Cell protection induced by Acacia salicina extracts: inhibition of genotoxic damage and determination of its antioxidant capacity.

Abstract:

:Antioxidant activity of Acacia salicina extracts was determined by the ability of each extract to inhibit lipid peroxidation, to protect against DNA strand scission induced by hydroxyl radicals, and to scavenge the free radical, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(*+)). The IC(50) values of the inhibitory activity toward lipid peroxidation of total oligomer flavonoids (TOF), methanol, ethyl acetate, and aqueous extracts were respectively 28, 52, 472, and 480 microg/mL. All extracts have the ability to scavenge the ABTS(*+) radical by a hydrogen-donating mechanism and to protect pKS plasmid DNA against hydroxyl radicals- induced DNA damage. An assay for the ability of A. salicina extracts to prevent mutations induced by various mutagens in Salmonella typhimurium TA102 and TA104 cells was conducted. TOF, methanol, ethyl acetate, and aqueous extracts from leaf parts of A. salicina showed no mutagenicity either with or without the metabolic enzymes preparation (S9). Protection against methylmethanesulfonate-induced mutagenicity was observed for TOF, methanol, and ethyl acetate extracts. Likewise, all extracts exhibited a high inhibition level of the Ames response induced by the indirect mutagen, 2-aminoanthracene. The antigenotoxic activity could be ascribed, at least in part, to their antioxidant properties, but we cannot exclude additionally mechanisms. Thus, A. salicina may serve as an ideal candidate for a cost- effective, readily exploitable natural phytochemical compound.

journal_name

Drug Chem Toxicol

authors

Bouhlel I,Bhouri W,Limem I,Boubaker J,Nefatti A,Skandrani I,Ben Sghaier M,Kilani S,Ghedira K,Chekir Ghedira L

doi

10.1080/01480540802593899

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

139-49

issue

2

eissn

0148-0545

issn

1525-6014

journal_volume

32

pub_type

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