Management site and level of health care for cannabis- and synthetic cannabinoid-related poison control center cases involving older adults, 2016-2019.

Abstract:

:Increasing numbers of older adults use cannabis and cannabis-derived products that can have adverse effects. This study examined management site and level of healthcare services for older adult poison control center cases involving cannabis products. Using the American Association of Poison Control Centers' (PCC) National Poison Data System, 2016-2019, we extracted the 3109 cases aged 50+ for which cannabis was the only or primary substance. Multinomial logistic regression models were fit to examine associations between specific cannabis forms and management/care site (on site [mostly at home], at a healthcare facility [HCF], or no follow-up due to referral refusal or leaving against medical advice) and level of healthcare services for cases managed at a HCF. The results show that between 2016 and 2019, PCC cannabis cases involving older adults increased twofold, largely due to cases of cannabidiol, edibles, and concentrated extracts. Plant form and synthetic cannabinoid cases declined substantially. Compared to plant forms, synthetic cannabinoid cases had 4.22 (95% CI = 2.59-6.89) greater odds of being managed at, rather than outside, a HCF and 2.17 (1.42-3.31) greater odds of critical care unit admission. Although e-cigarette cases, compared to plant form cases, had lower odds of being managed at a HCF, HCF-managed e-cigarette cases had 3.43 greater odds (95% CI = 1.08-10.88) of critical care unit admission. Synthetic cannabinoid cases also had 1.86 (95% CI = 1.03-3.35) greater odds of no follow-up, and the presence of a secondary substance was also a significant factor. Stricter regulations for listing chemical ingredients and providing safety guidelines are needed for cannabis-derived products.

journal_name

Drug Chem Toxicol

authors

Choi NG,DiNitto DM,Marti CN,Baker SD

doi

10.1080/01480545.2020.1868494

subject

Has Abstract

pub_date

2021-01-07 00:00:00

pages

1-9

eissn

0148-0545

issn

1525-6014

pub_type

杂志文章
  • Effect of celecoxib on Ca(2+) handling and viability in human prostate cancer cells (PC3).

    abstract::Celecoxib has been shown to have an antitumor effect in previous studies, but the mechanisms are unclear. Ca(2+) is a key second messenger in most cells. The effect of celecoxib on cytosolic free Ca(2+) concentrations ([Ca(2+)](i)) in human suspended PC3 prostate cancer cells was explored by using fura-2 as a fluoresc...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480545.2011.638927

    authors: Wang JL,Lin KL,Chou CT,Kuo CC,Cheng JS,Hsu SS,Chang HT,Tsai JY,Liao WC,Lu YC,Chen IS,Liu SI,Jan CR

    更新日期:2012-10-01 00:00:00

  • Toxic effect of acetamiprid on Rana ridibunda sciatic nerve (electrophysiological and histopathological potential).

    abstract::In this study, the effects of a neonicotinoid insecticide acetamiprid on the sciatic nerve of Rana ridibunda were investigated by using electrophysiological and histological methods. A total of 35 preparations of sciatic nerve isolated from 35 frogs (Nervus ischiadicus) were used in the experiments. Experiments were d...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2018.1442475

    authors: Çamlıca Y,Bediz SC,Çömelekoğlu Ü,Yilmaz ŞN

    更新日期:2019-05-01 00:00:00

  • Effect of endosulfan and bisphenol A on the expression of SUMO and UBC9.

    abstract::This study was designed to investigate possible interference of Xenobiotics with SUMOylation in eukaryotic cells. To begin with, we docked 71 chemical structures from PubChem with human SUMO1 and UBC9 protein structures using Auto Dock 4.2 and Hex 6.3 and selected five compounds for binding studies in Surface Plasmon ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2018.1526179

    authors: Yarahalli Jayaram V,Baggavalli S,Reddy D,Sistla S,Malempati R

    更新日期:2020-11-01 00:00:00

  • Oxidative stress-mediated myocardiotoxicity of ciprofloxacin and ofloxacin in juvenile rats.

    abstract::In this study, evaluation of the myocardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats and the role of oxidative stress in heart toxicity was conducted. Doses (25 and 50 mg/kg) of each drug were administered to the rats for 1 week. Serum biochemical cardiotoxicity parameters and tissue malond...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480540902882176

    authors: Saraçoğlu A,Temel HE,Ergun B,Colak O

    更新日期:2009-01-01 00:00:00

  • Effect of cotreatment of aspirin metabolites on mitomycin C-induced genotoxicity using the somatic mutation and recombination test in Drosophila melanogaster.

    abstract::In our previous reports, aspirin, an antipyretic analgesic, suppressed the genotoxicity of mitomycin C (MMC) in a somatic mutation and recombination test (SMART) in Drosophila melanogaster. In order to reveal the mechanism of the anti-genotoxicity of aspirin, we evaluated the suppressing ability of each aspirin metabo...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480540600820528

    authors: Niikawa M,Nakamura T,Nagase H

    更新日期:2006-01-01 00:00:00

  • Acute toxicity and primary irritancy of 2-amino-3,5-dicyano-4-o-chlorophenyl-6-ethoxypyridine.

    abstract::2-Amino-3,5-dicyano-4-o-chlorophenyl-6-ethoxypyridine (ACCPE) is a water soluble compound formed during the alkaline treatment of the alcoholic liquor in the production of 2-chlorobenzylidene malononitrile (CS). The acute toxicity and primary irritancy of ACCPE and CS were investigated and compared. Both perorally and...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480548508999168

    authors: Ballantyne B

    更新日期:1985-01-01 00:00:00

  • Continuous monitoring of temperature in laboratory animals during inhalation exposure.

    abstract::An automatic system was developed to monitor continuously the colonic temperature of laboratory animals during inhalation exposure to toxic chemicals. It includes: an automatic switchbox, a control circuit, a recorder and a digital voltmeter. The system was calibrated for different temperature ranges and used for a ye...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480547809105018

    authors: Laham S,Schrader K,Symonds G,Curtin W

    更新日期:1978-01-01 00:00:00

  • Inhibitory effect of chlormethiazole on the toxicokinetics of diethylnitrosamine in normal and hepatofibrotic rats.

    abstract::The effect of chlormethiazole (CMZ) at single and multiple doses on the toxicokinetics of diethylnitrosamine (DEN) was investigated in normal rats and those with DEN-induced liver fibrosis. Twelve rats were treated with DEN (50 mg/kg) alone and in combination with a single dose of CMZ (10, 50, or 100 mg/kg) by intrape...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2018.1455204

    authors: Wang G,Xiao K,Gao J,Jiang S,Wang S,Weng S,Xu C,Wang T,Qiao HL

    更新日期:2019-11-01 00:00:00

  • Use of the accelerating rotarod for assessment of motor performance decrement induced by potential anticonvulsant compounds in nerve agent poisoning.

    abstract::The accelerating rotarod was used to assess motor performance decrement in rats after administration of candidate anticonvulsant compounds (acetazolamide, amitriptyline, chlordiazepoxide, diazepam, diazepam-lysine, lorazepam, loprazolam, midazolam, phenobarbital and scopolamine) against nerve agent poisoning. All comp...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480549209014150

    authors: Capacio BR,Harris LW,Anderson DR,Lennox WJ,Gales V,Dawson JS

    更新日期:1992-01-01 00:00:00

  • Standardized aqueous stem bark extract of Gmelina arborea roxb. possesses nephroprotection against adriamycin-induced nephrotoxicity in Wistar rats.

    abstract::Nephrotoxicity is a major limitation of adriamycin (ADR) chemotherapy. We hypothesized that administration of standardized aqueous bark extract of Gmelina arborea Roxb. (GA) (Family; Verbenaceae), a traditional therapeutic agent, may reduce the nephrotoxicity caused by ADR in Wistar rats. The dose-dependent nephroprot...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2020.1811721

    authors: Amarasiri SS,Attanayake AP,Arawwawala LDAM,Jayatilaka KAPW,Mudduwa LKB

    更新日期:2020-08-30 00:00:00

  • Propoxur-induced oxidative DNA damage in human peripheral blood mononuclear cells: protective effects of curcumin and α-tocopherol.

    abstract::The present study enumerates the attenuating effects of curcumin and α-tocopherol against propoxur induced oxidative DNA damage in human peripheral blood mononuclear cells (PBMC). Cultured cells were isolated from peripheral blood of healthy volunteers, and were exposed to varying concentrations of propoxur (0-21 μg/m...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2017.1321010

    authors: Ahmed T,Goel V,Banerjee BD

    更新日期:2018-04-01 00:00:00

  • Cardiotoxicity evaluation and comparison of diterpene alkaloids on zebrafish.

    abstract::Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids (DDAs) including aconitine (AC), mesaconitine (MAC), hypaco...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2019.1586916

    authors: Ye Q,Liu H,Fang C,Liu Y,Liu X,Liu J,Zhang C,Zhang T,Peng C,Guo L

    更新日期:2019-03-21 00:00:00

  • Physiological responses in rats fed extracts of endophyte infected tall fescue seed.

    abstract::Three trials involving 184 male Sprague Dawley rats were conducted to identify the biologically active fraction of endophyte-infected tall fescue seed. In trial 1, seed infected (greater than 95%) with the endophytic fungus Acremonium coenophialum and shown to be toxic to cattle, was serially extracted with hexane, et...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480548709042993

    authors: Jackson JA,Hemken RW,Bush LP,Boling JA,Siegel MR,Zavos PM

    更新日期:1987-01-01 00:00:00

  • A computer program for conducting incinerator risk assessments.

    abstract::In 1994, the United States Environmental Protection Agency (USEPA) developed a screening methodology for conducting indirect exposure risk assessments for combustion facilities. The United States Army Center for Health Promotion and Preventive Medicine currently utilizes this methodology in conjunction with other USEP...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480549909029733

    authors: Walter MA

    更新日期:1999-02-01 00:00:00

  • Modulatory activities of polyphenols on crude acetylene-induced cardiac and hepatic dysfunctions in a rat model.

    abstract::Exposure to crude acetylene can occur in occupational settings. This study assessed the modulatory activities of selected polyphenols on the hematotoxic, cardiotoxic, and hepatotoxic effects of crude acetylene. Wistar rats were exposed to 58 000 ppm crude acetylene for 10 min at 12 h intervals for 30 days. Some expose...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2020.1853766

    authors: Aladesanmi OO,Akinmoladun AC,Josiah SS,Olaleye MT,Akindahunsi AA

    更新日期:2020-12-08 00:00:00

  • Subchronic oral toxicity, tissue distribution and clearance of hexachloroethane in the rat.

    abstract::Hexachloroethane (HCE) was fed to Fischer 344 rats at approximate doses of 0, 1, 15 or 62 mg/kg/day for 16 weeks. Selected tissues were assayed at termination for HCE content. Histopathological examination identified the kidney as the primary target organ with male rats more sensitive than female rats. The kidney conc...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480548508999167

    authors: Gorzinski SJ,Nolan RJ,McCollister SB,Kociba RJ,Mattsson JL

    更新日期:1985-01-01 00:00:00

  • A novel hepatoprotective activity of Alangium salviifolium in mouse model.

    abstract::In this study, the hepatoprotective activity of methanol bark extract of Alangium salviifolium (BEA) was evaluated for biochemical and histological parameters in swiss albino mice with CCl4-induced hepatotoxicity. The hepatomodulatory effect of two doses of BEA (20 and 50 mg/kg bw for 15 days by oral gavage) was asses...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2020.1733593

    authors: Dhruve P,Nauman M,Kale RK,Singh RP

    更新日期:2020-03-06 00:00:00

  • Oxime silanes: structure/toxicity relationships.

    abstract::Acute and repeated oral and dermal rat toxicology studies of standard designs were conducted on four methyl ethyl ketoxime (MEKO) silanes and four methyl isobutyl ketoxime (MIBKO) silanes. Each compound contained either MEKO or MIBKO groups (but not both) and either a single methyl, vinyl, or phenyl group (trifunction...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480540701688766

    authors: Derelanko MJ,Rusch GM

    更新日期:2008-01-01 00:00:00

  • Orlistat increases arsenite tolerance in THP-1 derived macrophages through the up-regulation of ABCA1.

    abstract::Orlistat is an FDA-approved over-the-counter drug to treat obesity through the inhibition of lipase activity. Macrophages, which express high levels of lipoprotein lipase (LPL), are important phagocytes in the innate immune system. Our previous studies indicated that environmentally relevant concentrations of arsenite...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2019.1683571

    authors: Lou K,Huang P,Ma H,Wang X,Xu H,Wang W

    更新日期:2019-10-31 00:00:00

  • Cadmium induced changes in gluconeogenic enzymes in rat kidney and liver.

    abstract::Male Sprague-Dawley rats were administered cadmium chloride 0, 50, 100, 150 and 200 ppm for 30 days. At the end of the treatments, the body weight gains, serum glucose, serum protein, serum glutamic oxalacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were determined. Renal and hepatic key glu...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480548009030129

    authors: Chapatwala KD,Rajanna B,Desaiah D

    更新日期:1980-01-01 00:00:00

  • Selenium in mainstream and sidestream smoke of cigarettes containing fly ash-grown tobacco.

    abstract::The quantities of selenium, tar and nicotine present in mainstream (MS) and sidestream (SS) smoke of machine-smoked cigarettes was studied. The cigarettes were prepared from tobacco purposely cultured on fly ash-amended soil so as to increase its selenium concentration. Selenium concentration was found to be the same ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480548709042980

    authors: Gutenmann WH,Lisk DJ,Shane BS,Hoffmann D,Adams JD

    更新日期:1987-01-01 00:00:00

  • Acute, subchronic, and mutagenicity studies with norbornene fluoroalcohol.

    abstract::The object of this study was to evaluate the toxicity of norbornene fluoroalcohol (NBFOH), which is used as an intermediate in the production of fluorinated monomers and polymers. NBFOH was evaluated for acute oral, dermal, and inhalation toxicity, dermal sensitization using the Local Lymph Node Assay (LLNA), mutagene...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480540500262680

    authors: DeLorme MP,Ladics GS,Donner EM,Wagner VO 3rd,Finlay C,Frame SR,Everds NE,Loveless SE

    更新日期:2005-01-01 00:00:00

  • Procainamide induces a transitory impairment of B cell mitogenesis in beagle dogs.

    abstract::Beagle dogs (3 to 6 years old) were treated with 100-150 mg procainamide HC1/kg/day. After 2, 5, and 9 months of treatment, peripheral blood lymphocytes were isolated and stimulated with pokeweed mitogen. The data demonstrated a suppression of mitogenesis only at 2 and 5 months after procainamide treatment. The lympho...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480548808998220

    authors: Mulhern SA,Daguillard F,Robinson CJ,Balazs T

    更新日期:1988-06-01 00:00:00

  • Thyme (Thymus vulgaris) leaf extract modulates purinergic and cholinergic enzyme activities in the brain homogenate of 5-fluorouracil administered rats.

    abstract::This study investigated the effect of Thyme (Thymus vulgaris) leaf aqueous extract (TE) on purine and acetylcholine hydrolyzing enzyme activities and antioxidant status in the brain of 5-fluorouracil (5-FLU) administered rats. Sixty adult Wistar rats (210-225 g) were divided into Ten groups (n = 6). Group 1: received ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2019.1659310

    authors: Adefegha SA,Oyeleye SI,Akintemi A,Okeke BM,Oboh G

    更新日期:2020-01-01 00:00:00

  • Contact hypersensitivity to dicyclohexylcarbodiimide and diisopropylcarbodiimide in female B6C3F1 mice.

    abstract::Dicyclohexylcarbodiimide (DCC) and diisopropylcarbodiimide (DIC) are two commonly used coupling reagents in protein synthesis resulting in exposure of individuals in chemical and pharmaceutical industries as well as research laboratories involved in protein synthesis and recombinant DNA techniques. The objectives of t...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480549809011647

    authors: Hayes BB,Gerber PC,Griffey SS,Meade BJ

    更新日期:1998-05-01 00:00:00

  • Differential effects of dehydroepiandrosterone and clofibrate on the binding of 7,12-dimethyl benz(a)anthracene to hepatic DNA in vivo--a preliminary study.

    abstract::The effects of feeding two compounds, dehydroepiandrosterone (DHEA), an adrenal steroid, and clofibrate (CLOF) to rats (which are both hypolipidemic, hepatomegaly inducing and hepatic peroxisome proliferating agents) on the binding of 7,12-dimethylbenz(a)anthracene (DMBA) to hepatic DNA in vivo is compared. Male Sprag...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480548908999162

    authors: Prasanna HR,Hart RW,Magee PN

    更新日期:1989-09-01 00:00:00

  • Areca nut procyanidins prevent ultraviolet light B-induced photoaging via suppression of cyclooxygenase-2 and matrix metalloproteinases in mouse skin.

    abstract::Chronic exposure to solar ultraviolet (UV) light induces photoaging in human skin. Our previous results have shown that areca nut procyanidins (ANPs) have antioxidant capacity and possess potential anti-inflammatory effects. Here, we aimed to investigate the effect of ANPs on UVB-induced photoaging. In the present stu...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2019.1696813

    authors: Weng CL,Chen CC,Tsou HH,Liu TY,Wang HT

    更新日期:2019-12-02 00:00:00

  • The beneficial effects of antioxidants combination on cardiac injury induced by tetrachloromethane.

    abstract::The purpose of this research was to evaluate the efficacy of carsil (CAR) either alone or in combination with α-tocopherol (α-TOCO) and/or turmeric (TUMR) against tetrachloromethane (TCM)-induced cardiomyocyte injury in rats. Administration of CAR either alone or in combination with α-TOCO and/or TUMR post-TCM injecti...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2020.1831012

    authors: Alshanwani AR,Faddah LM,Hagar H,Alhusaini AM,Shaheen S,Mohammad RA,Alharbi FMB,AlHarthii A,Badr AM

    更新日期:2020-10-15 00:00:00

  • Testicular effects of monensin, a golgi interfering agent in male rats.

    abstract:OBJECTIVE:The present study was undertaken to explore the effects of monensin, a potent Golgi disturbing agent on male fertility. METHODS:Male Wistar rats were administered monensin at the dose levels of 2.5, 5, and 10 mg/kg b wt. Animals were sacrificed after 67 days of the treatment. The activities of lactate dehydr...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480545.2013.866955

    authors: Singh M,Kalla NR,Sanyal SN

    更新日期:2014-10-01 00:00:00

  • Determination of preclinical safety of oil obtained from Pachira aquatica Aublet (Malvaceae) seeds: histopathological, biochemical, hematological, and genetic toxicity studies in rats.

    abstract::Pachira aquatica is a species used for medicinal and food purposes and has numerous phytochemicals that may have systemic toxic effects and damage to genetic material. This study aimed to evaluate acute and short-term oral toxicity, as well as genotoxic and clastogenic effects of oil extracted from P. aquatica (PASO) ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2020.1845713

    authors: Marcelino JM,Villas Boas GR,Cunha M,Deus Júnior R,Castro LH,Araújo FH,Traesel GK,Dos Santos AC,Souza RI,Paes M,Gubert P,Guterres ZDR,de Lima FF,Silva T,Silva RC,Cardoso CAL,Argandoña EJ,Macorini LF,Oesterreich SA

    更新日期:2020-11-30 00:00:00