Abstract:
:The effects of feeding two compounds, dehydroepiandrosterone (DHEA), an adrenal steroid, and clofibrate (CLOF) to rats (which are both hypolipidemic, hepatomegaly inducing and hepatic peroxisome proliferating agents) on the binding of 7,12-dimethylbenz(a)anthracene (DMBA) to hepatic DNA in vivo is compared. Male Sprague Dawley rats (two-three months old) were fed either DHEA or CLOF for 14 days at a dietary level of 0.8%. Control rats were pair fed. An increase in liver weight followed by increases per whole liver in total protein, without much change in DNA content was observed. Subsequently, all the animals were given a single intraperitoneal dose of [3H]DMBA (133 mumol/kg body weight, 102 microCi/rat) in 250 microliters dimethyl sulfoxide. Forty-eight hours later, binding of DMBA to hepatic DNA was determined. The results indicate that DMBA binding to DNA was reduced by 67% in DHEA-fed rats whereas in clofibrate-fed rats it was not significantly different from that of the controls.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Prasanna HR,Hart RW,Magee PNdoi
10.3109/01480548908999162subject
Has Abstractpub_date
1989-09-01 00:00:00pages
327-35issue
3-4eissn
0148-0545issn
1525-6014journal_volume
12pub_type
杂志文章abstract::The venoms of wasps are a complex mixture of biologically active compounds, such as low molecular mass compounds, peptides, and proteins. The aim of the study was to evaluate the action of wasp venoms, Polybia occidentalis and Polybia fastidiosa, on the DNA of human leukocytes and on the cell cycle and genetic materia...
journal_title:Drug and chemical toxicology
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doi:10.1080/01480545.2019.1631339
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abstract::A toxicity Evaluation of DDT and dieldrin was conducted using Japanese Quail. The effects of feeding DDT (5 and 50 ppm of diet) and dieldrin (0.1 and 1.0 ppm of diet) in this four generation study (parental, F1, F2 and F3) were examined in terms of growth, viability, and/or reproduction of offspring. Ten groups (inclu...
journal_title:Drug and chemical toxicology
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doi:10.3109/01480547809034431
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journal_title:Drug and chemical toxicology
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doi:10.3109/01480549109017866
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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更新日期:1978-01-01 00:00:00
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journal_title:Drug and chemical toxicology
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更新日期:1985-01-01 00:00:00
abstract::The objective of this study was to determine if single/double strand DNA breaks could be induced by monocrotophos (organophosphorus pesticide) in mice in vivo using the comet assay. Mice were dosed orally with 0.046, 0.093, 0.186, 0.373 and 0.746 mg/kg body weight of monocrotophos, and the assay was performed on whole...
journal_title:Drug and chemical toxicology
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更新日期:2002-02-01 00:00:00