Abstract:
:The availability of tissue glutathione (GSH) appears to depend upon a balance between tissue concentrations, the rate of reactive metabolite formation and the re-synthesis of GSH. To test this hypothesis, diethyl maleate (DEM, 5.8 mmol/kg bw) was administered intraperitoneally to male and female mice, hamsters, rats and guinea pigs. The regeneration of hepatic and renal GSH was examined at 0.5, 1, 2, 4, 8 and 24 hr post-treatment. DEM caused a rapid and marked depletion of tissue GSH but re-synthesis began to occur by 4 hr post-treatment in all species with the exception of the guinea pig. By 24 hr after treatment, the mouse, hamster and rat had tissue levels of GSH in excess of usual values but, in the guinea pig, recovery of hepatic GSH was still significantly reduced. Considering the reported species differences in S-alkenetransferases which detoxify DEM, the present results revealed that the conjugation of DEM proceeded rapidly in all four species but that the toxicity elicited in the guinea pig may have arisen from the unavailability of GSH during the slow re-synthesis stage following maximal depletion of this agent.
journal_name
Drug Chem Toxicoljournal_title
Drug and chemical toxicologyauthors
Ecobichon DJdoi
10.3109/01480548408998263subject
Has Abstractpub_date
1984-01-01 00:00:00pages
345-55issue
4eissn
0148-0545issn
1525-6014journal_volume
7pub_type
杂志文章abstract::The Salmonella typhimurium/microsome assay is a widely used bacterial genotoxicity assay to test potential carcinogens. The aim of this work was to evaluate the mutagenic and antimutagenic activities with and without the addition of an extrinsic metabolic activation system of essential oils obtained from an aerial par...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540903196790
更新日期:2009-01-01 00:00:00
abstract::Effects of diazinon, at different concentrations and exposure times, were investigated in freshwater fish, Cyprinus carpio, to elucidate the possible mode of action on lipid peroxidation together with the inhibitory effect of diazinon on acetylcholinesterase activity and changes in tissue protein levels. Cholinesteras...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540500408622
更新日期:2006-01-01 00:00:00
abstract:CONTEXT:Diplazium esculentum, a commonly consumed seasonal vegetable, has been reported to have some pathological effects in some animals. But, its effect on the male reproductive function has not yet been studied. OBJECTIVE:To investigate the effects of boiled D. esculentum (BDE), the form which human consumes, on ma...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2016.1190739
更新日期:2017-04-01 00:00:00
abstract::Previous work has suggested that endogenous sulfhydryls, such as glutathione (GSH) and cysteine, are involved in the uptake and toxicity of HgCl2. To study this possibility, uptake and toxicity of synthesized Hg(SG)2, Hg(cysteinylglycine)2 [Hg(CYS-GLY)2] and Hg(CYS)2 were investigated in rabbit renal proximal tubule s...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549909017838
更新日期:1999-05-01 00:00:00
abstract::A comparison of the fertility and cytogenetic analyses and the combination of both techniques as generally used in the heritable translocation assay was conducted with triethylenemelamine (TEM). CD-1 mice were used as the F0 generation and were divided into two groups that received i.p. either distilled water (control...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548309017808
更新日期:1983-01-01 00:00:00
abstract::The cross-reaction patterns of selected acrylate and methacrylate esters were investigated using the guinea pig maximization test. Methacrylates were less potent sensitizers than acrylates. Cross-sensitization was found between (meth)acrylates with closely related core structures, most extensively between hydroxyethyl...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548409042817
更新日期:1984-01-01 00:00:00
abstract::Methyl 2,2-difluoromalonyl fluoride (MMF) is highly toxic by inhalation producing mortality in rats exposed for 4 hours to 0.55 mg/L. Repeated inhalation exposures of rats to 0.009 mg/L produced irritation but no other signs of a toxic response. Mortality was encountered following repeated exposures to 0.066 mg/L. ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548808998223
更新日期:1988-06-01 00:00:00
abstract::Neurodegenerative diseases affect millions of people. Major reasons behind the onset and progression of these diseases are still under investigation. Therefore, any approach that would treat/prevent progression is important. In this study, we aimed to investigate the potential protective effects of Psephellus pyrrhobl...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1659808
更新日期:2019-09-02 00:00:00
abstract::Various chemical groups were evaluated for their skin sensitization potential in the guinea pig. In general, amines, acetanilides, pyridines, piperidines, and sulfones were positive in the guinea pig test. Since these tests were done over a period of years, any further structural-related correlations or predictions sh...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548109017825
更新日期:1981-01-01 00:00:00
abstract::Various antioxidants play an important role in reducing the reactive oxygen species (ROS) by scavenging them directly or indirectly. Mercury (Hg) is one of the known hazardous genotoxicant, induces the genotoxicity by enhancing the ROS. In the present study, three structurally different bioactive compounds such as mel...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2014.975354
更新日期:2015-10-01 00:00:00
abstract::Pefloxacin is a second-generation fluoroquinolone antibiotic. Besides its advantageous characteristics, side effects including the hypofunction of salivary glands, decreased saliva production, and peripheral neuropathy were observed during the administration of pefloxacin. The aim of this study was to investigate the ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1508217
更新日期:2020-09-01 00:00:00
abstract::Rotenone, an environmental toxin, triggers Parkinson's disease (PD)-like pathology through microglia-mediated neuronal death. The effects and molecular mechanisms of flavonoid luteolin against rotenone-induced toxicity was assessed in microglial BV2 cells. Cells were pretreated with luteolin (1-50 µM) for 12 h and the...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1504961
更新日期:2020-01-01 00:00:00
abstract::While it is well recognized that the combination of amoxicillin and clavulanic acid has been associated with hepatic adverse events, there are only a few reports about amoxicillin alone causing hepatic toxicity. We describe a 34-year-old woman who developed severe cholestatic hepatitis following amoxicillin treatment....
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2010.545067
更新日期:2011-10-01 00:00:00
abstract::Aluminum (Al)-induced toxicity in fruit fly (Drosophila melanogaster) is one of the established models for studying neurotoxicity and neurodegenerative diseases. Alkaloid phytochemicals have been reported to exhibit neuroprotective effects. Therefore, the aim of this study is to determine the effect of alkaloid extrac...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1708377
更新日期:2020-01-03 00:00:00
abstract::Gold nanorods (GNRs) are used for their wide variety of applications in various industries. There is a little availability of data related to toxicity and ecological implications of these GNRs. The study evaluated the oxidative stress induction following intra-tracheal instillation of 1 and 5 mg/kg b.w. doses of 10 an...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2017.1321012
更新日期:2018-04-01 00:00:00
abstract::A toxicity Evaluation of DDT and dieldrin was conducted using Japanese Quail. The effects of feeding DDT (5 and 50 ppm of diet) and dieldrin (0.1 and 1.0 ppm of diet) in this four generation study (parental, F1, F2 and F3) were examined in terms of growth, viability, and/or reproduction of offspring. Ten groups (inclu...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480547809034431
更新日期:1978-01-01 00:00:00
abstract::The purposes of this study was to determine the toxicological effect of repeated intravenous administration of Activin A/BMP-2 chimera (AB204) in beagle dogs for a long period of four weeks and evaluate two-week recovery. AB204 was administered at doses of 0.08, 0.16, or 0.32 mg/kg/day to three male and three female b...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2019.1572181
更新日期:2019-03-18 00:00:00
abstract:OBJECTIVE:The present study was undertaken to explore the effects of monensin, a potent Golgi disturbing agent on male fertility. METHODS:Male Wistar rats were administered monensin at the dose levels of 2.5, 5, and 10 mg/kg b wt. Animals were sacrificed after 67 days of the treatment. The activities of lactate dehydr...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2013.866955
更新日期:2014-10-01 00:00:00
abstract::The in vitro effect of methyl mercury (MM) and lead (Pb) on N-methyl-D-aspartate (NMDA)-specific glutamate receptor binding in neonatal (10 days old) and adult rat brain was investigated. The cerebral cortex was isolated from the neonatal and adult male Sprague-Dawley rats and the synaptic plasma membranes were prepar...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549709011076
更新日期:1997-02-01 00:00:00
abstract::The objective of this study was to determine if single/double strand DNA breaks could be induced by monocrotophos (organophosphorus pesticide) in mice in vivo using the comet assay. Mice were dosed orally with 0.046, 0.093, 0.186, 0.373 and 0.746 mg/kg body weight of monocrotophos, and the assay was performed on whole...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-100108472
更新日期:2002-02-01 00:00:00
abstract::Suppression of mitogen-induced splenocyte lymphoproliferation and interleukin 2 (IL-2) production can be used as indicators of immunotoxicity. Staphylococcal enterotoxin A (SEA) is both a potent mitogen and the most potent in vitro inducer of IL-2 production that has been described. An in vitro system was used to meas...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549409064043
更新日期:1994-01-01 00:00:00
abstract::The role of oxidative-stress as a mechanism of hepatotoxicity caused by combination of isoniazid (INH) and Rifampicin (RMP) was investigated in young growing rats. A successful model of hepatotoxicity was produced by giving 50 mg/kg/day each of INH and RMP in two weeks. Liver showed type II hepatocellular changes (mic...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549709003881
更新日期:1997-08-01 00:00:00
abstract::In 1994, the United States Environmental Protection Agency (USEPA) developed a screening methodology for conducting indirect exposure risk assessments for combustion facilities. The United States Army Center for Health Promotion and Preventive Medicine currently utilizes this methodology in conjunction with other USEP...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549909029733
更新日期:1999-02-01 00:00:00
abstract::Amiodarone is a high effectiveness anti-arrhythmia agent which is able to induce pulmonary fibrosis. Many studies have shown that the epithelial-mesenchymal transition (EMT) was a significant process in pulmonary fibrosis. So far, there are no studies about whether EMT was associated with amiodarone-induced pulmonary ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2018.1497055
更新日期:2020-07-01 00:00:00
abstract:CONTEXT:Heparin-binding epidermal growth factor like growth factor (HB-EGF) is an emerging therapeutic for the regeneration of the tympanic membrane (TM). OBJECTIVE:Our aim was to determine whether the doses of HB-EGF delivered in a sustained release hydrogel into a middle ear mouse model, would be measurable in the s...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2016.1143482
更新日期:2016-10-01 00:00:00
abstract::This study assessed possible adverse immunological effects of trans-1,2-dichloroethylene (DCE) on random-bred CD-1 mice following 14 and 90 days of exposure. A 14-day range-finding study was performed on male mice by gavage at doses 1/10 and 1/100 the LD50 (210 and 21 mg/kg). No alterations in either humoral or cell-m...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480548509041066
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Plasmodium yoelii nigeriensis (P. y. nigeriensis) produces lethal malaria infection in Swiss albino mice. Reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide along with endogenously produced tumor necrosis factor (TNF) have been implicated in the pathogenesis of malaria. OBJECTIVE:Stud...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-100101976
更新日期:2000-11-01 00:00:00
abstract::Cardiotoxicity is commonly associated with cocaine abuse. Previous studies have indicated that cocaine alters myocardial mitochondrial function. This study was undertaken to investigate the effect of cocaine on activity of the mitochondrial electron transport chain in cultures of neonatal rat cardiomyocytes and in iso...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-100100119
更新日期:2000-05-01 00:00:00
abstract::The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and the National Oil and Hazardous Substances Pollution Contingency Plan (NCP) mandate protection of public health, welfare, and the environment at Superfund hazardous waste sites. The NCP requires lead response agenciesto integrate bas...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480549709003889
更新日期:1997-11-01 00:00:00
abstract::The present study enumerates the attenuating effects of curcumin and α-tocopherol against propoxur induced oxidative DNA damage in human peripheral blood mononuclear cells (PBMC). Cultured cells were isolated from peripheral blood of healthy volunteers, and were exposed to varying concentrations of propoxur (0-21 μg/m...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480545.2017.1321010
更新日期:2018-04-01 00:00:00