Comparison of TGF-β, PDGF, and CTGF in hepatic fibrosis models using DMN, CCl4, and TAA.

abstract：:Fertilized hen eggs were topically applied with 2,4-Dichlorophenoxyacetic acid butyl ester (3.1 mg/egg) before starting incubation. During the incubation time 20% of the compound applied on eggs was lost by volatilization. At different incubation times (0, 1, 5, 10 and 15 days) the wash-off technique was applied to fe...

journal_title：Drug and chemical toxicology

authors： Castro de Cantarini SM,Evangelista de Duffard AM,Duffard RO

更新日期：1989-06-01 00:00:00

abstract：:The objective of this study was to determine if single/double strand DNA breaks could be induced by monocrotophos (organophosphorus pesticide) in mice in vivo using the comet assay. Mice were dosed orally with 0.046, 0.093, 0.186, 0.373 and 0.746 mg/kg body weight of monocrotophos, and the assay was performed on whole...

journal_title：Drug and chemical toxicology

authors： Mahboob M,Rahman MF,Danadevi K,Banu BS,Grover P

更新日期：2002-02-01 00:00:00

abstract：:Pefloxacin is a second-generation fluoroquinolone antibiotic. Besides its advantageous characteristics, side effects including the hypofunction of salivary glands, decreased saliva production, and peripheral neuropathy were observed during the administration of pefloxacin. The aim of this study was to investigate the ...

journal_title：Drug and chemical toxicology

authors： Skopkó BE,Deák Á,Matesz C,Kelentey B,Bácskai T

更新日期：2020-09-01 00:00:00

abstract：:In this study, the effects of a neonicotinoid insecticide acetamiprid on the sciatic nerve of Rana ridibunda were investigated by using electrophysiological and histological methods. A total of 35 preparations of sciatic nerve isolated from 35 frogs (Nervus ischiadicus) were used in the experiments. Experiments were d...

journal_title：Drug and chemical toxicology

authors： Çamlıca Y,Bediz SC,Çömelekoğlu Ü,Yilmaz ŞN

更新日期：2019-05-01 00:00:00

abstract：:Cisplatin (CP) is a widely used cytotoxic agent against cancer, and high doses of CP have been known to cause nephrotoxicity and hepatotoxicity. Some reports claim that antioxidants can reduce CP-induced toxicity. This study investigated the hepatoprotective, nephroprotective, and antioxidant activity of Urtica dioica...

journal_title：Drug and chemical toxicology

authors： Özkol H,Musa D,Tuluce Y,Koyuncu I

更新日期：2012-07-01 00:00:00

abstract：:The toxicity of etephon and maleic hydrazide, used as plant growth regulators in agriculture, were reported as low in mammals in previous studies. However, in vitro cytotoxicity studies in mammalian cells are currently missing to understand their toxicity at molecular level. In the current study, the cytotoxicity of t...

journal_title：Drug and chemical toxicology

authors： Yurdakok B,Baydan E,Okur H,Gurcan IS

更新日期：2014-10-01 00:00:00

abstract：:The purpose of this study was to assess the compatibility, in terms of red blood cell acetylcholinesterase (AChE) inhibition, of ondansetron (OND; a 5-hydroxytryptamine subtype-3 receptor antagonist) with the organophosphorus pretreatment compound pyridostigmine (PYR) after simultaneous oral (p.o.) administration to g...

journal_title：Drug and chemical toxicology

authors： Capacio BR,Byers CE,Anderson DR,Matthews RL,Brown DE

更新日期：1996-01-01 00:00:00

abstract：:Increasing numbers of older adults use cannabis and cannabis-derived products that can have adverse effects. This study examined management site and level of healthcare services for older adult poison control center cases involving cannabis products. Using the American Association of Poison Control Centers' (PCC) Nati...

journal_title：Drug and chemical toxicology

authors： Choi NG,DiNitto DM,Marti CN,Baker SD

更新日期：2021-01-07 00:00:00

abstract：:The genotoxic effect of CBZ has been investigated in few studies. There is little evidence linking carbamazepine (CBZ) with any genotoxic effects, particularly in vitro micronucleus test using cytogenesis-block technique. In this study, the genotoxicity of the antiepileptic drug, carbamazepine, was tested using cytoki...

journal_title：Drug and chemical toxicology

authors： Celik A

更新日期：2006-01-01 00:00:00

abstract：:Amiodarone is a high effectiveness anti-arrhythmia agent which is able to induce pulmonary fibrosis. Many studies have shown that the epithelial-mesenchymal transition (EMT) was a significant process in pulmonary fibrosis. So far, there are no studies about whether EMT was associated with amiodarone-induced pulmonary ...

journal_title：Drug and chemical toxicology

authors： Weng J,Chen H,Wu H,Tu M,Wang Z,Chen D,Wang Z,Chen C

更新日期：2020-07-01 00:00:00

abstract：:Three trials involving 184 male Sprague Dawley rats were conducted to identify the biologically active fraction of endophyte-infected tall fescue seed. In trial 1, seed infected (greater than 95%) with the endophytic fungus Acremonium coenophialum and shown to be toxic to cattle, was serially extracted with hexane, et...

journal_title：Drug and chemical toxicology

authors： Jackson JA,Hemken RW,Bush LP,Boling JA,Siegel MR,Zavos PM

更新日期：1987-01-01 00:00:00

abstract：:The in vitro effect of methyl mercury (MM) and lead (Pb) on N-methyl-D-aspartate (NMDA)-specific glutamate receptor binding in neonatal (10 days old) and adult rat brain was investigated. The cerebral cortex was isolated from the neonatal and adult male Sprague-Dawley rats and the synaptic plasma membranes were prepar...

journal_title：Drug and chemical toxicology

authors： Rajanna B,Rajanna S,Hall E,Yallapragada PR

更新日期：1997-02-01 00:00:00

abstract：:The relationship between lead concentration in the dry film of lead based paints applied to steel bulkheads aboard ship, the lead concentration found in the air when the paint is removed by mechanical means, and blood lead concentrations of workers involved in lead based paint removal has not been well characterized. ...

journal_title：Drug and chemical toxicology

authors： Alexander WK,Carpenter RL,Kimmel EC

更新日期：1999-02-01 00:00:00

abstract：:This study evaluated the tissue distribution of total radioactivity in male albino, male pigmented, and time-mated female albino rats after oral administration of a single dose of [¹⁴C]-bilastine (20 mg/kg). Although only 1 animal was analyzed at each time point, there were apparent differences in bilastine distributi...

journal_title：Drug and chemical toxicology

authors： Lucero ML,Patterson AB

更新日期：2012-06-01 00:00:00

abstract：:The effect of chlormethiazole (CMZ) at single and multiple doses on the toxicokinetics of diethylnitrosamine (DEN) was investigated in normal rats and those with DEN-induced liver fibrosis. Twelve rats were treated with DEN (50 mg/kg) alone and in combination with a single dose of CMZ (10, 50, or 100 mg/kg) by intrape...

journal_title：Drug and chemical toxicology

authors： Wang G,Xiao K,Gao J,Jiang S,Wang S,Weng S,Xu C,Wang T,Qiao HL

更新日期：2019-11-01 00:00:00

abstract：CONTEXT:Caffeine is the most widely consumed nervous stimulant that induces oxidative-mediated apoptosis and cell cycle arrest in neural cells. Due to low toxicity, high accumulation in neural cells, reduction of the free fatty acids and antioxidant property, l-carnitine (LC) is an interesting compound to be used in vi...

journal_title：Drug and chemical toxicology

authors： Bavari M,Tabandeh MR,Najafzadeh Varzi H,Bahramzadeh S

更新日期：2016-01-01 00:00:00

abstract：:The quantities of selenium, tar and nicotine present in mainstream (MS) and sidestream (SS) smoke of machine-smoked cigarettes was studied. The cigarettes were prepared from tobacco purposely cultured on fly ash-amended soil so as to increase its selenium concentration. Selenium concentration was found to be the same ...

journal_title：Drug and chemical toxicology

authors： Gutenmann WH,Lisk DJ,Shane BS,Hoffmann D,Adams JD

更新日期：1987-01-01 00:00:00

abstract：:Evidence suggests that the effect of heavy metals on neuroimmune cells lead to neurogenic inflammatory responses. In this study, immune cells [mast cells (MCs) and microglia] and pro-neuroinflammation cytokines (interleukin-1b and tumor necrosis factor-α) were assessed in the prefrontal lobe of rat brains exposed to t...

journal_title：Drug and chemical toxicology

authors： Afsordeh K,Sadeghi Y,Amini A,Namvarpour Z,Abdollahifar MA,Abbaszadeh HA,Aliaghaei A

更新日期：2019-03-01 00:00:00

abstract：:The present study enumerates the attenuating effects of curcumin and α-tocopherol against propoxur induced oxidative DNA damage in human peripheral blood mononuclear cells (PBMC). Cultured cells were isolated from peripheral blood of healthy volunteers, and were exposed to varying concentrations of propoxur (0-21 μg/m...

journal_title：Drug and chemical toxicology

authors： Ahmed T,Goel V,Banerjee BD

更新日期：2018-04-01 00:00:00

abstract：:Previous work has suggested that endogenous sulfhydryls, such as glutathione (GSH) and cysteine, are involved in the uptake and toxicity of HgCl2. To study this possibility, uptake and toxicity of synthesized Hg(SG)2, Hg(cysteinylglycine)2 [Hg(CYS-GLY)2] and Hg(CYS)2 were investigated in rabbit renal proximal tubule s...

journal_title：Drug and chemical toxicology

authors： Wei H,Qiu L,Divine KK,Ashbaugh MD,McIntyre LC Jr,Fernando Q,Gandolfi AJ

更新日期：1999-05-01 00:00:00

abstract：:Three alkyl diamines, which are by-products formed and separated during the production of hexamethylene diamine, have been tested, mostly for their acute toxicity. This paper reviews methodologies used and the results obtained from these three chemicals. All three tested [2-methyl-1,5-pentanediamine (2-MP), 1,3-diamin...

journal_title：Drug and chemical toxicology

authors： Kennedy GL Jr

更新日期：2007-01-01 00:00:00

abstract：:Many pharmaceuticals are administered to children and adults as sprays provided in nebulizers or metered-dose inhalers. Stress associated with possible eye irritation and injury attributable to exposure to vapors and particulates during the required safety testing procedures of such medicines is a potential confoundin...

journal_title：Drug and chemical toxicology

authors： Rothenberg SJ,Martin MM,Sherer KI,Parker RM,Dearlove GE,Christian MS

更新日期：1998-08-01 00:00:00

abstract：:Short-term lymphocyte cultures from human peripheral blood samples were incubated with various aliquots of the carbofuran pesticide. After 48 h of initiation and 24 h of exposure to the carbofuran pesticide aliquots, it was seen that carbofuran caused an increase in the frequency of chromosomal aberrations, and the in...

journal_title：Drug and chemical toxicology

authors： Naravaneni R,Jamil K

更新日期：2005-01-01 00:00:00

abstract：:Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids (DDAs) including aconitine (AC), mesaconitine (MAC), hypaco...

journal_title：Drug and chemical toxicology

authors： Ye Q,Liu H,Fang C,Liu Y,Liu X,Liu J,Zhang C,Zhang T,Peng C,Guo L

更新日期：2019-03-21 00:00:00

abstract：:The 24-h incorporation of 59Fe into circulating red blood cells, bone marrow, urine, liver, spleen, and skeletal muscle was measured in splenectomized and sham-splenectomized rats which had received a daily, oral dose of gossypol acetic acid (20 mg GAA/kg body wt) for 91 days. A significant decrease in total body weig...

journal_title：Drug and chemical toxicology

authors： Tone JN,Jensen DR

更新日期：1985-01-01 00:00:00

abstract：:The purposes of this study was to determine the toxicological effect of repeated intravenous administration of Activin A/BMP-2 chimera (AB204) in beagle dogs for a long period of four weeks and evaluate two-week recovery. AB204 was administered at doses of 0.08, 0.16, or 0.32 mg/kg/day to three male and three female b...

journal_title：Drug and chemical toxicology

authors： Han SH,Zheng GB,Lee JH

更新日期：2019-03-18 00:00:00

abstract：:Lavender and immortelle essential oils (EOs) are widely used to treat a spectrum of human conditions. The aim of this study was to investigate cyto/genotoxic effects of lavender and immortelle EOs using plant cells (Allium cepa) and human lymphocytes, as well as their antimicrobial potential using nine strains of bact...

journal_title：Drug and chemical toxicology

authors： Mesic A,Mahmutović-Dizdarević I,Tahirović E,Durmišević I,Eminovic I,Jerković-Mujkić A,Bešta-Gajević R

更新日期：2021-03-01 00:00:00

abstract：:Peroxysomicine A1, a novel potential anticancer compound induced cell death in established cell lines and in a primary culture of rat neonatal cardiomyocytes. Non-transformed cells are less sensitive to the compound than transformed cell lines. Fluorescent microscopy of dying cells stained with DNA-specific dyes revea...

journal_title：Drug and chemical toxicology

authors： Martinez FJ,Zeng GQ,Piñeyro A,Garza-Ocañas L,Tomei LD,Umansky SR

更新日期：2001-08-01 00:00:00

abstract：:The antioxidant and drug metabolizing potentials of Hibiscus anthocyanin extract in CCl(4)- induced oxidative damage of rat liver was investigated. Hibiscus anthocyanin extract effectively scavenge α-diphenyl-β-picrylhydrazyl (DPPH) radical, superoxide ion, and hydrogen peroxide. It produced a 92% scavenging effect of...

journal_title：Drug and chemical toxicology

authors： Ajiboye TO,Salawu NA,Yakubu MT,Oladiji AT,Akanji MA,Okogun JI

更新日期：2011-04-01 00:00:00

abstract：INTRODUCTION:Liver fibrosis is the excessive accumulation of extracellular matrix (ECM) proteins including collagen that occurs in most types of chronic liver diseases. This study aimed to investigate and compare the therapeutic efficacy of different magnesium (Mg)-containing supplements (formulations A, B, and C) on c...

journal_title：Drug and chemical toxicology

authors： El-Tantawy WH,Sabry D,Abd Al Haleem EN

更新日期：2017-01-01 00:00:00