Abstract:
:The 24-h incorporation of 59Fe into circulating red blood cells, bone marrow, urine, liver, spleen, and skeletal muscle was measured in splenectomized and sham-splenectomized rats which had received a daily, oral dose of gossypol acetic acid (20 mg GAA/kg body wt) for 91 days. A significant decrease in total body weight gain was observed in all GAA treated animals. Splenectomized rats dosed with GAA exhibited a significant decrease in hemoglobin concentration, hematocrit and erythrocyte count. A significant increase in 59Fe incorporation by red blood cells and a decrease in hepatic incorporation of 59Fe indicate a preferential utilization of iron in erythropoiesis among GAA treated animals.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Tone JN,Jensen DRdoi
10.3109/01480548509011635subject
Has Abstractpub_date
1985-01-01 00:00:00pages
69-82issue
1-2eissn
0148-0545issn
1525-6014journal_volume
8pub_type
杂志文章abstract::Adriamycin (ADR) causes morphological and functional alterations in mitochondrial structure in the heart. The study's aim was to determine whether there is a protective effect of selenium (Se) on ADR-induced cardiac damage. Rats were divided into four groups: The first group was injected saline intraperitoneally (i.p....
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2010.538693
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2020.1858853
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548509041066
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doi:10.1080/01480545.2017.1321010
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2010.536767
更新日期:2011-04-01 00:00:00
abstract::Mercuric chloride was administered by three routes--subcutaneous, intramuscular and intraperitoneal to adult female Wistar rats. The peroxidative status of the cerebral cortex, cerebellum and the sciatic nerves were studied. Enhanced levels of lipid peroxides indicate progressing cellular injury. All the experimental ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549809017850
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章,评审
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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doi:10.3109/01480548609042827
更新日期:1986-01-01 00:00:00
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journal_title:Drug and chemical toxicology
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doi:10.3109/01480548009030129
更新日期:1980-01-01 00:00:00
abstract::Dual inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX) pathways of arachidonic acid metabolism prevent cancer development and induce apoptosis. One of the most promising compounds that blocks both of these pathways is licofelone. We questioned whether licofelone affects the survival and/or promotes apoptosis o...
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章,评审
doi:10.3109/01480545.2012.710631
更新日期:2013-07-01 00:00:00
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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doi:10.1080/01480545.2018.1497051
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journal_title:Drug and chemical toxicology
pub_type: 杂志文章,评审
doi:10.3109/01480549608998231
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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更新日期:2016-01-01 00:00:00
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journal_title:Drug and chemical toxicology
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abstract::Adult male Sprague Dawley rats were gavaged with 2,4-dinitrotoluene (2,4-DNT) dissolved in corn oil at 0, 60, 180, or 240 mg/kg/day for five days. A single oral dose (0.5 mg/kg) of triethylenemelamine was used as a positive control. Induction of dominant lethal events was scored on the basis of early fetal deaths. At ...
journal_title:Drug and chemical toxicology
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更新日期:1985-01-01 00:00:00