Abstract:
CONTEXT:Crack cocaine is an illicit drug derived from cocaine, in which use and abuse have increased around the world, especially in developing countries. OBJECTIVES:The aim of this study was to evaluate genomic damage in multiple organs of mice following acute exposure to crack cocaine. For this purpose, single cell gel (comet) assay in peripheral blood, liver, kidney, and brain cells was performed and micronucleus test for bone narrow and liver cells was also made in this setting. MATERIAL AND METHODS:A total of 20 C57BL/10 male mice were distributed into four groups, as follows: 0, 4.5, 9, and 18 mg/kg b.w. of crack cocaine dissolved to 1% dimethyl sulfoxide by intraperitoneal (i.p.) route. All animals were sacrificed 24 h after i.p. injection. RESULTS:The results showed that crack cocaine induced DNA damage in peripheral blood, and brain cells for higher doses used as depicted by single cell gel (comet) assay data. Analysis of kidney cells showed no genetic damage for all groups tested. The number of micronucleated cells did not increase after crack cocaine exposure in bone narrow or liver cells. CONCLUSION:In summary, crack cocaine is a genotoxic agent in peripheral blood, liver, and brain cells but not mutagenic in multiple organs of mice.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Yujra VQ,Moretti EG,Claudio SR,Silva MJ,Oliveira Fd,Oshima CT,Ribeiro DAdoi
10.3109/01480545.2015.1126843subject
Has Abstractpub_date
2016-10-01 00:00:00pages
388-91issue
4eissn
0148-0545issn
1525-6014journal_volume
39pub_type
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