Abstract:
:Exposure to aldehydes represents potential risks to human and animal health. Cyclic aldehydes such as benzaldehyde, 2-furaldehyde, and paraldehyde were found to induce formation of stable DNA-protein cross-links (DPXs) in cultured human lymphoma cells. A relationship between increased cytotoxicity and DPX formation was observed with each aldehyde. Paraldehyde is a sedative drug used predominately in treatment of ethanol withdrawal. Paraldehyde was the most potent cross-linking aldehyde studied, yet least cytotoxic. Although DPX formation by aliphatic aldehydes is well-known, this study confirms the potential for cyclic aldehydes to cause formation of DPXs in cultured cells at therapeutically relevant doses.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Kuykendall JR,Jarvi EJ,Finley BL,Paustenbach DJdoi
10.1080/01480540601017603subject
Has Abstractpub_date
2007-01-01 00:00:00pages
1-16issue
1eissn
0148-0545issn
1525-6014pii
769425026journal_volume
30pub_type
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