Abstract:
:The nicotine metabolism of CYP2A6 (CYP2A6*1A,*1B, and *1C), and the cholecystokinin (CCK; which modulates the release of dopamine) and CCK-A receptor gene and personality traits for NEO-FFI, was investigated for the mechanism for elucidation of the smoking behavior in Japanese populations. The frequency of the CYP2A6*4C allele, which is a whole deleted allele of the human CYP2A6 gene, was higher, whereas that of CYP2A6*1A/*1B heterozygotes with higher nicotine metabolism activity was lower in nonsmokers than in smokers. There was also a significant difference between the current smoking and nonsmoking groups in the allele frequency of the CCK -45C/T polymorphism. It was also shown that the Openness (O) factor for smokers was significantly higher than that of nonsmokers; however, there were no significant differences in the Neuroticism (N), Extraversion (E), Agreeable (A), and Conscientiousness (C) scores among smokers than nonsmokers. It was suggested that the CYP2A6*4C allele may prevent the carrier from smoking, and being a CYP2A6*1A/*1B heterozygote and the CCK T allele may be risk factors for developing smoking behavior. Also, it is possible that persons with a low score in Openness may be refraining from smoking because they have a general negative impression toward smoking.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Iwahashi K,Aoki Jdoi
10.1080/01480540903203976subject
Has Abstractpub_date
2009-01-01 00:00:00pages
301-6issue
4eissn
0148-0545issn
1525-6014journal_volume
32pub_type
杂志文章,评审abstract::The frequency of dexamethasone-induced cleft palate in mouse fetuses was studied at four fixed times on day 13 of gestation. On day 18, the fetuses were examined for malformations and corticosterone concentration was additionally measured. Evidence of a diurnal rhythm in cleft palate frequency, as well as in corticost...
journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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journal_title:Drug and chemical toxicology
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