-01-22 00:00:00