Ocular toxicity in beagle dogs with lortalamine, a non tricyclic antidepressant compound.

abstract：:The toxicity of chloropicrin (CP) was assessed following its administration to rats via oral gavage for either 10 or 90 consecutive days at dose levels of 10, 20, 40, and 80 mg/kg and 2, 8 and 32 mg/kg, respectively. Control rats received corn oil at a dose of 1.0 ml/kg. Toxicological observations included organ and b...

journal_title：Drug and chemical toxicology

authors： Condie LW,Daniel FB,Olson GR,Robinson M

更新日期：1994-01-01 00:00:00

abstract：:The purposes of this study was to determine the toxicological effect of repeated intravenous administration of Activin A/BMP-2 chimera (AB204) in beagle dogs for a long period of four weeks and evaluate two-week recovery. AB204 was administered at doses of 0.08, 0.16, or 0.32 mg/kg/day to three male and three female b...

journal_title：Drug and chemical toxicology

authors： Han SH,Zheng GB,Lee JH

更新日期：2019-03-18 00:00:00

abstract：:Exposure to crude acetylene can occur in occupational settings. This study assessed the modulatory activities of selected polyphenols on the hematotoxic, cardiotoxic, and hepatotoxic effects of crude acetylene. Wistar rats were exposed to 58 000 ppm crude acetylene for 10 min at 12 h intervals for 30 days. Some expose...

journal_title：Drug and chemical toxicology

authors： Aladesanmi OO,Akinmoladun AC,Josiah SS,Olaleye MT,Akindahunsi AA

更新日期：2020-12-08 00:00:00

abstract：:Hexachloroethane (HCE) was fed to Fischer 344 rats at approximate doses of 0, 1, 15 or 62 mg/kg/day for 16 weeks. Selected tissues were assayed at termination for HCE content. Histopathological examination identified the kidney as the primary target organ with male rats more sensitive than female rats. The kidney conc...

journal_title：Drug and chemical toxicology

authors： Gorzinski SJ,Nolan RJ,McCollister SB,Kociba RJ,Mattsson JL

更新日期：1985-01-01 00:00:00

abstract：:Cisplatin (CP) is a widely used cytotoxic agent against cancer, and high doses of CP have been known to cause nephrotoxicity and hepatotoxicity. Some reports claim that antioxidants can reduce CP-induced toxicity. This study investigated the hepatoprotective, nephroprotective, and antioxidant activity of Urtica dioica...

journal_title：Drug and chemical toxicology

authors： Özkol H,Musa D,Tuluce Y,Koyuncu I

更新日期：2012-07-01 00:00:00

abstract：:Increasing numbers of older adults use cannabis and cannabis-derived products that can have adverse effects. This study examined management site and level of healthcare services for older adult poison control center cases involving cannabis products. Using the American Association of Poison Control Centers' (PCC) Nati...

journal_title：Drug and chemical toxicology

authors： Choi NG,DiNitto DM,Marti CN,Baker SD

更新日期：2021-01-07 00:00:00

abstract：:Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids (DDAs) including aconitine (AC), mesaconitine (MAC), hypaco...

journal_title：Drug and chemical toxicology

authors： Ye Q,Liu H,Fang C,Liu Y,Liu X,Liu J,Zhang C,Zhang T,Peng C,Guo L

更新日期：2019-03-21 00:00:00

abstract：:Methyl 2,2-difluoromalonyl fluoride (MMF) is highly toxic by inhalation producing mortality in rats exposed for 4 hours to 0.55 mg/L. Repeated inhalation exposures of rats to 0.009 mg/L produced irritation but no other signs of a toxic response. Mortality was encountered following repeated exposures to 0.066 mg/L. ...

journal_title：Drug and chemical toxicology

authors： Kennedy GL Jr,Burgess BA,Chen HC

更新日期：1988-06-01 00:00:00

abstract：:The accelerating rotarod was used to assess motor performance decrement in rats after administration of candidate anticonvulsant compounds (acetazolamide, amitriptyline, chlordiazepoxide, diazepam, diazepam-lysine, lorazepam, loprazolam, midazolam, phenobarbital and scopolamine) against nerve agent poisoning. All comp...

journal_title：Drug and chemical toxicology

authors： Capacio BR,Harris LW,Anderson DR,Lennox WJ,Gales V,Dawson JS

更新日期：1992-01-01 00:00:00

abstract：:Exposure to aldehydes represents potential risks to human and animal health. Cyclic aldehydes such as benzaldehyde, 2-furaldehyde, and paraldehyde were found to induce formation of stable DNA-protein cross-links (DPXs) in cultured human lymphoma cells. A relationship between increased cytotoxicity and DPX formation wa...

journal_title：Drug and chemical toxicology

authors： Kuykendall JR,Jarvi EJ,Finley BL,Paustenbach DJ

更新日期：2007-01-01 00:00:00

abstract：:Experiments were carried out to ascertain whether or not saffron (dried stigmas of Crocus sativus L.), a commonly used agent for flavoring and coloring food can exert modulatory effects on the in vivo genotoxicity of cisplatin (CIS), cyclophosphamide (CPH), mitomycin C (MMC) and urethane (URE). For this purpose, Swiss...

journal_title：Drug and chemical toxicology

authors： Premkumar K,Abraham SK,Santhiya ST,Gopinath PM,Ramesh A

更新日期：2001-11-01 00:00:00

abstract：:The antioxidant and drug metabolizing potentials of Hibiscus anthocyanin extract in CCl(4)- induced oxidative damage of rat liver was investigated. Hibiscus anthocyanin extract effectively scavenge α-diphenyl-β-picrylhydrazyl (DPPH) radical, superoxide ion, and hydrogen peroxide. It produced a 92% scavenging effect of...

journal_title：Drug and chemical toxicology

authors： Ajiboye TO,Salawu NA,Yakubu MT,Oladiji AT,Akanji MA,Okogun JI

更新日期：2011-04-01 00:00:00

abstract：:The intoxication of insecticides such as bifenthrin and diazinon has been reported to generate free radicals, and thereby alter the antioxidant defense system in erythrocytes. The present study is aimed to investigate the protective effects of acetone (DA) and methanolic (DM) extracts of lichen Dirinaria consimilis ag...

journal_title：Drug and chemical toxicology

authors： Tatipamula VB,Kukavica B

更新日期：2020-05-12 00:00:00

abstract：:Many pharmaceuticals are administered to children and adults as sprays provided in nebulizers or metered-dose inhalers. Stress associated with possible eye irritation and injury attributable to exposure to vapors and particulates during the required safety testing procedures of such medicines is a potential confoundin...

journal_title：Drug and chemical toxicology

authors： Rothenberg SJ,Martin MM,Sherer KI,Parker RM,Dearlove GE,Christian MS

更新日期：1998-08-01 00:00:00

abstract：:Oxidative stress is produced under diabetic conditions and is likely involved in the progression of pancreatic damage found in diabetes. This study was undertaken to evaluate the protective effect of Aegle marmelos leaf extract, a medicinal plant, on the tissue antioxidant defense system and lipid peroxidative status ...

journal_title：Drug and chemical toxicology

authors： Narendhirakannan RT,Subramanian S

更新日期：2010-04-01 00:00:00

abstract：:Cadmium (Cd) is a ubiquitous non-essential environmental and industrial toxicant that affects various organs in humans and experimental animals. Robust evidence confirms the contribution of oxidative stress to the pathogenesis of Cd-induced hepatic damage. Potent polyphenols found in virgin coconut oil (VCO) are free ...

journal_title：Drug and chemical toxicology

authors： Famurewa AC,Ugwu-Ejezie CS,Iyare EE,Folawiyo AM,Maduagwuna EK,Ejezie FE

更新日期：2019-04-25 00:00:00

abstract：:Toxic fungal metabolites - mycotoxins - cause poisonings after consumption of contaminated food commodities. The most probable intoxications are connected with eating poorly stored food or inhaling of moldy dust. One of the effective ways to protect people against mycotoxins is timely detection. Several methods such a...

journal_title：Drug and chemical toxicology

authors： Pohanka M,Jun D,Kuca K

更新日期：2007-01-01 00:00:00

abstract：:The disposition of N-[14C-vinyl]-2-pyrrolidinone was studied in male Sprague-Dawley rats following a single iv injection. Plasma levels of the intact compound dropped rapidly within the first 6 hours after dosing with a half life of 1.90 hours. Urinary excretion by 12 hours represented 74.9% of a 5 microCi dose while ...

journal_title：Drug and chemical toxicology

authors： McClanahan JS,Lin YC,Digenis GA

更新日期：1984-01-01 00:00:00

abstract：:The potential genotoxic effect of venlafaxine hydrochloride (venlafaxine), an antidepressant drug-active ingredient, was investigated by using in vitro chromosome aberrations (CAs) and cytokinesis-block micronucleus (CBMN) assays in human peripheral blood lymphocytes (PBLs). Mitotic index (MI) and cytokinesis-block pr...

journal_title：Drug and chemical toxicology

authors： Ayabaktı S,Yavuz Kocaman A

更新日期：2020-03-01 00:00:00

abstract：:Organoselenium compounds can cause anemia in mice, possibly as a consequence of impairment of the heme biosynthesis pathway. Such compounds can inhibit the sulfhydryl-containing enzyme delta-aminolevulinate dehydratase (delta-ALA-D), which is involved in the heme biosynthetic pathway, leading to a decrease in the synt...

journal_title：Drug and chemical toxicology

authors： Folmer V,Farina M,Maciel EN,Nogueira CW,Zeni G,Emanuelli T,Rocha JB

更新日期：2004-11-01 00:00:00

abstract：:The present study enumerates the attenuating effects of curcumin and α-tocopherol against propoxur induced oxidative DNA damage in human peripheral blood mononuclear cells (PBMC). Cultured cells were isolated from peripheral blood of healthy volunteers, and were exposed to varying concentrations of propoxur (0-21 μg/m...

journal_title：Drug and chemical toxicology

authors： Ahmed T,Goel V,Banerjee BD

更新日期：2018-04-01 00:00:00

abstract：:Orlistat is an FDA-approved over-the-counter drug to treat obesity through the inhibition of lipase activity. Macrophages, which express high levels of lipoprotein lipase (LPL), are important phagocytes in the innate immune system. Our previous studies indicated that environmentally relevant concentrations of arsenite...

journal_title：Drug and chemical toxicology

authors： Lou K,Huang P,Ma H,Wang X,Xu H,Wang W

更新日期：2019-10-31 00:00:00

abstract：:The availability of tissue glutathione (GSH) appears to depend upon a balance between tissue concentrations, the rate of reactive metabolite formation and the re-synthesis of GSH. To test this hypothesis, diethyl maleate (DEM, 5.8 mmol/kg bw) was administered intraperitoneally to male and female mice, hamsters, rats a...

journal_title：Drug and chemical toxicology

authors： Ecobichon DJ

更新日期：1984-01-01 00:00:00

abstract：:Various antioxidants play an important role in reducing the reactive oxygen species (ROS) by scavenging them directly or indirectly. Mercury (Hg) is one of the known hazardous genotoxicant, induces the genotoxicity by enhancing the ROS. In the present study, three structurally different bioactive compounds such as mel...

journal_title：Drug and chemical toxicology

authors： Patel TA,Rao MV

更新日期：2015-10-01 00:00:00

abstract：:Cisplatin-induced nephrotoxicity is closely associated with an increase in lipid peroxidation. In several previous reports it was claimed that acetylsalicylic acid (ASA) shows its therapeutic potential as a free radical scavenger. The aim of the study was to investigate effects of ASA on cisplatin induced nephrotoxici...

journal_title：Drug and chemical toxicology

authors： Ulubaş B,Cimen MY,Apa DD,Saritaş E,Muşlu N,Cimen OB

更新日期：2003-11-01 00:00:00

abstract：:In adult female Wistar rats, pretreated by gavage with two doses - 16 or 256 mumol/kg - of cyanamide, TMTD (tetramethylthiuram disulfide), TMTM (tetramethylthiuram monosulfide), Ziram or Zineb at 90 min or 18 h before administration of 2 g of ethanol/kg i.p., the blood acetaldehyde levels were significantly increased ...

journal_title：Drug and chemical toxicology

authors： García de Torres G,Römer KG,Torres Alanis O,Freundt KJ

更新日期：1983-01-01 00:00:00

abstract：:This Visual Basic computer program has been developed for drug dosage conversions using metabolically active mass (MAM) of the animals. The two body weights (one with known dosage and the other, for which the dosage has to be calculated) and the known dosage are entered in the respective input boxes and the appropriat...

journal_title：Drug and chemical toxicology

authors： Khan HA

更新日期：2003-02-01 00:00:00

abstract：:The immunomodulatory effects of two plant regulators, cycloheximide and maleic hydrazide, were investigated by injecting the compounds twice weekly for 4 weeks in female Swiss Webster white mice. The animals were antigenically challenged with sheep red blood cells on day 24 of the study. Although humoral immunity was ...

journal_title：Drug and chemical toxicology

authors： Olson LJ,Hinsdill RD,Weltman DJ

更新日期：1983-01-01 00:00:00

abstract：:This study was designed to test the pulmonary tumor response to intratracheally instilled silica in Strain A mice. Urethane was used as a positive control. Silica treatment was utilized to evaluate the effect of a potent fibrinogen on pulmonary adenoma formation in this unique animal model. Urethane produced an increa...

journal_title：Drug and chemical toxicology

authors： McNeill DA,Chrisp CE,Fisher GL

更新日期：1990-01-01 00:00:00

abstract：:Antioxidant activity of Acacia salicina extracts was determined by the ability of each extract to inhibit lipid peroxidation, to protect against DNA strand scission induced by hydroxyl radicals, and to scavenge the free radical, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(*+)). The IC(50) values of t...

journal_title：Drug and chemical toxicology

authors： Bouhlel I,Bhouri W,Limem I,Boubaker J,Nefatti A,Skandrani I,Ben Sghaier M,Kilani S,Ghedira K,Chekir Ghedira L

更新日期：2009-01-01 00:00:00