Effect of cocaine on mitochondrial electron transport chain evaluated in primary cultures of neonatal rat myocardial cells and in isolated mitochondrial preparations.

Abstract:

:Cardiotoxicity is commonly associated with cocaine abuse. Previous studies have indicated that cocaine alters myocardial mitochondrial function. This study was undertaken to investigate the effect of cocaine on activity of the mitochondrial electron transport chain in cultures of neonatal rat cardiomyocytes and in isolated myocardial mitochondria. Cocaine concentrations (10(-5) to 10(-3) M) were used, and these concentrations have been reported in human cocaine users and are within a similar range of cocaine concentrations used in studies in vivo. After 24 hr treatment of cocaine, there was a slight increase in lactate dehydrogenase leakage in the cells treated with cocaine (10(-3) M). Reduction of tetrazolium compounds, neotetrazolium chloride (NTC) and triphenyltetrazolium chloride (TTC) was analyzed in intact cells to assess activity of the mitochondrial electron transport chain. Cocaine (10(-3) M) did not significantly change TTC and NTC reduction. In isolated mitochondria, cocaine (10(-3) M) significantly inhibited glutamate/malate-mediated respiration. These data suggest that cocaine at high concentrations may inhibit complex I of the mitochondrial electron transport chain of myocardial cells.

journal_name

Drug Chem Toxicol

authors

Yuan C,Acosta D Jr

doi

10.1081/dct-100100119

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

339-48

issue

2

eissn

0148-0545

issn

1525-6014

journal_volume

23

pub_type

杂志文章
  • Coffee mitigates cyclophosphamide-induced genotoxic damage in Drosophila melanogaster germ cells.

    abstract::In the present study, coffee (CF) was evaluated for its protective effects against genotoxic damage and oxidative stress induced by the chemotherapeutic drug, cyclophosphamide (CPH). The sex-linked recessive lethal (SLRL) test was employed to study the induction of mutations in the larvae as well as in all the success...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2018.1438457

    authors: Nagpal I,Abraham SK

    更新日期:2019-09-01 00:00:00

  • Management site and level of health care for cannabis- and synthetic cannabinoid-related poison control center cases involving older adults, 2016-2019.

    abstract::Increasing numbers of older adults use cannabis and cannabis-derived products that can have adverse effects. This study examined management site and level of healthcare services for older adult poison control center cases involving cannabis products. Using the American Association of Poison Control Centers' (PCC) Nati...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2020.1868494

    authors: Choi NG,DiNitto DM,Marti CN,Baker SD

    更新日期:2021-01-07 00:00:00

  • Toxic effect of acetamiprid on Rana ridibunda sciatic nerve (electrophysiological and histopathological potential).

    abstract::In this study, the effects of a neonicotinoid insecticide acetamiprid on the sciatic nerve of Rana ridibunda were investigated by using electrophysiological and histological methods. A total of 35 preparations of sciatic nerve isolated from 35 frogs (Nervus ischiadicus) were used in the experiments. Experiments were d...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2018.1442475

    authors: Çamlıca Y,Bediz SC,Çömelekoğlu Ü,Yilmaz ŞN

    更新日期:2019-05-01 00:00:00

  • Inhibitory effect of chlormethiazole on the toxicokinetics of diethylnitrosamine in normal and hepatofibrotic rats.

    abstract::The effect of chlormethiazole (CMZ) at single and multiple doses on the toxicokinetics of diethylnitrosamine (DEN) was investigated in normal rats and those with DEN-induced liver fibrosis. Twelve rats were treated with DEN (50 mg/kg) alone and in combination with a single dose of CMZ (10, 50, or 100 mg/kg) by intrape...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2018.1455204

    authors: Wang G,Xiao K,Gao J,Jiang S,Wang S,Weng S,Xu C,Wang T,Qiao HL

    更新日期:2019-11-01 00:00:00

  • Toxicological study of pyridoxal isonicotinoyl hydrazone: acute and subchronic toxicity.

    abstract::Pyridoxal isonicotinoyl hydrazone (PIH) is a highly effective iron chelator. Acute toxicity testing was performed in mice and rats of both sexes, with 10 mice or rats/sex/group. The LD50 values of PIH in both species were 5 and 1 g/kg given orally and intraperitoneally, respectively. Microscopic examination of tissues...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480549109011641

    authors: Sookvanichsilp N,Nakornchai S,Weerapradist W

    更新日期:1991-01-01 00:00:00

  • Contact sensitivity to selected acrylate compounds in B6C3F1 mice: relative potency, cross reactivity, and comparison of test methods.

    abstract::Given the increasing prevalence of occupational sensitization to acrylate compounds, n-butyl acrylate (BAC), ethyl acrylate (EAC), and trimethylol propane triacrylate (TMT) were recommended by the National Toxicology Program for hypersensitivity testing in female B6C3F1 mice. The objectives of these studies were to de...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480549909042528

    authors: Hayes BB,Meade BJ

    更新日期:1999-08-01 00:00:00

  • Cadmium induced changes in gluconeogenic enzymes in rat kidney and liver.

    abstract::Male Sprague-Dawley rats were administered cadmium chloride 0, 50, 100, 150 and 200 ppm for 30 days. At the end of the treatments, the body weight gains, serum glucose, serum protein, serum glutamic oxalacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were determined. Renal and hepatic key glu...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480548009030129

    authors: Chapatwala KD,Rajanna B,Desaiah D

    更新日期:1980-01-01 00:00:00

  • Environmental and occupational exposure of metals and their role in male reproductive functions.

    abstract::This review summarizes the effects of more than 20 metals that, research has indicated, may influence male reproductive health. Though males lack an apparent, easily measurable reproductive cycle, progress has been made in evaluating tests to identify chemical hazards and estimate reproductive health risks. Some agent...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章,评审

    doi:10.3109/01480545.2012.710631

    authors: Sengupta P

    更新日期:2013-07-01 00:00:00

  • β-cypermethrin-induced acute neurotoxicity in the cerebral cortex of mice.

    abstract::A Type II pyrethroid pesticide β-cypermethrin is widely used in agriculture and domestic applications for pest control. However, the effect of β-cypermethrin on the glutamate neurotransmitter has not been well-documented. In the current study, mice were treated with 20, 40, or 80 mg/kg β-cypermethrin by a single oral ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480545.2014.900072

    authors: Cao D,Chen N,Zhu C,Zhao Y,Liu L,Yang J,An L

    更新日期:2015-01-01 00:00:00

  • Clinical effects of low-level exposures to chemical warfare agents in mice and chickens.

    abstract::Concerns that chemical warfare (CW) agents themselves or in combination with other chemicals may cause long-term damage to nerve and muscle are reviewed and discussed. Experiments on mice and hens underway with agent GA and pyridostigmine bromide (PB) and their effects (either separately or together) are presented. ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480549809007410

    authors: Wilson BW,Henderson JD,Spencer PS

    更新日期:1998-01-01 00:00:00

  • Ameliorative influence of Urtica dioica L against cisplatin-induced toxicity in mice bearing Ehrlich ascites carcinoma.

    abstract::Cisplatin (CP) is a widely used cytotoxic agent against cancer, and high doses of CP have been known to cause nephrotoxicity and hepatotoxicity. Some reports claim that antioxidants can reduce CP-induced toxicity. This study investigated the hepatoprotective, nephroprotective, and antioxidant activity of Urtica dioica...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480545.2011.598531

    authors: Özkol H,Musa D,Tuluce Y,Koyuncu I

    更新日期:2012-07-01 00:00:00

  • Immunosuppression and cancer: the ciclosporin case.

    abstract::Experimental and clinical data relevant for the evaluation of the carcinogenic potential of the immunosuppressant ciclosporin are reviewed. Ciclosporin binds reversibly to the cytosolic receptor protein ciclophilin. Ciclophilin is likely involved in the blockade of lymphocyte activation-induced gene transcription of v...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章,评审

    doi:10.3109/01480549209032293

    authors: Ryffel B,Mihatsch MJ,Fisher GL

    更新日期:1992-01-01 00:00:00

  • Modulation of fenthion-induced oxidative effects by BSO in the liver of Cyprinus carpio L.

    abstract::The objective of the present study was to evaluate the oxidative stress potential of low-level organophosphate fenthion exposure with the modulatory effect of buthionine sulfoximine in the liver of Cyprinus carpio L. The fish were exposed to 20% of 96-hour LC(50) of fenthion for 24 and 96 hours. Total and oxidized glu...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480540802171233

    authors: Uner N,Sevgiler Y,Piner P,Durmaz H

    更新日期:2008-01-01 00:00:00

  • A fourteen-day repeated dose oral toxicity study of APFO in rats.

    abstract::Ammonium perfluoroocanoate (APFO) was repeatedly administered orally to male Crj:CD(SD)IGS rats for 14 days. Doses of APFO were 0, 0.5, 5, and 50 mg/kg. Significant increases and increasing tendencies in absolute/relative weight of the liver and no change in weight of the spleen were observed in all groups. Although i...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480540600653143

    authors: Iwai H,Yamashita K

    更新日期:2006-01-01 00:00:00

  • Ten and ninety-day toxicity studies of chloropicrin in Sprague-Dawley rats.

    abstract::The toxicity of chloropicrin (CP) was assessed following its administration to rats via oral gavage for either 10 or 90 consecutive days at dose levels of 10, 20, 40, and 80 mg/kg and 2, 8 and 32 mg/kg, respectively. Control rats received corn oil at a dose of 1.0 ml/kg. Toxicological observations included organ and b...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480549409014306

    authors: Condie LW,Daniel FB,Olson GR,Robinson M

    更新日期:1994-01-01 00:00:00

  • Carcinogenesis: basic principles.

    abstract::Many steps are required to convert a normal cell into a cancerous one. The cancer cell must be able to multiply under conditions that a normal cell would not and to invade surrounding tissue and spread throughout the body. Both genetic changes, such as activation of oncogenes or inactivation of tumor suppressor genes,...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章,评审

    doi:10.3109/01480549608998231

    authors: Couch DB

    更新日期:1996-08-01 00:00:00

  • Neuro-protective effects of nano-formulated hesperetin in a traumatic brain injury model of Danio rerio.

    abstract::Understanding the mechanism behind neuronal regeneration is critical for treating ischemic stroke and traumatic brain injury. The presence of neural stem cells in and around the sub-ventricular zone of human and also in zebrafish is evidenced. In this current study, the neuro-protective potential of nano-formulated he...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2020.1722690

    authors: Paramita P,Sethu SN,Subhapradha N,Ragavan V,Ilangovan R,Balakrishnan A,Srinivasan N,Murugesan R,Moorthi A

    更新日期:2020-02-12 00:00:00

  • Assessment of antimutagenic action of Celtis glabrata Steven ex Planch. (Cannabaceae) extracts against base pair exchange and frame shift mutations on Salmonella typhimurium TA98 and TA100 strains by Ames test.

    abstract:CONTEXT:Celtis glabrata is used in Turkey for the treatment of various health disorders. OBJECTIVE:The acetone, chloroform, ethanol, and methanol extracts of C. glabrata leaf, fruit, and seed were investigated to evaluate their antimutagenic activities. MATERIAL AND METHODS:The antimutagenicity of these extracts was ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480545.2015.1121273

    authors: Akin D,Durak Y,Uysal A,Gunes E,Aladag MO

    更新日期:2016-01-01 00:00:00

  • The beneficial effects of antioxidants combination on cardiac injury induced by tetrachloromethane.

    abstract::The purpose of this research was to evaluate the efficacy of carsil (CAR) either alone or in combination with α-tocopherol (α-TOCO) and/or turmeric (TUMR) against tetrachloromethane (TCM)-induced cardiomyocyte injury in rats. Administration of CAR either alone or in combination with α-TOCO and/or TUMR post-TCM injecti...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2020.1831012

    authors: Alshanwani AR,Faddah LM,Hagar H,Alhusaini AM,Shaheen S,Mohammad RA,Alharbi FMB,AlHarthii A,Badr AM

    更新日期:2020-10-15 00:00:00

  • A collection of guinea pig sensitization test results--grouped by chemical class.

    abstract::Various chemical groups were evaluated for their skin sensitization potential in the guinea pig. In general, amines, acetanilides, pyridines, piperidines, and sulfones were positive in the guinea pig test. Since these tests were done over a period of years, any further structural-related correlations or predictions sh...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480548109017825

    authors: Rao KS,Betso JE,Olson KJ

    更新日期:1981-01-01 00:00:00

  • Pharmacologic and toxicologic profile of chymopapain B (Chemolase).

    abstract::The median lethal dose (LD50) of chymopapain B in mice was 82 mg/kg (22,000 units/kg) with 95% confidence limits of 75-90 mg/kg (20, 122-24, 146 units/kg) and in rats 92 (24,683 units/kg) with 95% confidence limits of 83-102 mg/kg (22,268-27, 366 units/kg). The mechanism of toxicity was hemorrhage due to destruction o...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480548409035110

    authors: Simmons JW,Upman PJ,Stavinoha WB

    更新日期:1984-01-01 00:00:00

  • Blood acetaldehyde levels in alcohol-dosed rats after treatment with ANIT, ANTU, dithiocarbamate derivatives, or cyanamide.

    abstract::In adult female Wistar rats, pretreated by gavage with two doses - 16 or 256 mumol/kg - of cyanamide, TMTD (tetramethylthiuram disulfide), TMTM (tetramethylthiuram monosulfide), Ziram or Zineb at 90 min or 18 h before administration of 2 g of ethanol/kg i.p., the blood acetaldehyde levels were significantly increased ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480548309082713

    authors: García de Torres G,Römer KG,Torres Alanis O,Freundt KJ

    更新日期:1983-01-01 00:00:00

  • Sublethal effects of organophosphate diazinon on the brain of Cyprinus carpio.

    abstract::Effects of diazinon, at different concentrations and exposure times, were investigated in freshwater fish, Cyprinus carpio, to elucidate the possible mode of action on lipid peroxidation together with the inhibitory effect of diazinon on acetylcholinesterase activity and changes in tissue protein levels. Cholinesteras...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480540500408622

    authors: Ozcan Oruç E,Uner N,Sevgiler Y,Usta D,Durmaz H

    更新日期:2006-01-01 00:00:00

  • The application of the fluoride reactivation process to the detection of sarin and soman nerve agent exposures in biological samples.

    abstract::The fluoride reactivation process was evaluated for measuring the level of sarin or soman nerve agents reactivated from substrates in plasma and tissue from in vivo exposed guinea pigs (Cava porcellus), in blood from in vivo exposed rhesus monkeys (Macaca mulatta), and in spiked human plasma and purified human albumin...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1081/dct-120027901

    authors: Adams TK,Capacio BR,Smith JR,Whalley CE,Korte WD

    更新日期:2004-02-01 00:00:00

  • Acute, subchronic, and mutagenicity studies with norbornene fluoroalcohol.

    abstract::The object of this study was to evaluate the toxicity of norbornene fluoroalcohol (NBFOH), which is used as an intermediate in the production of fluorinated monomers and polymers. NBFOH was evaluated for acute oral, dermal, and inhalation toxicity, dermal sensitization using the Local Lymph Node Assay (LLNA), mutagene...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480540500262680

    authors: DeLorme MP,Ladics GS,Donner EM,Wagner VO 3rd,Finlay C,Frame SR,Everds NE,Loveless SE

    更新日期:2005-01-01 00:00:00

  • Pefloxacin induced changes in serotonergic innervation and mast cell number in rat salivary glands.

    abstract::Pefloxacin is a second-generation fluoroquinolone antibiotic. Besides its advantageous characteristics, side effects including the hypofunction of salivary glands, decreased saliva production, and peripheral neuropathy were observed during the administration of pefloxacin. The aim of this study was to investigate the ...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2018.1508217

    authors: Skopkó BE,Deák Á,Matesz C,Kelentey B,Bácskai T

    更新日期:2020-09-01 00:00:00

  • Acute toxicity and primary irritancy of 2-amino-3,5-dicyano-4-o-chlorophenyl-6-ethoxypyridine.

    abstract::2-Amino-3,5-dicyano-4-o-chlorophenyl-6-ethoxypyridine (ACCPE) is a water soluble compound formed during the alkaline treatment of the alcoholic liquor in the production of 2-chlorobenzylidene malononitrile (CS). The acute toxicity and primary irritancy of ACCPE and CS were investigated and compared. Both perorally and...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480548508999168

    authors: Ballantyne B

    更新日期:1985-01-01 00:00:00

  • Protective effects of extracts of lichen Dirinaria consimilis (Stirton) D.D. Awasthi in bifenthrin- and diazinon-induced oxidative stress in rat erythrocytes in vitro.

    abstract::The intoxication of insecticides such as bifenthrin and diazinon has been reported to generate free radicals, and thereby alter the antioxidant defense system in erythrocytes. The present study is aimed to investigate the protective effects of acetone (DA) and methanolic (DM) extracts of lichen Dirinaria consimilis ag...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.1080/01480545.2020.1762632

    authors: Tatipamula VB,Kukavica B

    更新日期:2020-05-12 00:00:00

  • Captan metabolism in humans yields two biomarkers, tetrahydrophthalimide (THPI) and thiazolidine-2-thione-4-carboxylic acid (TTCA) in urine.

    abstract::Captan fungicide (N-(trichloromethylthio)-4-cyclohexene-1,2-dicarboximide) metabolism in two human volunteers rapidly yields THPI (tetrahydrophthalimide) and TTCA (thiazolidine-2-thione-4-carboxylic acid). The work was done to evaluate usefulness of TTCA and THPI as biomarkers of occupational exposure and to compare h...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480549309031997

    authors: Krieger RI,Thongsinthusak T

    更新日期:1993-01-01 00:00:00

  • Licofelone abolishes survival of carcinogenic fibroblasts by inducing apoptosis.

    abstract::Dual inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX) pathways of arachidonic acid metabolism prevent cancer development and induce apoptosis. One of the most promising compounds that blocks both of these pathways is licofelone. We questioned whether licofelone affects the survival and/or promotes apoptosis o...

    journal_title:Drug and chemical toxicology

    pub_type: 杂志文章

    doi:10.3109/01480545.2013.806525

    authors: Kabadere S,Kus G,Uyar R,Oztopcu-Vatan P

    更新日期:2014-01-01 00:00:00