Abstract：
:The natural response of immunocompetent adult animals to antigen inhalation is the development of T-lymphocyte mediated tolerance, particularly in the IgE-antibody class (Holt & Sedgwick, 1987). It has been suggested that this process functions as a protective mechanism to limit sensitization to aeroallergens. In the present report, it is shown that the inhalation tolerance process does not function during the early postnatal period, and the lack of this protective mechanism may contribute to the increased risk of allergic sensitization during infancy. These experiments also demonstrate that adoptive transfer of adult splenocytes to newborns confers adult capacity for tolerance development, which suggests that delayed maturation of certain T-cell subset(s) may underly this transfer defect.
journal_name
Immunologyjournal_title
Immunologyauthors
Holt PG,Vines J,Britten Dsubject
Has Abstractpub_date
1988-04-01 00:00:00pages
591-3issue
4eissn
0019-2805issn
1365-2567journal_volume
63pub_type
杂志文章相关文献
IMMUNOLOGY文献大全abstract：:Among peripheral T cells, the expression of CD4 and CD8 is almost mutually exclusive. However, here we show, using flow cytometric analysis, that ex vivo approximately 6% of rat T cells stained for both CD4 and CD8. These double positive cells were also detected by confocal microscopy. Only around 50% of double positi...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.2000.00071.x
更新日期：2000-10-01 00:00:00
abstract：:The biochemical analysis of murine Fc gamma RI has been difficult because this receptor is co-expressed with other Fc receptors on the cell surface of myeloid cells and all precipitate together with immune complexes. To overcome this problem and to study cells which expressed Fc gamma RI and only this Fc receptor, sta...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:Leukotriene B4 (LTB4 ) is a lipid mediator that is rapidly generated in inflammatory sites, and its functional receptor, BLT1, is mostly expressed on immune cells. Contact dermatitis is a common inflammatory skin disease characterized by skin oedema and abundant inflammatory infiltrates, primarily including neutrophil...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12478
更新日期：2015-09-01 00:00:00
abstract：:with AgB-primed B or T cells and injected into syngeneic X-irradiated recipients. Anti-THF and anti-Eid purified by an AgB-specific T suppressor factor (TSF) affi-gel adsorbent retain their ability to specifically initiate [3H]-thymidine incorporation of AgB-primed T cells. The data indicate that both anti-THF and ant...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1982-02-01 00:00:00
abstract：:Thoracic duct lymphocytes (TDL) from (AS2 x AS)F1 rats previously injected with human serum albumin (HSA) were transferred to 900 r irradiated syngeneic recipients which were challenged with various doses of soluble HSA (s-HSA). TDL from partially tolerant rats, which were deficient in high avidity B cells, produced a...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1977-10-01 00:00:00
abstract：:In recent years, nitric oxide (NO), a gas previously considered to be a potentially toxic chemical, has been established as a diffusible universal messenger that mediates cell-cell communication throughout the body. Constitutive and inducible NO production regulate numerous essential functions of the gastrointestinal ...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2004.01984.x
更新日期：2004-12-01 00:00:00
abstract：:Staphylococcus aureus is a major pathogen that can cause a broad spectrum of serious infections including skin infections, pneumonia and sepsis. Peritoneal mast cells have been implicated in the host response towards various bacterial insults and to provide mechanistic insight into the role of mast cells in intraperit...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12297
更新日期：2014-10-01 00:00:00
abstract：:Norovirus (NoV) -derived virus-like particles (VLPs) resemble empty shells of the virus and NoV P-particles contain only protruding domains of the NoV capsid. Both NoV-derived subviral particles show similar functionality and antigenicity in vitro and are considered to be potential vaccine candidates against NoV gastr...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2011.03516.x
更新日期：2012-01-01 00:00:00
abstract：:Expression of CD45RO on intraepithelial lymphocytes (IEL) bearing the T-cell receptor (TcR) alpha/beta or gamma/delta was studied in situ by three-colour immunofluorescence on jejunal tissue sections from 21 patients with coeliac disease and eight controls. CD45RA-TcR alpha/beta+ IEL expressed CD45RO significantly mor...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：:To assess the role of CD5 and CD28 in the pathogenesis of the decreased cellular immune function in patients with rheumatoid arthritis (RA) we analysed the expression and function of these T-cell surface molecules. The expression of CD5 as well as of CD28 in synovial and peripheral blood T cells was similar to that of...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：:Summary Diverse immunotherapy approaches have achieved success in controlling individual aspects of immune responses in animal models. Transfer of such immunotherapies to clinical trials has obtained some success in patients, with clinical responses observed or effective antigen specific immune responses achieved, but...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2567.2004.02001.x
更新日期：2005-01-01 00:00:00
abstract：:Protein kinase C (PKC) form a key family of enzymes involved in signalling pathways that specifically phosphorylates substrates at serine/threonine residues. Phosphorylation by PKC is important in regulating a variety of cellular events such as cell proliferation and the regulation of gene expression. In the immune sy...
journal_title：Immunology
pub_type： 杂志文章,评审
doi：10.1111/imm.12510
更新日期：2015-12-01 00:00:00
abstract：:When spleen cells of C57BL/6 mice or mast cell-deficient W/Wv mice were cultured, their histidine decarboxylase (HDC) activity increased with increases in the histamine concentration in the cells and the medium. Addition of concanavalin A (Con A) or Escherichia coli lipopolysaccharide (LPS) enhanced the increase. The ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：:Splenic immune responses having varying dependence on accessory cell co-operation have been studied after infection of mice with Friend virus. Infection has no effect on cell proliferation or antibody production in cultures stimulated with E. coli lipopolysaccharide. The response in vivo to type III pneumococcal polys...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1978-04-01 00:00:00
abstract：:Spleen lymphocytes from C4-deficient (C4D) and Albany strains of guinea-pigs, 1-7 days, 3-6 and 12-16 months old, genetically related to inbred strains 13 and 2 respectively, were analysed in terms of their expression of cell surface markers, allogenic and T- and B-cell mitogenic responses, and interleukin-1 (IL-1) an...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:The immunological outcome of infections and vaccinations is largely determined during the initial first days in which antigen-presenting cells instruct T cells to expand and differentiate into effector and memory cells. Besides the essential stimulation of the T-cell receptor complex a plethora of co-stimulatory signa...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/imm.12884
更新日期：2018-06-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease in which abnormal immune responses are mediated by tissue-binding autoantibodies and immune complex deposition. Because most SLE patients are women of child-bearing age, oestrogen has been suggested to play an important role in SLE pathogenesis. One proposed ...
journal_title：Immunology
pub_type： 临床试验,杂志文章
doi：10.1111/imm.12263
更新日期：2014-08-01 00:00:00
abstract：:Bile acids (BAs) play important roles not only in lipid metabolism, but also in signal transduction. TGR5, a transmembrane receptor of BAs, is an immunomodulative factor, but its detailed mechanism remains unclear. Here, we aimed to delineate how BAs operate in immunological responses via the TGR5 pathway in human mon...
journal_title：Immunology
pub_type： 临床试验,杂志文章
doi：10.1111/imm.12045
更新日期：2013-05-01 00:00:00
abstract：:Mice exposed to paramyxovirus (Sendai) generate specifically sensitized thymus-derived lymphocytes (T cells) which, in an in vitro 51Cr release assay, interact only with virus-infected target cells sharing strong transplantation antigens. Reciprocal exclusion of cytotoxic T-cell activity is found for Sendai virus, lym...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
abstract：:In our earlier studies we have observed that T lymphocytes of dengue type 2 virus (DV)-infected mouse spleen produce a cytotoxic factor (CF). In the present study it has been observed that CF induces mouse spleen and peritoneal macrophages to produce a cytotoxin (CF2) as has been revealed by DEAE-cellulose chromatogra...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1983-05-01 00:00:00
abstract：:Deficiency in gammadelta T cells aggravates colitis in animal models suggesting that gammadelta T cells have regulatory properties. Therefore, proliferation, suppression and cytokine secretion of human gammadelta T cells were determined in vitro. Human peripheral gammadelta T cells were isolated from the whole blood o...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2009.03162.x
更新日期：2009-12-01 00:00:00
abstract：:In the study described here, the effect of human tears and purified lactoferrin was investigated on the deposition of complement components on solid-phase bound immune complexes. After incubating immune complexes with fresh normal human serum, the deposition of complement components (C3, C4 and C5) was measured with a...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
abstract：:Docosahexaenoic (22:6 n-3) and eicosapentaenoic acid (20:5 n-3) stimulated the oxygen-dependent respiratory burst in intact neutrophils in a dose-dependent manner as measured by either superoxide dismutase (SOD)-inhibitable cytochrome c reduction and lucigenin-dependent chemiluminescence. A number of longer chain hexa...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:Polystyrene surfaces coated with proteins at alkaline pH were found to be useful to investigate the stimulation of neutrophils independently of phagocytosis. Human neutrophils, when exposed to appropriate stimuli, release superoxide anion (O2-). We have measured superoxide dismutase-inhibitable cytochrome c reduction ...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1978-10-01 00:00:00
abstract：:Oral tolerance promotes a generalized decrease in specific immune responsiveness to proteins previously encountered via the oral route. In addition, parenteral immunization with a tolerated protein also triggers a significant reduction in the primary responsiveness to a second unrelated antigen. This is generally expl...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2008.02901.x
更新日期：2009-03-01 00:00:00
abstract：:The interaction between five murine monoclonal antibodies (mAb) and beta2-glycoprotein I (beta2GPI) in the absence of phospholipids was studied using surface plasmon resonance-based biosensor technology. Two separate epitope regions were confirmed for the five mAb but epitopes of two mAb were shown to be overlapping b...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2567.1999.00780.x
更新日期：1999-07-01 00:00:00
abstract：:Therapeutic vaccination using T-cell receptor (TCR) peptides from V genes commonly expressed by potentially pathogenic T cells remains an approach of interest for treatment of multiple sclerosis (MS) and other autoimmune diseases. We developed a trivalent TCR vaccine containing complementarity determining region (CDR)...
journal_title：Immunology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1365-2567.2007.02703.x
更新日期：2008-01-01 00:00:00
abstract：:The contribution of gut-associated lymphoid tissue (GALT) to the local immune response in the respiratory mucosa of sheep has been investigated. Sheep were primed intraperitoneally (i.p.) with antigen in Freund's complete adjuvant, a procedure known to produce a large IgA-specific antibody-containing cell (ACC) respon...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：:Growth of Salmonella enterica in mammalian tissues results from continuous spread of bacteria to new host cells. Our previous work indicated that infective S. enterica are liberated from host cells via stochastic necrotic burst independently of intracellular bacterial numbers. Here we report that liver phagocytes can ...
journal_title：Immunology
pub_type： 杂志文章
doi：10.1111/j.1365-2567.2008.02814.x
更新日期：2008-09-01 00:00:00
abstract：:Neuropeptides can influence immune effector cell function at both systemic and mucosal immune sites. We examined the ability of substance P (SP) to modulate the natural killer (NK) activity of intestinal intraepithelial leucocytes (IEL). Yac-1 killing by IEL but not splenic cells was increased after either 18 hr prein...
journal_title：Immunology
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
