Abstract:
:Azaperone was evaluated for its mutagenic potential by the Salmonella/microsome test. No mutagenic activity towards six S. typhimurium strains could be evidenced with azaperone at doses up to 2,000 micrograms/plate, either without or with metabolic activation at usual test conditions. Higher concentrations of liver post-mitochondrial fraction from Aroclor 1254 (ARO)-pretreated rats did not reveal any increase in the number of revertants towards S. typhimurium strains TA1537, TA1538 and TA98. Moreover, a plate-incorporation test with liver post-mitochondrial fractions from mice pretreated with phenobarbital (PB) and a liquid preincubation test with liver post-mitochondrial fractions from rats pretreated with ARO also failed to reveal any mutagenic action of azaperone towards S. typhimurium strain TA98. Thus, none of the tests used provided any indication of azaperone having a mutagenic action.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Duverger-van Bogaert M,Vanparys P,de Meester C,Marsboom Rdoi
10.3109/01480548709042990subject
Has Abstractpub_date
1987-01-01 00:00:00pages
329-38issue
3-4eissn
0148-0545issn
1525-6014journal_volume
10pub_type
杂志文章abstract:CONTEXT:Celtis glabrata is used in Turkey for the treatment of various health disorders. OBJECTIVE:The acetone, chloroform, ethanol, and methanol extracts of C. glabrata leaf, fruit, and seed were investigated to evaluate their antimutagenic activities. MATERIAL AND METHODS:The antimutagenicity of these extracts was ...
journal_title:Drug and chemical toxicology
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doi:10.3109/01480545.2015.1121273
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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