Management site and level of health care for cannabis- and synthetic cannabinoid-related poison control center cases involving older adults, 2016-2019.


:Increasing numbers of older adults use cannabis and cannabis-derived products that can have adverse effects. This study examined management site and level of healthcare services for older adult poison control center cases involving cannabis products. Using the American Association of Poison Control Centers' (PCC) National Poison Data System, 2016-2019, we extracted the 3109 cases aged 50+ for which cannabis was the only or primary substance. Multinomial logistic regression models were fit to examine associations between specific cannabis forms and management/care site (on site [mostly at home], at a healthcare facility [HCF], or no follow-up due to referral refusal or leaving against medical advice) and level of healthcare services for cases managed at a HCF. The results show that between 2016 and 2019, PCC cannabis cases involving older adults increased twofold, largely due to cases of cannabidiol, edibles, and concentrated extracts. Plant form and synthetic cannabinoid cases declined substantially. Compared to plant forms, synthetic cannabinoid cases had 4.22 (95% CI = 2.59-6.89) greater odds of being managed at, rather than outside, a HCF and 2.17 (1.42-3.31) greater odds of critical care unit admission. Although e-cigarette cases, compared to plant form cases, had lower odds of being managed at a HCF, HCF-managed e-cigarette cases had 3.43 greater odds (95% CI = 1.08-10.88) of critical care unit admission. Synthetic cannabinoid cases also had 1.86 (95% CI = 1.03-3.35) greater odds of no follow-up, and the presence of a secondary substance was also a significant factor. Stricter regulations for listing chemical ingredients and providing safety guidelines are needed for cannabis-derived products.


Drug Chem Toxicol


Choi NG,DiNitto DM,Marti CN,Baker SD




Has Abstract


2021-01-07 00:00:00








  • Ten and ninety-day toxicity studies of chloropicrin in Sprague-Dawley rats.

    abstract::The toxicity of chloropicrin (CP) was assessed following its administration to rats via oral gavage for either 10 or 90 consecutive days at dose levels of 10, 20, 40, and 80 mg/kg and 2, 8 and 32 mg/kg, respectively. Control rats received corn oil at a dose of 1.0 ml/kg. Toxicological observations included organ and b...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Condie LW,Daniel FB,Olson GR,Robinson M

    更新日期:1994-01-01 00:00:00

  • The assessment of genotoxicity of carbamazepine using cytokinesis-block (CB) micronucleus assay in cultured human blood lymphocytes.

    abstract::The genotoxic effect of CBZ has been investigated in few studies. There is little evidence linking carbamazepine (CBZ) with any genotoxic effects, particularly in vitro micronucleus test using cytogenesis-block technique. In this study, the genotoxicity of the antiepileptic drug, carbamazepine, was tested using cytoki...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Celik A

    更新日期:2006-01-01 00:00:00

  • Comparison of the relative mutagenic activity for eight antineoplastic drugs in the Ames Salmonella/microsome and TK+/- mouse lymphoma assays.

    abstract::Eight antineoplastic drugs were evaluated for their ability to induce mutation in the Ames Salmonella/microsome and the TK+/- mouse lymphoma assay. Dose response data were utilized to determine the relative potency of each of these drugs. They were then ranked based on this information. Vincristine, the most potent co...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Matheson D,Brusick D,Carrano R

    更新日期:1978-01-01 00:00:00

  • Cell protection induced by Acacia salicina extracts: inhibition of genotoxic damage and determination of its antioxidant capacity.

    abstract::Antioxidant activity of Acacia salicina extracts was determined by the ability of each extract to inhibit lipid peroxidation, to protect against DNA strand scission induced by hydroxyl radicals, and to scavenge the free radical, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(*+)). The IC(50) values of t...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Bouhlel I,Bhouri W,Limem I,Boubaker J,Nefatti A,Skandrani I,Ben Sghaier M,Kilani S,Ghedira K,Chekir Ghedira L

    更新日期:2009-01-01 00:00:00

  • Prenatal developmental toxicity evaluation of Withania somnifera root extract in Wistar rats.

    abstract:CONTEXT:Withania somnifera (L) Dunal (Solanaceae) is an important traditional herbal medicine used for thousands of years and is considered as the Indian ginseng. Reports on the effect of Withania somnifera root (WSR) extract on the developing foetus of pregnant rats including mortality, structural abnormalities, chang...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Prabu PC,Panchapakesan S

    更新日期:2015-01-01 00:00:00

  • Apoptosis induction and cell cycle perturbation in established cell lines by peroxysomicine A1 (T-514).

    abstract::Peroxysomicine A1, a novel potential anticancer compound induced cell death in established cell lines and in a primary culture of rat neonatal cardiomyocytes. Non-transformed cells are less sensitive to the compound than transformed cell lines. Fluorescent microscopy of dying cells stained with DNA-specific dyes revea...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Martinez FJ,Zeng GQ,Piñeyro A,Garza-Ocañas L,Tomei LD,Umansky SR

    更新日期:2001-08-01 00:00:00

  • Neuroprotective, antiapoptotic and antioxidant effects of l-carnitine against caffeine-induced neurotoxicity in SH-SY5Y neuroblastoma cell line.

    abstract:CONTEXT:Caffeine is the most widely consumed nervous stimulant that induces oxidative-mediated apoptosis and cell cycle arrest in neural cells. Due to low toxicity, high accumulation in neural cells, reduction of the free fatty acids and antioxidant property, l-carnitine (LC) is an interesting compound to be used in vi...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Bavari M,Tabandeh MR,Najafzadeh Varzi H,Bahramzadeh S

    更新日期:2016-01-01 00:00:00

  • Mycotoxin assays using biosensor technology: a review.

    abstract::Toxic fungal metabolites - mycotoxins - cause poisonings after consumption of contaminated food commodities. The most probable intoxications are connected with eating poorly stored food or inhaling of moldy dust. One of the effective ways to protect people against mycotoxins is timely detection. Several methods such a...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章,评审


    authors: Pohanka M,Jun D,Kuca K

    更新日期:2007-01-01 00:00:00

  • Acute toxicity and primary irritancy of 2-amino-3,5-dicyano-4-o-chlorophenyl-6-ethoxypyridine.

    abstract::2-Amino-3,5-dicyano-4-o-chlorophenyl-6-ethoxypyridine (ACCPE) is a water soluble compound formed during the alkaline treatment of the alcoholic liquor in the production of 2-chlorobenzylidene malononitrile (CS). The acute toxicity and primary irritancy of ACCPE and CS were investigated and compared. Both perorally and...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Ballantyne B

    更新日期:1985-01-01 00:00:00

  • Protective effects of extracts of lichen Dirinaria consimilis (Stirton) D.D. Awasthi in bifenthrin- and diazinon-induced oxidative stress in rat erythrocytes in vitro.

    abstract::The intoxication of insecticides such as bifenthrin and diazinon has been reported to generate free radicals, and thereby alter the antioxidant defense system in erythrocytes. The present study is aimed to investigate the protective effects of acetone (DA) and methanolic (DM) extracts of lichen Dirinaria consimilis ag...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Tatipamula VB,Kukavica B

    更新日期:2020-05-12 00:00:00

  • Brain lipid peroxidation and antioxidant status after acute methacrylonitrile intoxication.

    abstract::The status of brain antioxidant enzymes and glutathione in methacrylonitrile (MeAN)-intoxicated Wistar rats was correlated with the levels of lipid peroxidation products. Optimum changes were observed 30 min and 60 min after oral administration of MeAN at dosages of 50 mg/kg body weight per day (0.25 LD50) and 100 mg/...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Zeenath Unnisa A,Niranjali Devaraj S

    更新日期:2005-01-01 00:00:00

  • The toxicological effect of 4-week repeated intravenous injection of activin a/BMP-2 chimera and 2-week recovery study in Beagle dog.

    abstract::The purposes of this study was to determine the toxicological effect of repeated intravenous administration of Activin A/BMP-2 chimera (AB204) in beagle dogs for a long period of four weeks and evaluate two-week recovery. AB204 was administered at doses of 0.08, 0.16, or 0.32 mg/kg/day to three male and three female b...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Han SH,Zheng GB,Lee JH

    更新日期:2019-03-18 00:00:00

  • Standardized aqueous stem bark extract of Gmelina arborea roxb. possesses nephroprotection against adriamycin-induced nephrotoxicity in Wistar rats.

    abstract::Nephrotoxicity is a major limitation of adriamycin (ADR) chemotherapy. We hypothesized that administration of standardized aqueous bark extract of Gmelina arborea Roxb. (GA) (Family; Verbenaceae), a traditional therapeutic agent, may reduce the nephrotoxicity caused by ADR in Wistar rats. The dose-dependent nephroprot...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Amarasiri SS,Attanayake AP,Arawwawala LDAM,Jayatilaka KAPW,Mudduwa LKB

    更新日期:2020-08-30 00:00:00

  • Effect of celecoxib and L-NAME on global ischemia-reperfusion injury in the rat hippocampus.

    abstract::Transient global ischemia continues to be an important clinical problem with limited treatment options. The present study aimed to investigate the possible protective effects of celecoxib [a selective cyclooxygenase (COX-2) inhibitor] and N-omega-nitro-L-arginine methyl ester (L-NAME) [a nonselective nitric oxide synt...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Abd El-Aal SA,El-Sawalhi MM,Seif-El-Nasr M,Kenawy SA

    更新日期:2013-10-01 00:00:00

  • Effect of Andrographis paniculata and Phyllanthus amarus leaf extracts on selected biochemical indices in Drosophila melanogaster model of neurotoxicity.

    abstract::Aluminum (Al)-induced toxicity in fruit fly (Drosophila melanogaster) is one of the established models for studying neurotoxicity and neurodegenerative diseases. Alkaloid phytochemicals have been reported to exhibit neuroprotective effects. Therefore, the aim of this study is to determine the effect of alkaloid extrac...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Adedayo BC,Ogunsuyi OB,Akinniyi ST,Oboh G

    更新日期:2020-01-03 00:00:00

  • Modulatory activities of polyphenols on crude acetylene-induced cardiac and hepatic dysfunctions in a rat model.

    abstract::Exposure to crude acetylene can occur in occupational settings. This study assessed the modulatory activities of selected polyphenols on the hematotoxic, cardiotoxic, and hepatotoxic effects of crude acetylene. Wistar rats were exposed to 58 000 ppm crude acetylene for 10 min at 12 h intervals for 30 days. Some expose...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Aladesanmi OO,Akinmoladun AC,Josiah SS,Olaleye MT,Akindahunsi AA

    更新日期:2020-12-08 00:00:00

  • Reproductive and repeated dose toxicity of cyclododecatriene (CDDT) in rats following oral (gavage) treatment.

    abstract::Cyclododecatriene (CDDT, CAS No. 4904-61-4) was administered daily by oral gavage to groups of Crl:CD (SD)IGS BR rats at dose levels of 0 (control), 30, 100, or 300 mg/kg/day. Female rats were dosed for four weeks premating, through mating, gestation, and lactation (a total of 55 to 63 days of treatment). Male rats we...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Malley LA,Everds NE,Makovec GT,Kennedy GL Jr

    更新日期:2002-05-01 00:00:00

  • A comparative evaluation of mutagenic, antimutagenic, radical scavenging and antibacterial activities of essential oils of Pituranthos chloranthus (Coss. et Dur.).

    abstract::The Salmonella typhimurium/microsome assay is a widely used bacterial genotoxicity assay to test potential carcinogens. The aim of this work was to evaluate the mutagenic and antimutagenic activities with and without the addition of an extrinsic metabolic activation system of essential oils obtained from an aerial par...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Neffati A,Limem I,Kilani S,Bouhlel I,Skandrani I,Bhouri W,Ben Sghaier M,Boubaker J,Ledauphin J,Barillier D,Ghedira LC,Ghedira K

    更新日期:2009-01-01 00:00:00

  • Radioiron utilization and gossypol acetic acid in male rats.

    abstract::The 24-h incorporation of 59Fe into circulating red blood cells, bone marrow, urine, liver, spleen, and skeletal muscle was measured in splenectomized and sham-splenectomized rats which had received a daily, oral dose of gossypol acetic acid (20 mg GAA/kg body wt) for 91 days. A significant decrease in total body weig...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Tone JN,Jensen DR

    更新日期:1985-01-01 00:00:00

  • Licofelone abolishes survival of carcinogenic fibroblasts by inducing apoptosis.

    abstract::Dual inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX) pathways of arachidonic acid metabolism prevent cancer development and induce apoptosis. One of the most promising compounds that blocks both of these pathways is licofelone. We questioned whether licofelone affects the survival and/or promotes apoptosis o...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Kabadere S,Kus G,Uyar R,Oztopcu-Vatan P

    更新日期:2014-01-01 00:00:00

  • Effect of cocaine on mitochondrial electron transport chain evaluated in primary cultures of neonatal rat myocardial cells and in isolated mitochondrial preparations.

    abstract::Cardiotoxicity is commonly associated with cocaine abuse. Previous studies have indicated that cocaine alters myocardial mitochondrial function. This study was undertaken to investigate the effect of cocaine on activity of the mitochondrial electron transport chain in cultures of neonatal rat cardiomyocytes and in iso...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Yuan C,Acosta D Jr

    更新日期:2000-05-01 00:00:00

  • Environmental and occupational exposure of metals and their role in male reproductive functions.

    abstract::This review summarizes the effects of more than 20 metals that, research has indicated, may influence male reproductive health. Though males lack an apparent, easily measurable reproductive cycle, progress has been made in evaluating tests to identify chemical hazards and estimate reproductive health risks. Some agent...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章,评审


    authors: Sengupta P

    更新日期:2013-07-01 00:00:00

  • Effect of endosulfan and bisphenol A on the expression of SUMO and UBC9.

    abstract::This study was designed to investigate possible interference of Xenobiotics with SUMOylation in eukaryotic cells. To begin with, we docked 71 chemical structures from PubChem with human SUMO1 and UBC9 protein structures using Auto Dock 4.2 and Hex 6.3 and selected five compounds for binding studies in Surface Plasmon ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Yarahalli Jayaram V,Baggavalli S,Reddy D,Sistla S,Malempati R

    更新日期:2020-11-01 00:00:00

  • The toxic effects of a chronic administration of the gut-stimulating principle in Croton penduliflorus hutch. seeds in mice.

    abstract::Albino mice (8-10 wks) weighing between 14 and 25 g were divided into 2 groups and dosed orally once per week with 2 doses (7 mg/kg and 21 mg/kg) of the gut-stimulating principle in Croton penduliflorus seeds (CP crystals) for 12 weeks. Some mice (3-4) from each group were killed at 10 days intervals for the first 6 w...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Asuzu IU,Shetty SN,Anika SM

    更新日期:1989-03-01 00:00:00

  • Treatment with p38 inhibitor intensifies the death of MG132-treated As4.1 juxtaglomerular cells via the enhancement of GSH depletion.

    abstract::MG132, as a proteasome inhibitor, has been shown to induce apoptotic cell death through the formation of reactive oxygen species (ROS). In this study, we investigated the effects of MG132 and/or MAPK inhibitors on As4.1 juxtaglomerular cells in relation to cell growth, cell death, ROS, and glutathione (GSH) levels. MG...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Han YH,Kim SZ,Kim SH,Park WH

    更新日期:2010-10-01 00:00:00

  • Whole-body tissue distribution of total radioactivity in rats after oral administration of [¹⁴C]-bilastine.

    abstract::This study evaluated the tissue distribution of total radioactivity in male albino, male pigmented, and time-mated female albino rats after oral administration of a single dose of [¹⁴C]-bilastine (20 mg/kg). Although only 1 animal was analyzed at each time point, there were apparent differences in bilastine distributi...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Lucero ML,Patterson AB

    更新日期:2012-06-01 00:00:00

  • Acute mitochondrial toxicity of caffeine in cultured heart cells.

    abstract::The cytotoxic effect of caffeine on heart cells was evaluated in primary cultures of rat heart muscle (M) and endothelioid (E) cells. The cultures were exposed to 5, 10, or 20 mM caffeine for 6, 12, or 24 hours. As an index of cytotoxicity produced by the treatments, in situ changes in mitochondrial membrane fragility...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Acosta D,Anuforo D

    更新日期:1977-01-01 00:00:00

  • Acid and alkaline phosphatase activities in a novel phosphorothionate (RPR-11) treated male and female rats. Evidence of dose and time-dependent response.

    abstract::The effect of a novel phosphorothionate, the methyl ester of 2-butenoic acid-3-diethoxy phosphinothioyl (RPR-II) was studied on membrane bound target enzymes Acid (AcP) and Alkaline (AkP) Phosphatases in different tissues of male and female albino Wistar rats. Three sub-chronic doses 0.014 (low), 0.028 (medium) and 0....

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Rahman MF,Siddiqui MK,Jamil K

    更新日期:2000-08-01 00:00:00

  • Toxicity and transport of three synthesized mercury-thiol-complexes in isolated rabbit renal proximal tubule suspensions.

    abstract::Previous work has suggested that endogenous sulfhydryls, such as glutathione (GSH) and cysteine, are involved in the uptake and toxicity of HgCl2. To study this possibility, uptake and toxicity of synthesized Hg(SG)2, Hg(cysteinylglycine)2 [Hg(CYS-GLY)2] and Hg(CYS)2 were investigated in rabbit renal proximal tubule s...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Wei H,Qiu L,Divine KK,Ashbaugh MD,McIntyre LC Jr,Fernando Q,Gandolfi AJ

    更新日期:1999-05-01 00:00:00

  • Optimization of an exogenous metabolic activation system for FETAX. II. Preliminary evaluation.

    abstract::The developmental toxicities of five test compounds including carbon tetrachloride, urethane, phenacetin, parathion, and chloroform, were evaluated using Frog Embryo Teratogenesis Assay--Xenopus (FETAX), with minor modification. Post-isolation mixtures of differently-induced rat liver microsomes (phenobarbital- (PB), ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章


    authors: Fort DJ,Rogers RL,Paul RR,Stover EL,Finch RA

    更新日期:2001-05-01 00:00:00