解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::S-[3-carbamoylsulfanyl-2-(dimethylamino)propyl] carbamothioate (Cartap) (CAS number: 15263-52-2) is a synthetic insecticide of thiocarbamates group that is extensively used in field of agriculture for controlling of several pests like rice stem borer, leaf folder pests in paddy field and diamond back moth, aphids in c...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1551900
更新日期:2021-03-01 00:00:00
abstract::Lavender and immortelle essential oils (EOs) are widely used to treat a spectrum of human conditions. The aim of this study was to investigate cyto/genotoxic effects of lavender and immortelle EOs using plant cells (Allium cepa) and human lymphocytes, as well as their antimicrobial potential using nine strains of bact...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1538234
更新日期:2021-03-01 00:00:00
abstract::We designed this study to identify the factors associated with time to successful weaning in mechanically ventilated organophosphate (OP)-poisoned patients as the primary outcomes while duration of mechanical ventilation (MV) support, intensive care unit (ICU), and hospital length of stay (LOS) and in-hospital mortali...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1870487
更新日期:2021-01-12 00:00:00
abstract::Increasing numbers of older adults use cannabis and cannabis-derived products that can have adverse effects. This study examined management site and level of healthcare services for older adult poison control center cases involving cannabis products. Using the American Association of Poison Control Centers' (PCC) Nati...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1868494
更新日期:2021-01-07 00:00:00
abstract::Copper (Cu) is a heavy metal with the ability to induce, at high levels, neurobehavioral alterations, and oxidative stress (OS). On the other hand, melatonin (Mel) is a neurohormone that protects neurons from OS and has a modulatory effect on several behavioral processes. The present experiment was aimed to examine th...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1858853
更新日期:2021-01-07 00:00:00
abstract::Exposure to crude acetylene can occur in occupational settings. This study assessed the modulatory activities of selected polyphenols on the hematotoxic, cardiotoxic, and hepatotoxic effects of crude acetylene. Wistar rats were exposed to 58 000 ppm crude acetylene for 10 min at 12 h intervals for 30 days. Some expose...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1853766
更新日期:2020-12-08 00:00:00
abstract::For centuries, Turkey has been a significant location here around 80 species of Hypericum with differing names widely occur, which is also known as Turkish folk medicine in treating some bacterial diseases as well as stomach and intestine inflammation. Recent studies have reported this herb family to contain numbers o...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1856130
更新日期:2020-12-06 00:00:00
abstract::Pachira aquatica is a species used for medicinal and food purposes and has numerous phytochemicals that may have systemic toxic effects and damage to genetic material. This study aimed to evaluate acute and short-term oral toxicity, as well as genotoxic and clastogenic effects of oil extracted from P. aquatica (PASO) ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1845713
更新日期:2020-11-30 00:00:00
abstract::This study was designed to investigate possible interference of Xenobiotics with SUMOylation in eukaryotic cells. To begin with, we docked 71 chemical structures from PubChem with human SUMO1 and UBC9 protein structures using Auto Dock 4.2 and Hex 6.3 and selected five compounds for binding studies in Surface Plasmon ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1526179
更新日期:2020-11-01 00:00:00
abstract::Tempol (4-hydroxy tempo), a pleiotropic antioxidant is reported to afford protection against cisplatin (CP)-induced nephrotoxicity. However, molecular mechanisms of action of tempol in improving the renal function in CP-induced nephrotoxicity are not fully understood. We investigated the attenuating effect of tempol a...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1831011
更新日期:2020-10-20 00:00:00
abstract::The purpose of this research was to evaluate the efficacy of carsil (CAR) either alone or in combination with α-tocopherol (α-TOCO) and/or turmeric (TUMR) against tetrachloromethane (TCM)-induced cardiomyocyte injury in rats. Administration of CAR either alone or in combination with α-TOCO and/or TUMR post-TCM injecti...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1831012
更新日期:2020-10-15 00:00:00
abstract::This study investigated the exposure of pyrethroids in the development of Alzheimer's type neurodegeneration by analyzing β- amyloid, tau and Glial Fibrillary Acidic Protein (GFAP) in adult Wistar rats. Forty adult Wistar rats (130-150 g) of both sexes were assigned into five groups (n = 8). Groups A-C were treated wi...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1778020
更新日期:2020-09-09 00:00:00
abstract::Pefloxacin is a second-generation fluoroquinolone antibiotic. Besides its advantageous characteristics, side effects including the hypofunction of salivary glands, decreased saliva production, and peripheral neuropathy were observed during the administration of pefloxacin. The aim of this study was to investigate the ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1508217
更新日期:2020-09-01 00:00:00
abstract::Nephrotoxicity is a major limitation of adriamycin (ADR) chemotherapy. We hypothesized that administration of standardized aqueous bark extract of Gmelina arborea Roxb. (GA) (Family; Verbenaceae), a traditional therapeutic agent, may reduce the nephrotoxicity caused by ADR in Wistar rats. The dose-dependent nephroprot...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1811721
更新日期:2020-08-30 00:00:00
abstract::Modafinil is used for the treatment of various sleep disorders; however, its usage among healthy individuals is also increasing. There are a limited number of cardiovascular side effects, including ischemic T-wave changes, dyspnea, hypertension, and tachycardia in the literature. Our research aimed to investigate the ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1803906
更新日期:2020-08-11 00:00:00
abstract::The objective of this study was to evaluate the residues of 42 pesticides subject to public concern in Tieguanyin tea produced in Fujian, China. The presence of 42 pesticide residues in 90 Tieguanyin tea samples were determined. A total of 17 pesticides were detected. At least one pesticide residue was detected in 65 ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1802476
更新日期:2020-08-04 00:00:00
abstract::Butea monosperma (Lam.) Taub. is an ethnomedicinal tree of remedial value in the treatment of diabetes, bone fractures, and liver and neurological disorders. However, the information available on DNA-protective and anti-proliferative potential of bark of this tree is scarce. In the present study, the extract/fractions...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1497051
更新日期:2020-07-01 00:00:00
abstract::The present study was aimed to report the toxicity of the chlorpyrifos, an organophosphorus insecticide, with regard to histological and cytological effects through light and transmission electron microscopes in the gills of freshwater fish, Anabas testudineus. The fish were exposed to 0.125 (5% of 96 h LC50), 0.250 (...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1497052
更新日期:2020-07-01 00:00:00
abstract::Amiodarone is a high effectiveness anti-arrhythmia agent which is able to induce pulmonary fibrosis. Many studies have shown that the epithelial-mesenchymal transition (EMT) was a significant process in pulmonary fibrosis. So far, there are no studies about whether EMT was associated with amiodarone-induced pulmonary ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1497055
更新日期:2020-07-01 00:00:00
abstract::Endophytic fungi are promising sources of bioactive substances; however, their secondary metabolites are toxic to plants, animals, and humans. This study aimed toevaluate the toxic, cytotoxic, mutagenic and oxidant/antioxidant activities of acetonitrile extract (AEPc), citrinin (CIT) and dicitrinin-A (DIC-A) of Penici...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1769642
更新日期:2020-05-25 00:00:00
abstract::The intoxication of insecticides such as bifenthrin and diazinon has been reported to generate free radicals, and thereby alter the antioxidant defense system in erythrocytes. The present study is aimed to investigate the protective effects of acetone (DA) and methanolic (DM) extracts of lichen Dirinaria consimilis ag...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1762632
更新日期:2020-05-12 00:00:00
abstract::Prolonged exposure to aluminum through occupational hazards or food/water intake has been linked to the occurrence of Alzheimer's disease (AD). This study aimed at investigating the neuroprotective effects of Gallic Acid (GA) against aluminum-chloride induced AD in adult Wistar rats. Twenty eight (28) adult Wistar rat...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1754849
更新日期:2020-04-24 00:00:00
abstract::In this study, the hepatoprotective activity of methanol bark extract of Alangium salviifolium (BEA) was evaluated for biochemical and histological parameters in swiss albino mice with CCl4-induced hepatotoxicity. The hepatomodulatory effect of two doses of BEA (20 and 50 mg/kg bw for 15 days by oral gavage) was asses...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1733593
更新日期:2020-03-06 00:00:00
abstract::The potential genotoxic effect of venlafaxine hydrochloride (venlafaxine), an antidepressant drug-active ingredient, was investigated by using in vitro chromosome aberrations (CAs) and cytokinesis-block micronucleus (CBMN) assays in human peripheral blood lymphocytes (PBLs). Mitotic index (MI) and cytokinesis-block pr...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1486410
更新日期:2020-03-01 00:00:00
abstract::Understanding the mechanism behind neuronal regeneration is critical for treating ischemic stroke and traumatic brain injury. The presence of neural stem cells in and around the sub-ventricular zone of human and also in zebrafish is evidenced. In this current study, the neuro-protective potential of nano-formulated he...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1722690
更新日期:2020-02-12 00:00:00
abstract::Aluminum (Al)-induced toxicity in fruit fly (Drosophila melanogaster) is one of the established models for studying neurotoxicity and neurodegenerative diseases. Alkaloid phytochemicals have been reported to exhibit neuroprotective effects. Therefore, the aim of this study is to determine the effect of alkaloid extrac...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1708377
更新日期:2020-01-03 00:00:00
abstract::This study investigated the effect of Thyme (Thymus vulgaris) leaf aqueous extract (TE) on purine and acetylcholine hydrolyzing enzyme activities and antioxidant status in the brain of 5-fluorouracil (5-FLU) administered rats. Sixty adult Wistar rats (210-225 g) were divided into Ten groups (n = 6). Group 1: received ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1659310
更新日期:2020-01-01 00:00:00
abstract::Rotenone, an environmental toxin, triggers Parkinson's disease (PD)-like pathology through microglia-mediated neuronal death. The effects and molecular mechanisms of flavonoid luteolin against rotenone-induced toxicity was assessed in microglial BV2 cells. Cells were pretreated with luteolin (1-50 µM) for 12 h and the...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1504961
更新日期:2020-01-01 00:00:00
abstract::Chronic exposure to solar ultraviolet (UV) light induces photoaging in human skin. Our previous results have shown that areca nut procyanidins (ANPs) have antioxidant capacity and possess potential anti-inflammatory effects. Here, we aimed to investigate the effect of ANPs on UVB-induced photoaging. In the present stu...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1696813
更新日期:2019-12-02 00:00:00
abstract::The effect of chlormethiazole (CMZ) at single and multiple doses on the toxicokinetics of diethylnitrosamine (DEN) was investigated in normal rats and those with DEN-induced liver fibrosis. Twelve rats were treated with DEN (50 mg/kg) alone and in combination with a single dose of CMZ (10, 50, or 100 mg/kg) by intrape...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1455204
更新日期:2019-11-01 00:00:00
abstract::Orlistat is an FDA-approved over-the-counter drug to treat obesity through the inhibition of lipase activity. Macrophages, which express high levels of lipoprotein lipase (LPL), are important phagocytes in the innate immune system. Our previous studies indicated that environmentally relevant concentrations of arsenite...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1683571
更新日期:2019-10-31 00:00:00
abstract::Neurodegenerative diseases affect millions of people. Major reasons behind the onset and progression of these diseases are still under investigation. Therefore, any approach that would treat/prevent progression is important. In this study, we aimed to investigate the potential protective effects of Psephellus pyrrhobl...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1659808
更新日期:2019-09-02 00:00:00
abstract::In the present study, coffee (CF) was evaluated for its protective effects against genotoxic damage and oxidative stress induced by the chemotherapeutic drug, cyclophosphamide (CPH). The sex-linked recessive lethal (SLRL) test was employed to study the induction of mutations in the larvae as well as in all the success...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1438457
更新日期:2019-09-01 00:00:00
abstract::The venoms of wasps are a complex mixture of biologically active compounds, such as low molecular mass compounds, peptides, and proteins. The aim of the study was to evaluate the action of wasp venoms, Polybia occidentalis and Polybia fastidiosa, on the DNA of human leukocytes and on the cell cycle and genetic materia...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1631339
更新日期:2019-07-01 00:00:00
abstract::Hyperlipidemia causes lipotoxicity which prompts an inflammatory response linked to the development of cardiovascular diseases. Natural compounds have been receiving special attention for its potential to treat diseases, inexpensiveness, and safety. Guarana (Paullinia cupana) has demonstrated notable anti-inflammatory...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1624767
更新日期:2019-06-14 00:00:00
abstract::Medications show their biological effects by interaction with enzymes, which have been known to play an essential role in the pathogenesis of many diseases. Inhibition or induction of drug metabolizing enzymes has an essential place in the drug design for many kinds of diseases including cardiovascular, neurological, ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1620266
更新日期:2019-06-09 00:00:00
abstract::In this study, the effects of a neonicotinoid insecticide acetamiprid on the sciatic nerve of Rana ridibunda were investigated by using electrophysiological and histological methods. A total of 35 preparations of sciatic nerve isolated from 35 frogs (Nervus ischiadicus) were used in the experiments. Experiments were d...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1442475
更新日期:2019-05-01 00:00:00
abstract::Cadmium (Cd) is a ubiquitous non-essential environmental and industrial toxicant that affects various organs in humans and experimental animals. Robust evidence confirms the contribution of oxidative stress to the pathogenesis of Cd-induced hepatic damage. Potent polyphenols found in virgin coconut oil (VCO) are free ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1598428
更新日期:2019-04-25 00:00:00
abstract::Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids (DDAs) including aconitine (AC), mesaconitine (MAC), hypaco...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1586916
更新日期:2019-03-21 00:00:00
abstract::The purposes of this study was to determine the toxicological effect of repeated intravenous administration of Activin A/BMP-2 chimera (AB204) in beagle dogs for a long period of four weeks and evaluate two-week recovery. AB204 was administered at doses of 0.08, 0.16, or 0.32 mg/kg/day to three male and three female b...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1572181
更新日期:2019-03-18 00:00:00