Abstract:
:As part of an occupational hazard evaluation, p-bromobenzyl bromide (p-BBB) was evaluated for genotoxic activity in the Ames microbial mutagenicity assay, the alkaline elution assay for DNA strand breaks in rat hepatocytes and the in vitro chromosome aberration assay in Chinese hamster ovary cells. The compound produced equivocal results in the microbial mutagenicity assay but was negative in the alkaline elution assay for DNA strand breaks in rat hepatocytes. The compound produced weakly positive results in the in vitro chromosome aberration assay. There was substantial cytotoxicity in all three assays. It is concluded that p-BBB is weakly genotoxic.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Sargent EV,Sina JF,Barnum JE,Storer RD,Johnson TE,Galloway SM,Prato MG,Kirsten NN,Naumann BDdoi
10.3109/01480549908993169subject
Has Abstractpub_date
1999-11-01 00:00:00pages
583-93issue
4eissn
0148-0545issn
1525-6014journal_volume
22pub_type
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