Modulatory activities of polyphenols on crude acetylene-induced cardiac and hepatic dysfunctions in a rat model.

abstract：:Alkylphenols, a nonionic surface-active agent group, such as nonylphenol (NP) and octylphenol (OP) are important endocrine-disrupting chemicals (EDC). In this study, the dose- and time-dependent effects of NP and OP were investigated in the primary hepatocyte culture of Van Fish. In this study, samples were taken at d...

journal_title：Drug and chemical toxicology

authors： Çilingir Yeltekin A,Oğuz AR

更新日期：2018-10-01 00:00:00

abstract：:MG132, as a proteasome inhibitor, has been shown to induce apoptotic cell death through the formation of reactive oxygen species (ROS). In this study, we investigated the effects of MG132 and/or MAPK inhibitors on As4.1 juxtaglomerular cells in relation to cell growth, cell death, ROS, and glutathione (GSH) levels. MG...

journal_title：Drug and chemical toxicology

authors： Han YH,Kim SZ,Kim SH,Park WH

更新日期：2010-10-01 00:00:00

abstract：:Various chemical groups were evaluated for their skin sensitization potential in the guinea pig. In general, amines, acetanilides, pyridines, piperidines, and sulfones were positive in the guinea pig test. Since these tests were done over a period of years, any further structural-related correlations or predictions sh...

journal_title：Drug and chemical toxicology

authors： Rao KS,Betso JE,Olson KJ

更新日期：1981-01-01 00:00:00

abstract：:The venoms of wasps are a complex mixture of biologically active compounds, such as low molecular mass compounds, peptides, and proteins. The aim of the study was to evaluate the action of wasp venoms, Polybia occidentalis and Polybia fastidiosa, on the DNA of human leukocytes and on the cell cycle and genetic materia...

journal_title：Drug and chemical toxicology

authors： José Palmieri M,Ribeiro Barroso A,Fonseca Andrade-Vieira L,Monteiro MC,Martins Soares A,Souza Cesar PH,Aparecida Braga M,Cardoso Trento MV,Marcussi S,Chamma Davide L

更新日期：2019-07-01 00:00:00

abstract：:During a preclinical safety evaluation study, an indication of ocular toxicity was noted in beagle dogs receiving orally (gelatin capsules) once a day, 7 days a week for, respectively, 7 and 91 days, 10 mg/kg/day of Lortalamine, a new non-tricyclic anti-depressant compound. Lortalamine treated dogs showed, progressive...

journal_title：Drug and chemical toxicology

authors： Mally C,Thiebault JJ

更新日期：1990-01-01 00:00:00

abstract：:This study investigated the exposure of pyrethroids in the development of Alzheimer's type neurodegeneration by analyzing β- amyloid, tau and Glial Fibrillary Acidic Protein (GFAP) in adult Wistar rats. Forty adult Wistar rats (130-150 g) of both sexes were assigned into five groups (n = 8). Groups A-C were treated wi...

journal_title：Drug and chemical toxicology

authors： Iteire KA,Sowole AT,Ogunlade B

更新日期：2020-09-09 00:00:00

abstract：:The relationship between lead concentration in the dry film of lead based paints applied to steel bulkheads aboard ship, the lead concentration found in the air when the paint is removed by mechanical means, and blood lead concentrations of workers involved in lead based paint removal has not been well characterized. ...

journal_title：Drug and chemical toxicology

authors： Alexander WK,Carpenter RL,Kimmel EC

更新日期：1999-02-01 00:00:00

abstract：:In a chronic toxicity study in the rat, bidisomide administered as a dietary admixture produced a dose-related lowering of reticulocytes and leucocytes. Plasma alanine aminotransferase activity was increased at 300 mg/kg and decreased at 900 mg/kg. The potential mechanisms of these effects were investigated by compari...

journal_title：Drug and chemical toxicology

authors： Vandenberghe Y,Masson M,Palate B,Roba J

更新日期：1995-11-01 00:00:00

abstract：:The accelerating rotarod was used to assess motor performance decrement in rats after administration of candidate anticonvulsant compounds (acetazolamide, amitriptyline, chlordiazepoxide, diazepam, diazepam-lysine, lorazepam, loprazolam, midazolam, phenobarbital and scopolamine) against nerve agent poisoning. All comp...

journal_title：Drug and chemical toxicology

authors： Capacio BR,Harris LW,Anderson DR,Lennox WJ,Gales V,Dawson JS

更新日期：1992-01-01 00:00:00

abstract：:Experimental and clinical data relevant for the evaluation of the carcinogenic potential of the immunosuppressant ciclosporin are reviewed. Ciclosporin binds reversibly to the cytosolic receptor protein ciclophilin. Ciclophilin is likely involved in the blockade of lymphocyte activation-induced gene transcription of v...

journal_title：Drug and chemical toxicology

authors： Ryffel B,Mihatsch MJ,Fisher GL

更新日期：1992-01-01 00:00:00

abstract：:This study assessed possible adverse immunological effects of trans-1,2-dichloroethylene (DCE) on random-bred CD-1 mice following 14 and 90 days of exposure. A 14-day range-finding study was performed on male mice by gavage at doses 1/10 and 1/100 the LD50 (210 and 21 mg/kg). No alterations in either humoral or cell-m...

journal_title：Drug and chemical toxicology

authors： Shopp GM Jr,Sanders VM,White KL Jr,Munson AE

更新日期：1985-01-01 00:00:00

abstract：:In our previous reports, aspirin, an antipyretic analgesic, suppressed the genotoxicity of mitomycin C (MMC) in a somatic mutation and recombination test (SMART) in Drosophila melanogaster. In order to reveal the mechanism of the anti-genotoxicity of aspirin, we evaluated the suppressing ability of each aspirin metabo...

journal_title：Drug and chemical toxicology

authors： Niikawa M,Nakamura T,Nagase H

更新日期：2006-01-01 00:00:00

abstract：:The cytotoxic effect of caffeine on heart cells was evaluated in primary cultures of rat heart muscle (M) and endothelioid (E) cells. The cultures were exposed to 5, 10, or 20 mM caffeine for 6, 12, or 24 hours. As an index of cytotoxicity produced by the treatments, in situ changes in mitochondrial membrane fragility...

journal_title：Drug and chemical toxicology

authors： Acosta D,Anuforo D

更新日期：1977-01-01 00:00:00

abstract：:Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids (DDAs) including aconitine (AC), mesaconitine (MAC), hypaco...

journal_title：Drug and chemical toxicology

authors： Ye Q,Liu H,Fang C,Liu Y,Liu X,Liu J,Zhang C,Zhang T,Peng C,Guo L

更新日期：2019-03-21 00:00:00

abstract：:Evidence suggests that the effect of heavy metals on neuroimmune cells lead to neurogenic inflammatory responses. In this study, immune cells [mast cells (MCs) and microglia] and pro-neuroinflammation cytokines (interleukin-1b and tumor necrosis factor-α) were assessed in the prefrontal lobe of rat brains exposed to t...

journal_title：Drug and chemical toxicology

authors： Afsordeh K,Sadeghi Y,Amini A,Namvarpour Z,Abdollahifar MA,Abbaszadeh HA,Aliaghaei A

更新日期：2019-03-01 00:00:00

abstract：:The toxicity of chloropicrin (CP) was assessed following its administration to rats via oral gavage for either 10 or 90 consecutive days at dose levels of 10, 20, 40, and 80 mg/kg and 2, 8 and 32 mg/kg, respectively. Control rats received corn oil at a dose of 1.0 ml/kg. Toxicological observations included organ and b...

journal_title：Drug and chemical toxicology

authors： Condie LW,Daniel FB,Olson GR,Robinson M

更新日期：1994-01-01 00:00:00

abstract：:In 1994, the United States Environmental Protection Agency (USEPA) developed a screening methodology for conducting indirect exposure risk assessments for combustion facilities. The United States Army Center for Health Promotion and Preventive Medicine currently utilizes this methodology in conjunction with other USEP...

journal_title：Drug and chemical toxicology

authors： Walter MA

更新日期：1999-02-01 00:00:00

abstract：CONTEXT:Withania somnifera (L) Dunal (Solanaceae) is an important traditional herbal medicine used for thousands of years and is considered as the Indian ginseng. Reports on the effect of Withania somnifera root (WSR) extract on the developing foetus of pregnant rats including mortality, structural abnormalities, chang...

journal_title：Drug and chemical toxicology

authors： Prabu PC,Panchapakesan S

更新日期：2015-01-01 00:00:00

abstract：:Dual inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX) pathways of arachidonic acid metabolism prevent cancer development and induce apoptosis. One of the most promising compounds that blocks both of these pathways is licofelone. We questioned whether licofelone affects the survival and/or promotes apoptosis o...

journal_title：Drug and chemical toxicology

authors： Kabadere S,Kus G,Uyar R,Oztopcu-Vatan P

更新日期：2014-01-01 00:00:00

abstract：:Male Sprague-Dawley rats were administered cadmium chloride 0, 50, 100, 150 and 200 ppm for 30 days. At the end of the treatments, the body weight gains, serum glucose, serum protein, serum glutamic oxalacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were determined. Renal and hepatic key glu...

journal_title：Drug and chemical toxicology

authors： Chapatwala KD,Rajanna B,Desaiah D

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Parkinsonism describes Parkinson's disease and other associated degenerative changes in the brain resulting in movement disorders. The motor cortex, extrapyramidal tracts and nigrostriatal tract are brain regions forming part of the motor neural system and are primary targets for drug or chemotoxins induced ...

journal_title：Drug and chemical toxicology

authors： Ogundele OM,Nanakumo ET,Ishola AO,Obende OM,Enye LA,Balogun WG,Cobham AE,Abdulbasit A

更新日期：2015-10-01 00:00:00

abstract：:This Visual Basic computer program has been developed for drug dosage conversions using metabolically active mass (MAM) of the animals. The two body weights (one with known dosage and the other, for which the dosage has to be calculated) and the known dosage are entered in the respective input boxes and the appropriat...

journal_title：Drug and chemical toxicology

authors： Khan HA

更新日期：2003-02-01 00:00:00

abstract：CONTEXT:Celtis glabrata is used in Turkey for the treatment of various health disorders. OBJECTIVE:The acetone, chloroform, ethanol, and methanol extracts of C. glabrata leaf, fruit, and seed were investigated to evaluate their antimutagenic activities. MATERIAL AND METHODS:The antimutagenicity of these extracts was ...

journal_title：Drug and chemical toxicology

authors： Akin D,Durak Y,Uysal A,Gunes E,Aladag MO

更新日期：2016-01-01 00:00:00

abstract：:In this study, we investigated the effect of vernolide-A on the induction of apoptosis as well as its regulatory effect on the activation of transcription factors in B16F-10 melanoma cells. Treatment of B16F-10 cells with nontoxic concentrations of vernolide-A showed the presence of apoptotic bodies and induced DNA fr...

journal_title：Drug and chemical toxicology

authors： Pratheeshkumar P,Kuttan G

更新日期：2011-07-01 00:00:00

abstract：CONTEXT:Caffeine is the most widely consumed nervous stimulant that induces oxidative-mediated apoptosis and cell cycle arrest in neural cells. Due to low toxicity, high accumulation in neural cells, reduction of the free fatty acids and antioxidant property, l-carnitine (LC) is an interesting compound to be used in vi...

journal_title：Drug and chemical toxicology

authors： Bavari M,Tabandeh MR,Najafzadeh Varzi H,Bahramzadeh S

更新日期：2016-01-01 00:00:00

abstract：:Copper (Cu) is a heavy metal with the ability to induce, at high levels, neurobehavioral alterations, and oxidative stress (OS). On the other hand, melatonin (Mel) is a neurohormone that protects neurons from OS and has a modulatory effect on several behavioral processes. The present experiment was aimed to examine th...

journal_title：Drug and chemical toxicology

authors： Lamtai M,Zghari O,Azirar S,Ouakki S,Mesfioui A,El Hessni A,Berkiks I,Marmouzi I,Ouichou A

更新日期：2021-01-07 00:00:00

abstract：:Heme oxygenase-1 (HO-1) expression, in response to various stimuli, has been generally reported to protect against cellular stress. However, we previously demonstrated simvastatin-induced HO-1-exaggerated nuclear factor kappa beta (NF-κβ) activation and superoxide production on exposure to lipopolysaccharide (LPS). Th...

journal_title：Drug and chemical toxicology

authors： Hsieh CH,Jeng JC,Hsieh MW,Chen YC,Lu TH,Rau CS,Jeng SF

更新日期：2011-01-01 00:00:00

abstract：:Many pharmaceuticals are administered to children and adults as sprays provided in nebulizers or metered-dose inhalers. Stress associated with possible eye irritation and injury attributable to exposure to vapors and particulates during the required safety testing procedures of such medicines is a potential confoundin...

journal_title：Drug and chemical toxicology

authors： Rothenberg SJ,Martin MM,Sherer KI,Parker RM,Dearlove GE,Christian MS

更新日期：1998-08-01 00:00:00

abstract：:Experiments were carried out to ascertain whether or not saffron (dried stigmas of Crocus sativus L.), a commonly used agent for flavoring and coloring food can exert modulatory effects on the in vivo genotoxicity of cisplatin (CIS), cyclophosphamide (CPH), mitomycin C (MMC) and urethane (URE). For this purpose, Swiss...

journal_title：Drug and chemical toxicology

authors： Premkumar K,Abraham SK,Santhiya ST,Gopinath PM,Ramesh A

更新日期：2001-11-01 00:00:00

abstract：:The purpose of this study was to evaluate the effects of bleached kraft mill effluent on selected physiological and hematological endpoints in fingerling largemouth bass (Micropterus salmoides). Fish were exposed for 35 days to surface water collected at sites up- and downstream from a pulp and paper mill treatment-ef...

journal_title：Drug and chemical toxicology

authors： Baer KN,Bankston CR,Mosadeghi S,Schlenk D

更新日期：2009-01-01 00:00:00