Abstract:
:Peroxysomicine A1, a novel potential anticancer compound induced cell death in established cell lines and in a primary culture of rat neonatal cardiomyocytes. Non-transformed cells are less sensitive to the compound than transformed cell lines. Fluorescent microscopy of dying cells stained with DNA-specific dyes revealed chromatin condensation and nuclear fragmentation as well as membrane blebbing characteristic of apoptosis. Flow cytometry of cells treated with peroxysomicine A1, demonstrated appearance of cells containing less than 2C DNA, that indicated degradation of nuclear DNA, another hallmark of apoptotic cell death. Z-VAD, a nonspecific caspase inhibitor, prevented DNA fragmentation but not cell death registered by permeabilization of cell outer membrane. Peroxysomicine A1 also inhibited proliferation of various cell lines. Flow cytometry analysis showed significant accumulation of dividing cells in G2/M phases of cell cycle indicating, most likely delay in G2. These results provide initial insight into the mechanisms of action of peroxysomicine A1 and suggest that peroxysomicine A1 is a potent inhibitor of cell proliferation and inducer of apoptosis and may be a useful antineoplastic chemotherapeutic agent.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Martinez FJ,Zeng GQ,Piñeyro A,Garza-Ocañas L,Tomei LD,Umansky SRdoi
10.1081/dct-100103725subject
Has Abstractpub_date
2001-08-01 00:00:00pages
287-99issue
3eissn
0148-0545issn
1525-6014journal_volume
24pub_type
杂志文章abstract::This study was conducted to evaluate the potential reproductive toxicity of epichlorohydrin in a one-generation reproduction toxicity study in compliance with OECD Test Guideline 415. Twenty-four male and female rats per group were given epichlorohydrin by gavage at 0, 3.3, 10, and 30 mg/kg/day. Males were dosed for 1...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480541003734030
更新日期:2010-07-01 00:00:00
abstract::Transient global ischemia continues to be an important clinical problem with limited treatment options. The present study aimed to investigate the possible protective effects of celecoxib [a selective cyclooxygenase (COX-2) inhibitor] and N-omega-nitro-L-arginine methyl ester (L-NAME) [a nonselective nitric oxide synt...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2012.749270
更新日期:2013-10-01 00:00:00
abstract::The status of brain antioxidant enzymes and glutathione in methacrylonitrile (MeAN)-intoxicated Wistar rats was correlated with the levels of lipid peroxidation products. Optimum changes were observed 30 min and 60 min after oral administration of MeAN at dosages of 50 mg/kg body weight per day (0.25 LD50) and 100 mg/...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-52536
更新日期:2005-01-01 00:00:00
abstract::This study aimed at comparing the cytotoxicity of a new octenidine mouth rinse (MR) on gingival fibroblasts and epithelial cells using different established MRs. Octenidol (OCT), Chlorhexidine 0.2% (CHX), Meridol (MER), Oral B (OB), and control (PBS only) were used. Human primary gingival fibroblasts (HGFIBs) and huma...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2017.1337124
更新日期:2018-04-01 00:00:00
abstract::This study investigated the exposure of pyrethroids in the development of Alzheimer's type neurodegeneration by analyzing β- amyloid, tau and Glial Fibrillary Acidic Protein (GFAP) in adult Wistar rats. Forty adult Wistar rats (130-150 g) of both sexes were assigned into five groups (n = 8). Groups A-C were treated wi...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1778020
更新日期:2020-09-09 00:00:00
abstract::1-((2-methyl-4-[(2-methyl phenyl)azo] phenyl)azo)-2-naphthalenol (C.I. Solvent Red 24) was prepared having a 14C label on the methyl group of the central ring and was administered in suspension intra-tracheally to a male and a female rat. After 96 hours in metabolism cages, the animals were sacrificed and 14C counted ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480547909016034
更新日期:1979-01-01 00:00:00
abstract::The teratogenicity of p-tert-butylphenol formaldehyde resin, novolak type, (PTBP-FR) was examined in Wistar rats. Pregnant rats were fed diets containing 0, 2.5, 5 or 10% of PTBP-FR ad libitum from day 6 to day 15 of pregnancy. Maternal toxicity, as evidenced by a decreased maternal body weight gain and food consumpti...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549308998227
更新日期:1993-01-01 00:00:00
abstract::The present study was aimed at exploring the effect of monensin, an antibiotic carboxylic polyether ionophore specific for Na(+), on the structural, chemical, and physiological changes of the epididymal sperm of Wistar rats. Animals received monensin at the dose of 3.5 mg/kg body weight daily orally for 70 days, a tre...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2011.650174
更新日期:2013-01-01 00:00:00
abstract:CONTEXT:Withania somnifera (L) Dunal (Solanaceae) is an important traditional herbal medicine used for thousands of years and is considered as the Indian ginseng. Reports on the effect of Withania somnifera root (WSR) extract on the developing foetus of pregnant rats including mortality, structural abnormalities, chang...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2014.900073
更新日期:2015-01-01 00:00:00
abstract::The availability of tissue glutathione (GSH) appears to depend upon a balance between tissue concentrations, the rate of reactive metabolite formation and the re-synthesis of GSH. To test this hypothesis, diethyl maleate (DEM, 5.8 mmol/kg bw) was administered intraperitoneally to male and female mice, hamsters, rats a...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548408998263
更新日期:1984-01-01 00:00:00
abstract::The potential maternal and developmental toxicity of cyclododecatriene (CDDT) was assessed in rats. Groups of 22 time-mated female Crl:CD (SD) BR rats were exposed by inhalation (whole-body, 6 h/day) to either 0 (control), 10, 25, or 67 ppm CDDT over days 6-20 of gestation (days 6-20 G); the day of copulation plug det...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-120022649
更新日期:2003-08-01 00:00:00
abstract:INTRODUCTION:Liver fibrosis is the excessive accumulation of extracellular matrix (ECM) proteins including collagen that occurs in most types of chronic liver diseases. This study aimed to investigate and compare the therapeutic efficacy of different magnesium (Mg)-containing supplements (formulations A, B, and C) on c...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2016.1172083
更新日期:2017-01-01 00:00:00
abstract::In adult female Wistar rats, pretreated by gavage with two doses - 16 or 256 mumol/kg - of cyanamide, TMTD (tetramethylthiuram disulfide), TMTM (tetramethylthiuram monosulfide), Ziram or Zineb at 90 min or 18 h before administration of 2 g of ethanol/kg i.p., the blood acetaldehyde levels were significantly increased ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548309082713
更新日期:1983-01-01 00:00:00
abstract::We designed this study to identify the factors associated with time to successful weaning in mechanically ventilated organophosphate (OP)-poisoned patients as the primary outcomes while duration of mechanical ventilation (MV) support, intensive care unit (ICU), and hospital length of stay (LOS) and in-hospital mortali...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1870487
更新日期:2021-01-12 00:00:00
abstract::The effect of a novel phosphorothionate, the methyl ester of 2-butenoic acid-3-diethoxy phosphinothioyl (RPR-II) was studied on membrane bound target enzymes Acid (AcP) and Alkaline (AkP) Phosphatases in different tissues of male and female albino Wistar rats. Three sub-chronic doses 0.014 (low), 0.028 (medium) and 0....
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-100100131
更新日期:2000-08-01 00:00:00
abstract::Increasing numbers of older adults use cannabis and cannabis-derived products that can have adverse effects. This study examined management site and level of healthcare services for older adult poison control center cases involving cannabis products. Using the American Association of Poison Control Centers' (PCC) Nati...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1868494
更新日期:2021-01-07 00:00:00
abstract::In the present study, coffee (CF) was evaluated for its protective effects against genotoxic damage and oxidative stress induced by the chemotherapeutic drug, cyclophosphamide (CPH). The sex-linked recessive lethal (SLRL) test was employed to study the induction of mutations in the larvae as well as in all the success...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1438457
更新日期:2019-09-01 00:00:00
abstract::The effect of chlormethiazole (CMZ) at single and multiple doses on the toxicokinetics of diethylnitrosamine (DEN) was investigated in normal rats and those with DEN-induced liver fibrosis. Twelve rats were treated with DEN (50 mg/kg) alone and in combination with a single dose of CMZ (10, 50, or 100 mg/kg) by intrape...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1455204
更新日期:2019-11-01 00:00:00
abstract::Rotenone, an environmental toxin, triggers Parkinson's disease (PD)-like pathology through microglia-mediated neuronal death. The effects and molecular mechanisms of flavonoid luteolin against rotenone-induced toxicity was assessed in microglial BV2 cells. Cells were pretreated with luteolin (1-50 µM) for 12 h and the...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1504961
更新日期:2020-01-01 00:00:00
abstract::The developmental toxicities of five test compounds including carbon tetrachloride, urethane, phenacetin, parathion, and chloroform, were evaluated using Frog Embryo Teratogenesis Assay--Xenopus (FETAX), with minor modification. Post-isolation mixtures of differently-induced rat liver microsomes (phenobarbital- (PB), ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-100102605
更新日期:2001-05-01 00:00:00
abstract::The relationship between lead concentration in the dry film of lead based paints applied to steel bulkheads aboard ship, the lead concentration found in the air when the paint is removed by mechanical means, and blood lead concentrations of workers involved in lead based paint removal has not been well characterized. ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549909029723
更新日期:1999-02-01 00:00:00
abstract::Mercuric chloride was administered by three routes--subcutaneous, intramuscular and intraperitoneal to adult female Wistar rats. The peroxidative status of the cerebral cortex, cerebellum and the sciatic nerves were studied. Enhanced levels of lipid peroxides indicate progressing cellular injury. All the experimental ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549809017850
更新日期:1998-02-01 00:00:00
abstract::Chronic exposure to solar ultraviolet (UV) light induces photoaging in human skin. Our previous results have shown that areca nut procyanidins (ANPs) have antioxidant capacity and possess potential anti-inflammatory effects. Here, we aimed to investigate the effect of ANPs on UVB-induced photoaging. In the present stu...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1696813
更新日期:2019-12-02 00:00:00
abstract::Adverse reactions induced by Chinese herbal injections have been frequently reported. However, the precise causes of these adverse reactions are not yet fully understood. The aim of the present study was to determine the role of chlorogenic acid (a ubiquitous component of Chinese herbs) in the toxicity of Chinese herb...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480540903580055
更新日期:2010-10-01 00:00:00
abstract::Given the increasing prevalence of occupational sensitization to acrylate compounds, n-butyl acrylate (BAC), ethyl acrylate (EAC), and trimethylol propane triacrylate (TMT) were recommended by the National Toxicology Program for hypersensitivity testing in female B6C3F1 mice. The objectives of these studies were to de...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549909042528
更新日期:1999-08-01 00:00:00
abstract::Nephrotoxicity is a major limitation of adriamycin (ADR) chemotherapy. We hypothesized that administration of standardized aqueous bark extract of Gmelina arborea Roxb. (GA) (Family; Verbenaceae), a traditional therapeutic agent, may reduce the nephrotoxicity caused by ADR in Wistar rats. The dose-dependent nephroprot...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1811721
更新日期:2020-08-30 00:00:00
abstract::Azaperone was evaluated for its mutagenic potential by the Salmonella/microsome test. No mutagenic activity towards six S. typhimurium strains could be evidenced with azaperone at doses up to 2,000 micrograms/plate, either without or with metabolic activation at usual test conditions. Higher concentrations of liver po...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548709042990
更新日期:1987-01-01 00:00:00
abstract::The 24-h incorporation of 59Fe into circulating red blood cells, bone marrow, urine, liver, spleen, and skeletal muscle was measured in splenectomized and sham-splenectomized rats which had received a daily, oral dose of gossypol acetic acid (20 mg GAA/kg body wt) for 91 days. A significant decrease in total body weig...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548509011635
更新日期:1985-01-01 00:00:00
abstract::Cisplatin-induced nephrotoxicity is closely associated with an increase in lipid peroxidation. In several previous reports it was claimed that acetylsalicylic acid (ASA) shows its therapeutic potential as a free radical scavenger. The aim of the study was to investigate effects of ASA on cisplatin induced nephrotoxici...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-120024841
更新日期:2003-11-01 00:00:00
abstract::The antioxidant and drug metabolizing potentials of Hibiscus anthocyanin extract in CCl(4)- induced oxidative damage of rat liver was investigated. Hibiscus anthocyanin extract effectively scavenge α-diphenyl-β-picrylhydrazyl (DPPH) radical, superoxide ion, and hydrogen peroxide. It produced a 92% scavenging effect of...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2010.536767
更新日期:2011-04-01 00:00:00