Cadmium induced changes in gluconeogenic enzymes in rat kidney and liver.

abstract：CONTEXT:Caffeine is the most widely consumed nervous stimulant that induces oxidative-mediated apoptosis and cell cycle arrest in neural cells. Due to low toxicity, high accumulation in neural cells, reduction of the free fatty acids and antioxidant property, l-carnitine (LC) is an interesting compound to be used in vi...

journal_title：Drug and chemical toxicology

authors： Bavari M,Tabandeh MR,Najafzadeh Varzi H,Bahramzadeh S

更新日期：2016-01-01 00:00:00

abstract：:Tempol (4-hydroxy tempo), a pleiotropic antioxidant is reported to afford protection against cisplatin (CP)-induced nephrotoxicity. However, molecular mechanisms of action of tempol in improving the renal function in CP-induced nephrotoxicity are not fully understood. We investigated the attenuating effect of tempol a...

journal_title：Drug and chemical toxicology

authors： Afjal MA,Goswami P,Ahmad S,Dabeer S,Akhter J,Salman M,Mangla A,Raisuddin S

更新日期：2020-10-20 00:00:00

abstract：:A comparison of the fertility and cytogenetic analyses and the combination of both techniques as generally used in the heritable translocation assay was conducted with triethylenemelamine (TEM). CD-1 mice were used as the F0 generation and were divided into two groups that received i.p. either distilled water (control...

journal_title：Drug and chemical toxicology

authors： Moreland FM,Sheu CJ

更新日期：1983-01-01 00:00:00

abstract：:Peroxysomicine A1, a novel potential anticancer compound induced cell death in established cell lines and in a primary culture of rat neonatal cardiomyocytes. Non-transformed cells are less sensitive to the compound than transformed cell lines. Fluorescent microscopy of dying cells stained with DNA-specific dyes revea...

journal_title：Drug and chemical toxicology

authors： Martinez FJ,Zeng GQ,Piñeyro A,Garza-Ocañas L,Tomei LD,Umansky SR

更新日期：2001-08-01 00:00:00

abstract：:In this study, we investigated the effect of vernolide-A on the induction of apoptosis as well as its regulatory effect on the activation of transcription factors in B16F-10 melanoma cells. Treatment of B16F-10 cells with nontoxic concentrations of vernolide-A showed the presence of apoptotic bodies and induced DNA fr...

journal_title：Drug and chemical toxicology

authors： Pratheeshkumar P,Kuttan G

更新日期：2011-07-01 00:00:00

abstract：:We designed this study to identify the factors associated with time to successful weaning in mechanically ventilated organophosphate (OP)-poisoned patients as the primary outcomes while duration of mechanical ventilation (MV) support, intensive care unit (ICU), and hospital length of stay (LOS) and in-hospital mortali...

journal_title：Drug and chemical toxicology

authors： Abdel Hamid WG,Mansour W,Nafea OE

更新日期：2021-01-12 00:00:00

abstract：:The effects of various levels of dietary iron on hepatic lipid peroxidation (malondialdehyde [MDA] content), reduced glutathione (GSH) and GSH peroxidase (GSH-PX) activity as well as liver and body weights of female rats following TCDD administration were examined. Rats were fed diets containing deficient (6 ppm), nor...

journal_title：Drug and chemical toxicology

authors： al-Turk WA,Shara MA,Mohammadpour H,Stohs SJ

更新日期：1988-01-01 00:00:00

abstract：:This study assessed possible adverse immunological effects of trans-1,2-dichloroethylene (DCE) on random-bred CD-1 mice following 14 and 90 days of exposure. A 14-day range-finding study was performed on male mice by gavage at doses 1/10 and 1/100 the LD50 (210 and 21 mg/kg). No alterations in either humoral or cell-m...

journal_title：Drug and chemical toxicology

authors： Shopp GM Jr,Sanders VM,White KL Jr,Munson AE

更新日期：1985-01-01 00:00:00

abstract：:Exposure to aldehydes represents potential risks to human and animal health. Cyclic aldehydes such as benzaldehyde, 2-furaldehyde, and paraldehyde were found to induce formation of stable DNA-protein cross-links (DPXs) in cultured human lymphoma cells. A relationship between increased cytotoxicity and DPX formation wa...

journal_title：Drug and chemical toxicology

authors： Kuykendall JR,Jarvi EJ,Finley BL,Paustenbach DJ

更新日期：2007-01-01 00:00:00

abstract：:The relationship between lead concentration in the dry film of lead based paints applied to steel bulkheads aboard ship, the lead concentration found in the air when the paint is removed by mechanical means, and blood lead concentrations of workers involved in lead based paint removal has not been well characterized. ...

journal_title：Drug and chemical toxicology

authors： Alexander WK,Carpenter RL,Kimmel EC

更新日期：1999-02-01 00:00:00

abstract：:The teratogenicity of p-tert-butylphenol formaldehyde resin, novolak type, (PTBP-FR) was examined in Wistar rats. Pregnant rats were fed diets containing 0, 2.5, 5 or 10% of PTBP-FR ad libitum from day 6 to day 15 of pregnancy. Maternal toxicity, as evidenced by a decreased maternal body weight gain and food consumpti...

journal_title：Drug and chemical toxicology

authors： Itami T,Ema M,Kawasaki H

更新日期：1993-01-01 00:00:00

abstract：:The antigenotoxic activity of glucosamine (GlcN) and N-acetylglucosamine (GlcNAc) in human peripheral lymphocytes exposed to oxidative stress was investigated. Human lymphocytes were treated with different concentrations of these aminosugars (0, 2.5, 5, 10, 20 and 40 mM) and 25 µM H2O2 simultaneously and evaluated by ...

journal_title：Drug and chemical toxicology

authors： Jamialahmadi K,Soltani F,Nabavi Fard M,Behravan J,Mosaffa F

更新日期：2014-10-01 00:00:00

abstract：:2-Amino-3,5-dicyano-4-o-chlorophenyl-6-ethoxypyridine (ACCPE) is a water soluble compound formed during the alkaline treatment of the alcoholic liquor in the production of 2-chlorobenzylidene malononitrile (CS). The acute toxicity and primary irritancy of ACCPE and CS were investigated and compared. Both perorally and...

journal_title：Drug and chemical toxicology

authors： Ballantyne B

更新日期：1985-01-01 00:00:00

abstract：:Toxic fungal metabolites - mycotoxins - cause poisonings after consumption of contaminated food commodities. The most probable intoxications are connected with eating poorly stored food or inhaling of moldy dust. One of the effective ways to protect people against mycotoxins is timely detection. Several methods such a...

journal_title：Drug and chemical toxicology

authors： Pohanka M,Jun D,Kuca K

更新日期：2007-01-01 00:00:00

abstract：:Methyl 2,2-difluoromalonyl fluoride (MMF) is highly toxic by inhalation producing mortality in rats exposed for 4 hours to 0.55 mg/L. Repeated inhalation exposures of rats to 0.009 mg/L produced irritation but no other signs of a toxic response. Mortality was encountered following repeated exposures to 0.066 mg/L. ...

journal_title：Drug and chemical toxicology

authors： Kennedy GL Jr,Burgess BA,Chen HC

更新日期：1988-06-01 00:00:00

abstract：CONTEXT:Heparin-binding epidermal growth factor like growth factor (HB-EGF) is an emerging therapeutic for the regeneration of the tympanic membrane (TM). OBJECTIVE:Our aim was to determine whether the doses of HB-EGF delivered in a sustained release hydrogel into a middle ear mouse model, would be measurable in the s...

journal_title：Drug and chemical toxicology

authors： Santa Maria PL,Kim S,Yang YP

更新日期：2016-10-01 00:00:00

abstract：:The responses of atria isolated from four groups of rats: (a) control (air/H2O) and test animals treated with (b) 5 PPM nitrogen dioxide NO2 for 72 hours, (NO2/H2O), (c) 10% ethanol (ET) in water for 13 days, (air/ET), or (d) combination of NO2 and ET (NO2/ET). Isolated atria were tested with norepinephrine and dose r...

journal_title：Drug and chemical toxicology

authors： Early J,McGrath J,Messiha FS,Hughes MJ

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:The present study was undertaken to explore the effects of monensin, a potent Golgi disturbing agent on male fertility. METHODS:Male Wistar rats were administered monensin at the dose levels of 2.5, 5, and 10 mg/kg b wt. Animals were sacrificed after 67 days of the treatment. The activities of lactate dehydr...

journal_title：Drug and chemical toxicology

authors： Singh M,Kalla NR,Sanyal SN

更新日期：2014-10-01 00:00:00

abstract：:Azaperone was evaluated for its mutagenic potential by the Salmonella/microsome test. No mutagenic activity towards six S. typhimurium strains could be evidenced with azaperone at doses up to 2,000 micrograms/plate, either without or with metabolic activation at usual test conditions. Higher concentrations of liver po...

journal_title：Drug and chemical toxicology

authors： Duverger-van Bogaert M,Vanparys P,de Meester C,Marsboom R

更新日期：1987-01-01 00:00:00

abstract：:Copper (Cu) is a heavy metal with the ability to induce, at high levels, neurobehavioral alterations, and oxidative stress (OS). On the other hand, melatonin (Mel) is a neurohormone that protects neurons from OS and has a modulatory effect on several behavioral processes. The present experiment was aimed to examine th...

journal_title：Drug and chemical toxicology

authors： Lamtai M,Zghari O,Azirar S,Ouakki S,Mesfioui A,El Hessni A,Berkiks I,Marmouzi I,Ouichou A

更新日期：2021-01-07 00:00:00

abstract：:Studies have demonstrated that benzodiazepine compounds are effective at antagonizing seizure activity produced by the organophosphate (OP) cholinesterase inhibitor soman. In this present study we have investigated the pharmacokinetics of midazolam and its associated effects on electroencephalographic (EEG) activity f...

journal_title：Drug and chemical toxicology

authors： Capacio BR,Byers CE,Merk KA,Smith JR,McDonough JH

更新日期：2004-05-01 00:00:00

abstract：:The 24-h incorporation of 59Fe into circulating red blood cells, bone marrow, urine, liver, spleen, and skeletal muscle was measured in splenectomized and sham-splenectomized rats which had received a daily, oral dose of gossypol acetic acid (20 mg GAA/kg body wt) for 91 days. A significant decrease in total body weig...

journal_title：Drug and chemical toxicology

authors： Tone JN,Jensen DR

更新日期：1985-01-01 00:00:00

abstract：:A toxicity Evaluation of DDT and dieldrin was conducted using Japanese Quail. The effects of feeding DDT (5 and 50 ppm of diet) and dieldrin (0.1 and 1.0 ppm of diet) in this four generation study (parental, F1, F2 and F3) were examined in terms of growth, viability, and/or reproduction of offspring. Ten groups (inclu...

journal_title：Drug and chemical toxicology

authors： Shellenberger TE

更新日期：1978-01-01 00:00:00

abstract：:The cytotoxic effect of caffeine on heart cells was evaluated in primary cultures of rat heart muscle (M) and endothelioid (E) cells. The cultures were exposed to 5, 10, or 20 mM caffeine for 6, 12, or 24 hours. As an index of cytotoxicity produced by the treatments, in situ changes in mitochondrial membrane fragility...

journal_title：Drug and chemical toxicology

authors： Acosta D,Anuforo D

更新日期：1977-01-01 00:00:00

abstract：:Doxorubicin (DOX), a highly active chemotherapeutic drug, faces limitations in clinical application due to severe cardiotoxic effects (mainly through increased oxidative stress). Therefore, its effect is exacerbated in subjects with ischemic heart disease. We have recently reported that saffron extract (SAF), a natura...

journal_title：Drug and chemical toxicology

authors： Chahine N,Nader M,Duca L,Martiny L,Chahine R

更新日期：2016-01-01 00:00:00

abstract：:Concerns that chemical warfare (CW) agents themselves or in combination with other chemicals may cause long-term damage to nerve and muscle are reviewed and discussed. Experiments on mice and hens underway with agent GA and pyridostigmine bromide (PB) and their effects (either separately or together) are presented. ...

journal_title：Drug and chemical toxicology

authors： Wilson BW,Henderson JD,Spencer PS

更新日期：1998-01-01 00:00:00

abstract：:The potential maternal and developmental toxicity of cyclododecatriene (CDDT) was assessed in rats. Groups of 22 time-mated female Crl:CD (SD) BR rats were exposed by inhalation (whole-body, 6 h/day) to either 0 (control), 10, 25, or 67 ppm CDDT over days 6-20 of gestation (days 6-20 G); the day of copulation plug det...

journal_title：Drug and chemical toxicology

authors： Munley SM,Kelly DP,Kennedy GL Jr

更新日期：2003-08-01 00:00:00

abstract：:As a measure of glutathione (GSH) conjugation, urinary, fecal and biliary excretion of thioethers and hepatic GSH content were measured in rhesus monkeys following administration of single doses of naphthalene and diethylmaleate (DEM). Naphthalene had little or no effect on hepatic GSH content and the excretion of thi...

journal_title：Drug and chemical toxicology

authors： Rozman K,Summer KH,Rozman T,Greim H

更新日期：1982-01-01 00:00:00

abstract：:Adult male Sprague Dawley rats were gavaged with 2,4-dinitrotoluene (2,4-DNT) dissolved in corn oil at 0, 60, 180, or 240 mg/kg/day for five days. A single oral dose (0.5 mg/kg) of triethylenemelamine was used as a positive control. Induction of dominant lethal events was scored on the basis of early fetal deaths. At ...

journal_title：Drug and chemical toxicology

authors： Lane RW,Simon GS,Dougherty RW,Egle JL Jr,Borzelleca JF

更新日期：1985-01-01 00:00:00

abstract：:Adriamycin (ADR) causes morphological and functional alterations in mitochondrial structure in the heart. The study's aim was to determine whether there is a protective effect of selenium (Se) on ADR-induced cardiac damage. Rats were divided into four groups: The first group was injected saline intraperitoneally (i.p....

journal_title：Drug and chemical toxicology

authors： Dursun N,Taşkın E,Yerer Aycan MB,Sahin L

更新日期：2011-04-01 00:00:00